Neuroblastoma breakpoint family, member 1, or NBPF1, is a protein that is encoded by the gene NBPF1 in humans. This protein is ... Aberrant Wnt signaling in the brain is a common cause of tumor growth and drug resistance in neuroblastomas, further suggesting ... Ille F, Sommer L (May 2005). "Wnt signaling: multiple functions in neural development" (PDF). Cellular and Molecular Life ... In non-primate mammals, the gene sequences of NBPF-like genes have little similarity to the primate NBPF genes. These genes ...
"Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent ... "Anti-Inflammatory Bioactives of Honokiol through Inhibition of Protein Kinase C, Mitogen-Activated Protein Kinase, and the NF- ... Chao, Louis Kuoping; Liao, Pei-Chun; Ho, Chen-Lung; Wang, Eugene I-Chen; Chuang, Chao-Chin; Chiu, Huan-Wen; Hung, Lang-Bang; ... So potent is honokiol's pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple ...
This protein localizes to the endoplasmic reticulum and is known to metabolize many drugs. Polymorphism within this gene is ... "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily". Biochemistry. 30 ... Center for Drug Evaluation and Research. "Drug Interactions & Labeling - Drug Development and Drug Interactions: Table of ... it is the CYP2C19 gene that encodes the CYP2C19 protein. CYP2C19 is a liver enzyme that acts on at least 10% of drugs in ...
... including those of multi-drug resistance. It was given a U.S. Food and Drug Administration (FDA) fast-track approval and was ... In some Enterobacteriaceae species, mutations in ribosomal genes such as rpsJ have been found to cause resistance to ... Arora R, Jain S, Rahimi H (1 April 2018). "Evaluating the efficacy of Tigecycline to target multiple cancer-types: A Review". ... The antileukemic activity of tigecycline can be attributed to the inhibition of mitochondrial protein translation in eukaryotic ...
Pan D, Xue W, Zhang W, Liu H, Yao X (October 2012). "Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ... In a modular gene network, for example, a gene that induces a limited set of other genes that control a specific trait under ... For protein engineering we wish to increase evolvability, and in medicine and agriculture we wish to decrease it. Protein ... For example, consider an enzyme with multiple alleles in the population. Each allele catalyzes the same reaction, but with a ...
Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but ... Obtaining estimates for the ages of all the protein-coding genes and most of the ontology-identified noncoding genes of the ... This experiment demonstrated that understanding clinical drug resistance will require knowledge of the drug levels to which ... contribute to drug resistance. Their kinetic studies further supported the hypothesis that drug transport via PfCRT and PfMDR1 ...
... which imparted resistance in myeloma cells to chemotherapeutic drug. NF-κB is a major transcription factor that regulates genes ... which are proteins that contain multiple copies of a sequence called ankyrin repeats. By virtue of their ankyrin repeat domains ... Genes on human chromosome 11, Protein pages needing a picture, Genes on human chromosome 10, Genes on human chromosome 19, ... The NAD+-dependent protein deacetylase and longevity factor SIRT1 inhibits NF-κB gene expression by deacetylating the RelA/p65 ...
... the MupA gene may co-transfer with other antibacterial resistance genes. This has been observed already with resistance genes ... "Relationship of protein structure of isoleucyl-tRNA synthetase with pseudomonic acid resistance of Escherichia coli. A proposed ... "Mupirocin". Drug Information Portal. U.S. National Library of Medicine. Portal: Medicine (Articles with short description, ... This may be an adaptation to increase the throughput rate or to bind multiple substrates simultaneously. Pseudomonic acid A is ...
December 2014). "Patient-derived models of acquired resistance can identify effective drug combinations for cancer". Science. ... "A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts". Scientific ... using the genetic material encoding reprogramming protein factors, recombinant proteins; microRNA, a synthetic, self- ... when reprogramming genes (Ascl1, Brn2a and Myt1l) are activated after transplantation using a drug. Astrocytes - the most ...
These drugs are only functional against IAV but are no longer recommended for use because of widespread resistance to them ... The matrix protein (M1) and membrane protein (M2) share a segment, as do the non-structural protein (NS1) and the nuclear ... Avian H9N2 is also of concern because although it is LPAI, it is a common donor of genes to H5N1 and H7N9 during reassortment. ... Children who have not had multiple prior exposures to influenza viruses shed the virus at greater quantities and for a longer ...
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. TYK2 was the first member of ... Development of a TYK2 inhibitor appears to be a rational approach in the drug discovery. A mutation in this gene has been ... Further elucidation of molecular mechanisms of LPS signaling, showed that TYK2 and IFN-β deficiency leads resistance to LPS- ... This gene encodes a member of the tyrosine kinase and, to be more specific, the Janus kinases (JAKs) protein families. This ...
