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*  Ligand binding assay
"In situ drug-receptor binding kinetics in single cells: a quantitative label-free study of anti-tumor drug resistance". ... These discoveries provided precious information regarding both the sensitivity and specificity of protein hormones found within ... Drugs that act upon these receptors are incredibly selective in order to produce required responses from signaling molecules. ... The effects of a drug are a result of their binding selectivity with macromolecule properties of an organism, or the affinity ...
*  DNA-encoded chemical library
The aim of DEL technology is to accelerate the drug discovery process and in particular early phase discovery activities such ... Drug discovery High-throughput screening Combinatorial chemistry DNA sequencing Phage display Smith GP (June 1985). " ... Mukund S. Chorghade (2006). Drug discovery and development. New York: Wiley-Interscience. pp. 129-167. ISBN 0-471-39848-9. ... Expert Opinion on Drug Discovery. 4 (11): 1201-1213. doi:10.1517/17460440903206940. Mannocci L, Zhang Y, Scheuermann J, ...
*  Drug discovery
The "final product" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III ... Drug Discovery. 9 (3): 203-14. doi:10.1038/nrd3078. PMID 20168317. Warren J (April 2011). "Drug discovery: lessons from ... Antitarget Bioinformatics Biomedical informatics Cheminformatics Drug discovery hit to lead Drug metabolism Fragment-based drug ... Dynamic combinatorial diversity in drug discovery". In Jahnke W, Erlanson DA. Fragment-based approaches in drug discovery. ...
*  Drug Discovery Today
... : Disease Models, Drug Discovery Today: Therapeutic Strategies, and Drug Discovery Today: Technologies. The ... In 2004, the Drug Discovery Today journal series expanded with the launch of four online-only review journals: Drug Discovery ... Drug Discovery Today is a monthly peer-reviewed scientific journal that is published by Elsevier. It was established in 1996 ... Trends in Pharmacological Sciences "Drug Discovery Today". 2015 Journal Citation Reports. Web of Science (Science ed.). ...
*  Collaborative Drug Discovery
... (CDD) is a software company founded in 2004 as a spin-out of Eli Lilly by Barry Bunin, PhD. CDD ... CDD Product Page Collaborative Drug Discovery Receives Grant to Support the Development of a Database to Accelerate Discovery ... offers a web-based database solution for managing drug discovery data, primarily around small molecules and associated bio- ... free database for fostering open collaboration containing over 3 million molecules accessible to everyone in the drug discovery ...
*  Nature Reviews Drug Discovery
... is a peer-reviewed review journal covering drug discovery and development. According to the ... Nature Biotechnology Annual Review of Pharmacology and Toxicology Pharmacological Reviews "Nature Reviews Drug Discovery". 2016 ... Guide : Information : Nature Reviews Drug Discovery. Nature.com. Retrieved on 2011-06-29. Official website. ...
*  Open Source Drug Discovery
Project Director, Open Source Drug Discovery. ""OPEN SOURCE DRUG DISCOVERY" AN OPEN COLLABORATIVE DRUG DISCOVERY MODEL FOR ... "OPEN SOURCE DRUG DISCOVERY: A GLOBAL COLLABORATIVE DRUG DISCOVERY MODEL FOR TUBERCULOSIS" (PDF). Scienceandculture-isna.org\ ... "About Us - Open Source Drug Discovery". Osdd.net. Retrieved 2015-04-30. "Open source drug discovery - timesofindia- ... The process of drug discovery is divided into ten work packages, namely WP1 - Drug target identification. This promotes ...
*  Alzheimer's Drug Discovery Foundation
... Retrieved April 2, 2014. Donnelly, Shannon (May 22, 2013). "Alzheimer's Drug Discovery ... including the International Conference on Alzheimer's Drug Discovery and the Drug Discovery for Neurodegeneration Conference. ... In 2013, 69 percent of the ADDF's drug portfolio was focused on preclinical drug discovery. Though more than 300 potential ... The Alzheimer's Drug Discovery Foundation (ADDF) is a nonprofit organization founded in 1998 by co-chairmen Leonard A. Lauder ...
