Schaffer, Regina (July 27, 2021). "Rare genetic variant may protect against obesity, provide new drug target". Healio. ... O'Connell, Jon (December 31, 2016). "Geisinger acquisition opens doors for TCMC research, financial stability". The Scranton ... of the Arthritis Foundation awarded a grant to Geisinger to study the potential treatment of Raynaud syndrome with drugs ...

Peplow M (April 2013). "Sanofi launches malaria drug production to maintain stability in artemisinin availability". ... After negotiation with the WHO, Novartis and Sanofi provide ACT drugs at cost on a nonprofit basis; however, these drugs are ... Two main mechanisms of resistance drive Plasmodium resistance to antimalarial drugs. The first one is an efflux of the drug ... Taylor WR, White NJ (2004). "Antimalarial drug toxicity: a review". Drug Safety. 27 (1): 25-61. doi:10.2165/00002018-200427010- ...

... is an immune stimulant drug. It has a molecular weight of 64.9 KDa that activated dendritic cells of the human immune ... It specifically targets endosomal TLR3 with good solubility and serum stability. Naumann, Kai; Wehner, Rebekka; Schwarze, Anett ...

In 4 years, Paz Estenssoro's administration achieved economic and social stability. The military stayed out of politics, and ... ambassador Manuel Rocha warned the Bolivian electorate that if they voted for a candidate known to have links with drug- ...

An increase in the world price of silver brought Bolivia a measure of relative prosperity and political stability in the late ... Hyperinflation had reached an annual rate of 24,000%. Social unrest, chronic strikes, and unchecked drug trafficking were ... In 4 years, Paz Estenssoro's administration achieved economic and social stability. The military stayed out of politics, and ... which under both the Carter and Ronald Reagan administrations refused to recognize García's government due to its drug ties. [1 ...

There also is a lack of local stability, as mayors cannot be re-elected. This requires electing a new mayor each term. Drug ... Drug seizures "Drug seizures Report From Year: 2009 Until Year: 2012 Drug Group: Cocaine-type". United Nations Office on Drugs ... European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), 2006. Annual Report 2006: The State of the Drugs Problem in ... medications Drug liberalization Drug trafficking organizations Illegal drug trade in the Indian Ocean region Maritime drug ...

"Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence". ACS Chem Biol. 14 (4): 751-757. ... Lai AC, Crews CM (February 2017). "Induced protein degradation: an emerging drug discovery paradigm". Nature Reviews. Drug ... possibly because of drug patents and/or drug exclusivity. A later patent for Faslodex expires in January 2021. Atossa Genetics ... Hormonal antineoplastic drugs, Organofluorides, Peripherally selective drugs, Selective estrogen receptor degraders, World Anti ...

... improving driving stability and handling; and also to improve downforce while reducing drag. The GT-R Nismo GT3 have competed ... All GT-R variants had a drag coefficient of Cd=0.26, which was the lowest drag coefficient for a production sports car at the ... The target of the team was to make the GT-R have a drag coefficient of Cd=0.28 or lower, combined with front and rear downforce ... This was a rear biased all-wheel-drive system, helping the GT-R for its incredible handling and stability at high speeds. In ...

Conway said that he had had experience with such drugs himself, and that "with psychedelic drugs, hallucinogens, if they've ... This affects his mental stability and his relationships with his friends. Spider-Man uses this to his advantage during one ... In 1977, Harry is engaged to Mary Jane, but shows signs of a drug addiction brought upon by the stress of his position and his ... Troubled by what she finds, Norah concludes that Harry has a drug problem and resolves to help him through it. After many near- ...

United Nations Office on Drugs and Crime, 2013. Ledebur, K.; Youngers, C. (2013). "From Conflict to Collaboration: An ... Innovative Approach to Reducing Coca Cultivation in Bolivia". Stability: International Journal of Security and Development. 2 ( ...

The anti-cancer drug Samarium (153Sm) lexidronam is also derived from EDTMP. Svara, J.; Weferling, N.; Hofmann, T. "Phosphorus ... It has good chemical stability and thermal tolerance. It shows excellent scale inhibition ability under temperature 200 °C. It ...

Stability, Biological Activities and Its Commercial Applications-A Review". Marine Drugs. 12 (1): 128-152. doi:10.3390/ ... "Summary of Color Additives for Use in United States in Foods, Drugs, Cosmetics, and Medical Devices". Food and Drug ... Stability, Biological Activities and Its Commercial Applications-A Review". Marine Drugs. 12 (1): 128-152. doi:10.3390/ ... Summary of Color Additives for Use in the United States in Foods, Drugs, Cosmetics, and Medical Devices. Fda.gov. Retrieved on ...

