Loading...
*  Protein kinase R
RNA-dependent P1/eIF-2 alpha protein kinase from human cells". Virology. 188 (1): 33-46. doi:10.1016/0042-6822(92)90732-5. PMID ... Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein ... "Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis ... Protein kinase-R is activated by double-stranded RNA (dsRNA), introduced to the cells by a viral infection. PKR can also be ...
*  EIF-2 kinase
... heme-regulated inhibitor kinase (HRI) EIF2AK2: the double-stranded RNA-dependent kinase (PKR) EIF2AK3: PEK/PERK EIF2AK4: GCN2 ... eIF-2 Kinase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal. ... eIF-2 is a kinase enzyme that phosphorylates eIF-2. There are four forms in mammals: EIF2AK1: ... These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized ...
*  Gcn2
"Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase". ... Heme-regulated inhibitor kinase) or EIF2AK1 PKR (Protein kinase R) PERK (PKR-like ER-localized eIF2α kinase) EIF2AK4 Zaborske ... Protein kinase GCN2 is a multidomain protein and its C-terminus contains a region homologous to histidyl-tRNA synthetase (HisRS ... So the recycling of eIF2, needed for TC formation, is inhibited by phosphorylation of eIF-2α, which in the end leads to a ...
*  EIF2AK1
... is a kinase, thus it catalyses the following reaction: ATP + a protein = ADP + a phosphoprotein EIF2AK1 is induced by ... eIF-2 alpha) kinase from bone marrow culture". DNA Seq. 13 (3): 133-7. doi:10.1080/10425170290023428. PMID 12391722. Strausberg ... Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while ... Hwang SY, Kim MK, Kim JC (2001). "Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2alpha kinase: down- ...
*  RNA transfection
Levin DH, Petryshyn R, London IM (1981). "Characterization of purified double-stranded RNA-activated eIF-2 alpha kinase from ... protein kinase R (PKR, a.k.a. EIF2AK2), members of the oligoadenylate synthetase family of proteins (OAS1, OAS2, OAS3), and ... 23 (2): 165-175. doi:10.1016/j.immuni.2005.06.008. PMID 16111635. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C (2004 ... 29 (2): 178-181. doi:10.1016/j.immuni.2008.07.009. PMID 18701081. Schmidt A, Schwerd T, Hamm W, Hellmuth JC, Cui S, et al. ( ...
*  List of MeSH codes (D08)
... dna-activated protein kinase MeSH D08.811.913.696.620.682.700.300 --- eif-2 kinase MeSH D08.811.913.696.620.682.700.429 --- ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 3 MeSH D08.811.913.696.620.682.700.559.400 --- map kinase kinase kinase 4 MeSH D08.811.913.696.620.682 ... map kinase kinase 1 MeSH D08.811.913.696.620.682.700.565.200 --- map kinase kinase 2 MeSH D08.811.913.696.620.682.700.565.300 ...
*  Index of biochemistry articles
... ribosomal protein S6 kinase - ribosome - RNA - RNA virus - RNA-binding protein - RNA-directed DNA polymerase - rod outer ... eIF-2 - eIF-2 kinase - electrochemical potential - electron - electron capture - Electron configuration - electron microscopy ... CDC28 protein kinase - cell - cell adhesion molecule - Cell biology - cell cycle protein - cell membrane - cell membrane ... kinase - kinesin - kinetic energy - kinetics - knock-out mouse - Krebs cycle - lactalbumin - Lactic acid - lactic acid ...
*  METAP2
... inhibits RNA-dependent protein kinase (PKR)-catalyzed eIF-2 R-subunit phosphorylation, and also reverses PKR-mediated ... Prigmore E, Ahmed S, Best A, Kozma R, Manser E, Segal AW, Lim L (May 1995). "A 68-kDa kinase and NADPH oxidase component ... Gil J, Esteban M, Roth D (2001). "In vivo regulation of the dsRNA-dependent protein kinase PKR by the cellular glycoprotein p67 ... Gil J, Esteban M, Roth D (December 2000). "In vivo regulation of the dsRNA-dependent protein kinase PKR by the cellular ...
