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*  Pharmacodynamics
... places particular emphasis on dose-response relationships, that is, the relationships between drug ... Dose-response relationship Pharmacokinetics ADME Antimicrobial pharmacodynamics Pharmaceutical company Schild regression Lees P ... The relationship between occupancy and pharmacological response is usually non-linear. This explains the so-called receptor ... Colchicine, a drug for gout, interferes with the function of the structural protein tubulin, while Digitalis, a drug still used ...
*  Dose-response relationship
Food and Drug Administration also has guidance to elucidate dose-response relationships during drug development. Dose-response ... The dose-response relationship, or exposure-response relationship, describes the change in effect on an organism caused by ... of the drug after its administration. Studying dose response, and developing dose-response models, is central to determining " ... The concept of linear dose-response relationship, thresholds, and all-or-nothing responses may not apply to non-linear ...
*  Homeopathy
... is inconsistent with the law of mass action and the observed dose-response relationships characteristic of therapeutic drugs ( ... This dose-response relationship has been confirmed in myriad experiments on organisms as diverse as nematodes, rats, and humans ... This idea is also inconsistent with observed dose-response relationships, where effects are dependent on the concentration of ... but the dose-response relationship outside the zone of hormesis declines with dilution as normal, and nonlinear pharmacological ...
*  Toxic leukoencephalopathy
The dose-response relationship for these substances remains unclear. Various chemotherapy drugs have shown increased risk of ... Other drugs that have been associated with toxic leukoencephalopathy in much more rare occurrences include psychoactive drug 2C ... due to causes such as exposure to drugs of abuse, environmental toxins, or chemotherapeutic drugs. The prevalence of this ... High doses of opiates such as oxycodone can lead to leukoencephalopathy. The activity of various opioid and nociceptive ...
*  Schild regression
Dose-response relationship Ligand receptor binding: Kenakin T, 1993. Pharmacological analysis of drug-receptor interaction New ... Using a dose-response curve or an equivalent curve with concentration and binding %, it is possible to determine the dose ratio ... The dose ratio dr is the ratio of the dose of agonist required for half maximal response with the antagonist B present divided ... curvefit.com - Dose-response curves in the presence of antagonists, for a clear explanation.. ...
*  No-observed-adverse-effect level
This level may be used in the process of establishing a dose-response relationship, a fundamental step in most risk assessment ... In drug development, NOAEL of a new drug is assessed in laboratory animals drugs prior to initiation of clinical trials to ... In toxicology it is specifically the highest tested dose or concentration of a substance (i.e. a drug or chemical) or agent (e. ... It either does not provide the effects of drug with respect to duration and dose, or it does not address the interpretation of ...
*  Index of HIV/AIDS-related articles
... dose-ranging study - dose-response relationship - double burden of disease - double-blind study - drug resistance - drug-drug ... antiretroviral drugs - antisense drugs - antitoxins - Antiviral drug - aphasia - aphthous ulcer - apoptosis - approved drugs - ... multi-drug rescue therapy - multiple drug-resistant tuberculosis (MDR-TB) - mutation - myalgia - mycobacterium - mycobacterium ... New Drug Application (NDA) - New York Cares - NIAID - NICHD - night sweat - NIH - NK cell - NLM - NNRTI - non-Hodgkin's ...
*  Effect
... an unwanted change in medical condition caused by a drug Dose-response effect, the relationship between a drug dose and its ... plotted on a dose-response curve In media: Special effect, an artificial illusion Sound effect, an artificially created or ... Drug effect, a change resulting from the administration of a drug Therapeutic effect, a beneficial change in medical condition ... a measure of the strength of a relationship between two variables Effect system, formal system which describes the ...
*  Hepatotoxicity
Drugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves ( ... This type of injury does not have a clear dose-response nor temporal relationship, and most often does not have predictive ... To diagnose hepatotoxicity, a causal relationship between the use of the toxin or drug and subsequent liver damage has to be ... The risk of liver injury is influenced by several factors including the dose ingested, concurrent alcohol or other drug intake ...