MarC is encoded by a gene at the multiple antibiotic resistance (mar) locus. The mar locus consists of two divergently ... KS-1. The cloned gene, snatA, encodes a protein of 216 amino acid residues, SnatA (TC# 2.A.95.1.4), with six membrane-spanning ... Loss of MppA causes overproduction of MarA which activates acrAB, causing pleiotropic drug resistance. MppA probably functions ... a small protein of 71 amino acyl residues of unknown function. A periplasmic binding protein, MppA, essential for the uptake of ...
Internal viral protein encoding gene segments (RNA molecule): (M, NP, NS, PA, PB1, PB2) M codes for the matrix proteins (M1 and ... HA, NA, and M specify the structure of proteins that are most medically relevant as targets for antiviral drugs and antibodies ... As of 2007, "The emergence of 3 (or more) substrains from the EMA [EMA=Europe, Middle East, Africa] clade represents multiple ... The amino acid substitution (Ser31Asn) in M2 some H5N1 genotypes is associated with amantadine resistance. NP codes for ...
Chen HY, Shao CJ, Chen FR, Kwan AL, Chen ZP (2010). "Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in ... Zou XP, Zhang B, Zhang XQ, Chen M, Cao J, Liu WJ (November 2009). "Promoter hypermethylation of multiple genes in early gastric ... In cancer, a number of mutational changes are found in protein coding genes. Colorectal cancers typically have 3 to 6 driver ... Individual miRNAs can each target, and repress transcription of, on average, roughly 200 messenger RNAs of protein coding genes ...
... is caused by a genetic mutation in one of two genes. Mutation of the DMPK gene causes myotonic dystrophy ... DMPK codes for myotonic dystrophy protein kinase, a protein expressed predominantly in skeletal muscle. Between 5 and 37 ... Insulin resistance can also occur. Signs and symptoms vary considerably by severity, unusual phenotype, and form (DM1/DM2).[ ... As a result, people with multiple symptoms that may be explained by a complex disorder such as DM1 or DM2 will generally be ...
FHA has multiple risk factors, with links to stress-related, weight-related, and exercise-related factors. FHA is caused by ... The genes implicated included the following: FGFR1, which is involved in the specification, fate, migration, and survival of ... These drugs, which can include conjugated estrogen, micronized estradiol, and transdermal estrogen may be implicated to prevent ... Implicated loci encode proteins necessary for proper GnRH secretion, action, and neuronal development. The variable ...
This is especially true of tuberculosis, with increasing occurrence of multiple drug-resistant tuberculosis (MDR-TB) worldwide ... or by one species acquiring resistance from another through horizontal gene transfer. Extended use of antibiotics appears to ... Factors include:: §1:72 An antigen is a protein on the virus' surface that host antibodies can recognize and attack. Changes in ... Antibiotic resistance applies specifically to bacteria that become resistant to antibiotics. Resistance in bacteria can arise ...
... where the two drugs lead to a synergistic response. JNK kinases are implicated in the development of insulin resistance in ... There are indeed a number of proteins involved in ERK signaling, that can bind to multiple elements of the pathway: MP1 binds ... Thus ERK1 and ERK2 both correspond to the Drosophila kinase rolled, JNK1, JNK2 and JNK3 are all orthologous to the gene basket ... A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine ...
... gene and drug delivery. Attaching a single polymer chain to a specific site away from the active center of the protein has less ... A polymer shell is formed by conjugation of multiple molecules of polymers onto the protein core. The polymer shell can either ... These polymer-ferritin constructs exhibited protease resistance, enabling longer retention time within the bloodstream while ... whose protein core can adsorb high numbers of hydrophobic drugs. An efficient way to synthesize protein-polymer hybrid ...
... change the protein that the gene encodes-but others can confer evolutionary advantages such as resistance to antiviral drugs. ... and reproduce by creating multiple copies of themselves through self-assembly. Although they have genes, they do not have a ... One of the most effective is the presence of so-called resistance (R) genes. Each R gene confers resistance to a particular ... Dinesh-Kumar SP, Tham WH, Baker BJ (December 2000). "Structure-function analysis of the tobacco mosaic virus resistance gene N ...
... but also re-localization of eIF4E protein. eIF4E mRNA stability are also regulated by HuR and TIAR proteins. eIF4E gene ... however drug resistance to ribavirin is an emergent problem to long term disease control. eIF4E has also been targeted by ... "Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation ... Regulation of eIF4E by Partner Proteins Assembly of the eIF4F complex is inhibited by proteins known as eIF4E-binding proteins ...
