Drug discovery and biomedical research[edit]. The ability to grow up functional adult tissues indefinitely in culture through ... tools to understand diseases and enable tissue regeneration and drug discovery". Vet. J. 191 (1): 19-27. doi:10.1016/j.tvjl. ... On 23 January 2009, the US Food and Drug Administration gave clearance to Geron Corporation for the initiation of the first ... Researchers are able to grow up differentiated cell lines and then test new drugs on each cell type to examine possible ...
Drug and poison discovery[edit]. Protein-protein signalling interactions pose suitable therapeutic targets due to their ... The random drug discovery approach uses compound banks that comprise random chemical structures, and requires a high-throughput ... "Yeast two-hybrid methods and their applications in drug discovery". Trends in Pharmacological Sciences. 33 (2): 109-18. doi: ...
Drug discovery[edit]. Main article: Drug discovery. In the fields of medicine, biotechnology and pharmacology, drug discovery ... The "final product" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III ... Informations and Leaflets of approved pharmaceutical drugs , Medikamio. *SuperCYP: Database for Drug-Cytochrome- and Drug-Drug- ... anabolic drugs, haematopoietic drugs, food product drugs For neoplastic disorders[edit]. cytotoxic drugs, therapeutic ...
Clinical practice and drug discovery[edit]. Main articles: Drug development and Drug Discovery Hit to Lead ... It encompases the subfields of drug design and development.[citation needed] Drug discovery starts with drug design, which is ... drug development involves bringing the drug to the market.[citation needed] Drug discovery is related to pharmacoeconomics, ... Drug policy[edit]. Main article: Drug policy. In the United States, the Food and Drug Administration (FDA) is responsible for ...
Little is known about where different complexes are located in the brain, complicating drug discovery.[6] For example, the ... Case studies of discovery and development of drug classes. *5α-Reductase inhibitors ... Gringauz A (1997). Medicinal Chemistry How drugs act and why. United States of America: WILEY-VCH. pp. 578-579. ISBN 0-471- ... Gringauz A (1997). Medicinal Chemistry How drugs act and why. United States of America: Wiley-VCH. pp. 572-574. ISBN 0-471- ...
Drug Discovery. 5 (3): 247-64. doi:10.1038/nrd1983. PMC 3463109. PMID 16518376.. ... "Expert Opinion on Emerging Drugs. 12 (3): 479-92. doi:10.1517/14728214.12.3.479. PMID 17874974.. ... Cardiovascular Drugs and Therapy. 21 (3): 171-94. doi:10.1007/s10557-007-6014-6. PMID 17373584.. ... which is now resulting in a new generation of more selective drugs with many potential medical uses. Some of these compounds ...
Drug Discovery & Development News. Retrieved 19 December 2013. *^ Anderson C (2003-06-01). "The Bad News Isn't In: A Look at ... "Recent Patents on CNS Drug Discovery. 1 (1): 29-41. doi:10.2174/157488906775245327. PMID 18221189. Archived from the original ... Case studies of discovery and development of drug classes. *5α-Reductase inhibitors ... Recent Patents on CNS Drug Discovery. 1 (3): 261-270. doi:10.2174/157488906778773706. PMID 18221208.. ...
Kolb, H.C.; Sharpless, B.K. (2003). "The growing impact of click chemistry on drug discovery". Drug Discov Today. 8 (24): 1128- ... click chemistry has sped up new drug discoveries by making each reaction in a multistep synthesis fast, efficient, and ... Meldal and co-workers also chose not to label this reaction type "click chemistry" which allegedly caused their discovery to be ... Advanced Drug Delivery Reviews. 60 (9): 958-970. doi:10.1016/j.addr.2008.02.004. PMID 18406491.. ...
Drug Discovery. 6 (1): 21-2. doi:10.1038/nrd2227. PMID 17269160.. *^ Wang YP, Lei QY (May 2018). "Metabolic recoding of ... "Current Opinion in Drug Discovery & Development. 12 (5): 659-65. PMC 2921942. PMID 19736624.. ... Approved in 2006 by the U.S. Food and Drug Administration (FDA), Vorinostat represents a new category for anticancer drugs that ... a b Substance Abuse and Mental Health Services Administration, Results from the 2013 National Survey on Drug Use and Health: ...