*  Atypical antipsychotic
"Single oral dose kinetics of zotepine and its relationship to prolactin response and side effects". Therapeutic Drug Monitoring ... These drugs have relatively long half-lives. Each drug has a different half-life, but the occupancy of the D2 receptor falls ... There is a good response in 40-50% of patients, a partial response in 30-40%, and treatment resistance (failure of symptoms to ... It has been suggested that there is no validity to the term "second-generation antipsychotic drugs" and that the drugs that ...
*  Liquorice (confectionery)
... a linear dose-response relationship". Journal of Human Hypertension. 15 (8): 549-52. doi:10.1038/sj.jhh.1001215. PMID 11494093 ... liquorice candy (in Dutch). Black Licorice: Trick or Treat? from US Food & Drug Administration, Consumer Updates, 25 Oct 2011. ... Black Licorice: Trick or Treat? from US Food & Drug Administration, Consumer Updates, 25 Oct 2011. Räikkönen, Katri; et al. ( ...
*  Nootropic
MPH effects are dose-dependent and the dose-response relationship differs between cognitive domains. Urban, KR; Gao, WJ (2014 ... This suggests that cortical networks that normally process spatial working memory become more efficient in response to the drug ... In particular, in both animals and humans, lower doses maximally improve performance in tests of working memory and response ... The most commonly used class of drug is stimulants, such as caffeine. These drugs are purportedly used primarily to treat ...
*  Dose (biochemistry)
Dose-response curves may illustrate the relationship of these metabolic effects. In over-the-counter medicines, dosage is based ... the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose. In drugs ... By combining these drugs with a system that detects the concentration of drug particles in the blood, proper dosing could be ... Prescription drug dosage is based typically on body weight. Drugs come with a recommended dose in milligrams or micrograms per ...
*  Surgical sieve
... and dose-response relationships thereof) What are the causes of an acute confusional state in a patient? Treatment induced: ... polypharmacy, sedatives, analgesics, steroids, drug withdrawal Vascular: stroke, TIA, vascular dementia Inflammatory: infection ... systemic inflammatory response syndrome Traumatic: head injury, Intracranial hemorrhage, shock Autoimmune: thyroid disease ... conditions relating to a physical response between two or more objects) Psychological/Neurological (conditions relating to the ...
*  Quintin McKellar
Evaluation of dose response relationships. European Journal of Pharmacology (1994) 253, 191-200. Benchaoui, H.A. and McKellar, ... Drug Metabolism and Disposition (2002), 30, 1230-1239. Sarasola, P., Lees, P., Ali Abadi, F.S., McKellar, Q.A., Donachie, W., ... His research interests are in the pharmacology of anti-infective and anti-inflammatory drugs in domestic animals, and he is ... Pharmacokinetic and Pharmacodynamic Profiles of Danofloxacin Administered by Two Dosing Regimens in Claves Infected with ...
*  List of designer drugs
MPH effects are dose-dependent and the dose-response relationship differs between cognitive domains. Urban, KR; Gao, WJ (2014 ... "Isophenmetrazine". New Synthetic Drugs Database. "3-FPE". New Synthetic Drugs Database. "Phenmetetrazine". New Synthetic Drugs ... In particular, in both animals and humans, lower doses maximally improve performance in tests of working memory and response ... This suggests that cortical networks that normally process spatial working memory become more efficient in response to the drug ...
*  Cardiac fibrosis
The precise mechanisms involved remain elusive however, as while the cardiotoxicity shows some dose-response relationship, it ... These drugs include ergotamine and methysergide and both drugs can also cause cardiac fibrosis. Certain antiparkinson drugs, ... The drugs most classically associated with the condition are weight loss drugs such as fenfluramine and chlorphentermine, and ... Drugs which act as 5-HT2B agonists tend to be less likely to cause heart problems when used sparingly.[citation needed] The ...
*  Long-term effects of cannabis
... and that a dose-response relationship exists between the level of cannabis use and risk of psychosis. The analysis was not able ... The gateway drug hypothesis asserts that the use of cannabis may ultimately lead to the use of harder drugs. A 2013 literature ... underlying psychiatric pathology that preceded drug use, and combined use of other psychoactive drugs. A 2014 review said that ... Cannabis is the most widely used illicit drug in the Western world, and in the US 10 to 20% of consumers who use cannabis daily ...