179-. ISBN 978-94-011-4439-1. "Drugs@FDA: FDA Approved Drug Products". United States Food and Drug Administration. Retrieved 28 ... Methyltestosterone has dramatically improved oral bioavailability and metabolic stability relative to testosterone. This ... Erectile dysfunction drugs, Female sexual dysfunction drugs, Hepatotoxins, Hormonal antineoplastic drugs, Synthetic estrogens, ... The drug was introduced for medical use in 1936. Methyltestosterone is the INN, USAN, USP, BAN, and JAN of the drug and its ...

Winglets at the tips reducing both induced drag and providing yaw stability. Positive lift from the canard for stability ... reduces drag and increases net lift. Improved roll-rate due to reduced roll damping and inertia. Good yaw stability from the ... Reduced drag through reduction in fuselage wetted area. ... stability and control properties, as well as a high L/D ratio ... but used a controllable foreplane for stability and control in the pitch and yaw axes. One built. FVA-4 Pipö The FVA-4 was a ...

Some aircraft have low stability to reduce trim drag. This has the benefit of reducing fuel consumption. Some aerobatic and ... The longitudinal stability of an aircraft, also called pitch stability, refers to the aircraft's stability in its plane of ... Low or negative stability is called relaxed stability. An aircraft with low or negative static stability will typically have ... Longitudinal static stability refers to the aircraft's initial tendency on pitching. Dynamic stability refers to whether ...

The cyclodextrin confers solubility and stability to these drugs. The inclusion compounds of cyclodextrins with hydrophobic ... Cyclodextrins were also shown to enhance mucosal penetration of drugs. β-cyclodextrins are used to produce stationary phase ... They are used in food, pharmaceutical, drug delivery, and chemical industries, as well as agriculture and environmental ... They have been applied for delivery of a variety of drugs, including hydrocortisone, prostaglandin, nitroglycerin, itraconazol ...

Koenigbauer, MJ; Brooks SH; Rullo G; Couch RA (1992). "Solid-state stability testing of drugs by isothermal calorimetry". ... from solid-state stability of polymers (Hardison et al. 2003) to efficacy of drug compounds against parasitic worms (Maneck et ... The extreme stability of research-grade instruments (< ±100 μK/24h ) means that accurate measurements can be (and often are) ... Also, IMC not only documents the general metabolic decline over time due to the drugs, but also the overall frequency of worm ...

"Recent advances in co-amorphous drug formulations". Advanced Drug Delivery Reviews. 100: 116-125. doi:10.1016/j.addr.2015.12. ... Rossotti, F. J. C.; Rossotti, H. (1961). "Chapter 9: Solubility". The Determination of Stability Constants. McGraw-Hill. ... Amorphous drugs have higher solubility than their crystalline counterparts due to the absence of long-distance interactions ... The effect of amorphous phase on solubility is widely used to make drugs more soluble. For condensed phases (solids and liquids ...

Drugs missing an ATC code, Drugs with no legal status, Articles containing unverified chemical infoboxes, All articles with ... Stability of cannabinoids in stored plant material". Journal of Pharmaceutical Sciences. 62 (10): 1601-1605. doi:10.1002/jps. ... Garrett ER, Gouyette AJ, Roseboom H (January 1978). "Stability of tetrahydrocannabinols II". Journal of Pharmaceutical Sciences ... Drug Metabolism and Disposition. 20 (1): 79-83. PMID 1347001. Golombek P, Müller M, Barthlott I, Sproll C, Lachenmeier DW (June ...

The drug has shown neuroprotective effects in an animal model of cerebral ischemia. Aceburic acid Aceturic acid N- ... Aceglutamide functions as a prodrug to glutamine with improved potency and stability. Aceglutamide is used as a psychostimulant ... 3-. ISBN 978-1-4757-2085-3. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 6-. ISBN 978- ... on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats". Japanese Journal of Pharmacology. ...

"Stability of resveratrol over time and in the various stages of grape transformation". Drugs Exp Clin Res. 24 (4): 207-211. ... Sharan S, Nagar S; Nagar (2013). "Pulmonary metabolism of resveratrol: In vitro and in vivo evidence". Drug Metabolism and ... Baur JA, Sinclair DA (2006). "Therapeutic potential of resveratrol: the in vivo evidence". Nature Reviews Drug Discovery. 5 (6 ... Baell, J; Walters, MA (25 September 2014). "Chemistry: Chemical con artists foil drug discovery". Nature. 513 (7519): 481-483. ...

"Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates". Bioconjugate ... The latter drawback is especially important for the preparation of targeted therapies, such as antibody-drug conjugates. The ... Due to increased stability of bioconjugates obtained with analogous APN-based payloads (a schematic reaction is shown in the ... drug conjugates and other biologics. Standard procedure for APN protein labeling consists in incubation of a protein containing ...

October 2014). "Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates". ... "Approved Drugs > FDA Approves Gemtuzumab Ozogamicin for CD33-positive AML". fda.gov. Silver Spring, USA: U.S. Food and Drug ... As the antibody-drug conjugate field has matured a more accurate definition of ADC is now Anything-Drug Conjugate. Alternatives ... Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. ...

The drugs cyclandelate and homatropine are esters of mandelic acid. Merck Index, 11th Edition, 5599. Bjerrum, J., et al. ... Stability Constants, Chemical Society, London, 1958. See: Winckler, F. L. (1831) "Ueber die Zersetzung des Calomels durch ... It is a useful precursor to various drugs. The molecule is chiral. The racemic mixture is known as paramandelic acid. Mandelic ...

For stability, the wing would have carried floats near each wingtip; these would have incorporated a retraction mechanism to ... reduce drag. It would have been powered by an arrangement of six de Havilland Ghost turbojet engines mounted inside of the ...

Drug and Alcohol Dependence, 1; 142:333-340, 2014. Mazure CM, Weinberger AH, Pittman B, Sibon I, Swendsen J. Gender and stress ... Stability of smoking status in the US population: a longitudinal investigation. Addiction, 109(9):1541-1553, 2014. Smith PH, ... Weinberger, AH; Pilver, CE; Mazure, CM; McKee, SA (2015-09-28). "Stability of smoking status in the US population: a ... Drug Alcohol Depend. 142: 333-40. doi:10.1016/j.drugalcdep.2014.07.003. PMC 4158455. PMID 25064023. Mazure, CM; Weinberger, AH ...

Klamt, Andreas (2005). COSMO-RS from quantum chemistry to fluid phase thermodynamics and drug design (1st ed.). Amsterdam: ... "Project: Ionic Strength Corrections for Stability Constants". IUPAC. Archived from the original on 29 October 2008. Retrieved ...

"A prodrug approach to increasing the oral potency of a phenolic drug. 1. Synthesis, characterization, and stability of an O-( ... George W.A Milne (8 May 2018). Drugs: Synonyms and Properties: Synonyms and Properties. Taylor & Francis. pp. 1406-. ISBN 978-1 ... J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. ... Expert Opin Investig Drugs. 7 (4): 575-89. doi:10.1517/13543784.7.4.575. PMID 15991994. Elger W, Schwarz S, Hedden A, Reddersen ...

Trissel LA, Zhang Y (2004). "Long-term stability of trimix: a three-drug injection used to treat erectile dysfunction". ... Drugs missing an ATC code, Drugs that are a combination of chemicals, Erectile dysfunction drugs, Combination drugs, All stub ... Erectile Dysfunction Drugs v t e (Articles with short description, Short description is different from Wikidata, Chemicals that ... Trimix is an injectable three-drug prescribed medication used to treat erectile dysfunction. The active ingredients in the ...

It is difficult to measure the plasma concentration due to low stability of Phenethylamine. There are two possible metabolism ... the pharmacology and drug effects of most of the synthetic drugs are not well-known. Misuse of synthetic drugs can be fatal so ... As the drug also affects the central nervous system, administration of such drug before surgery is not recommended. ... Synthetic drugs refer to substances that are artificially modified from naturally-occurring drugs and are capable of exhibiting ...

The configurational stability of a drug is therefore an area of interest in pharmaceutical research. The production and ... The drug is therefore not considered safe for use by women of child-bearing age, and while it has other uses, its use is ... Another commonly used drug is ibuprofen which is only anti-inflammatory as one enantiomer while the other is biologically inert ... Many psychotropic drugs show differing activity or efficacy between isomers, e.g. amphetamine is often dispensed as racemic ...

Another synthetic drug specific to the adenosine A2A receptor subtype is CGS-21680 that has been shown to cause apneas in 14- ... Two key features of the pre-BötC are its stability and its ability to adapt to changing environmental and behavioral conditions ...

Prostitution, gambling, and drug abuse (particularly of opium) were widespread. Chinese criminal secret societies (analogous to ... The British were concerned about communist influence and labour strikes which were undermining Singapore's economic stability, ...