Drug Discovery. 3 (2): 115-124. doi:10.1038/nrd1304. PMID 15040576.. *^ Gao, X.; Cui, Y.; Levenson, R.; Chung, L.; Nie, S. ( ... Transdermal patches have been limited to administer a small number of drugs, such as nicotine, because of the limitations in ... Development of techniques that increase skin permeability has led to more drugs that can be applied via transdermal patches and ... Prausnitz, M.; Mitragotri, S.; Langer, R. (February 2004). "Current Status and Future Potential of Transdermal Drug Delivery". ...
Drug Discovery. 7 (8): 694-710. doi:10.1038/nrd2572. PMID 18670432. S2CID 7466788.. ... Drug Abuse Medications[edit]. The NOP receptor has shown potential as a target for medications designed to alleviate the ... Since its discovery, nociceptin has been of great interest to researchers. Nociceptin is a peptide related to the opioid class ... Areas in the hypothalamus and amygdala that correlate to the reward process of drug abuse have been found to contain NOP ...
Drug Discovery. 12 (7): 507-25. doi:10.1038/nrd4024. PMID 23977697.. *^ Yoon SO, Casaccia-Bonnefil P, Carter B, Chao MV (May ...
"Nature Reviews Drug Discovery. 16 (3): 203-222. doi:10.1038/nrd.2016.246. ISSN 1474-1784. PMID 28209991.. ... Nature Reviews Drug Discovery. 16 (3): 203-222. doi:10.1038/nrd.2016.246. ISSN 1474-1784. PMID 28209991.. ... Nature Reviews Drug Discovery. 3 (12): 1011-1022. doi:10.1038/nrd1580. ISSN 1474-1784. PMID 15573100.. ... Silmitasertib was granted orphan drug status by the U.S. Food and Drug Administration for cholangiocarcinoma and is currently ...
Drug Discovery. 6 (12): 967-74. doi:10.1038/nrd2400. PMID 18049471.. *^ Palese P, Tobita K, Ueda M, Compans RW (October 1974 ... Dyason JC, Itzstein Mv (2001). "Anti-Influenza Virus Drug Design: Sialidase Inhibitors". Australian Journal of Chemistry. 54 ( ... The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection ... von Itzstein M (December 2007). "The war against influenza: discovery and development of sialidase inhibitors". Nature Reviews ...
"Drugging the undruggable RAS: Mission possible?". Nature Reviews. Drug Discovery. 13 (11): 828-51. doi:10.1038/nrd4389. PMC ... In July 2009, the US Food and Drug Administration (FDA) updated the labels of two anti-EGFR monoclonal antibody drugs indicated ... As a drug target[edit]. Driver mutations in KRAS underlie the pathogenesis of up to 20% of human cancers.[36] Hence KRAS is an ... It suggests to perform an early initiation of a MEK inhibitor as a rational strategy for delaying or reversing drug resistance. ...
... an emerging drug discovery paradigm". Nature Reviews. Drug Discovery. 16: 101-114. doi:10.1038/nrd.2016.211. PMC 5684876. PMID ... Walter Sneader (23 June 2005). Drug Discovery: A History. John Wiley & Sons. pp. 367-. ISBN 978-0-471-89979-2.. ... Androgen receptor antagonists: Drugs that bind directly to and block the AR.[66][67] These drugs include the steroidal ... Smith HJ, Williams H (10 October 2005). Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth ...
... drug discovery and therapeutic options". Nature Reviews. Drug Discovery. 15 (5): 327-47. doi:10.1038/nrd.2015.37. PMID 26868298 ... Butler, Declan (2013). "Tensions linger over discovery of coronavirus". Nature. doi:10.1038/nature.2012.12108.. ...
Drug Discovery. 5 (2): 160-70. doi:10.1038/nrd1958. PMID 16424917. S2CID 21379258. Nakamura T, Lipton SA (February 2010). " ...
Drug Discovery. 4 (2): 107-20. doi:10.1038/nrd1631. PMID 15665857. S2CID 32781560. Cox, Joanna H., Stefano Seri, and Andrea E. ... Drug Discovery. 4 (2): 107-20. doi:10.1038/nrd1631. PMID 15665857. S2CID 32781560. Esbenshade TA, Fox GB, Cowart MD (Apr 2006 ... Leurs R, Bakker RA, Timmerman H, de Esch IJ (Feb 2005). "The histamine H3 receptor: from gene cloning to H3 receptor drugs". ... Leurs R, Bakker RA, Timmerman H, de Esch IJ (Feb 2005). "The histamine H3 receptor: from gene cloning to H3 receptor drugs". ...
