A transposable element (TE, transposon, or jumping gene) is a nucleic acid sequence in DNA that can change its position within ... Repbase - a database of transposable element sequences Dfam - a database of transposable element families, multiple sequence ... Zhou W, Liang G, Molloy PL, Jones PA (August 2020). "DNA methylation enables transposable element-driven genome expansion". ... Transposable elements represent one of several types of mobile genetic elements. TEs are assigned to one of two classes ...
Transposable elements (transposons, TEs, 'jumping genes') are short strands of repetitive DNA that can self-replicate and ... Chromatin and siRNA pathways cooperate to maintain DNA methylation of small transposable elements in Arabidopsis." Genome ... While transposable elements may affect any number of different cell-types in an animal, be a skin cell, a liver cell, a brain ... Though transposable elements were discovered due in large part to their deleterious effects, epigenetic research has shown that ...
"DNA methylation enables transposable element-driven genome expansion". Proceedings of the National Academy of Sciences of the ... In DNA, this reaction, if detected prior to passage of the replication fork, can be corrected by the enzyme thymine-DNA ... Cytosine deamination can alter the genome's many regulatory functions; previously silenced transposable elements (TEs) may ... product of cytosine deamination and not part of DNA) by uracil-DNA glycosylase, generating an abasic (AP) site. The resulting ...
... and provided the definitive link between transposable elements (active elements) and interspersed repetitive DNA (mutated ... Alu elements are retrotransposons and look like DNA copies made from RNA polymerase III-encoded RNAs. Alu elements do not ... Kidwell, Margaret G; Lisch, Damon R (2001). "Perspective: Transposable Elements, Parasitic Dna, and Genome Evolution". ... Alu elements are the most abundant transposable elements, containing over one million copies dispersed throughout the human ...
... (MITEs) are a group of non-autonomous Class II transposable elements (DNA ... "Unexpected invasion of miniature inverted-repeat transposable elements in viral genomes". Mobile DNA. 9: 19. doi:10.1186/s13100 ... "Miniature inverted-repeat transposable elements (MITEs) and their relationship with established DNA transposons". In Craig N, ... Lu C, Chen J, Zhang Y, Hu Q, Su W, Kuang H (March 2012). "Miniature inverted-repeat transposable elements (MITEs) have been ...
Since DNA methylation occurs mostly in transposable elements (TE), DDM1 is thought to be a crucial function in silencing TEs. ... DDM1 is required for DNA methylation in highly heterochromatin transposable elements. DDM1, therefore, often silences ... Decreased DNA Methylation I (DDM1), is a plant gene that encodes a nucleosome remodeler which facilitates DNA methylation. The ... transposable elements but the mutation in Arabidopsis thaliana is not embryo lethal. DDM1 mutants have also been described to ...
It is even suggested that DNA methylation evolved precisely for this purpose. DNA methylation of transposable elements has been ... suggesting that the DNA methylation of transposable elements led to a noticeable increase in the mass of DNA. A function that ... Zhou W, Liang G, Molloy PL, Jones PA (August 2020). "DNA methylation enables transposable element-driven genome expansion". ... Ancient DNA methylation reconstruction, a method to reconstruct high-resolution DNA methylation from ancient DNA samples. The ...
A transposable element (TE) (also called a transposon or jumping gene) is a mobile segment of DNA that can sometimes pick up a ... Successful transfer of a transposable element requires delivery of DNA from donor to host cell (and to the germ line for multi- ... HTT can occur with any type of transposable elements, but DNA transposons and LTR retroelements are more likely to be capable ... Schaack S, Gilbert C, Feschotte C (September 2010). "Promiscuous DNA: horizontal transfer of transposable elements and why it ...
... transposable elements that are mobile fragments of DNA, most of which are nonfunctional in humans; and pseudogenes, ... ENCODE Project Consortium) (September 2012). "An integrated encyclopedia of DNA elements in the human genome". Nature. 489 ( ... The sheer amount of DNA in an organism, measured by the mass of DNA present in the nucleus or the number of constituent ... Susumu Ohno coined the phrase "junk DNA" to describe these nonfunctional swaths of DNA. They include introns, genetic sequences ...
