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*  List of MeSH codes (E05)
... drug screening assays, antitumor MeSH E05.337.550.200.800 --- tumor stem cell assay MeSH E05.337.550.200.900 --- xenograft ... drug screening assays, antitumor MeSH E05.200.500.388.930 --- tumor stem cell assay MeSH E05.200.500.410 --- electroporation ... multiphasic screening MeSH E05.318.308.250.580.580 --- neonatal screening MeSH E05.318.308.250.580.925 --- vision screening ... model antitumor assays MeSH E05.337.550.200.900.830 --- subrenal capsule assay MeSH E05.337.550.400 --- microbial sensitivity ...
*  Kalkitoxin
These isolated molecules are screened via in-vitro assays to measure their effects in standardized paradigms designed to select ... Many efforts to discover cancer therapeutic drugs focus on the screening of novel biomolecules produced and isolated from ... Kalkitoxin was originally isolated from Lyngbya majuscula as an effort to collect new molecules for testing as antitumor or ... One of the first tests of kalkitoxin tumor-selective cytotoxicity used an in-vitro assay to test solid tumor selectivity of ...
*  Streptomyces lavendulae
Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay. ... Microbial drug discovery: 80 years of progress. J Antibiot. 62:5-16. Lown JW, Begetter A, Johnson D, Morgan AR. 1976. ... Research on Antibiotic Screening in Japan over the Last Decade: A Producing Microorganisms Approach. Actinomycetologica. 9:100- ... Many natural compounds have led to the discovery of drugs used to treat human disease. Out of the 22,500 biologically active ...
*  MTOR inhibitors
It enhances antitumor activity of some other drugs such as vincristine. Dactolisib seems to inhibit effectively both wild-type ... New mTOR-specific inhibitors came forth from screening and drug discovery efforts. These compounds block activity of both mTOR ... Thus, this data is based on preclinical assays, based on in vitro cultured tumor cell lines, which suggest that the effects of ... Temsirolimus is pro-drug of rapamycin. It is approved by the U.S. Food and Drug Administration (FDA) and the European Medicines ...
*  DNA polymerase beta
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens ... Yeast three-hybrid assays have shown that this protein binds to the stem loops within the 3'UTR of the POLB mRNA, however the ... and drug resistance. DNA polymerase beta maintains genome integrity by participating in base excision repair. Overexpression of ... impact on sensitivity towards antitumor agents". Oncogene. 20 (43): 6181-7. doi:10.1038/sj.onc.1204743. PMID 11593426. ...
*  Hartmann F. Stähelin
Guided by Stähelin's in-vitro and in-vivo assays, they found the active compound responsible for the good antitumor activity of ... Stähelin's invention of this procedure initiated an innovative screening system for discovering immunosuppressant drugs lacking ... Stähelin had used a similar screen to discover the nonmyelotoxic immunosuppressant ovalicin. Applying the revised screen led to ... This drug was to revolutionize organ transplantation in the 1970s and the paper became a citation classic (CC/6:16-16, February ...
*  Folate targeting
2007). "Preclinical antitumor activity of a novel folate-targeted dual drug conjugate". Mol. Pharm. 4 (5): 659-67. doi:10.1021/ ... Because novel FR-targeted therapies are now being tested clinically, having the ability to screen patients for FR-positive ... These include an invasive tissue-based immunohistochemical assay, and a non-invasive radiodiagnostic approach. The latter ... Targeted drug therapy is advantageous because it deposits the drug at the specific location where it can be most useful in ...
*  Camptothecin
It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was ... M.E. Wall; M.C.Wani; C.E. Cook; K.H.Palmer; A.I.McPhail; G.A.Sim (1966). "Plant antitumor agents. I. The isolation and ... Replacement in any position results in much less potent compound than parent compound in other cytotoxicity assay. The E-ring ... Reduced drug-HSA interactions could result in improved activity. Studies have shown that substitution at position 7, 9, 10 and ...
