Her research focuses on the molecular mechanisms of transposable elements, or mobile sequences of DNA found in the genomes of ... Throughout her career, Craig has focused her research interests on transposable elements, or sequences of DNA that can change ... where she studied the chemistry of DNA repair and the mechanisms of the cellular SOS response to DNA damage. She was ... position in a genome; such elements are found in the genomes of nearly all known organisms and gave rise to a large fraction of ...

... with a specific focus on transposable elements in DNA. It was established in 2010 and is published by BioMed Central. The ... Editorial Board, Mobile DNA (2022-12-28). "Obituary: Haig Kazazian and Horizontal Transfer (1937 - 2022)". Mobile DNA. 13 (1): ... Mobile DNA is a peer-reviewed online-only open access scientific journal covering genomics, ...

... is an enzyme that in humans is encoded by the PGBD5 gene. PGBD5 is a DNA transposase ... "PGBD5 piggyBac transposable element derived 5 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 8 April ... Shao, Benjamin (May 2018). Effects of PiggyBac Transposable Element Derived 5 (PGBD5) in Cortical Tissue (BS thesis). ... Research, American Association for Cancer (2018-01-01). "The DNA Transposase PGBD5 Sensitizes Tumors to Inhibition of DNA ...

Since nearly all RT genes function in retrovirus replication and/or the movement of transposable elements, it is reasonable to ... Multicopy single-stranded DNA (msDNA) is a type of extrachromosomal satellite DNA that consists of a single-stranded DNA ... or even between DNA polymerases using DNA as a template, versus DNA polymerases using RNA as a template. The catalytic region ... The priming of msDNA synthesis offers a fascinating challenge to our understanding of DNA synthesis. DNA polymerases (which ...

... s are a superfamily of DNA transposons, or Class II transposable elements, that are common in the genomes of ... "A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture ... "Comparative Analysis of Transposable Elements Highlights Mobilome Diversity and Evolution in Vertebrates". Genome Biology and ... the Activator or Ac element from Zea mays, and the Tam3 element from Antirrhinum majus. The superfamily has been divided based ...

When a transposable element does not proceed through RNA as an intermediate, it is called a DNA transposon. Other ... transposable elements. Transposable elements are estimated to constitute 45% of the human genome. Since uncontrolled ... Transposable elements that are transcribed into RNA, reverse-transcribed into DNA, then reintegrated into the genome are called ... decaying remnants of Transposable elements, these have been labelled "junk" or "selfish" DNA. Nevertheless, occasionally some ...

They are class II transposable elements (TEs) that move through a DNA intermediate, as opposed to class I TEs, retrotransposons ... DNA transposons can move in the DNA of an organism via a single-or double-stranded DNA intermediate. DNA transposons have been ... Dfam, a database of repeating DNA sequences Repbase, a database and classification system for repeating DNA sequences DNA ... particularly Rag1 and Rag2 are derived from transposable elements. There is evidence suggesting that at least 40 human DNA ...

Transposable elements-repetitious sequences of DNA that can insert themselves into any part of the genome-can encourage ectopic ... The frequency of ectopic recombination of transposable elements has been linked to both higher copy numbers of transposable ... It follows that transposable elements that are shorter, transpose themselves less often, and have mutation rates high enough to ... A test for the role of natural selection in the stabilization of transposable element copy number in a population of Drosophila ...

October 2004). "Human endogenous retroviruses: transposable elements with potential?". Clinical and Experimental Immunology. ... It's important to note that there are many examples of functional DNA elements in non-coding DNA (see above) and there are no ... Non-coding DNA (ncDNA) sequences are components of an organism's DNA that do not encode protein sequences. Some non-coding DNA ... These are regions of the genome where the DNA replication machinery is assembled and the DNA is unwound to begin DNA synthesis ...

... are homologous to other subtelomeres that are located at different chromosomes and are a type of transposable element, DNA ... Most vertebrate telomeric DNA consists of long (TTAGGG)n repeats of variable length, often around 3-20kb. Subtelomeres are ... Subtelomeres are considered to be the most distal (farthest from the centromere) region of unique DNA on a chromosome, and they ... Sgo2 remains in subtelomeres, whose cells lack telomere DNA. Sgo2 represses the expression of subtelomeric genes that is in a ...

