*  Dexrazoxane
2004). "The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia". New ... 300 mg/m2 doxorubicin (an anthracycline) or > 540 mg/m2 epirubicin (another chemotherapeutic agent) and general approval for ... such as daunorubicin or doxorubicin or other chemotherapeutic agents. However, in July 2011 the US Food and Drug Administration ... "Effects of Dexrazoxane and Amifostine on Evolution of Doxorubicin Cardiomyopathy in Vivo". Experimental Biology and Medicine. ...
*  Doxorubicin
... was originally made from the bacteria Streptomyces peucetius. Doxorubicin is commonly used to treat some leukemias ... "Doxorubicin HCL". International Drug Price Indicator Guide. Retrieved 8 December 2016. "Doxorubicin: British National Formulary ... Substitution would be desirable because liposome-encapsulated doxorubicin is less cardiotoxic than unencapsulated doxorubicin. ... Doxorubicin is also known to be fluorescent. This has often been used to characterize doxorubicin concentrations, and has ...
*  Doxorubicin cardiotoxicity
Doxorubicin is an effective chemotherapeutic agent against multiple types of malignancies. Despite its efficacy, a well-known ... Since Doxorubicin is a quinone, redox reactions can generate large amount of reactive oxygen species (ROS), including ... Doxorubicin-induced cardiomyopathy typically has the morphological and functional abnormalities as that of dilated ... These results led the researchers to hypothesize that inhibition of apoptosis in Doxorubicin-treated cardiomyocytes was due to ...
*  Zoptarelin doxorubicin
... (developmental code names AEZS-108, AN-152) consists of doxorubicin linked to a small peptide agonist to ... Zoptarelin doxorubicin acetate) an LHRH agonist linked to doxorubicin in women with platinum refractory or resistant ovarian ... Zoptarelin doxorubicin was invented by Andrew V. Schally while at the Tulane University School of Medicine, New Orleans and ... Zoptarelin doxorubicin was discontinued for all indications under development in May 2017. The U.S. Food and Drug ...
*  CBR96-doxorubicin immunoconjugate
... (BMS-182248/SGN-15; also known as cBR96-Dox) is an antibody-drug conjugate or (ADC) directed ... The payload is the chemotherapy drug doxorubicin which is connected with a hydrazone linker to cysteine residues of the Lewis-Y ... Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science 1993; 261:212-5. ... even in doxorubicin-resistant tumors. A randomized 60-patient phase II study of cBR96-Dox in NSCLC patients who had failed ...
*  Biosynthesis of doxorubicin
Doxorubicin is synthesized by a specialized polyketide synthase. The initial event in DXR synthesis is the selection of the ... Doxorubicin (DXR) is a 14-hydroxylated version of daunorubicin, the immediate precursor of DXR in its biosynthetic pathway. ... Gandlur SM, Wei L, Levine J, Russell J, Kaur P (2004). "Membrane topology of the DrrB protein of the doxorubicin transporter of ... 1999). "Doxorubicin Overproduction in Streptomyces peucetius: Cloning and Characterization of the dnrU Ketoreductase and dnrV ...
*  DMOZ - Health: Pharmacy: Drugs and Medications: D: Doxorubicin
MedlinePlus: Doxorubicin Provides description of drug, list of cancers medicine is used for, precautions, side effects, and ...
*  Aromatization
Fornari, F. A.; Randolph, J. K.; Yalowich, J. C.; Ritke, M. K.; Gewirtz, D. A. (1994). "Interference by Doxorubicin with DNA ... "Doxorubicin". Drugs.com. Retrieved 1 June 2016. "Clonazepam". Drugs.com. Retrieved 1 June 2016. "Lornoxicam". Drugs.com. ... doxorubicin). Polycyclic aromatic hydrocarbons like benzopyrenes and dibenz[a,h]anthracene are some of the 43 known carcinogens ...
*  Dihydroxyanthraquinone
Arcamone F. (1981). Doxorubicin Anticancer Antibiotics. Academic Press, New York. Quoted by Khalafy and Bruce. Kelly T.R. (1984 ...
*  Polyketide synthase
Doxorubicin Khosla, C.; Gokhale, R. S.; Jacobsen, J. R.; Cane, D. E. (1999). "Tolerance and Specificity of Polyketide Synthases ...
*  Streptomyces capoamus
ISBN 0-412-46620-1. Federico, Arcamone (1981). DOXORUBICIN Anticancer Antibiotics. Oxford: Elsevier Science. ISBN 0-323-13973-6 ...
