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*  Adverse drug reaction
Evans WE, McLeod HL (2003). "Pharmacogenomics--drug disposition, drug targets, and side effects". N. Engl. J. Med. 348 (6): 538 ... or a low therapeutic index of the drug (e.g. nausea from digoxin), and they are therefore predictable. They are dose-related ... Pathogenesis of adverse drug reactions. In: Davies DM, ed. Textbook of adverse drug reactions. Oxford: Oxford University Press ... of patients had an adverse drug reaction to at least one drug, and pharmacist involvement helps to pick up adverse drug ...
*  Generation Scotland
... to work out which genetic factors contribute to our chances of becoming unwell or of suffering from drug-related side-effects. ... Adverse reactions to prescription drugs delay recovery and drain healthcare resources. Generation Scotland is therefore ... Kongkaew C, Noyce PR, Ashcroft DM (July 2008). "Hospital admissions associated with adverse drug reactions: a systematic review ... Disease risk and drug response are examples of complex traits. Instead of having a single cause, complex traits typically ...
*  Spironolactone
Side Effects of Drugs Annual: A worldwide yearly survey of new data in adverse drug reactions. Elsevier Science. 1 December ... This may be related to the fact that spironolactone has been regarded as a comparatively weak antiandrogen relative to other ... The most common side effect of spironolactone is urinary frequency. Other general side effects include dehydration, ... However, a Cochrane review found adverse effects at high doses and little effect on blood pressure at low doses in the majority ...
*  Lamotrigine
Reported adverse reactions and side-effects. U.S. National Library of Medicine: Drug Information Portal - Lamotrigine Pharmacy ... The basis for this broader spectrum of activity of lamotrigine is unknown, but could relate to actions of the drug on voltage- ... The side-effect profile varies for different patient populations. Overall adverse effects in treatment are similar between men ... Common side effects include sleepiness, headache, vomiting, trouble with coordination, and rash. Serious side effects include ...
*  VIR-576
The side effects were less severe in the high- dose treatment group and thus were not related to the dosage of VIR- 576. In ... VIR-576 was well tolerated and did not cause major adverse effects. Retrovirus HIV Antiretroviral drug Fusion inhibitor T ... This fact allows the union of the subunits during the reaction with the gp41 and also allows them to act simultaneously. Thanks ... and most of them didn't show secondary effects. Generally, the effects were temporal and tolerable like constipation, headaches ...
*  Vardenafil
... adverse drug reactions (side effects) are the same as with other PDE5 inhibitors. The frequent vardenafil-specific side-effect ... Vardenafil's indications and contraindications are the same as with other PDE5 inhibitors; it is closely related in function to ... One possibly serious, but rare, side effect with vardenafil is heart attack. Also, in rare cases, vardenafil use may cause ... Kloner, Robert A. (2005-12-26). "Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on ...
*  Opioid
All of the opioids can cause side effects. Common adverse reactions in patients taking opioids for pain relief include nausea ... Due to severe side effects such as tardive dyskinesia, haloperidol is now rarely used. A related drug, prochlorperazine is more ... Candiotti KA, Gitlin MC (July 2010). "Review of the effect of opioid-related side effects on the undertreatment of moderate to ... Opioid side effects (Vimeo) (YouTube)-A short educational film about the practical management of opioid side effects.. ...
*  Loperamide
Recent studies suggest that loperamide is more effective and has lower neural side effects. Adverse drug reactions (ADRs) most ... Florey, Klaus (1991). Profiles of Drug Substances, Excipients and Related Methodology, Volume 19. Academic Press. p. 342. ISBN ... side-effects include: toxic megacolon, paralytic ileus, angioedema, anaphylaxis/allergic reactions, toxic epidermal necrolysis ... Common side effects include abdominal pain, constipation, sleepiness, vomiting, and a dry mouth. It may increase the risk of ...