*  CDC37
It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK, as well as ... eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. CDC37 has been shown to ... Stepanova L, Leng X, Parker SB, Harper JW (Aug 1996). "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that ... The N-terminal domain binds to protein kinases. The central domain is the Hsp90 chaperone (heat shock protein 90) binding ...
*  Tim Hunt
Nebreda, A.R.; Hunt, T. (1993). "The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but ... They showed that inhibition of protein synthesis is mediated by reversible phosphorylation of initiation factor eIF-2 by two ... "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat ... He and others subsequently showed that cyclins bind and activate a family of protein kinases, now called the cyclin-dependent ...
*  List of MeSH codes (D12.644)
... cdc2 protein kinase MeSH D12.644.360.275 --- eif-2 kinase MeSH D12.644.360.287 --- focal adhesion protein-tyrosine kinases MeSH ... map kinase kinase kinase 3 MeSH D12.644.360.400.400 --- map kinase kinase kinase 4 MeSH D12.644.360.400.500 --- map kinase ... map kinase kinase kinases MeSH D12.644.360.400.100 --- map kinase kinase kinase 1 MeSH D12.644.360.400.200 --- map kinase ... map kinase kinase 3 MeSH D12.644.360.440.400 --- map kinase kinase 4 MeSH D12.644.360.440.500 --- map kinase kinase 5 MeSH ...
*  Interferon
Type I IFNs further activate p38 mitogen-activated protein kinase (MAP kinase) to induce gene transcription. Antiviral and ... the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within the ... Production of protein kinase R, for example, can be disrupted in cells infected with JEV Some viruses escape the anti-viral ... The phosphatidylinositol 3-kinase (PI3K) signaling pathway is also regulated by both type I and type II IFNs. PI3K activates ...
*  EIF2
Heme-regulated inhibitor kinase) or EIF2AK1 PKR (Protein kinase R) PERK (PKR-like ER-localized eIF2α kinase) GCN2 (eukaryotic ... EIF-2 at the US National Library of Medicine Medical Subject Headings (MeSH) Cap-dependent translation initiation from Nature ... Those kinases act as a result of stress such as amino acid deprivation (GCN2), ER stress (PERK), the presence of dsRNA (PKR) ... Phosphorylation takes place at the α-subunit, which is a target for a number of serine kinases that phosphorylate serine 51. ...
*  EIF-W2 protein domain
... a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase ... eIF-4 gamma and eIF-5 and it may be involved in the interaction of eIF-2B, eIF-4 gamma, and eIF-5 with eIF-2. In molecular ... the eIF-W2 domain functions as the binding site for Mnk eIF4E kinase, an enzyme that phosphorylates eukaryotic initiation ... eIF-2B-epsilon) [1] Eukaryotic translation initiation factor 4 gamma (eIF-4-gamma) [2] Eukaryotic translation initiation factor ...
*  EIF2AK3
Hayes SE, Conner LJ, Stramm LE, Shi Y (1999). "Assignment of pancreatic eIF-2alpha kinase (EIF2AK3) to human chromosome band ... also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the ... and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian ... Yan W, Frank CL, Korth MJ, Sopher BL, Novoa I, Ron D, Katze MG (December 2002). "Control of PERK eIF2alpha kinase activity by ...
*  EIF2A
Wang J, Laschinger C, Zhao XH, Mak B, Seth A, McCulloch CA (Apr 2005). "Mechanical force activates eIF-2alpha phospho-kinases ... "Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the ... "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase". ... "Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 ...