*  Genistein
etoposide and doxorubicin. In high doses it was found to be strongly toxic to normal cells. This effect may be responsible for ...
*  Streptomyces purpurascens
ISBN 81-88237-58-2. CS1 maint: Extra text: authors list (link) Federico, Arcamone (1981). DOXORUBICIN Anticancer Antibiotics. ...
*  Anthramycin
Alternatives such as doxorubicin are today more widely available and prescribed, due to more mild side effects along with ... Doxorubicin Azithromycin Kitamura, Tsuyoshi; Yoshihiro Sato; Miwako Mori (2004). "Synthetic study of (+)-anthramycin using ring ...
*  Brivanib alaninate
Doxorubicin (trade name Adriamycin; also known as hydroxydaunorubicin), the most widely used agent in HCC, has shown a 4% to ... Studies have shown that the overall response (OR) rate, but not overall survival (OS), doubles when doxorubicin was given in ...
*  N-(2-Hydroxypropyl) methacrylamide
January 1999). "Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: ... HPMA copolymer-doxorubicin conjugate). Karel Ulbrich, Vladimír Šubr (2010-02-17), "Structural and chemical aspects of HPMA ...
*  Daunorubicin
Similar to doxorubicin, daunorubicin interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This ... Doxorubicin Idarubicin "daunorubicin hydrochloride". The American Society of Health-System Pharmacists. Archived from the ... Fornari FA, Randolph JK, Yalowich JC, Ritke MK, Gewirtz DA (April 1994). "Interference by doxorubicin with DNA unwinding in MCF ... Weiss RB (December 1992). "The anthracyclines: will we ever find a better doxorubicin?". Seminars in Oncology. 19 (6): 670-86. ...
*  Male breast cancer
Cyclophosphamide plus doxorubicin plus fluorouracil (CAF). Trastuzumab (monoclonal antibody therapy). Hormonal options include ...
*  Lymphoma in animals
Doxorubicin is used in some cases. Chemotherapy in relatively healthy ferrets is tolerated very well, but possible side effects ... The most common treatment is a combination of cyclophosphamide, vincristine, prednisone, L-asparaginase, and doxorubicin. Other ...
*  ANKRD1
Aihara Y, Kurabayashi M, Tanaka T, Takeda SI, Tomaru K, Sekiguchi KI, Ohyama Y, Nagai R (Aug 2000). "Doxorubicin represses CARP ... In cardiomyocytes treated with doxorubicin, a model of anthracycline-induced cardiomyopathy, CARP mRNA and protein levels were ... "A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and ... and whose mRNA levels are exquisitely sensitive to Doxorubicin, mediated through a hydrogen peroxide/ERK/p38MAP kinase- ...
*  Flavagline
"Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27". PLoS ONE. 6: e25302. Bibcode:2011PLoSO...625302B. doi: ...
*  RALBP1
"Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4- ... Doxorubicin transport in lung cancer by RLIP76". Int. J. Oncol. 22 (4): 713-20. doi:10.3892/ijo.22.4.713. PMID 12632060. ... Awasthi S, Singhal SS, Singhal J, Yang Y, Zimniak P, Awasthi YC (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: ... Awasthi S, Singhal SS, Singhal J, Cheng J, Zimniak P, Awasthi YC (2003). "Role of RLIP76 in lung cancer doxorubicin resistance ...
*  Mammary tumor
Doxorubicin has shown some promise in treatment. Most mammary tumors in rats are benign fibroadenomas, which are also the most ... "Retrospective Evaluation of Adjunctive Doxorubicin for the Treatment of Feline Mammary Gland Adenocarcinoma: 67 Cases". J Am ...
*  FL3 (flavagline)
It was also shown that FL3 may enhance the efficacy of one of the most widely used anticancer agents, doxorubicin, and ... "Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27". PLoS ONE. 6: e25302. doi:10.1371/journal.pone.0025302 ...
*  Spermatogonium
In addition to a DNA repair response, exposure of spermatogonia to doxorubicin can also induce programmed cell death (apoptosis ... Anticancer drugs such as doxorubicin and vincristine can adversely affect male fertility by damaging the DNA of proliferative ... Habas K, Anderson D, Brinkworth MH (2017). "Germ cell responses to doxorubicin exposure in vitro". Toxicol. Lett. 265: 70-76. ... Experimental exposure of rat undifferentiated spermatogonia to doxorubicin and vincristine indicated that these cells are able ...