... dolichyl phosphate N-acetylglucosaminyltransferase, UDP-N-acetylglucosamine-dolichol phosphate, and N- ... Other names in common use include uridine diphosphoacetylglucosamine-dolichol phosphate, acetylglucosaminyltransferase, ... dolichyl phosphate ⇌ {\displaystyle \rightleftharpoons } UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate Thus, the two ... A probable dolichol pyrophosphate derivative". Biochem. Biophys. Res. Commun. 52 (4): 1285-92. doi:10.1016/0006-291X(73)90640-2 ...
Maeda, Yusuke; Kinoshita, Taroh (2008). "Dolichol-phosphate mannose synthase: Structure, function and regulation". Biochimica ... Dolichol monophosphate mannose is a chemical compound involved in glycosylation. ...
Also of note, a reduction of dolichol phosphate mannose . CDG I (DPM2) weak muscle tone starting in first weeks of the infant, ...
UDP-glucose dolichyl-phosphate glucosyltransferase, uridine diphosphoglucose-dolichol glucosyltransferase, UDP-glucose:dolichol ... dolichyl phosphate ⇌ {\displaystyle \rightleftharpoons } UDP + dolichyl beta-D-glucosyl phosphate Thus, the two substrates of ... Formation of dolichyl D[14C]glucosyl phosphate and 14C-labeled lipid-linked oligosaccharides from UDP-D-[14C]glucose". J. Biol ... The systematic name of this enzyme class is UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase. Other names in common ...
Through dolichols, the dolichol phosphate cycle occurs. The dolichol phosphate cycle plays a major role in the synthesis of ... Decreased levels of dolichols are registered with acute rheumatism and other immunodeficient conditions. The dolichol phosphate ... Dolichols, which are found in all living creatures, including humans, are their 2,3-dihydro derivatives. Live trees are known ... What polyprenols are to plants, dolichols are to all living creatures, including man. They are in fact of a very similar ...
Dolichols are the major lipid component (14% by mass) of human substantia nigra (SN) neuromelanin. Dolichol phosphate was ... Dolichols play a role in the co-translational modification of proteins known as N-glycosylation in the form of dolichol ... Dolichol is also involved in transfer of the monosaccharides to the forming Glc3-Man9-GlcNAc2-Dolichol carrier. In addition, ... Dolichol kinase Polyprenols Solagran Mevalonate inhibition#Dolichol Inhibition Fedorow, Heidi; Pickford, Russell; Hook, James M ...
N-linked glycosylation requires participation of a special lipid called dolichol phosphate. O-linked glycans attached to the ... Phosphoglycans linked through the phosphate of a phosphoserine. C-linked glycans, a rare form of glycosylation where a sugar is ...
... dolichyl-phosphate GlcNAc-1-phosphate transferase, UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1- ... UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase, and UDP-acetylglucosamine-dolichol phosphate ... "Properties of a soluble polyprenyl phosphate UDP-D-N-acetylglucosamine N-acetylglucosamine-1-phosphate transferase". J. Biol. ... phosphate transferase, uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase, ...
dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene. Dolichol-phosphate mannose (Dol-P- ... Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate ... 2000). "Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3". EMBO J. 19 (11): 2475-82. ... 2001). "Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated ...
The systematic name is dolichyl-β-D-glucosyl-phosphate dolichylphosphohydrolase. Other names in common use include dolichol ... The enzyme dolichylphosphate-glucose phosphodiesterase (EC 3.1.4.48) catalyzes the reaction dolichyl β-D-glucosyl phosphate + ... H2O ⇌ {\displaystyle \rightleftharpoons } dolichyl phosphate + D-glucose This enzyme belongs to the family of hydrolases, ...
... guanosine diphosphomannose-dolichol phosphate mannosyltransferase, dolichol phosphate mannose synthase, dolichyl phosphate ... Bretthauer RK, Wu S, Irwin WE (1973). "Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate ... Richards JB, Hemming FW (1972). "The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein ... mannosyltransferase, dolichyl-phosphate mannose synthase, GDP-mannose-dolichol phosphate mannosyltransferase, GDP-mannose- ...
Other names in common use include dolichol phosphomannose-protein mannosyltransferase, and protein O-D-mannosyltransferase. A ... Babczinski P, Haselbeck A, Tanner W (1980). "Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate ... dolichyl phosphate + O-D-mannosylprotein Thus, the two substrates of this enzyme are dolichyl phosphate D-mannose and protein, ... In enzymology, a dolichyl-phosphate-mannose-protein mannosyltransferase (EC 2.4.1.109) is an enzyme that catalyzes the chemical ...
March 2007). "A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy". Am. J. ... Dolichol kinase deficiency is a cutaneous condition caused by a mutation in the dolichol kinase gene. It is also known as ...
2007). "A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy". Am. J. Hum. ... In enzymology, a dolichol kinase (EC 2.7.1.108) is an enzyme that catalyzes the chemical reaction CTP + dolichol ⇌ {\ ... The systematic name of this enzyme class is CTP:dolichol O-phosphotransferase. This enzyme is also called dolichol ... "A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy". Am. J. Hum. Genet. 80 ...
Dolichol Phosphate N-Acetylglucosamine-1 Phosphate Transferase (DPAGT1) causes a novel congenital disorder of Glycosylation ... This enzyme is responsible for the interconversion of mannose-6-phosphate and mannose-1-phosphate, and its deficiency leads to ... "A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy". American Journal of ... synthesized in the ER on a dolichol-phosphate (Dol-P) anchor. The mature LLO is transferred co-translationally to consensus ...