*  Piperacillin/tazobactam
The most common adverse reaction is diarrhea (7-11%). One other side effect is inhibition of platelets (thrombocytopenia). ... "Drug Shortages › Piperacillin Tazobactam Injection". Drugs.com. 10 July 2017. Retrieved 12 July 2017. "Major shortage forces ... Its main uses are in intensive care medicine (pneumonia, peritonitis), some diabetes-related foot infections, and empirical ... Common side effects include headache, trouble sleeping, rash, nausea, constipation, and diarrhea. Serious side effects include ...
*  Cyclophosphamide
Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced ... Most people develop side effects. Common side effects include low white blood cell counts, loss of appetite, vomiting, hair ... Other severe side effects include an increased future risk of cancer, infertility, allergic reactions, and pulmonary fibrosis. ... increasing both pharmacologic and toxic effects of the drug; alternatively, drugs that inhibit hepatic microsomal enzymes (e.g ...
*  Glossary of clinical research
Adverse reaction An unwanted effect caused by the administration of drugs. Onset may be sudden or develop over time (NLM) ... ICH E6) Adverse effect An unwanted side effect of treatment. (NCI) Adverse event An unexpected medical problem that happens ... all noxious and unintended responses to a medicinal product related to any dose should be considered adverse drug reactions. ... NCI) Drug-drug interaction A modification of the effect of a drug when administered with another drug. The effect may be an ...
*  Alpha-1 blocker
... might show adverse drug reactions (ADRs) characteristic of the sulfa related drugs. Silodosin shows high affinity and ... Today phenoxybenzamine is not the first choice due to many side effects like lowering blood pressure. First selective alpha-1 ... Carruthers, S. G. (July 1994). "Adverse effects of alpha 1-adrenergic blocking drugs". Drug Safety. 11 (1): 12-20. ISSN 0114- ... since the adverse effects of Prazosin are dose-related. This is also the case for Tamsulosin and it may be assumed that the ...
*  Neuroenhancement
... and rated the adverse effects of these drugs lower than non-users, showing more confidence in the result of these drugs. In a ... While there were no reported side effects from DBS, 18% of the patients suffered from device related complications such as ... In the drug trials, participants reported the following adverse reactions to the consumption of donepezil, memantine, MPH, or ... Neuroenhancement drugs need to be assessed further for their merits and adverse effects, making it easier for policy makers to ...
*  Darbepoetin alfa
To avoid side effects, it is recommended for patients with chronic renal failure or cancer to use the lowest possible dose ... Other reported adverse reactions include increased risk of seizure, hypotension, and chest pain. Darbepoetin alfa is a ... The drug was approved in September 2001 by the Food and Drug Administration for treatment of anemia in patients with chronic ... A recent study has extended these findings to treatment of patients exhibiting cancer-related anemia (distinct from anemia ...
*  Modafinil
"Australian Adverse Drug Reactions Bulletin 2008" (etext). Australian Adverse Drug Reactions Bulletin. Retrieved 2017-11-29. CS1 ... other negative side-effects such as nervousness, diarrhea, insomnia, anxiety, dizziness, and gastrointestinal problems were ... and pleaded guilty to a federal criminal charge relating to its promotion of off-label uses for Provigil and two other drugs." ... The Adverse Drug Reactions Advisory Committee (ADRAC) & the Office of Medicine Safety Monitoring (OMSM) of the TGA (2008-12-01 ...
*  PharmGKB
Examples of drug responses include adverse drug reactions, changes in drug efficacy and alterations in how quickly or slowly a ... drugs, phenotypes (including diseases and side effects) and PubMed IDs (PMIDs). Variant annotations are summaries describing ... PharmGKB has many different types of PGx-related information available through the website, discussed in the sections below. ... EMA-approved drug labels (known as European Public Assessment Reports (EPARs)) are manually searched for using the drugs in the ...