Drug Discovery. 4 (2): 131-44. doi:10.1038/nrd1630. PMID 15665858. S2CID 15037387. Skeberdis VA, Lan J, Opitz T, Zheng X, ... a potential target for drug discovery?". Annals of the New York Academy of Sciences. 1053 (1): 55-73. Bibcode:2005NYASA1053... ... The same drug has been shown to interfere in the hypothalamic-pituitary-adrenal axis, with chronic oral administration of this ... The drug LY354740 (also known as Eglumegad, an mGlu2/3 agonist) was shown to attenuate physiologic and cognitive abnormalities ...
Drug Discovery. 17 (4): 243-260. doi:10.1038/nrd.2017.229. PMC 5936084. PMID 29302067. Cahill TJ, Thomsen AR, Tarrasch JT, ...
Drug Discovery. 4 (7): 581-93. doi:10.1038/nrd1775. PMID 16052241. Nayerossadat N, Maedeh T, Ali PA (6 July 2012). "Viral and ... The 10th US-Japan Symposium on Drug Delivery Systems Nature: Gene Delivery Genetic Science Learning Center: Gene Delivery ...
Overington JP, Al-Lazikani B, Hopkins AL (December 2006). "How many drug targets are there?". Nature Reviews. Drug Discovery. 5 ... Drug Discovery. 3 (11): 950-64. doi:10.1038/nrd1551. PMID 15520817. S2CID 205475111. Busch BB, Stevens WC, Martin R, Ordentlich ... Food and Drug Administration (FDA) approved drugs target nuclear receptors. A number of nuclear receptors, referred to as ... A number of drugs that work through nuclear receptors display an agonist response in some tissues and an antagonistic response ...
Drug Discovery. 5 (11): 932-40. doi:10.1038/nrd2159. PMID 17080029. S2CID 413230. Fineberg AM, Ellman LM (May 2013). " ... U.S. Food and Drug Administration. April 5, 2019. Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz ... "Thimerosal in vaccines". Center for Biologics Evaluation and Research, U.S. Food and Drug Administration. June 3, 2008. ... U.S. Food and Drug Administration. April 19, 2019. "Vaccine Ingredients-Formaldehyde". chop.edu/. Children's Hospital of ...
Drug Discovery. 16 (4): 296. doi:10.1038/nrd.2017.42. PMID 28303022. Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR (May 2016 ... There are now more publications on CRISPR than ZFN and TALEN despite how recent the discovery of CRISPR is. Both CRISPR and ... In recognition of their discovery of how homologous recombination can be used to introduce genetic modifications in mice ... with stem cells Transgenic animals Endogenous gene labeling Targeted transgene addition The combination of recent discoveries ...
Drug Discovery. 12 (6): 447-64. doi:10.1038/nrd4010. PMID 23722347. S2CID 39842610. Ewald B, Sampath D, Plunkett W (October ... "Zidovudine Monograph for Professionals - Drugs.com". Drugs.com. Retrieved 30 November 2017. Lodish H, Berk A, Zipursky SL, ... Galmarini CM, Mackey JR, Dumontet C (2001). "Nucleoside analogues: mechanisms of drug resistance and reversal strategies". ...
Drug Discovery. 11 (5): 401-19. doi:10.1038/nrd3705. PMID 22543469. S2CID 7875371. Walker EP (February 7, 2012). "Benefit of ... Pollack A (19 October 2009). "F.D.A. Says No to an Amgen Bone Drug". The New York Times. "FDA Approves Denosumab for ... On 13 August 2009, a meeting was held between Amgen and the Advisory Committee for Reproductive Health Drugs (ACRHD) of the U.S ... "Denosumab". Drug Information Portal. U.S. National Library of Medicine. Medicine portal. ...
Hydrazine (antidepressant) Isoniazid Robert A. Maxwell; Shohreh B. Eckhardt (1990). Drug discovery. Humana Press. pp. 143-154. ... edu.drugs. "Side Effects of Iproniazid". edudrugs.com. Retrieved 2018-03-27. Cheng, Feixiong; Li, Weihua; Zhou, Yadi; Shen, Jie ... I. Role of drug metabolism". The Journal of Pharmacology and Experimental Therapeutics. 187 (1): 185-194. ISSN 0022-3565. PMID ... Examples of antidepressant drugs that are nowadays used instead of iproniazid are isocarboxazid, phenelzine, and ...
