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*  Acute myeloid dendritic cell leukemia
Initial response to multiagent chemotherapy is seen in about 80-90% cases, but relapses with subsequent resistance to drugs is ... Kaur V (2016). "A rare case of blastic plasmacytoid dendritic cell neoplasm with deletion 7q.31, in the setting of heavy pre- ... 2016). "A rare case of blastic plasmacytoid dendritic cell neoplasm with deletion 7q.31, in the setting of heavy pre-treatment ... A few cases of therapy related blastic plasmacytoid dendritic cell neoplasm (BPDCN) have also been reported. The clinical ...
*  PDGFRB
Primary or acquired drug resistance to this drug is very rare. Additional adjuvant chemotherapy may be necessary if a patients ... This continuous signaling, it is presumed, leads to the development of myeloid and/or lymphoid neoplasms that commonly include ... The drug often causes long-term complete hematological and cytogenic remissions as doses well below those used to treat chronic ... The disease is treated with a chemotherapy drug, lenalidomide. Human chromosome translocations between the PDGFRB gene and at ...
*  Clonal hypereosinophilia
... lymphoid neoplasms, or features of both types of neoplasms. Most commonly, the present with features of myeloid neoplasms with ... This resistance is linked to the occurrence of a S601P mutation in PDGFRA. Acquired resistance to imatinib have in most cases ... That is, many types of these disorders are remarkably susceptible to relatively non-toxic drugs. Hematopoietic stem cells give ... Like the latter neoplasm, hematologic neoplasms cause by ETV6-JAK2 and BCR-JAK2 are aggressive and progress rapidly. Too few ...
*  Lung cancer
Spaans, JN; Goss, GD (August 2014). "Trials to overcome drug resistance to EGFR and ALK targeted therapies-past, present, and ... Horn, L; Lovly, CM; Johnson, DH (2015). "Chapter 107: Neoplasms of the lung". In Kasper, DL; Hauser, SL; Jameson, JL; Fauci, AS ... Clinical trials are underway to evaluate how well these drugs kill lung cancer cells in humans. Several drugs that target ... Targeting these tags with drugs can kill cancer cells. Early-stage research in NSCLC using drugs aimed at epigenetic ...
*  Tetracycline antibiotics
Inactivation is the rarest type of resistance, where an acetyl group is added to the molecule, causing inactivation of the drug ... diabetes and various types of neoplasms. Incyclinide was announced to be ineffective for rosacea in September 2007. Several ... Expert Opinion on Drug Safety. 7 (5): 571-577. doi:10.1517/14740338.7.5.571. ISSN 1744-764X. PMID 18759709. Resistance,, WHO ... although drug-resistance is mounting and their effect on overall mortality is questioned. Tetracycline derivatives are ...
*  Somatic evolution in cancer
Sequential application of drugs can lead to the sequential evolution of resistance mutations to each drug in turn. Gleevec is ... which may be benign neoplasms) or else a malignant neoplasm (cancer). These neoplasms are also indicated, in the diagram below ... However, most patients' tumors eventually become resistant to these drugs. Two major mechanisms of acquired resistance have ... Schimke RT (May 1984). "Gene amplification, drug resistance, and cancer". Cancer Res. 44 (5): 1735-42. PMID 6713376. Curt GA, ...
*  List of MeSH codes (G12)
... drug resistance, multiple, viral MeSH G12.392.395 --- drug resistance, neoplasm MeSH G12.392.491 --- insecticide resistance ... drug resistance, fungal MeSH G12.392.269.383.500 --- drug resistance, multiple, fungal MeSH G12.392.269.420 --- drug resistance ... drug resistance, multiple, viral MeSH G12.392.300 --- drug resistance, multiple MeSH G12.392.300.500 --- drug resistance, ... herb-drug interactions MeSH G12.392.269 --- drug resistance, microbial MeSH G12.392.269.347 --- drug resistance, bacterial MeSH ...