*  Integrated stress response
Protein kinase R stress pathway induced by dsRNA (indicative of a potential viral infection). Heme-regulated inhibitor kinase ... ISR is a common denominator of different types of cellular stresses resulting in activation of at least one of the eIF-2 alpha ... Pathways that activate eIF-2 alpha include: mTOR pathway induced by insufficient glucose and other nutrients. unfolded protein ...
*  Insulin-like growth factor 1
Phosphorylation of eukaryotic initiation factor 4e (eif-4E) [4EBP] by mTOR inhibits the capacity of 4EBP to inhibit eif-4E and ... Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a ... Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural ... A key pathway is regulated by phosphatidylinositol-3 kinase (PI3K) and its downstream partner, the mammalian target of ...
*  EIF2S1
Kramer G (1990). "Two phosphorylation sites on eIF-2 alpha". FEBS Lett. 267 (2): 181-182. doi:10.1016/0014-5793(90)80919-A. ... 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol ... Miyamoto S, Chiorini JA, Urcelay E, Safer B (1996). "Regulation of gene expression for translation initiation factor eIF-2 ... 1993). "Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase". Proc. Natl. ...
*  EIF2B4
Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene. GRCh38: Ensembl ... activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J ... "The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at ... J. 318 (2): 637-43. PMC 1217679 . PMID 8929216. Henderson RA, Krissansen GW, Yong RY, Leung E, Watson JD, Dholakia JN (Dec 1994 ...
*  Guanine nucleotide exchange factor
eIF-2b regenerates the GTP-bound form of eIF-2 for an additional cycle in protein synthesis initiation, i.e., its binding to ... The GEF SOS1 activates Ras, whose target is the kinase Raf. Raf is a proto-oncogene because mutations in this protein have been ... Price N, Proud C (1994). "The guanine nucleotide-exchange factor, eIF-2B". Biochimie. 76 (8): 748-60. doi:10.1016/0300-9084(94) ... eIF-2b is a eukaryotic initiation factor necessary to initiate protein translation. ...
*  Torreyanic acid
... was found to be 5-10 times more potent in cell lines sensitive to protein kinase C (PKC) agonists, 12-o- ... It has been proposed that the eukaryotic translation initiation factor EIF-4a is a potential biochemical target for the natural ... A 2-methyl-2-butenoic acid moiety was installed to afford 11. Intermediate 11 underwent a Stille vinylation with (E)-tributyl-1 ... There are over 150 natural products that are presumed to undergo a [4+2] Diels-Alder type cycloaddition, belonging to classes ...
*  EIF2S2
1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol ... 1994). "Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2". Biochem. ... 2004). "Eukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on CK2alpha activity". Biochem. ... virally activated protein kinase, PKR". J. Biol. Chem. 272 (13): 8388-95. doi:10.1074/jbc.272.13.8388. PMID 9079663. Das S, ...
*  Protein phosphatase 1
... and protein kinase R then phosphorylates a protein called eukaryotic initiation factor-2A (eIF-2A), which inactivates eIF-2A. ... EIF-2A is required for translation so by shutting down eIF-2A, the cell prevents the virus from hijacking its own protein- ... Protein kinase A can reduce the activity of PP1. The glycogen binding region, GM, becomes phosphorylated, which causes its ... Also, when other substrates become phosphorylated by protein kinase A, they can bind to the catalytic subunit of PP1 and ...
*  DDX5
2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. ... Ford MJ, Anton IA, Lane DP (1988). "Nuclear protein with sequence homology to translation initiation factor eIF-4A". Nature. ... Buelt MK, Glidden BJ, Storm DR (1994). "Regulation of p68 RNA helicase by calmodulin and protein kinase C". J. Biol. Chem. 269 ... "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem. 276 ( ...
*  Eukaryotic translation initiation factor 4 gamma 1
"The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the ... "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine ... "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the ... Yan R, Rhoads RE (Mar 1995). "Human protein synthesis initiation factor eIF-4 gamma is encoded by a single gene (EIF4G) that ...