... is a kinase, thus it catalyses the following reaction: ATP + a protein = ADP + a phosphoprotein EIF2AK1 is induced by ... eIF-2 alpha) kinase from bone marrow culture". DNA Seq. 13 (3): 133-7. doi:10.1080/10425170290023428. PMID 12391722. Strausberg ... Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while ... Hwang SY, Kim MK, Kim JC (2001). "Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2alpha kinase: down- ...
Levin DH, Petryshyn R, London IM (1981). "Characterization of purified double-stranded RNA-activated eIF-2 alpha kinase from ... protein kinase R (PKR, a.k.a. EIF2AK2), members of the oligoadenylate synthetase family of proteins (OAS1, OAS2, OAS3), and ... 23 (2): 165-175. doi:10.1016/j.immuni.2005.06.008. PMID 16111635. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C (2004 ... 29 (2): 178-181. doi:10.1016/j.immuni.2008.07.009. PMID 18701081. Schmidt A, Schwerd T, Hamm W, Hellmuth JC, Cui S, et al. ( ...
"Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase". ... Heme-regulated inhibitor kinase) or EIF2AK1 PKR (Protein kinase R) PERK (PKR-like ER-localized eIF2α kinase) EIF2AK4 Zaborske ... Protein kinase GCN2 is a multidomain protein and its C-terminus contains a region homologous to histidyl-tRNA synthetase (HisRS ... So the recycling of eIF2, needed for TC formation, is inhibited by phosphorylation of eIF-2α, which in the end leads to a ...
... dna-activated protein kinase MeSH D08.811.913.696.620.682.700.300 --- eif-2 kinase MeSH D08.811.913.696.620.682.700.429 --- ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 3 MeSH D08.811.913.696.620.682.700.559.400 --- map kinase kinase kinase 4 MeSH D08.811.913.696.620.682 ... map kinase kinase 1 MeSH D08.811.913.696.620.682.700.565.200 --- map kinase kinase 2 MeSH D08.811.913.696.620.682.700.565.300 ...
... inhibits RNA-dependent protein kinase (PKR)-catalyzed eIF-2 R-subunit phosphorylation, and also reverses PKR-mediated ... Prigmore E, Ahmed S, Best A, Kozma R, Manser E, Segal AW, Lim L (May 1995). "A 68-kDa kinase and NADPH oxidase component ... Gil J, Esteban M, Roth D (2001). "In vivo regulation of the dsRNA-dependent protein kinase PKR by the cellular glycoprotein p67 ... Gil J, Esteban M, Roth D (December 2000). "In vivo regulation of the dsRNA-dependent protein kinase PKR by the cellular ...
It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK, as well as ... eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. CDC37 has been shown to ... Stepanova L, Leng X, Parker SB, Harper JW (Aug 1996). "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that ... The N-terminal domain binds to protein kinases. The central domain is the Hsp90 chaperone (heat shock protein 90) binding ...
Nebreda, A.R.; Hunt, T. (1993). "The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but ... They showed that inhibition of protein synthesis is mediated by reversible phosphorylation of initiation factor eIF-2 by two ... "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat ... He and others subsequently showed that cyclins bind and activate a family of protein kinases, now called the cyclin-dependent ...
RNA-dependent P1/eIF-2 alpha protein kinase from human cells". Virology. 188 (1): 33-46. doi:10.1016/0042-6822(92)90732-5. PMID ... Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein ... "Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis ... Protein kinase-R is activated by double-stranded RNA (dsRNA), introduced to the cells by a viral infection. PKR can also be ...
... heme-regulated inhibitor kinase (HRI) EIF2AK2: the double-stranded RNA-dependent kinase (PKR) EIF2AK3: PEK/PERK EIF2AK4: GCN2 ... eIF-2 Kinase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal. ... eIF-2 is a kinase enzyme that phosphorylates eIF-2. There are four forms in mammals: EIF2AK1: ... These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized ...
... ribosomal protein S6 kinase - ribosome - RNA - RNA virus - RNA-binding protein - RNA-directed DNA polymerase - rod outer ... eIF-2 - eIF-2 kinase - electrochemical potential - electron - electron capture - Electron configuration - electron microscopy ... CDC28 protein kinase - cell - cell adhesion molecule - Cell biology - cell cycle protein - cell membrane - cell membrane ... kinase - kinesin - kinetic energy - kinetics - knock-out mouse - Krebs cycle - lactalbumin - Lactic acid - lactic acid ...
protein kinase activity. • kinase activity. • protein serine/threonine kinase activity. • cyclin-dependent protein serine/ ... Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene ...
"Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational ... 234 (2): 257-80. doi:10.1006/jmbi.1993.1582. PMID 8230212.. *^ Swanson R, Hoben P, Sumner-Smith M, Uemura H, Watson L, Söll D ( ... It aminoacylates at the 2'-OH of a terminal adenosine nucleotide on tRNA, and it is usually monomeric or dimeric (one or two ... Regardless of where the aminoacyl is initially attached to the nucleotide, the 2'-O-aminoacyl-tRNA will ultimately migrate to ...