Drug Discovery Today. 10 (10): 688-91. doi:10.1016/S1359-6446(05)03395-7. PMID 15896681. Li JJ, Corey EJ (3 April 2013). Drug ... However, these drugs have a higher rate of fatal adverse events in cancer patients than control drugs. A combination therapy of ... Drug levels are, therefore, taken to make sure patients get the right dose for their condition. This is determined by taking a ... Dose-corrected drug exposure of TAC correlates with SRL (r2 = 0.8), so patients have similar bioavailability of both.[non- ...
With the discovery of the Goose Creek Oil Field, the rival communities of Pelly in the late 1910s, and East Baytown in the ... Houston Raceway is a motorsports complex featuring National Hot Rod Association (NHRA) races and a weekly drag racing program. ... Following the discovery of oil nearby, the population of Baytown and the Tri-Cities boomed. Many immigrants arrived in Baytown ...
"PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. PMID 20970519. doi:10.1016/j.drudis. ...
Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 509. ISBN 9783527607495. .. ... After 38 weeks, 6% of the people in the three-drug group died while 11% of the people died in the two-drug group. There were ... Viral resistance to the drug leads to the drug becoming useless since the virus evolves to have cells that are able to resist ... It is recommended that users drink at least 1.5 liters a day when intaking the drug. Drug users must significantly increase ...
De Smet, Peter A.G.M. (December 1997). "The Role of Plant-Derived Drugs and Herbal Medicines in Healthcare". Drugs. 54 (6): 801 ... as western medicine increasingly incorporated scientific methods and discoveries, and had a corresponding increase in success ... 2006). "Drug-related hepatotoxicity". New England Journal of Medicine. 354 (7): 731-39. doi:10.1056/NEJMra052270. PMID 16481640 ... The U.S. Food and Drug Administration (FDA), has issued online warnings for consumers about medication health fraud.[157] This ...
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and ... Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations". J. Biol. Chem. 247: 1727-1734. PMID ... "Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. ... http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C. ...
"PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. PMID 20970519. doi:10.1016/j.drudis. ...
... biology publications and is one of several tools for systems biology researchers and bioinformaticians in drug discovery and ... IPA also lets researchers search for information on genes, proteins, chemicals, drugs, and reagents. Resulting information can ... Food and Drug Administration to use IPA in review of Pharmacogenomics Submissions" (Press release). Ingenuity Systems. June 21 ... US Food and Drug Administration adopts IPA to review pharmacogenomics submissions 2006 - Ingenuity enters into partnerships ...
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and ... http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C. ...
Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ... Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. These ... They are a class of cell cycle-specific cytotoxic drugs that work by inhibiting the ability of cancer cells to divide: Acting ...
"U.S. Food and Drug Administration (FDA).. *Ebola: What You Need to Know - Scientific American articles related to Ebola; note ... Feldmann H, Jones S, Klenk HD, Schnittler HJ (August 2003). "Ebola virus: from discovery to vaccine". Nature Reviews Immunology ... "U.S. Food and Drug Administration (FDA) (Press release). 14 October 2020. Retrieved 14 October 2020.. This article incorporates ... "U.S. Food and Drug Administration (FDA) (Press release). 20 December 2019. Retrieved 22 December 2019.. ...
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.". Drug Discov Today. 15 (23-24): ... of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug ...
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.". Drug Discov Today. 15 (23-24): ... of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug ...
DiscoveryEdit. The original discovery of Substance P (SP) was in 1931 by Ulf von Euler and John H. Gaddum as a tissue extract ... by drugs known as neurokinin type 1 antagonists (also termed: SP antagonists, or tachykinin antagonists.) One such drug is ... Muñoz M, Rosso M, Coveñas R (Jun 2011). "The NK-1 receptor: a new target in cancer therapy". Current Drug Targets. 12 (6): 909- ... The actions of aprepitant are said to be entirely central, thus requiring passage of the drug into the central nervous system.[ ...
Aminorex a drug bearing an oxazoline ring. References[edit]. *^ a b Wenker, H. (1938). "Syntheses from Ethanolamine. V. ... Kobayashi, Shiro; Uyama, Hiroshi (15 January 2002). "Polymerization of cyclic imino ethers: From its discovery to the present ... "Advanced Drug Delivery Reviews. 59 (15): 1504-1520. doi:10.1016/j.addr.2007.08.018. PMID 17904246.. ...
"PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. PMID 20970519. doi:10.1016/j.drudis. ... 2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. PMID ... of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug ...
