This DNA intermediate state of the virus is called the provirus. When the virus DNA is inserted inside or even near a gene, it ... Mouse mammary tumor virus (MMTV) is a milk-transmitted retrovirus like the HTL viruses, HI viruses, and BLV. It belongs to the ... As a result, mice with endogenous MMTV have the virus's DNA in every cell of its body, as the virus is present in the DNA of ... The majority of mammary tumors in mice are caused by mouse mammary tumor virus. Several mouse strains carry the virus ...
1972). DNA Tumour Viruses. Cold Spring Harbor: Cold Spring Harbor Laboratory. ISBN 0879691425. Watson, J. D.; Tooze, J. (1981 ... 1973). The Molecular Biology of Tumour Viruses. Cold Spring Harbor: Cold Spring Harbor Laboratory. ISBN 0879691085. Tooze, J., ... The DNA Story. San Francisco: W. H. Freeman. ISBN 978-0716715900. Watson, J. D.; Tooze, J.; Kurz, D. (1983). Recombinant DNA: A ... Hunt, D.; Tooze, J.; Kurz, D. (1983). DNA makes RNA makes Protein. Elsevier Biomedical Press. ISBN 978-0444804914. Branden, C. ...
Loeb L A, Harris C C Cancer Res 2008;68:6863-6872 "DNA and RNA Tumor Viruses." DNA and RNA Tumor Viruses. N.p., n.d. Web. 11 ... some virus are co-carcinogens like Herpesviruses, Epstein-Barr virus (EBV) and human herpesvirus 4 (HHV-4) Over intake beta ... A chemical may act as a co-carcinogen even if it does not cause direct DNA damage such as mutation, as long as it can affect a ... For example, sodium arsenite can be administered to mice at a low enough concentration that it does not cause tumors on its own ...
"DNA and RNA tumor viruses". The Lasker Foundation. Retrieved 30 December 2017. Deubler, M. Josephine (Summer 1984). "Centennial ... ISBN 978-0-415-92038-4. Moscou MJ, Bogdanove AJ (December 2009). "A simple cipher governs DNA recognition by TAL effectors". ... particularly of the tobacco mosaic virus; Fellow of the American Academy of Arts and Sciences and of the Biophysical Society ( ... known for his work in Tobacco mosaic virus; first president of the Biophysical Society; member of the National Academy of ...
DNA polymerase and many others. While no other human tumor virus possesses these same genes, other tumor viruses target the ... "Circular DNA tumor viruses make circular RNAs". Proceedings of the National Academy of Sciences of the United States of America ... the genomic DNA in the two samples should be precisely identical except for DNA belonging to the virus. In their initial RDA ... all tumor viruses appear to attack the same cellular control pathways, so-called tumor suppressor pathways.[citation needed] ...
T-cell Leukemia virus type I, and hepatitis B. Viral oncogenesis are most common with DNA and RNA tumor viruses, most ... and T-cell Leukemia virus type I. As many as 20% of human tumors are caused by viruses. Some such viruses that are commonly ... Acute transforming viruses induce a rapid tumor growth since they carry viral oncogenes in their DNA/RNA to induce such growth ... Many transforming infections by DNA tumor viruses are also cytocidal. Table 1: Cellular effects of viral infections Cytocidal ...
Tumor viruses come in a variety of forms: Viruses with a DNA genome, such as adenovirus, and viruses with an RNA genome, like ... it now refers to any virus with a DNA or RNA genome causing cancer and is synonymous with "tumor virus" or "cancer virus". The ... direct tumor viruses must have at least one virus copy in every tumor cell expressing at least one protein or RNA that is ... "The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53 ...
Baltimore D. (June 1970). "RNA-dependent DNA polymerase in virions of RNA tumour viruses". Nature. 226 (5252): 1209-11. Bibcode ... Reverse transcription - David Baltimore independently isolated, in 1970 at MIT, two RNA tumor viruses: R-MLV and again RSV. ...
Baltimore D (June 1970). "RNA-dependent DNA polymerase in virions of RNA tumour viruses". Nature. 226 (5252): 1209-11. doi: ... Temin HM, Mizutani S (June 1970). "RNA-dependent DNA polymerase in virions of Rous sarcoma virus". Nature. 226 (5252): 1211-3. ... These effects are referred to as epigenetic and involve the higher order structure of DNA, non-sequence specific DNA binding ... An expression system consists of a gene, normally encoded by DNA, and the molecular machinery required to transcribe the DNA ...
Baltimore D (June 1970). "RNA-dependent DNA polymerase in virions of RNA tumour viruses". Nature. 226 (5252): 1209-11. Bibcode: ... In the lab, Temin studied the Rous sarcoma virus, a tumor-causing virus that infects chickens. During his research on the virus ... Temin showed that certain tumor viruses carried the enzymatic ability to reverse the flow of information from RNA back to DNA ... which inhibits the expression of DNA, he determined that the provirus was DNA or was located on the cell's DNA. These results ...