... a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses". Gene. 390 (April): 3-17. doi ... Jurka is best known for his work on eukaryotic transposable elements (TEs), including the discovery of the major families of ... In 2006 they reported a study of a new, self-synthesizing transposable element called Polinton or Maverick, which is present ... Jurka J, Bao W, Kojima K (June 2011). "Families of transposable elements, population structure and the origin of species". ...
"Genomic deletions and precise removal of transposable elements mediated by short identical DNA segments in primates". Genome ... The analysis of SINEs - Short INterspersed Elements - LINEs - Long INterspersed Elements - or truncated LTRs - Long Terminal ... October 2003). "Alu elements and hominid phylogenetics". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 12787-91. doi:10.1073/pnas. ... The target sites are relatively unspecific so that the chance of an independent integration of exactly the same element into ...
... a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses". Gene. 390 (1-2): 3-17. doi: ... Polintons encode up to 10 proteins, the key elements being the protein-primed type B DNA polymerase and the retroviral-like ... Meanwhile, an overlapping class of transposable element was described under the name polintons, derived from the key proteins ... Feschotte, C; Pritham, E (October 2005). "Non-mammalian c-integrases are encoded by giant transposable elements". Trends in ...
In addition, spermatogenesis fails due to sperm DNA damage caused by the derepression of transposable elements. MAEL has also ... Short RNAs are well-known to silence TEs (transposable elements) through the RNAi (RNA interference) pathway, and Piwi- ... Identification of a novel human cancer/testis gene MAEL that is regulated by DNA methylation. Molecular Biology Reports. 37: ...
Kidwell, M. G. and D. R. Lisch (2001) Perspective: Transposable elements, parasitic DNA and genome evolution. Evolution 55:1-24 ... Transposable elements as sources of variation in animals and plants. Proc. Natl. Acad. Sci. 94: 7704-7711. ... lead to collaborative studies resulting in the discovery of hybrid dysgenesis and the isolation of transposable P elements. ... at the University of Arizona has increasingly focused on the evolutionary significance of transposable genetic elements. ...
... a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses". Gene. 390 (1-2): 3-17. doi: ... Putative proteins with homology to the KilA-N domain have also been identified in Maverick transposable elements of the ... In molecular biology, the KilA-N domain is a conserved DNA-binding domain found at the N-terminus of the poxvirus D6R/NIR ... The KilA-N domain has been suggested to be homologous to the fungal DNA-binding APSES domain. In all proteins shown to contain ...
Martienssen's work explains the effect on plants of 'jumping genes', or DNA transposable elements, reported in 1951 by Barbara ... "Somatically heritable switches in the DNA modification of Mu transposable elements monitored with a suppressible mutant in ... Subscription or UK public library membership required.) Slotkin, R. Keith; Martienssen, Robert (2007). "Transposable elements ... Working with maize, yeast and the weed Arabidopsis, he focuses on the chemical modifications to DNA that determine which genes ...
... including long terminal repeat transposable elements. Despite recent advances in massively parallel DNA sequencing, the ... A large proportion of the spruce genome consists of repetitive DNA sequences, ...
... : a retrotransposon of Drosophila combining structural features of DNA viruses, retroviruses and non-viral transposable ... The name micropia is an artificial word, i.e. a concoction of "microcloning" and "copia-like element". Huijser, P., C. ... elements. J Mol Biol 204:233-46. Lankenau, S., V. G. Corces, and D. H. Lankenau. 1994. The Drosophila micropia retrotransposon ...
The sugar pine contains extended regions of non-coding DNA, most of which is derived from transposable elements. The genome of ... The transposable elements that make up the megagenome are linked to the evolutionary change of the sugar pine. ... with a stable diploid genome that is expanded by the proliferation of transposable elements, in contrast to the frequent ...
Tol2 is the only natural DNA transposable element in vertebrates from which an autonomous member has been identified. Examples ... Tol2 element which encodes a gene for a fully functional transposase capable of catalyzing transposition in the zebrafish germ ... These genes have the DNA base pairs AC and TG as repeated sequences at the ends of each intron. On the 3'ss (3' splicing site ... 2005 uncover the role of two of these elements in oocytes of this species. By interfering via a dominant nonfunctional allele ...