*  MHC multimer
Tetramer assays are used for single-cell phenotyping and cell counting, and offer an important advantage over other methods, ... MHC tetramers are used in studies of pathogen immunity and vaccine development, in evaluation of antitumor responses, in ... covering a broad range of epitopes to assist with screening and monitoring CMV progression in future clinical settings. ... These reagents are therefore important for future drug and vaccine development. Immudex has currently developed a CMV Dextramer ...
*  Ligand binding assay
"In situ drug-receptor binding kinetics in single cells: a quantitative label-free study of anti-tumor drug resistance". ... Many ligand binding assays require a filtration step to separate bound and unbound ligands before screening. A method called ... binding-assay.com/binding-assay-types/solid-phase-assays/on-bead-assays Moss, ed. by Tom (2001). "Filter-Binding Assays". DNA- ... 2009). Ligand-binding assays development, validation, and implementation in the drug development arena. Hoboken, N.J.: John ...
*  Zidovudine
Using a line of CD4+ T cells that they had made, they developed an assay to screen drugs for their ability to protect CD4+ T ... leading to the development of the antitumor agent 6-mercaptopurine. Jerome Horwitz of the Barbara Ann Karmanos Cancer Institute ... another drug that had shown effective anti-HIV activity in the laboratory. This initial trial of AZT proved that the drug could ... This assay could simultaneously test both the anti-HIV effect of the compounds and their toxicity against infected T cells. In ...
*  Drug discovery
One example of a successful use of this strategy is the screening for antitumour agents by the National Cancer Institute, ... for example compounds that are hits in almost every assay, classified by medicinal chemists as "pan-assay interference ... The "final product" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III ... informatics Cheminformatics Drug discovery hit to lead Drug metabolism Fragment-based drug discovery High content screening ...
*  Kinesin family member 11
"In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities". Mol Cancer Ther ... microtubule gliding assays, single molecule motility assays, and optical trap assays. In microtubule gliding assays, kinesins ... Drugs that specifically inhibit only human Kinesin-5 are alternatives to the taxanes and vinc alkaloids that target ... In single molecule motility assays, velocities for Kinesin-5 were similar to those seen in microtubule gliding assays, and the ...
*  Discovery and development of antiandrogens
In vitro assays have shown them both to be selective AR agonists and that they inhibit proliferation of several prostate cancer ... Screening of chemical libraries for AR blockers led to the discovery of the first antiandrogen, cyproterone. An acetate group ... These drugs may therefore be effective as a second-line therapy for refractory prostate cancer previously treated with ... "Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study". Lancet. 375 (9724): 1437-46. doi: ...
*  Chemotherapy
Ther Drug Monit. 36 (1): 93-99. "ARK™ Methotrexate Assay". Ark Diagnostics. "Customizing Chemotherapy for Better Cancer Care". ... DNA-Interactive Alkylating Agents and Antitumour Platinum-Based Drugs. John Wiley & Sons, Ltd. doi:10.1002/0470025077.chap84b. ... and hence it has been recommended that the babies be screened. Between 30 and 40 percent of patients undergoing chemotherapy ... drug-to-drug interactions, genetics, and obesity, which has a major impact on the actual concentration of the drug in the ...
*  Vaccine
... s are complex mixtures of biological compounds, and unlike the case of drugs, there are no true generic vaccines. The ... Pregnant women are often screened for continued resistance to rubella. The human papillomavirus vaccine is recommended in the U ... Van Oirschot JT, Gielkens AL, Moormann RJ, Berns AJ (1990). "Marker vaccines, virus protein-specific antibody assays and the ... 2016). "Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor ...
*  Paclitaxel
ISBN 978-0-521-56123-5. NCI Drug Information Summary for Patients. NCI Drug Dictionary Definition Molecule of the Month: TAXOL ... In general, in vitro assays involving microtubules, such as motility assays, rely on paclitaxel to maintain microtubule ... The discovery of paclitaxel began in 1962 as a result of a U.S. National Cancer Institute-funded screening program. A number of ... Wani M, Taylor H, Wall M, Coggon P, McPhail A (1971). "Plant antitumor agents. VI. The isolation and structure of taxol, a ...