Baltimore D (June 1970). "RNA-dependent DNA polymerase in virions of RNA tumour viruses". Nature. 226 (5252): 1209-11. Bibcode: ... Baltimore extended this work and examined two RNA tumor viruses, Rauscher murine leukemia virus and Rous sarcoma virus. He went ... "RNA-dependent DNA polymerase in virions of RNA tumour viruses". Nature. 226 (5252): 1209-11. Bibcode:1970Natur.226.1209B. doi: ... used recombinant DNA technology to generate a plasmid encoding the genome of poliovirus, an animal RNA virus. The plasmid DNA ...
Similar proteins from related viruses are known as large tumor antigen in general. TAg is a product of an early gene ... Protein-protein interactions between T-antigen and DNA polymerase-alpha directly stimulate replication of the virus genome. T- ... SV40 is a double-stranded, circular DNA virus belonging to the Polyomaviridae (earlier Papovavirus) family, Orthopolyomavirus ... which promotes DNA replication. The SV40 genome is very small and does not encode all the information necessary for DNA ...
Oncolytic viruses - "TG6002" is an oncolytic virus designed to express a recombinant enzyme within tumor cells capable of ... The expression of this enzyme is enabled by the addition of the FCU1 gene into the viral DNA of TG6002. - "BT-001" is an ... The genome of these viruses has been modified to express anti-tumor therapies directly within the tumor. Myvac is a platform ... The platform enables the design of personalized viruses based on each patient's tumor mutations. Transgene selects around 30 ...
Research publications at Pubmed Ucker, DS; Ross, SR; Yamamoto, KR (December 1981). "Mammary tumor virus DNA contains sequences ... Chandler, VL; Maler, BA; Yamamoto; KR (June 1983). "DNA sequences bound specifically by glucocorticoid receptor in vitro render ... dependence on hormone and DNA". Proc. Natl. Acad. Sci. 69 (8): 2105-2109. Bibcode:1972PNAS...69.2105Y. doi:10.1073/pnas.69.8. ...
"Herpes viruses and tumors evolved to learn how to manipulate the same ancient RNA". v t e (All stub articles, Genetics stubs, ... and it goes awry in 50 percent of tumors. Because HSAT-II DNA is normally methylated (a form of gene regulation), it remains ... Human satellite II is an exceptionally high-copy but unexplored sequence of the human genome thought of as junk DNA has a ... Both herpes viruses and cancer manipulate this same pathway causing genetic instability and disease. "Scientists find ...
Accumulation of DNA damage may result in cells with oncogenic mutations and thus the development of a tumor. Multinodular ... Infection by RNA viruses can trigger the RNAi cascade. It is likely dicer is involved in viral immunity as viruses that infect ... DNA damage increases in mammalian cells with decreased Dicer expression as a result of decreased efficiency of DNA damage ... Similarly to humans, insect viruses have evolved mechanisms to avoid the RNAi pathway. As an example, Drosophila C virus ...
Andres, Gabrielle (22 April 2022). "MP Baey Yam Keng's nose tumour 'gone', blood clear of cancer-related virus DNA". CNA. ... On 22 April, Baey was cleared of tumours and other cancer-related virus DNA. "Changes to Cabinet and Other Appointments (June ...
... is considered a chordopoxvirus due to its ability to infect vertebrates and consists of linear double-stranded DNA. Being a ... The virus caused the formation of tumors on the bodies of the monkeys. From these tumors the virus was isolated and determined ... In general the only symptoms of the virus will be the formation of tumors.[citation needed] The Yaba monkey tumor virus (YMTV) ... The Yaba monkey tumor virus is a type of poxvirus. The first case of the virus was obtained from a colony of rhesus monkeys in ...
... of Murine Type-C RNA Tumor Viruses". Proceedings of the National Academy of Sciences. 71 (5): 1871-1876. Bibcode:1974PNAS... ... Wu, Alan M.; Sarngadharan, M. G.; Gallo, Robert C. (May 1974). "Separation of Ribonuclease H and RNA Directed DNA Polymerase ( ... Wu, A M; Schultz, A; Gallo, R C (July 1976). "Synthesis of type C virus particles from murine-cultured cells induced by ... Wu applied this knowledge to probe the effects of drugs on mouse tumours induced by oncogenic viruses. He became director of ...
In 1974 van der Eb and Graham demonstrated that loose virus DNA could cause cancer. In 1974 van der Eb became a lector of ... In 1979 he was named professor of fundamental tumor virology. From 1987 to 1992 he performed research on the chicken anemia ... He studied adenoviruses and characterized the virus DNA in 1966. He obtained his PhD at Leiden University in 1968 with a thesis ... "HEK293: when the virus meets the cell". synabs.be. 6 October 2020. Archived from the original on 16 October 2020. Sander Becker ...
"Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA". Retrovirology. 13 (1 ... did not show any trace of BLV DNA and thus excludes clonal insertion (integration into human genomic DNA) of BLV into the DNA ... It is closely related to the human T‑lymphotropic virus type 1 (HTLV-I). BLV may integrate into the genomic DNA of B‑ ... Buehring GC, Shen HM, Jensen HM, Choi KY, Sun D, Nuovo G (May 2014). "Bovine leukemia virus DNA in human breast tissue". ...
Phase I of the trial recruited patients with metastatic solid tumors and showed evidence for virus replication within tumour ... It blocks cell progression in response to cellular stress or DNA damage. Many viruses replicate by altering the cell cycle and ... Oncolytic virus Oncolytic AAV Oncolytic herpes virus Virotherapy Pandha, K. J. Harrington; edited by Richard G. Vile, Hardev ( ... When these molecules selectively expressed in tumor cells, oncolytic adenoviruses promote immune responses against tumor and ...
The initial approach incorporated DNA into an engineered virus to deliver the DNA into a chromosome. Naked DNA approaches have ... The goal was to cure malignant brain tumors by using recombinant DNA to transfer a gene making the tumor cells sensitive to a ... The two major classes are recombinant viruses (sometimes called biological nanoparticles or viral vectors) and naked DNA or DNA ... a helper virus. Adenovirus and the herpes viruses act as helper viruses for AAV. AAV persists within the cell outside of the ...
Sambrook is best known for his studies on DNA tumor viruses and the molecular biology of normal and neoplastic cells. His ... Tumour Virus Group at Cold Spring Harbor identified and mapped all of the major genes of adenoviruses and SV40, determined ... He is also co-editor of Inspiring Science: Jim Watson and the Age of DNA and Life Illuminated: Selected Papers from Cold Spring ... Joseph Frank Sambrook (1 March 1939 - 14 June 2019) was a British molecular biologist known for his studies of DNA oncoviruses ...
Cells infected by these viruses contain latent viral DNA which is transcribed and the resulting protein produces an immune ... Certain tumor antigens are thus used as tumor markers. More importantly, tumor antigens can be used in cancer therapy as tumor ... Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host. Tumor ... Tumor antigens, because of their relative abundance in tumor cells are useful in identifying specific tumor cells. Certain ...
His studies included characterizing the viruses' DNA, investigating the tumor-inducing properties of the viruses, and ... Later, Green's research extended to the RNA tumor viruses (tumor-inducing viruses with an RNA genome). Before reverse ... Green collected over 2500 tumor samples and analyzed them for the presence of different DNA and RNA tumor viruses. Nearly all ... This pioneering work helped establish the principle - applicable to all tumor viruses and relevant to tumor oncogenesis more ...
"Biological activity of cloned mammary tumor virus DNA fragments that bind purified glucocorticoid receptor protein in vitro". ... Mouse mammary tumor virus (MMTV), is a retro virus that has been a known promoter to cause breast tumors once activated. MMTV ... Nusse, R; Varmus, H. E. (1982). "Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same ... 2010). Mouse mammary tumor virus molecular biology and oncogenesis. Viruses 2(9), 2000-2012. doi: 10.3390/v2092000 Campbell, S ...
". "Frequently Asked Questions on Viral Tumor Diseases - Compiled by the AAAP Tumor Virus Committee". v t e (CS1 maint: ... such as a similarity to mammalian retroviruses and its presence in the genome of some large DNA viruses. To explain them a ... MI is the primary laboratory for research in REV and other tumor viruses. The American Association of Avian Pathologists ... Reticuloendotheliosis virus represents a third distinct etiological group of avian viral neoplasms, after Marek's disease and ...
... a tumor-causing virus affecting monkeys and humans, he did not pay much attention to this protein. The p53 protein is a tumor- ... This results in the release of many reactive oxygen species, causing DNA damage. When DNA is damaged, a DNA damage response ... circular minus-strand DNA found in the Chicken Anemia Virus (CAV) genome. This virus belongs to the Gyrovirus genus, and is ... to specific DNA sequences; the CTD is a positive regulator of DNA binding and stabilizes the interaction of the DNA with the ...
Levine, A.J. The Origins of Small DNA Tumor Viruses In: Foundations in Cancer Research, Academic Press, 1994 pp. 152-153. ... At Eddy's suggestion, the virus was dubbed polyoma, which means many tumors. The virus was named the Stewart-Eddy or SE polyoma ... The rivalry came to a peak in 1958, when Jacob Furth attributed the discovery of the parotid tumor virus to both Stewart and ... When Stewart and Eddy, along with Borgese, published their 1958 paper on a parotid tumor-inducing virus (later named the SE ...
According to Randy Schekman, "these studies were influential in suggesting how certain human tumor viruses may combine with a ... Echols also performed pioneering work in determining how phage DNA moves in and out of a host cell's DNA during infection. ... Echols became interested in factors controlling fidelity of DNA replication and the SOS response caused by DNA damage. He spent ... Using his broad palette of techniques, he wrote a number of papers of "virtuosic science" starting in 1982 studying DNA ...