An alcoholic drink (or alcoholic beverage) is a drink that contains the recreational drug ethanol, a type of alcohol produced ... Discovery of late Stone Age jugs suggest that intentionally fermented drinks existed at least as early as the Neolithic period ... 10,000-5000 BC: Discovery of late Stone Age jugs suggests that intentionally fermented drinks existed at least as early as the ... Alcohol is one of the most widely used recreational drugs in the world, with about 33% of people being current drinkers.[4] As ...
"PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. PMID 20970519. doi:10.1016/j.drudis. ... 2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. PMID ... "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic acids research 36 (Database issue): D901-6. PMC ... Drug Discov Today. 2013 Jun 13. pii: S1359-6446(13)00163-3. doi: 10.1016/j.drudis.2013.05.017. PMID 23769988 23769988 ...
Discovery[edit]. Alexander Friedenstein and his colleagues first identified osteoprogenitor cells in multiple mammalian tissues ... fluid space geometry and dimension results in a profound underprediction of nano-microscale stresses imparted by fluid drag on ...
Robert Koch's discoveries around 1880 of the transmission of disease by bacteria, and then the discovery of antibiotics around ... Pharmacology is the study of drugs and their actions.. *Photobiology is the study of the interactions between non-ionizing ... The modern era really began with Edward Jenner's discovery of the smallpox vaccine at the end of the 18th century (inspired by ... of Essential Drugs and Medicines Policy (2002). "Traditional medicine: growing needs and potential". World Health Organization. ...
That begins when increasing rainfall drags with it an area of quickly descending air known as the rear flank downdraft (RFD). ... Numerical modeling also provides new insights as observations and new discoveries are integrated into our physical ... This downdraft accelerates as it approaches the ground, and drags the supercell's rotating mesocyclone towards the ground with ...
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.". Drug Discov Today. 15 (23-24): ...
"Infection and Drug Resistance. 8: 119-128. doi:10.2147/IDR.S66739. PMC 4440423. PMID 26028977.. ... Burgdorfer subsequently confirmed his discovery by isolating, from people with Lyme disease, spirochetes identical to those ... A hexavalent (OspA) protein subunit-based vaccine candidate VLA15 was granted fast track designation by the U.S. Food and Drug ... disease-modifying antirheumatic drugs (DMARDs), or arthroscopic synovectomy.[30] Physical therapy is recommended for adults ...
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and ... http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C. ...
U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ "Title 21-Food and drugs: Chapter i-Food and drug administration: ... Discovery of what would be considered a medical device by modern standards dates as far back as c. 7000 BC in Baluchistan where ... U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ a b c d e f "General and Special Controls". Medical Devices. U.S. ... United States (Food and Drug Administration)Edit. Section 201(h) of the Federal Food Drug & Cosmetic (FD&C) Act[6] defines a ...
However the unexpected discovery of the strong respiratory stimulant effects of the ampakine drugs on the pre-Botzinger complex ... In 2005 the U.S. Food and Drug Administration (FDA) accepted Cortex Pharmaceuticals' Investigational New Drug (IND) application ... These drugs were reasonably effective at reducing the symptoms of Alzheimer's and it was hoped that they could also slow the ... Other AMPAkine drugs from Cortex Pharmaceuticals such as CX-546 and CX-614 have already been researched for use in treating ...
2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. PMID ...
Ancient Discoveries]], Episode 12: Machines of the East, History Channel, dicapai 2008-09-08. Konflik URL-wikilink (bantuan) ... A. Al Dayela and N. al-Zuhair (2006), "Single drug therapy in the treatment of male sexual/erectile dysfunction in Islamic ... Ancient Discoveries]], Episode 12: Machines of the East, History Channel, dicapai 2008-09-07. Konflik URL-wikilink (bantuan) ... Ancient Discoveries]], Episode 12: Machines of the East, History Channel, dicapai 2008-09-06. Konflik URL-wikilink (bantuan) ...
... an emerging drug discovery paradigm". Nature Reviews. Drug Discovery. 16: 101-114. doi:10.1038/nrd.2016.211. PMC 5684876 . PMID ... Walter Sneader (23 June 2005). Drug Discovery: A History. John Wiley & Sons. pp. 367-. ISBN 978-0-471-89979-2.. ... Androgen receptor antagonists: drugs that bind directly to and block the AR.[57][58] These drugs include the steroidal ... Drug class. Bicalutamide, a nonsteroidal antiandrogen and the most widely used androgen receptor antagonist in the treatment of ...
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and ... http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C. ...
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and ... http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C. ...