... including highly repetitive DNA sequences for their size. Transposable elements accumulate nucleotide substitutions over ... high genome wide repetitive DNA density; and recent transposable element expansions. Genetic diversity in leafy seadragons and ... Transposable element density is enriched near expanded gene families, and low near contracted gene families. For example, BovB ... Often, transposable elements have significant mutational effects on their hosts, some even contributing to organismic evolution ...
Transposable elements are regions of DNA that can be inserted into the genetic code through one of two mechanisms. These ... The most common transposable element in the human genome is the Alu sequence, which is present in the genome over one million ... "A unified classification system for eukaryotic transposable elements". Nature Reviews Genetics. 8 (12): 973-82. doi:10.1038/ ... Gene duplication is the process by which a region of DNA coding for a gene is duplicated. This can occur as the result of an ...
Transposable elements (TEs) are sequences of DNA with a defined structure that are able to change their location in the genome ... Retrotransposon is a transposable element that transpose through an RNA intermediate. Retrotransposons are composed of DNA, but ... However, this special characteristic is caused by the presence of repetitive DNA, and transposable elements (TEs). A typical ... Most DNA virus genomes are composed of a single, linear molecule of DNA, but some are made up of a circular DNA molecule. ...
"Nomenclature of transposable elements in prokaryotes". DNA insertion elements, plasmids, and episomes. [Cold Spring Harbor, N.Y ... "Nomenclature of transposable elements in prokaryotes" (PDF). Plasmid. 2 (3): 466-473. doi:10.1016/0147-619X(79)90030-1. PMID ... "Nomenclature of transposable elements in prokaryotes". Gene. 5 (3): 197-206. doi:10.1016/0378-1119(79)90078-7. PMID 467979. ... His most prominent discovery was the proposal of the "Campbell model" of virus insertion, where viral DNA is inserted into the ...
Spontaneous mutations arise from sources including errors in DNA replication, spontaneous lesions, and transposable genetic ... "Shaping bacterial genomes with integrative and conjugative elements". Research in Microbiology. 155 (5): 376-86. doi:10.1016/j. ... It can occur during meiosis or replication of DNA, as well as due to ionizing or UV radiation, transposons, mutagenic chemicals ... Carroll, Sean B.; Grenier, Jennifer; Weatherbee, Scott (2005). From DNA to Diversity: Molecular Genetics and the Evolution of ...
Her research focuses on the molecular mechanisms of transposable elements, or mobile sequences of DNA found in the genomes of ... Throughout her career, Craig has focused her research interests on transposable elements, or sequences of DNA that can change ... where she studied the chemistry of DNA repair and the mechanisms of the cellular SOS response to DNA damage. She was ... position in a genome; such elements are found in the genomes of nearly all known organisms and gave rise to a large fraction of ...
... with a specific focus on transposable elements in DNA. It was established in 2010 and is published by BioMed Central. The ... Editorial Board, Mobile DNA (2022-12-28). "Obituary: Haig Kazazian and Horizontal Transfer (1937 - 2022)". Mobile DNA. 13 (1): ... Mobile DNA is a peer-reviewed online-only open access scientific journal covering genomics, ...
... is an enzyme that in humans is encoded by the PGBD5 gene. PGBD5 is a DNA transposase ... "PGBD5 piggyBac transposable element derived 5 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 8 April ... Shao, Benjamin (May 2018). Effects of PiggyBac Transposable Element Derived 5 (PGBD5) in Cortical Tissue (BS thesis). ... Research, American Association for Cancer (2018-01-01). "The DNA Transposase PGBD5 Sensitizes Tumors to Inhibition of DNA ...
Since nearly all RT genes function in retrovirus replication and/or the movement of transposable elements, it is reasonable to ... Multicopy single-stranded DNA (msDNA) is a type of extrachromosomal satellite DNA that consists of a single-stranded DNA ... or even between DNA polymerases using DNA as a template, versus DNA polymerases using RNA as a template. The catalytic region ... The priming of msDNA synthesis offers a fascinating challenge to our understanding of DNA synthesis. DNA polymerases (which ...
... s are a superfamily of DNA transposons, or Class II transposable elements, that are common in the genomes of ... "A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture ... "Comparative Analysis of Transposable Elements Highlights Mobilome Diversity and Evolution in Vertebrates". Genome Biology and ... the Activator or Ac element from Zea mays, and the Tam3 element from Antirrhinum majus. The superfamily has been divided based ...