Repetitive DNA is primarily derived from transposable elements (TEs), which include DNA transposons belonging to around 20 ... GIRI has hosted three international conferences devoted to the genomic impact of eukaryotic transposable elements. "Home Page ... "2nd International Conference/Workshop on Genomic Impact of Eukaryotic Transposable Elements". Official Website of the Institute ... An ancient element from the Transib superfamily was identified as the evolutionary precursor of the Recombination activating ...

... (also L1 and LINE-1) is a family of related class I transposable elements in the DNA of some organisms, classified with ... Erwin JA, Marchetto MC, Gage FH (August 2014). "Mobile DNA elements in the generation of diversity and complexity in the brain ... Mobile genetic elements, Molecular biology, Repetitive DNA sequences). ... A typical L1 element is approximately 6,000 base pairs (bp) long and consists of two non-overlapping open reading frames (ORFs ...

Much of the DNA in large genomes originates from selfish amplification of transposable elements. Some of this sequence has ... Junk DNA (non-functional DNA) is a DNA sequence that has no relevant biological function. Most organisms have some junk DNA in ... The proponents of junk DNA tended to dismiss intron sequences as mostly nonfunctional DNA (junk) but junk DNA opponents ... of human genomic DNA by the Encyclopedia of DNA Elements (ENCODE) project. This forms an upper estimate of the functional ...

... an insertion sequence element, or an IS element) is a short DNA sequence that acts as a simple transposable element. Insertion ... certain eukaryotic DNA sequences belonging to the family of Tc1/mariner transposable elements may be considered to be, ... DNA composition).. Recombination between genomic IS sites can enable bacteria to adapt to new environments, making IS elements ... they are small relative to other transposable elements (generally around 700 to 2500 bp in length) and only code for proteins ...

... physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements. J ... Plasterk, R.H., Z. Izsvak, and Z. Ivics, Resident aliens: the Tc1/mariner superfamily of transposable elements. Trends Genet, ... are engineered DNA-binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at ... SB, like other DNA transposons, mobilizes itself via a cut-and-paste mechanism whereby a transposase enzyme, encoded by the ...

At first, T-DNA was applied for insertional mutagenesis. However, using transposable element can bring more advantages. ... The size of transposable element is between 750 and 40000bp. Transposable element can be mainly classified as two classes: One ... Transposable elements were first discovered by Barbara McClintock in maize plants. She identified the first transposable ... "DNA sequencing How to determine the sequence of bases in a DNA molecule". Archived from the original on 2013-10-21. Retrieved ...

Kazazian's book Mobile DNA: Finding Treasure in Junk (2011) gives an overview of research on transposable elements. It does a " ... Lab member Hagop Youssoufian found a long interspersed nuclear element (LINE) insertion, a mobile DNA element or transposon ... The Kazazian lab was the first to discover a jumping gene in humans, and to demonstrate that a transposable element caused ... Feschotte, Cédric (3 October 2012). "Review of Mobile DNA - finding treasure in junk by Haig H Kazazian". Mobile DNA. 3 (1): 16 ...

... a short DNA transposable element Intersex, an organism with sex characteristics neither exclusively male nor female .is, the ...

... a type of transposable DNA element Piggybacking (security), when an authorized person allows (intentionally or unintentionally ...

... resulting in a far deeper understanding of mobile DNA and the mechanisms underlying transposable elements.[citation needed] ... This discovery opened up the world to an investigation of transposable elements and their effects on a wide variety of ... Shapiro JA (1979). "Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements ... Harshey RM (December 2012). "The Mu story: how a maverick phage moved the field forward". Mob DNA. 3 (1): 21. doi:10.1186/1759- ...

Later he characterized important epigenetic phenomena, showing that DNA methylation of transposable elements affects gene ... Hollister, Jesse D.; Gaut, Brandon S. (August 2009). "Epigenetic silencing of transposable elements: A trade-off between ... "Transposable elements and small RNAs contribute to gene expression divergence between Arabidopsis thaliana and Arabidopsis ... as well as the evolution of transposable elements and their role in shaping genetic architecture and epigenetic state in plants ...