Most detainees in re-education through labor facilities are reported to be drug users, petty criminals, and prostitutes, as ... China's security agencies have defended the use of the system as being necessary to maintain social stability. A 1997 report in ... Although drug abusers are ostensibly placed in re-education through labor to be treated for their addictions, some testimonial ... and trafficking illegal drugs, as well as political dissidents, petitioners, and Falun Gong followers. It was separate from the ...

After Todd is sent to prison for Marty's rape, he vows he will escape, and does so by drugging himself and forcing himself to ... demonstrating Todd's damaged personality and calling into question his mental stability. Carlivati said that Todd was convinced ... He witnesses Dani collapse from a drug overdose due to her abuse of oxycodone. While she is recovering at the hospital, an ... to plant drugs in Jason Webb's jacket. All I knew was that my first name was Todd. I don't know what happened next. They called ...

... sensitizes drug-resistant lung tumors to chemotherapy". Proc Natl Acad Sci U S A. 107 (48): 20786-91. doi:10.1073/pnas. ... Is Critical for Cell Viability and Chromosome Stability". Cell. 107 (1): 67-77. doi:10.1016/s0092-8674(01)00504-9. ISSN 0092- ...

For high-powered aircraft, the loss of lift (and increase in drag) beyond the stall angle is less of a problem than maintaining ... "Airplane stability and control" by Malcolm J. Abzug, E. Eugene Larrabee. Chapter 17. ISBN 0-521-80992-4. Pugachev's Cobra ... Unlike powered airplanes, which can control descent by increasing or decreasing thrust, gliders have to increase drag to ... increase the drag, and allow the aircraft to descend more rapidly without gaining speed. Spoilers are also deployed ...

"FDA Drug Safety Communication: Completed safety review of Xenical/Alli (orlistat) and severe liver injury". U.S. Food and Drug ... However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity ... "Drug Patent Expirations in June 2009". DrugPatentWatch.com, in "Drug Patent Expirations in June 2009". Biotech Blog. 1 June ... an immunosuppressive drug frequently used to prevent transplant rejection; the two drugs should therefore not be administered ...

The drug dealer and cult leader Adolfo Constanzo orchestrated several executions during rituals that included the victims' ... by removing individuals that have a negative effect on societal stability (criminals, religious heretics, foreign slaves or ... possibly carried out in a drug induced state. At about 2800 BCE, any possible evidence of such practices disappeared, though ... with their faces painted red and drugged with large doses of nicotine, were ritually strangled. Tattooed Serpent was then ...

... and housing stability at risk, particularly that they were not utilizing drugs or alcohol. Housing was seen as the end goal of ... Housing was not removed from someone if their drug or alcohol use did not stop, or if they refused to comply with treatment. If ... There was no requirement to stop drinking or using drugs and no requirement to accept treatment in return for housing. ... Participants were often evicted from housing due to failure to abstain from drugs and alcohol and refusing to undergo ...

Despite the stability provided by their relationship with youth club worker J.J. (Geoffrey Rhue), the boys are tempted by the ... fast money of the drug trade and touched by untimely death. Amid the flurry of mixed messages, the boys must decide which paths ...

The maximum load torque that can be applied to a motor without losing its synchronism is called steady state stability limit of ... "dragged behind the resultant air-gap flux by the retarding torque of a shaft load". There are two major types of synchronous ... Stability.) Record player turntables Increased efficiency in low-speed applications (e.g. ball mills). AC Polyphase synchronous ...

Haiti's potential as a trading partner and an actor in the drug trade makes the nation strategically important to the United ... Because of Haiti's location, Haiti has the potential to affect the stability of the Caribbean and Latin America and is ... In fact, the question of minimum wage could be another drag on investors' interest. Under a recently enacted law, the minimum ... and counter illegal migration and drug trafficking. The US also supports and facilitates bilateral trade and investment along ...

In 1928, they improved the synthesis of CFCs and demonstrated their usefulness for such a purpose and their stability and ... Sneader W (2005). "Chapter 8: Systematic medicine". Drug discovery: a history. Chichester, England: John Wiley and Sons. pp. 74 ...

... and that in many cases they move away from alcohol and drug use, gaining "a degree of intellectual security, emotional ... stability and organised behavioural patterns that contrast sharply with their previously confused and chaotic existences". He ...

... and stability in flight. The autopilot system can control the aircraft's course via waypoints, or it can be controlled in real ... Mohajer-4s are used by Iran's border guard to interdict drug smuggling. Also known as the Sadiq, the Mohajer-4B is a ... The Mohajer-4 features a squarish body and low-mounted trapezoidal wings with upward-canted wingtips to lessen drag. It is ...