12 (2): 857-872. doi:10.1093/nar/12.2.857. ISSN 0305-1048. PMC 318541 . PMID 6694911.. ...
Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... protein kinase activity. • PDZ domain binding. • SH3 domain binding. • scaffold protein binding. • metal ion binding. • kinase ... "Entrez Gene: CIT citron (rho-interacting, serine/threonine kinase 21)".. *^ a b c Madaule P, Furuyashiki T, Reid T, Ishizaki T ...
Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... Receptor protein serine/threonine kinase (EC 2.7.11.30). *Bone morphogenetic protein receptors *BMPR1 ... a kinase and a phosphorylase. The BCKDHA gene encodes the alpha subunit of E1, and the BCKDHB gene (MIM 248611) encodes the ...
2 (2): 83-91. doi:10.1016/s0022-2836(60)80029-0.. *^ Wilson, Daniel N.; Doudna Cate, Jamie H. (May 2012). "The Structure and ... doi:10.1016/S0092-8674(00)00084-2. PMID 11007480.. *^ Yusupov MM, Yusupova GZ, Baucom A, et al. (May 2001). "Crystal structure ... Figure 5 : Translation of mRNA (1) by a ribosome (2)(shown as small and large subunits) into a polypeptide chain (3). The ... Ribosomes consist of two subunits that fit together (Figure 2) and work as one to translate the mRNA into a polypeptide chain ...
kinase activity. • protein binding. • ATP binding. • protein serine/threonine kinase activity. • protein kinase activity. ... Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second ...
Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... protein kinase activity. • protein serine/threonine kinase activity. • protein binding. • ATP binding. • magnesium ion binding ... Microtubule-associated serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MAST1 gene.[5] ...
PF00400 Receptor for activated C kinase 1. Table of Human large 60S ribosomal subunit proteins[edit]. Subunit No.. Subunit name ... 39 (2): 658-62. doi:10.1042/BST0390658. PMID 21428957.. *^ a b c d e f Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis ... A ribosomal protein (r-protein or rProtein[1][2][3]) is any of the proteins that, in conjunction with rRNA, make up the ... 2. 50S ribosomal protein L2. RL2_ ECOLI. PF03947 Ribosomal Proteins L2, C-terminal domain. P60422. ...
Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is ... protein kinase binding. • protein serine/threonine kinase activity. • identical protein binding. • MAP kinase kinase activity. ... kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for ... protein kinase activity. • kinase activity. • protein binding. • protein tyrosine kinase activity. • ATP binding. • ...
protein tyrosine kinase activity. • nucleotide binding. • MAP kinase kinase activity. • protein kinase activity. • protein ... kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for ... This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide ... Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ...
Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... protein serine/threonine kinase activity. • ATP binding. • kinase activity. • protein binding. Cellular component. • cell ... Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.[5][6][7] ...
Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... kinase activity. • protein binding. • RNA polymerase II carboxy-terminal domain kinase activity. • ATP binding. • protein ... Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.[5][6] ...
A major target of Akt kinases is glycogen synthase kinase-3. EC 2.7.1.37 Pelle. is a serine/threonine kinase that can ... Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... A serine/threonine protein kinase (EC 2.7.11.1) is a kinase enzyme that phosphorylates the OH group of serine or threonine ( ...
protein kinase activity. • cAMP-dependent protein kinase activity. • ADP binding. • AMP-activated protein kinase activity. • ... Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... cAMP-dependent protein kinase regulator activity. • protein kinase binding. • ATP binding. • adenyl ribonucleotide binding. ...
... protein tyrosine kinases and protein serine/threonine kinases. Dual-specificity kinases are subclass of the tyrosine kinases.[8 ... mTOR is a kinase within the family of phosphatidylinositol-3 kinase-related kinases (PIKKs),[9] which is a family of serine/ ... Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ...
... the eukaryotic initiation factors eIF-4E and eIF-4G, and poly(A)-binding protein. eIF-4E and eIF-4G block the decapping enzyme ... Quaresma, Alexandre J.; Sievert, Jeffrey A.; Nickerson, J. A. (2013), "Regulation of mRNA export by the PI3 kinase/AKT signal ... 2 (10): 17056. doi:10.1038/natrevmats.2017.56.. *^ a b Gousseinov, Elina; Kozlov, Mikhail; Scanlan, Claire; Hammons, Aaron; Bei ... 6 (2): 149-52. doi:10.4161/rna.6.2.8046.. *^ Cenik, Can; Chua, Hon Nian; Zhang, Hui; Tarnawsky, Stefan P.; Akef, Abdalla; Derti ...
Type I IFNs further activate p38 mitogen-activated protein kinase (MAP kinase) to induce gene transcription. Antiviral and ... the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within the ... Production of protein kinase R, for example, can be disrupted in cells infected with JEV Some viruses escape the anti-viral ... The phosphatidylinositol 3-kinase (PI3K) signaling pathway is also regulated by both type I and type II IFNs. PI3K activates ...