... a transposable element in DNA Lowest unique bid L1, in linguistics, a subject's first language or mother tongue L-1 Identity ... transposable elements in the DNA L1, Lagrangian point 1, the most intuitive position for an object to be gravitationally ...

... introns as mobile genetic elements Junk DNA Mobile genetic elements Mutation Noncoding DNA Retrotransposon Transposable element ... While many transposable elements seem to do no good for the host, some transposable elements have been "tamed" by molecular ... B chromosomes and transposable elements. The contribution of transposable elements to the genome is especially well studied in ... Transposable elements (TEs) include a wide variety of DNA sequences that all have the ability to move to new locations in the ...

... dna transposable elements MeSH G06.184.603.080.708.330.200.500 - integrons MeSH G06.184.603.080.708.330.330 - genomic islands ... alu elements MeSH G06.184.603.080.708.800 - tandem repeat sequences MeSH G06.184.603.080.708.800.140 - dna repeat expansion ... enhancer elements (genetics) MeSH G06.184.603.080.689.330.240 - e-box elements MeSH G06.184.603.080.689.330.400 - hiv enhancer ... serum response element MeSH G06.184.603.080.689.675.700.920 - vitamin d response element MeSH G06.184.603.080.689.675.850 - ...

Characterization of CpG islands by flanking regions De novo detection of repeated sequence such as transposable element DNA ... When k = 1, there are four DNA k-mers, i.e., A, T, G, and C. At the molecular level, there are three hydrogen bonds between G ... This is due to the fact that the k-mer will contain a balance of the repeat region and the adjoining DNA sequences (given it ... For example, all the possible k-mers of a DNA sequence are shown below: A method of visualizing k-mers, the k-mer spectrum, ...

... dna transposable elements MeSH G14.080.708.330.330 - genomic islands MeSH G14.080.708.330.800 - retroelements MeSH G14.080. ... dna transposable elements MeSH G14.340.024.425.500 - genomic islands MeSH G14.340.024.425.800 - retroelements MeSH G14.340. ... serum response element MeSH G14.080.689.330.700.920 - vitamin d response element MeSH G14.080.689.390 - insulator elements MeSH ... alu elements MeSH G14.080.708.800 - tandem repeat sequences MeSH G14.080.708.800.074 - dna repeat expansion MeSH G14.080. ...

"The Dfam community resource of transposable element families, sequence models, and genome annotations". Mobile DNA. 12 (1): 2. ... Stockholm format is a multiple sequence alignment format used by Pfam, Rfam and Dfam, to disseminate protein, RNA and DNA ...

DNA repeats (interspersed repetitive sequences) are copies of transposable elements interspersed throughout the genome. ... is referred to as microsatellite DNA. Thus direct repeat tandem sequences are a form of microsattelite DNA. The process of DNA ... The ribosomal RNA and transfer RNA genes belong to the class of middle repetitive DNA. A tract of repetitive DNA in which a ... In directly repeated sequences of the tobacco plant genome, DNA double-strand breaks can be efficiently repaired by homologous ...

... junk DNA Onion test Plant DNA C-values Database Selfish DNA Transposable elements Greilhuber J, Doležel J, Lysák M, Bennett MD ... with the remainder being various types of non-coding DNA (especially transposable elements). The term "C-value enigma" ... to picograms of DNA and vice versa are: genome size (bp) = (0.978 x 109) x DNA content (pg) DNA content (pg) = genome size (bp ... C-value is the amount, in picograms, of DNA contained within a haploid nucleus (e.g. a gamete) or one half the amount in a ...

... the efficiency by which cells can take up extracellular DNA and express genes encoded by it Transposable element, a sequence of ... a chemical element Test engineer, a professional that designs testing processes Type enforcement, an IT security concept Te ( ... DNA that can move about in the genome, including transposons Echo time in magnetic resonance imaging TE cooler, a solid-state ...