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*  P-selectin
In human, P-selectin has nine repeats while E-selectin contains six and L-selectin has only two. P-selectin is anchored in ... P-selectin has a functional role in metastasis of tumor similar to E-selectin. P-selectin is expressed on the surface of both ... However, PSGL-1 is not specific for P-selectin, as it can also function as a ligand for both E- and L-selectin. P-selectin ... "Comparison of human eosinophil and neutrophil ligands for P-selectin: ligands for P-selectin differ from those for E-selectin ...
*  Soluble cell adhesion molecules
E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular expression of CAMs is ... Soluble forms of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin (termed sICAM-1, sVCAM-1 ... and sE-selectin respectively) are found in the plasma, and are elevated during inflammatory conditions in which there is ...
*  Cell adhesion molecule
L-selectin (leukocyte), and P-selectin (platelet). The best-characterized ligand for the three selectins is P-selectin ... The selectins are a family of heterophilic CAMs that bind fucosylated carbohydrates, e.g., mucins. The three family members are ... Integrins and the Ig-superfamily CAMs do not depend on Ca2+ while cadherins and selectins depend on Ca2+. In addition, ... and the selectins. One classification system involves the distinction between calcium-independent CAMs and calcium-dependent ...
*  Epithelial cell adhesion molecule
... selectins, and members of the immunoglobulin super-family. EpCAM is a glycosylated, 30- to 40-kDa type I membrane protein. The ...
*  Selectin
There are three subsets of selectins: E-selectin (in endothelial cells) L-selectin (in lymphocytes) P-selectin (in platelets ... In addition to E-selectin, the role of P-selectin (expressed on platelets) and L-selectin (on leukocytes) in cancer ... E-selectin to the plasma membrane, and L-selectin to the tips of microfolds on leukocytes. The name selectin comes from the ... "Comparison of human eosinophil and neutrophil ligands for P-selectin: ligands for P-selectin differ from those for E-selectin ...
*  FERMT3
... compromises their adhesion to the inflamed endothelia and affects neutrophil granulocyte binding and spreading while selectin ...
*  P-selectin glycoprotein ligand-1
... which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of ... 1997). "Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin". J. Cell Biol. 137 (2): 509-19. doi: ... 1996). "P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation". Blood. 88 (7): 2415-21 ... The first step in this interaction process is carried out by PSGL-1 interacting with P-selectin and/or E-selectin on ...
*  E-selectin
Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene. E selectin ... The E-selectin locus flanks the L-selectin locus on chromosome 1. Different from P-selectin, which is stored in vesicles called ... "Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic ... E-selectin is found to mediate the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands on the tumor ...
*  L-selectin
1997). "L-selectin from human, but not from mouse neutrophils binds directly to E-selectin". J. Cell Biol. 136 (3): 707-16. doi ... L-selectin is also present on the surface of human embryo trophoblasts prior to implantation into the uterus. Similar to its ... L-selectin, also known as CD62L, is a cell adhesion molecule found on lymphocytes and the preimplantation embryo. It belongs to ... 1997). "L-selectin activates the Ras pathway via the tyrosine kinase p56lck". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15376-81. ...
*  Cell junction
There are three types of selectins found in humans; L-selectin, P-selectin and E-selectin. L-selectin deals with lymphocytes, ... There are four main types: selectins, cadherins, integrins, and the immunoglobulin superfamily. Selectins are cell adhesion ... monocytes and neutrophils, P-selectin deals with platelets and endothelium and E-selectin deals only with endothelium. They ... Tedder TF, Steeber DA, Chen A, Engel P (July 1995). "The selectins: vascular adhesion molecules". FASEB J. 9 (10): 866-73. PMID ...
*  Thromboxane receptor
... and E-selectin); stimulates apoptosis (i.e. cell death) of CD4+ and CD8+ lymphocytes; causes the chemokinesis (i.e. cell ...