Dolichol-phosphate mannosyltransferase is an enzyme that in humans is encoded by the DPM1 gene. Dolichol-phosphate mannose (Dol ... Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate ... Maeda Y, Tanaka S, Hino J, Kangawa K, Kinoshita T (Jun 2000). "Human dolichol-phosphate-mannose synthase consists of three ... Ashida H, Maeda Y, Kinoshita T (Jan 2006). "DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to ...
Mannose 1-phosphate is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in the ... Phosphomannomutase 2 catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. ...
During aging the human brain shows a progressive increase in levels of dolichol, a reduction in levels of ubiquinone, but ... The increase in the sugar carrier dolichyl phosphate may reflect an increased rate of glycosylation in the diseased brain and ... In Alzheimer's disease, the situation is reversed with decreased levels of dolichol and increased levels of ubiquinone. The ... concentrations of dolichyl phosphate are also increased, while cholesterol remains unchanged. ...
Typically, the dolichol generated is further modified into dolichol-linked oligosaccharide (DLO) by the addition of phosphates ... This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol- ... Dolichol is a key building block in the body's glycosylation process. ... "SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder". Cell. 142 (2 ...
This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. ...
Dolichyl β-d-glucosyl phosphate is a molecule involved in glycosylation. It is a polyprenyl glycosyl phosphate having dolichol ... Dolichylphosphate-glucose phosphodiesterase "Dolichyl b-D-glucosyl phosphate". PubChem. National Library of Medicine. Archived ...
Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene. Dolichol- ... Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate ... 2000). "Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3". EMBO J. 19 (11): 2475-82. ... Ashida H, Maeda Y, Kinoshita T (2006). "DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and ...
Other names in common use include dolichol phosphate phosphatase, dolichol phosphatase, dolichol monophosphatase, dolichyl ... dolichol + phosphate This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester ... Rip JW, Rupar CA, Chaudhary N, Carroll KK (1981). "Localization of a dolichyl phosphate phosphatase in plasma membranes of rat ... Adrian GS, Keenan RW (1979). "A dolichyl phosphate-cleaving acid phosphatase from Tetrahymena pyriformis". Biochim. Biophys. ...
... such as dolichol phosphates in eukaryotic organism, or undecaprenyl phosphate in bacteria. Glycosyltransferases that use sugar ... The phosphate(s) of these donor molecules are usually coordinated by divalent cations such as manganese, however metal ... Transferases may also use lipids as an acceptor, forming glycolipids, and even use lipid-linked sugar phosphate donors, ... Some glycosyltransferases catalyse transfer to inorganic phosphate or water. Glycosyl transfer can also occur to protein ...
Orlean P. (1990) Dolichol phosphate mannose synthase is required in vivo for glycosyl-phosphatidylinositol membrane anchoring, ... Vainauskas S. and Menon A. K. (2006) Ethanolamine phosphate linked to the first mannose residue of glycosylphosphatidylinositol ... molecule embedded in the membrane using sugars donated from sugar nucleotides and dolichol-P-mannose outside and inside the ER ...
It is a member of the Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase class of enzymes. This gene ... That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide ...
Sugar molecules are attached to the dolichol through a pyrophosphate linkage (one phosphate was originally linked to dolichol, ... The process of N-linked glycosylation starts with the formation of dolichol-linked GlcNAc sugar. Dolichol is a lipid molecule ... This reaction is driven by the energy released from the cleavage of the pyrophosphate bond between the dolichol-glycan molecule ... The biosynthesis of N-linked glycans occurs via 3 major steps: Synthesis of dolichol-linked precursor oligosaccharide En bloc ...
This enzyme catalyses the following chemical reaction dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2 ... Dolichyl-P-Man:Man5GlcNAc2-PP-dolichol+alpha-1,3-mannosyltransferase at the U.S. National Library of Medicine Medical Subject ... Cipollo JF, Trimble RB (February 2000). "The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae ... Dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase (EC 2.4.1.258, Man5GlcNAc2-PP-Dol mannosyltransferase, ...
... ingested polyprenols are metabolised by human and animal liver into dolichols which then take part in the dolichol phosphate ... Polyprenols are similar to compounds found in the cells of humans and animals known as dolichols. Research indicates that ...
This enzyme catalyses the following chemical reaction dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2 ... Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol+alpha-1,2-mannosyltransferase at the U.S. National Library of Medicine Medical Subject ... Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase (EC 2.4.1.261, ALG9, ALG9 alpha1,2 mannosyltransferase, ... is an enzyme with systematic name dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-( ...
GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the ... Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for ...
... polyisoprenyl phosphates MeSH D02.455.849.690.250 - dolichol phosphates MeSH D02.455.849.690.700 - polyisoprenyl phosphate ... dolichol MeSH D02.033.415.230.250 - dolichol phosphates MeSH D02.033.415.400 - farnesol MeSH D02.033.415.500 - heptanol MeSH ... dolichol MeSH D02.455.849.365.250 - dolichol phosphates MeSH D02.455.849.440 - gefarnate MeSH D02.455.849.486 - hemiterpenes ... dolichol phosphates MeSH D02.715.650.700 - silicones MeSH D02.715.650.700.150 - dimethylpolysiloxanes MeSH D02.715.650.700. ...