*  C-peptide
Creative Peptides, Eli Lilly, and Cebix all had drug development programs for a C-peptide product. Cebix had the only ongoing ... C-peptide may be used for determining the possibility of gastrinomas associated with Multiple Endocrine Neoplasm syndromes (MEN ... to help determine degree of insulin resistance. Therapeutic use of C-peptide has been explored in small clinical trials in ... Bigelow, Bruce V. (23 February 2015). "Cebix Shuts Down Following Mid-Stage Trial of C-Peptide Drug". Xconomy. Garde, Damian ( ...
*  Oncogenomics
Metastasis and drug resistance are distinguishable. Access to methylation profiling is important to cancer research because: ... caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm ... Drug therapies can inhibit PIK3CA. Another example is the BRAF gene, one of the first to be implicated in melanomas. BRAF ... Some anticancer drugs target mtDNA and have shown positive results in killing tumor cells. Research has used mitochondrial ...
*  Ubiquitin
Dou QP, Li B (August 1999). "Proteasome inhibitors as potential novel anticancer agents". Drug Resistance Updates. 2 (4): 215- ... Kales SC, Ryan PE, Nau MM, Lipkowitz S (June 2010). "Cbl and human myeloid neoplasms: the Cbl oncogene comes of age". Cancer ... Vries EG, Verweij J (2000). "Clinical Cancer Research 2000: New Agents and Therapies". Drug Resistance Updates. 3 (4): 197-201 ... Drug Resistance Updates. 5 (6): 249-58. doi:10.1016/s1368-7646(02)00121-8. PMID 12531181. Clifford SC, Cockman ME, Smallwood AC ...
*  Regulation of transcription in cancer
Chen HY, Shao CJ, Chen FR, Kwan AL, Chen ZP (2010). "Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in ... Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms). Thus, CpG island hyper/hypo- ...
*  Topoisomerase inhibitor
... indicative of prolonged drug action The indenoisoquinolines are seldom or not used as substrates for the multidrug resistance ... Use of topoisomerase inhibitors for antineoplastic treatments may lead to secondary neoplasms because of DNA damaging ... rapid reversal of the trapped cleavable complex after drug removal, requiring prolonged infusions, 3) resistance of cancer ... These drugs are anti-cancer therapies. bacterial type II topoisomerase inhibitors (gyrase and topo IV): fluoroquinolones. These ...
*  List of MeSH codes (G04)
... drug resistance, fungal MeSH G04.185.515.286.383.500 --- drug resistance, multiple, fungal MeSH G04.185.515.286.420 --- drug ... neoplasm regression, spontaneous MeSH G04.335.119.260 --- erythrocyte aging MeSH G04.335.122.100 --- autocrine communication ... drug resistance, multiple MeSH G04.185.515.329.500 --- drug resistance, multiple, bacterial MeSH G04.185.515.329.625 --- drug ... drug resistance, microbial MeSH G04.185.515.286.347 --- drug resistance, bacterial MeSH G04.185.515.286.347.500 --- beta-lactam ...
*  Follicular lymphoma
Trial results released in June 2012 show that bendamustine, a drug first developed in East Germany in the 1960s, more than ... ISBN 0-7817-5007-5. Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and ... clinical evidence suggests that rituximab could be also used in combination with integrin inhibitors to overcome the resistance ... This combination therapy also left patients with fewer side effects than the older treatment (a combination of five drugs- ...
*  Boil
... lymphoproliferative neoplasms, malnutrition, and use of immunosuppressive drugs.. People with recurrent boils are as well more ... It may occur following antibiotic use due to the development of resistance to the antibiotics used. An associated skin disease ... Knowledge of the antimicrobial resistance of S. aureus is important in the selection of antimicrobials for treatment. Nodule ( ... Laube S, Farrell M (2002). "Bacterial skin infection in the elderly: diagnosis and treatment". Drugs and Aging. 19 (5): 331-42 ...
*  BRAF (gene)
"Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance". Nature. 494 (7436): 251-256. ... a benign but locally infiltrative odontogenic neoplasm. The V600E mutation may also be linked, as a single-driver mutation (a ... In spite of the drug's high efficacy, 20% of tumors still develop resistance to the treatment. In mice, 20% of tumors become ... Drugs that treat cancers driven by BRAF mutations have been developed. Two of these drugs, vemurafenib and dabrafenib are ...