*  Computational Resource for Drug Discovery
Computational Resources for Drug Discovery (CRDD) is one of the important silico modules of Open Source for Drug Discovery ( ... It is developed under the umbrella of Open Source Drug Discovery (OSDD) project and covers wide range of subjects around drugs ... A Wikipedia for Drug Discovery is a Wiki created for collecting and compiling information related to computer-aided drug design ... It is developed under the umbrella of Open Source Drug Discovery (OSDD) project. The CRDD Forum was launched to discuss the ...
*  Expert Opinion on Drug Discovery
... is a monthly peer-reviewed medical journal publishing review articles on novel technologies ... involved in drug discovery. The editor-in-chief David Janero (Northeastern University). The journal is abstracted and indexed ...
*  Community for Open Antimicrobial Drug Discovery
... (CO-ADD). Retrieved 25 June 2015. Community for Open Antimicrobial Drug ... confronting the challenges of antibacterial discovery". Nature Reviews Drug Discovery. 6: 29-40. doi:10.1038/nrd2201. PMID ... The Community for Open Antimicrobial Drug Discovery (CO-ADD) is a not-for-profit initiative created in 2015 reaching out to ... These academic compounds are screened against a key panel of drug-resistant bacterial strains -superbugs. Multi-drug resistant ...
*  Development and discovery of SSRI drugs
Before the discovery of SSRI drugs the treatment for mood disorders were relatively limited. Now, however there are dozens of ... After the discovery of SSRIs the interest for newer antidepressant drugs with broader mechanism of action increased.[citation ... "The Discovery of The SSRIs: A Milestone In Neuropsychopharmacology and Rational Drug Design" (PDF). landesbioscience.com. Laned ... doi:10.1007/978-1-60327-435-7_2. ISBN 978-1-60327-434-0. Fischer, J., & Ganellin, C. R. (2010). Analogue-based drug discovery ...
*  List of drugs by year of discovery
The following is a table with drugs organized by year of discovery. In 4th millenium BC is named Soma (drink) and Haoma but is ... www.centerwatch.com/drug-information/fda-approved-drugs/year/2004. ...
*  Histamine H3 receptor
Drug Discovery. 4 (2): 107-20. doi:10.1038/nrd1631. PMID 15665857. Esbenshade TA, Fox GB, Cowart MD (Apr 2006). "Histamine H3 ... Drug Discovery. 4 (2): 107-20. doi:10.1038/nrd1631. PMID 15665857. Cox, Joanna H., Stefano Seri, and Andrea E. Cavanna. " ... Leurs R, Bakker RA, Timmerman H, de Esch IJ (Feb 2005). "The histamine H3 receptor: from gene cloning to H3 receptor drugs". ... Leurs R, Bakker RA, Timmerman H, de Esch IJ (Feb 2005). "The histamine H3 receptor: from gene cloning to H3 receptor drugs". ...
*  Metabotropic glutamate receptor
Drug Discovery. 4 (2): 131-44. doi:10.1038/nrd1630. PMID 15665858. Skeberdis VA, Lan J, Opitz T, Zheng X, Bennett MV, Zukin RS ... a potential target for drug discovery?". Annals of the New York Academy of Sciences. 1053 (1): 55-73. doi:10.1196/annals. ... The same drug has been shown to interfere in the hypothalamic-pituitary-adrenal axis, with chronic oral administration of this ... The drug LY354740 (also known as Eglumegad, an mGlu2/3 agonist) was shown to attenuate physiologic and cognitive abnormalities ...
*  Arrestin
Drug Discovery. doi:10.1038/nrd.2017.229. PMID 29302067. Cahill TJ, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, et ...
*  GABAA receptor positive allosteric modulator
Drug Discovery. 10 (9): 685-97. doi:10.1038/nrd3502. PMC 3375401 . PMID 21799515. Lambert JJ, Belelli D, Peden DR, Vardy AW, ... Little is known about where different complexes are located in the brain, complicating drug discovery. For example, the binding ... and the barbiturate drugs. The GABAA receptors have historically been a target of drug treatment research. The earliest ... Possible drug candidates were then synthesized from that compound and screened for activity. One of these compounds was active ...