*  Tripterygium wilfordii
... careful extraction gives an acceptable frequency of adverse reactions, which are largely related to the gastrointestinal tract ... a drug safety bulletin advising consumers not to use medicines containing lei gong teng due to potentially serious side effects ... A 2016 review found gastrointestinal symptoms in 13%, adverse reproductive outcomes in 12%, adverse skin reactions in 8%, ... Serious side effects, however, occur frequently enough to make the risks of taking it higher than the possible benefits. At ...
*  Melarsoprol
Of those, about 50% die due to encephalopathy-related adverse reactions. Additional potentially serious side effects of ... The inability to distinguish between host and parasites renders this drug highly toxic with many side effects. Mel Ox reacts ... Melarsoprol has a high number of side effects. Common side effects include brain dysfunction, numbness, rashes, and kidney and ... Severe and life-threatening adverse reactions are associated with melarsoprol. It is known to cause a range of side effects ...
*  Pharmacogenomics
... minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic ... pharmacogenomic tests provide tools for physicians and care givers to better manage medication selection and side effect ... Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene ... Drugs can be classified into two main groups: active drugs and prodrugs. Active drugs refer to drugs that are inactivated ...
*  Delamanid
Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. Elsevier. 2016. p. 284. ISBN ... Pretomanid, a related drug "Deltyba (delamanid): Summary of Product Characteristics. 5.2. Pharmacokinetic Properties" (PDF). ... Common side effects include headache, dizziness, and nausea. Other side effects include QT prolongation. It has not been ... Common side effects include headache, dizziness, and nausea. Other side effects include QT prolongation. It has not been ...
*  Prescription cascade
Another drug is prescribed to treat the new condition, and an adverse drug side-effect occurs that is again mistakenly ... related physiological changes when trying to minimize the likelihood that an older person will develop an adverse drug reaction ... As each condition is treated with a specific drug, a correlating side-effect of each drug comes into play. If a doctor fails to ... Prescription cascade refers to the process whereby the side effects of drugs are misdiagnosed as symptoms of another problem ...
*  Nilutamide
Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. Elsevier. pp. 874-. ISBN 978-0- ... Nilutamide is structurally related to the first-generation NSAAs flutamide and bicalutamide as well as to the second-generation ... 356-. ISBN 978-1-59259-152-7. Jeffrey K. Aronson (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. ... These unfavorable side effects, along with a number of associated cases of death, have limited the use of nilutamide. ...
*  Ampicillin
Less common side effects can be nausea, vomiting, itching, blood dyscrasias, and mild allergic reactions. Other conditions may ... The most serious adverse effects are seizures, serum sickness, anaphylaxis, pseudomembranous colitis. The most common side ... Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1 ed.). Weinheim: Wiley- ... healthcare-associated infections related to infection from urinary catheter use unresponsive to other medications. Haemophilus ...
*  Echinacea
... "gastrointestinal and skin-related." Such side effects include nausea, abdominal pain, diarrhea, itch, and rash. Echinacea has ... and that it may have adverse reactions with other medications. One of the most extensive and systematic studies to review the ... Echinacea does not usually cause side effects, but may have undesirable interactions with various drugs prescribed for diseases ... Some therapists have claimed that echinacea can help relieve side effects from cancer treatments such as chemotherapy and ...
*  Acemetacin
Gastrointestinal tolerability is better than that of the related drug indometacin. Severe allergic reactions and haematopoietic ... Common side effects (in about 1-10% of patients) include gastrointestinal problems typical of NSAIDs, such as nausea, diarrhoea ... as well as for the typical NSAID adverse effects. An advantage of acemetacin is that it reduces gastric damage as compared to ... increased frequency of side effects, especially peptic ulcers and gastrointestinal bleeding diuretics, ACE inhibitors and other ...
*  Childbirth
Side effects appear later, including irritation, redness, and multiple superficial scratches from the razor. Another effort to ... Even women who show little reaction to labour pains, in comparison to other women, show a substantially severe reaction to ... "no adverse effects" in the health of the mothers or babies. Medical researchers find that neonates born before 39 weeks ... As of June 2011, about one third of American births have some complications, "many of which are directly related to the ...