*  Arndt-Schulz rule
... was called upon to provide some explanation for observed relationships between dose and response during the early days of ... Stumpf, Walter E. (June 2006). "The dose makes the medicine". Drug Discovery Today. 11 (11-12): 550-555. doi:10.1016/j.drudis. ... It states that: For every substance, small doses stimulate, moderate doses inhibit, large doses kill. That is to say, highly ... For instance, many paralysing substances have no exciting effect in weak doses, and what constitutes a weak, medium or strong ...
*  EC50
Measures of pollutant concentration Dose-response relationship Certain safety factor IC50 (half maximal inhibitory ... It is commonly used as a measure of a drug's potency. EC50 is expressed in molar units (M), where 1 M is equivalent to 1 mol/L ... The EC50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a ... concentration) LD50 (median lethal dose) Therapeutic index Introducing dose response curves Archived 2007-02-19 at the Wayback ...
*  Lysergic acid hydroxyethylamide
There was a satisfactory dose/response relationship. This contracture was very similar to that produced by ergmetrine maleate, ... two ancient magic drugs of Mexico. Bulletin on Narcotics. 1: 3 - 14. Ergot - A Rich Source of Pharmacologically Active ... the blood pressure increased moderately without showing any dose/response relationship. Ergometrine maleate seemed to be less ... when given in small doses, on the blood pressure of cats anaethetized with chloralose. Higher intravenous doses (0.1-0.3mg/kg) ...
*  Prenatal methamphetamine exposure
... it is important that researchers seek to determine this pattern to examine a possible dose-response relationship between MA use ... Methamphetamine is a highly addictive drug that can make users crave more as soon as the end of the last dose, which makes it ... Prenatal drug use by women in the United States came to the forefront of media and public health attention in the 1980s when ... In this study they gave doses of 5 mg/day from days 8 to 22 of pregnancy . The offspring were sacrificed at days 7,14, and 21. ...
*  Hydromorphinol
"Influence of polarity on dose-response relationships of intrathecal opioids in rats". Pain. 40 (3): 339-347. doi:10.1016/0304- ... In the United States, it was never available and is classified as a Schedule I drug with a DEA ACSCN of 9301. The salts in use ... but is twice as potent as morphine and has a steeper dose-response curve and longer half-life. It is used in medicine as the ... It is controlled under the Single Convention On Narcotic Drugs. Oxymorphol N-Phenethylhydromorphinol (RAM-378) US 2960505, ...
*  TIK-301
... was shown to be effective at promoting sleep at various doses; there is a positive dose response relationship between ... 20 mg dose had a different elimination constant from all other doses above 35 mg. TIK-301 is intended to be a take-as-need drug ... In a phase I clinical trial, TIK-301 was shown to be effective as a chronobiotic at a dose of 5 mg/L, but not in lower doses. ... Acquires Drug in Clinical Development to Treat Sleep Disorders". Phase 2 Discovery, Inc. Acquires Drug in Clinical Development ...
*  Tardive dyskinesia
The D2 hypersensitivity hypothesis is also supported by evidence of a dose-response relationship, withdrawal effects, studies ... Vijayakumar, D; Jankovic, J (May 2016). "Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia". Drugs. 76 (7): 779- ... this can happen from the individual having an increased dose of an antipsychotic drug. Often the symptoms of tardive dyskinesia ... antipsychotic drugs to that of first generation drugs. The newer antipsychotics appear to have a substantially reduced ...
*  Hemoencephalography
70% of sufferers saw a 50% or more reduction in their migraines following combined neurotherapy and drug treatment, as opposed ... This is also referred to as the haemodynamic response. Developed by the godfather of hemoencephalography, Dr. Hershel Toomim, ... cats at the behest of NASA that proved that cats trained to consciously alter their sensorimotor rhythm were resistant to doses ... changes in blood oxygenation level are not instantaneous Mechanistic claims are unsupported as no reverse causal relationship ...