Profiling of abundant proteins associated with dichlorodiphenyltrichloroethane (DDT)-resistance in Drosophila melanogaster. ... Pittendrigh has used Drosophila melanogaster as a model system to understand how organisms respond to dietary factors or drugs ... Genotyping of human lice reveals multiple emergences of body lice from local head louse populations. PLoS Neglected Tropical ... Evolutionary toxicogenomics: diversification of the Cyp12d1 and Cyp12d3 genes in Drosophila species. Journal of Molecular ...
Drug therapies can inhibit PIK3CA. Another example is the BRAF gene, one of the first to be implicated in melanomas. BRAF ... "SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein ... 264-bp deletion and 66-bp deletion in the complex 1 subunit gene ND1) in multiple types of cancer provide some evidence that ... Metastasis and drug resistance are distinguishable. Access to methylation profiling is important to cancer research because: ...
While 3T3-L1 gene expression mimics that of a white adipocyte, some literature suggests some phenotypic 3T3-L1 characteristics ... 3T3-L1 cells can be utilized to study a number of cellular and molecular mechanisms related to insulin-resistance, obesity, and ... Isopanduratin A also inhibited adipogenesis in 3T3-L1 adipocytes by impacting multiple targets in the adipogenic growth cycle ... These cells are also sensitive to lipogenic and lipolytic hormones, as well as drugs, including epinephrine, isoproterenol, and ...
"Mutations in Genes Encoding Penicillin-Binding Proteins and Efflux Pumps Play a Role in β-Lactam Resistance in Helicobacter ... Using any of these, bacteria commonly develop resistance to different antibiotics, a phenomenon called multi-drug resistance. ... there are multiple mutations in different genes that make PBP variants. Enzymatic destruction by β-lactamases is the most ... In MRSA, mutations in the genes (mec system) for PBP produce a variant protein called PBP2a (also termed PBP2'), while making ...
May 2012). "A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of ... Evidence has also implicated HER2 signaling in resistance to the EGFR-targeted cancer drug cetuximab. The high expression of ... multiple names: authors list, Articles with short description, Short description is different from Wikidata, Genes on human ... ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also ...
This will, in turn, slow the development of resistance to this drug. Fourth, severe shortages of plant-derived artemisinin are ... These and other gene expression tools now enable precise control of the expression of the genes that encode novel metabolic ... and a protein engineering approach to attach several enzymes of a metabolic pathway onto a synthetic protein scaffold to ... "The regulatory mechanisms of human immunodeficiency virus replication predict multiple expression rates". Proceedings of the ...
C. parvum possesses multiple oxysterol-binding proteins (OSBPs), and oxysterol related proteins (OSRPs). Only OSBPs are capable ... GP900 may also play a role in C. parvum's resistance to proteolysis by the numerous proteases found in the mammalian gut. In ... Unlike other apicomplexans, C. parvum has no genes in its plastids or mitochondria. Treatment of gastrointestinal infection in ... As of January 2015[update], nitazoxanide is the only drug approved for the treatment of cryptosporidiosis in immunocompetent ...
... as well as making it easy to avoid multiple ingredients if a canine is allergic to more than one. In novel protein recipes, ... Food and Drug Administration - Center for Veterinary Medicine. Archived from the original on June 25, 2006. Retrieved 2005-01- ... Peterson, Mark D.; Sen, Ananda; Gordon, Paul M. (February 2011). "Influence of resistance exercise on lean body mass in aging ... yet also have ten genes that are responsible for starch and glucose digestion, as well as the ability to produce amylase, an ...
Measured resistance to the standard antiviral drugs amantadine and rimantadine in H3N2 has increased from 1% in 1994 to 12% in ... in which genes from multiple subtypes reassorted to form a new virus. This pandemic killed an estimated 1-4 million people ... position 627 in the PB2 protein encoded by the PB2 RNA gene. Until H5N1, all known avian influenza viruses had a glutamic acid ... There also is the potential of viruses to evolve drug resistance. Some H5N1-infected persons treated with oseltamivir have ...
Two main mechanisms of resistance drive Plasmodium resistance to antimalarial drugs. The first one is an efflux of the drug ... The parasite's kelch gene on chromosome 13 appears to be a reliable molecular marker for clinical resistance in Southeast Asia ... To be effective, it would have to be administered multiple times each day.[citation needed] The WHO recommends avoiding ACT for ... This process produces free radicals that in turn damage susceptible proteins, resulting in the death of the parasite. In 2016 ...
Treatment of A. terreus is clinically challenging due to its nearly complete resistance to amphotericin B, the fallback drug ... A. terreus contains 30-35 Mbp and roughly 10,000 protein-coding genes. Identification of virulence determinants within the ... CS1 maint: multiple names: authors list, Articles with short description, Short description is different from Wikidata, ... It was also the initial source for the drug mevinolin (lovastatin), a drug for lowering serum cholesterol. Aspergillus terreus ...