*  CD34
It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell. Conversely, under other ... It also interacts with L-selectin, important in inflammation. Cluster of differentiation List of histologic stains that aid in ... "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin". The ... "Complexity and differential expression of carbohydrate epitopes associated with L-selectin recognition of high endothelial ...
*  Catch bond
Because one leukocyte has many selectins around the surface, these selectin binding/ unbinding cause a rolling motion on the ... January 2004). "Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan". The ... Catch-slip behavior has also been reported for dissociation of L-selectin from endoglycan, P-selectin from PSGL-1, FimH from ... Similar to selectin binding, FimH binding also have a threshold where it only starts binding to the host cells above this ...
*  C5a receptor
"C5a-induced expression of P-selectin in endothelial cells". The Journal of Clinical Investigation. 94 (3): 1147-55. doi:10.1172 ...
*  HP59
Endothelial involvement is indicated by levels of Soluble E-Selectin. Fu C, Bardhan S, Cetateanu ND, Wamil BD, Wang Y, Yan HP, ... Wamil BD, Thurman GB, Sundell HW, DeVore RF, Wakefield G, Johnson DH, Wang YF, Hellerqvist CG (1997). "Soluble E-selectin in ...
*  LAMP2
This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also ... LAMP2, along with LAMP1, interact with E-selectin and galectins to mediate the adhesion of some cancer cells to the ECM. The ...
*  Platelet alpha-granule
The alpha granules express the adhesion molecule P-selectin and CD63. These are transferred to the membrane after synthesis. ...
*  Proteases in angiogenesis
Additional examples are the proteolytic shedding of soluble E-selectin, shedding of urokinase receptor (uPAR) by MMP-12 ... "Src and phosphatidylinositol 3-kinase mediate soluble E-selectin induced angiogenesis". Blood. 101 (10): 3960-3968. doi:10.1182 ...
*  SNX27
"Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Molecular Biology of the Cell. 15 (7): ...
*  Addressin
They carry carbohydrates in order to be recognized by L-selectin. The protein encoded by this gene is an endothelial cell ... adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA- ...
*  Leukocyte extravasation
E-selectins: E-selectin is expressed on activated endothelial cells. Synthesis of E-selectin follows shortly after P-selectin ... E-selectins bind PSGL-1 and ESL-1. L-selectins: L-selectins are constitutively expressed on some leukocytes, and are known to ... P-selectins: P-selectin is expressed on activated endothelial cells and platelets. Synthesis of P-selectin can be induced by ... If L-selectin is not produced, the immune response may be ten times slower, as P-selectins (which can also be produced by ...
*  Implantation (human embryo)
Carson, D. D.; et al., (2006). "MUC1 is a scaffold for selectin ligands in the human uterus". Front. Biosci. 11 (1): 2903. doi: ... An in vitro model of implantation developed by Genbacev et al., gave evidence to support the hypothesis that L-selectin ... MUC1 displays carbohydrate moieties on its extracellular domain that are ligands of L-selectin, a protein expressed on the ... Genbacev, O. D.; et al., (2003). "Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface". Science. 299: 405- ...
*  Gut-specific homing
The adhesin expressed by the naïve T cells is L-selectin (1). once the T cells are activated they repress the expression of L ... An example of this is the interaction between L-selectin and the PNAD (peripheral node addressin) ligand. Arrest of the ' ... This 'rolling interaction' occurs in three stages: Initial binding of a lymphocyte selectin and its ligand. This creates an ... These integrins interact with E-selectin molecules found on inflamed skin. Breast specific homing- Involved in the redirection ...
*  SNX17
This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P- ... selectin. SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8 GRCh38: Ensembl release 89: ... "A new member of the sorting nexin family interacts with the C-terminus of P-selectin". Biochem. Biophys. Res. Commun. 281 (4): ... "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J. Mol. Biol. 347 (4): 813-25. doi: ...
*  Versican
The binding of versican with leukocyte adhesion molecules L-selectin, P-selectin, and CD44 is also mediated by the interaction ... Both CD44 and L-selectin have been implicated in leukocyte trafficking. The ability of versican to bind a large panel of ...