"PCIJ findings: What's flawed, fuzzy with drug war numbers? - Philippine Center for Investigative Journalism". www.pcij.org. " ... stability and prosperity in East Asia and the world", the joint statement said. They likewise underlined their commitment to ... towards forging lasting peace and stability in East Asia. The leaders agreed to strengthen cooperation in addressing common ... of the heads of states and governments of Asean and its dialogue partners to work toward the attainment of peace and stability ...

Ghana: Peace and Stability: Chapters from the Intelligence Sector. Cocaine hits drug family, mama don't die. National Security ... In November 1999 he was awarded the ECOWAS Drug Control Merit Award in Dakar, Senegal in recognition of his outstanding ... contribution to the war against drug abuse and illicit trafficking in West Africa. On the 40th Anniversary of Ghana's ...

The P-1 featured a semi-retractable tail wheel to decrease drag. Armament consisted of an MG 15 in the nose, and a sliding hood ... During the second test flight Nitschke revealed there was insufficient longitudinal stability during climb and flight at full ... Carrying bombs externally increased weight and drag and impaired the aircraft's performance significantly. Carrying the maximum ...

She also struggled with insomnia and an eating disorder and began using drugs; by age 20, she had used "just about every drug ... Two years later, after adopting her first child, Jolie found stability in her life, later stating, "I knew once I committed to ... Celebrity profiles routinely covered her fascination with blood and knives, experiences with drugs, and her sex life, ...

Various health authorities, including Health Canada and the U.S. Food and Drug Administration (FDA), consider kōji-kin (A. ... that makes it bitter as it ages Sake has high microbiological stability due to its high content of ethanol, but incidences[ ...

"NZ votes for stability after chaos". News.com.au. 27 November 2011. Retrieved 13 December 2020. "Third term lucky". The ... Berry, Stephen (23 March 2018). "Pharmac's anti-HIV drug subsidy is an own goal for LGBT". The Spinoff. Retrieved 22 March 2021 ...

Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE (June 1976). "The effects of morphine- and nalorphine- like drugs in ... structure-affinity relationships and in vitro metabolic stability". Bioorganic & Medicinal Chemistry. 17 (10): 3630-3641. doi: ... Brimson JM, Prasanth MI, Malar DS, Brimson S, Thitilertdecha P, Tencomnao T (June 2021). "Drugs that offer the potential to ... Hayashi T, Su TP (2004). "Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders". CNS Drugs. 18 (5 ...

... a change which allowed Ray to develop as a songwriter while leaving him increasingly separated from the emerging youth and drug ... the presence of the singer's friends both deepens his embarrassment and strengthens his stability and sense of companionship". ...

"Kelly Lynch on Magic City, John Hughes, and playing a drag king". The A.V. Club. "BIGFOOT #7 " Bigfoot 4×4, Inc. - Monster ... and he needs a first-rate cooler to maintain stability. Handed control of all bar operations and hiring by Frank, Dalton fires ... "Kelly Lynch on Magic City, John Hughes, and playing a drag king". Archived from the original on December 12, 2017. Retrieved ... "Kelly Lynch on Magic City, John Hughes, and playing a drag king". Archived from the original on December 12, 2017. Retrieved ...

The war had dragged on since 1917 and cost Spain $800 million. The Spanish officers of the war ended up taking the brutality of ... Isabella ensured long-term political stability in Spain by arranging strategic marriages for each of her five children. Her ...

It has been used not only in the study of neuronal plasticity and information processing but also in drug and toxin effects on ... Their goal was to establish the stability of network burst profiles on the timescale of minutes to hours and to establish ... set out to establish the stability of spontaneous network bursts as a function of time. They saw bursts throughout the lifetime ... In summary, they were successful in demonstrating stability over minutes to hours, but the PPs gathered over the course of days ...

Kontact has gained a new planner summary and support for drag and drop in the free/busy view. KSnapshot now uses the window ... The release primarily focused on stability, with numerous bugs fixed and few new features added. This was the final KDE SC 4 ... "4.9 Releases - Quality, Stability". "KDE - KDE Software Compilation 4.10". kde.org. 6 February 2013. "KDE - KDE Software ... "KDE - KDE Development Platform 4.5.0 gains performance, stability, new high-speed cache and support for WebKit". kde.org. ...

Because of zinc's antibiotic nature, it is often used in many drugs against bacterial infections in humans. Inversely, due to ... calcium and this abundance is reflected in its lack of redox toxicity and its participation in the structure stability of ...

The weight and drag of the floats reduced the maximum speed to 241 mph (388 km/h). As the performance of the basic F4F-3 was ... To restore the stability, small auxiliary fins were added to the tailplane. Because this was still insufficient, a ventral fin ...