*  Nuclear receptor
Overington JP, Al-Lazikani B, Hopkins AL (2006). "How many drug targets are there?". Nature Reviews. Drug Discovery. 5 (12): ... Drug Discovery. 3 (11): 950-64. doi:10.1038/nrd1551. PMID 15520817. Busch BB, Stevens WC, Martin R, Ordentlich P, Zhou S, Sapp ... Food and Drug Administration (FDA) approved drugs target nuclear receptors. A number of nuclear receptors, referred to as ... A number of drugs that work through nuclear receptors display an agonist response in some tissues and an antagonistic response ...
*  Docking (molecular)
"Docking and scoring in virtual screening for drug discovery: methods and applications". Nature Reviews. Drug Discovery. 3 (11 ... Docking is most commonly used in the field of drug design - most drugs are small organic molecules, and docking may be applied ... Molecular docking is one of the most frequently used methods in structure-based drug design, due to its ability to predict the ... Drug design Katchalski-Katzir algorithm List of molecular graphics systems Macromolecular docking Molecular mechanics Protein ...
*  Nucleoside triphosphate
Drug Discovery. 12 (6): 447-64. doi:10.1038/nrd4010. PMID 23722347. Ewald B, Sampath D, Plunkett W (October 2008). "Nucleoside ... "Zidovudine Monograph for Professionals - Drugs.com". Drugs.com. Retrieved 30 November 2017. Lodish H, Berk A, Zipursky SL, ... Galmarini CM, Mackey JR, Dumontet C (2001). "Nucleoside analogues: mechanisms of drug resistance and reversal strategies". ...
*  Iproniazid
Hydrazine (antidepressant) Nialamide Robert A. Maxwell; Shohreh B. Eckhardt (1990). Drug discovery. Humana Press. pp. 143-154. ... It was withdrawn a few years later in 1961 due to a high incidence of hepatitis, and was replaced by less hepatotoxic drugs ...
*  Leptin
"Adipokines as drug targets in joint and bone disease". Drug Discovery Today. 19 (3): 241-58. doi:10.1016/j.drudis.2013.07.012. ... Drug Discovery. 11 (9): 692-708. doi:10.1038/nrd3757. PMC 4019022 . PMID 22935803. Gualillo O (2007). "Further evidence for ... The discovery of leptin also is documented in a series of books including Fat: Fighting the Obesity Epidemic by Robert Pool, ... ISBN 978-0-374-10398-9. [page needed] Castracane VD, Henson MC (2006). "The Obese (ob/ob) Mouse and the Discovery of Leptin". ...
*  Ion channel
Verkman AS, Galietta LJ (February 2009). "Chloride channels as drug targets". Nature Reviews. Drug Discovery. 8 (2): 153-71. ... In the search for new drugs, ion channels are a frequent target. There are over 300 types of ion channels just in the cells of ...
*  Genetically modified bacterium
Drug Discovery. A guide to drug discovery. 7 (1): 21-39. doi:10.1038/nrd2399. PMID 18097458. Walsh G (April 2005). "Therapeutic ... Four years later, it was approved by the U.S. Food and Drug Administration. The drug industry has made use of this discovery to ...
*  Toxicogenomics
"Use of proteomics for the discovery of early markers of drug toxicity". Expert Opinion on Drug Metabolism & Toxicology. 3 (5): ... Drug Discovery. 3 (9): 763-9. doi:10.1038/nrd1499. PMID 15340386. Lesko LJ, Salerno RA, Spear BB, Anderson DC, Anderson T, ... In pharmaceutical drug discovery and development toxicogenomics is used to study adverse, i.e. toxic, effects, of ... Both the EPA and the U.S. Food and Drug Administration currently preclude basing regulatory decision making on genomics data ...
*  Guineesine
Potential Leads for Drug Discovery and Development". Evidence-Based Complementary and Alternative Medicine. 2015: 238482. doi: ...
*  Adenosine receptor
Drug Discovery. 5 (3): 247-64. doi:10.1038/nrd1983. PMC 3463109 . PMID 16518376. Mediero A, Frenkel SR, Wilder T, HeW, Mazumder ... Gao ZG, Jacobson KA (September 2007). "Emerging adenosine receptor agonists". Expert Opinion on Emerging Drugs. 12 (3): 479-92 ... which is now resulting in a new generation of more selective drugs with many potential medical uses. Some of these compounds ... Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. 21 (3): 171-94. ...