*  Isothermal microcalorimetry
2008). Analogous successful use of IMC to determine the effects of antitumor drugs on tumor cells in culture within a few hours ... If absolute data are required (e.g. quantity of product produced by a process), then assays can be conducted in parallel on ... This is especially useful for comparative screening-e.g. the effects of different combinations of material composition and/or ... Also, IMC not only documents the general metabolic decline over time due to the drugs, but also the overall frequency of worm ...
*  Induced stem cells
... human antibody generation and drug screening applications. Using MitoBloCK-6 and/or PluriSIn # 1 the differentiated progenitor ... iPSCs have been shown to support the development of all-iPSC mice using a tetraploid (4n) embryo, the most stringent assay for ... They augment anti-tumor responses by producing interferon-gamma (IFN-γ). The approach of collection, reprogramming/ ... of drugs, toxicity testing of various drugs. It is interesting to note that the tissue grown from iPSCs, placed in the " ...
*  Survivin
... survivin was expressed in all 60 different human tumour lines used in the National Cancer Institute's cancer drug-screening ... In vitro assays and other tests were also performed to validate the idea of the occurrence of an actual immune response to ... "Survivin-derived peptide epitopes and their role for induction of antitumor immunity in hematological malignancies". Leuk. ... A. Cellular T Cell Response The first evidence of survivin-specific CTL recognition and killing was shown in an assay wherein ...
*  C-Met inhibitor
A number of similar analogues were found and assayed. Structurally similar series of c-Met inhibitors in which a phenolic hinge ... Still, the risk of accumulated toxicity and interactions with other drugs remains. Ultimately, as a key element in the ... "The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approach", Bioorganic & ... offered the first proof that relatively selective c-Met inhibitors could be identified and that the inhibition leads to an anti ...
*  GRB2
Robertson H, Langdon WY, Thien CB, Bowtell DD (Nov 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 ... Vidal M, Liu WQ, Gril B, Assayag F, Poupon MF, Garbay C (2004). "[Design of new anti-tumor agents interrupting deregulated ... VanderNoot VA, Fitzpatrick FA (Sep 1995). "Competitive binding assay of src homology domain 3 interactions between 5- ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ...
*  Platinum nanoparticle
In another study, a Pt nanoparticle of diameter 140 nm was encapsulated within a PEG nanoparticle to move an antitumor drug, ... The damage to the DNA was measured for individual cells using single-gel electrophoresis via the comet assay. Researchers have ... Combinatorial electrochemistry: A highly parallel, optical screening method for discovery of better electrocatalysts, Science. ... Current research using platinum nanoparticles in drug delivery uses platinum-based carries to move antitumor medicine. In one ...
*  Multiple myeloma
... the serum free light chain assay, has recently been recommended by the International Myeloma Working Group for the screening, ... Curran M, McKeage K (2009). "Bortezomib: A Review of its Use in Patients with Multiple Myeloma". Drugs. 69 (7): 859-888. doi: ... they have also been observed to have a direct anti-tumor effect even in patients without known skeletal disease.[citation ...
*  Index of oncology articles
... antitumor antibiotic - Antiviral drug - anxiolytic - APC - APC vaccine - APC8015 - apheresis - aplastic anemia - aplidine - ... CA 19-9 assay - CA-125 - CA-125 test - cachexia - calcitonin - calcitriol - CAM - Campath-1H - camptothecin - camptothecin ... screening mammogram - Scutellaria barbata - SDX-102 - SDX-105 - second primary cancer - second-line therapy - second-look ... drug tolerance - dry orgasm - DTGM fusion protein - ductal carcinoma - ductal carcinoma in situ - ductal lavage - Dukes' ...