*  H19 (gene)
Curiously, mutant revertant MCF-7/AdrVp cells that lost their multidrug resistance and became drug-sensitive also lost H19 ... In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... Drug-resistant MCF-AdrVp cells do not overexpress P-glycoprotein, a cell membrane efflux pump commonly found in multidrug ... p95, or NCA-90, is related to carcinoembryonic antigens, which have been found to reduce drug toxicity by Kawaharata et al. NCI ...
*  FIP1L1
Acquired resistance to Gleevec is uncommon but has been observed in patients whose mutated cells develop a T674I or D842V ... This drug, also known as Gleevec, has been a FDA-approved and most successful treatment for Philadelphia chromosome-positive ... While the success of Gleevec in treating the myeloproliferative neoplasm/myeloblastic leukemia or T-lymphoblastic leukemia/ ... "Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1". American Journal of Clinical Pathology. ...
*  Chemotherapy
... can occur which prevent the drugs from binding to the protein, leading to resistance to these types of drugs. Drugs used in ... Survivors of childhood cancer are more than 13 times as likely to get a secondary neoplasm during the 30 years after treatment ... Resistance is a major cause of treatment failure in chemotherapeutic drugs. There are a few possible causes of resistance in ... drug-to-drug interactions, genetics, and obesity, which has a major impact on the actual concentration of the drug in the ...
*  Hepatotoxicity
... in P-450 metabolism should be considered when patients exhibit unusual sensitivity or resistance to drug effects at normal ... Oral contraceptives Neoplasm Neoplasms have been described with prolonged exposure to some medications or toxins. ... Drug metabolism is usually divided into two phases: phase 1 and phase 2. Phase 1 reaction is thought to prepare a drug for ... Drugs interact with the enzyme family in several ways. Drugs that modify cytochrome P-450 enzyme are referred to as either ...
*  Gastrointestinal stromal tumor
KIT-D816V point mutations in c-KIT exon 17 are responsible for resistance to targeted therapy drugs like imatinib mesylate, a ... Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in ... Imatinib (Glivec/Gleevec), an orally administered drug initially marketed for chronic myelogenous leukemia based on bcr-abl ...
*  PELP-1
... and colon neoplasms. PELP1 signaling contributes to hormonal therapy resistance. Altered localization of PLP1 contributes to ... Since PELP1 lacks known enzymatic activity, drugs that target PELP1 interactions with other proteins should have clinical ... AR, PELP1 and Src form constitutive complexes in prostate neoplasms model cells that exhibit androgen independence. Cytoplasmic ... Since PELP1 interacts with histone modifications and epigenetic enzymes, drugs targeting epigenetic modifier enzymes may be ...
*  Mir-708 microRNA precursor family
"A set of miRNAs that involve in the pathways of drug resistance and leukemic stem-cell differentiation is associated with the ... "MiR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets ...
*  Smooth muscle tissue
Intravascular leiomyomatosis is a benign neoplasm that extends through the veins; angioleiomyoma is a benign neoplasm of the ... They can then re-bind to the actin molecule and drag it along further. This process is called crossbridge cycling and is the ... The Rhoa and Rac portion of the signaling pathway provides a calcium-independent way to regulate resistance artery tone. To ... The myosin heads tilt and drag along the actin filament a small distance (10-12 nm). The heads then release the actin filament ...
*  Infective endocarditis
Intravenous drug users tend to get their right-sided heart valves infected because the veins that are injected drain into the ... High rates of resistance to oxacillin are also seen, in which cases treatment with vancomycin is required. Viridans group ... colonoscopy to be done immediately due to concerns regarding hematogenous spread of bacteria from the colon due to the neoplasm ... HACEK organisms are a group of bacteria that live on the dental gums, and can be seen with IV drug users who contaminate their ...
*  Prostate cancer
Seruga B, Ocana A, Tannock IF (January 2011). "Drug resistance in metastatic castration-resistant prostate cancer". Nature ... "Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... "FDA approves new drug for advanced prostate cancer" (Press release). Food and Drug Administration. 15 May 2013. Archived from ... A 2007 report by the U.S.-based National Prostate Cancer Coalition stated that for every prostate cancer drug on the market, ...