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*  HIST1H2AC
2006). "DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A". Genes Dev. 20 (10): 1343- ... The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher ... 2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312-26. doi:10.1006/viro. ... around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. ...
*  Genome instability
The likely major underlying cause of mutations in cancer is DNA damage. For example, in the case of lung cancer, DNA damage is ... A high frequency of externally caused DNA damage can be one source of genome instability since DNA damages can cause inaccurate ... Bernstein C, Prasad AR, Nfonsam V, Bernstein H. (2013). DNA Damage, DNA Repair and Cancer, New Research Directions in DNA ... www.intechopen.com/books/new-research-directions-in-dna-repair/dna-damage-dna-repair-and-cancer Cunningham, FH; Fiebelkorn, S; ...
*  ERCC1
... damaged DNA and locally separate the DNA helix for a short distance on either side of the site of a site of DNA damage. The ... "DNA Damage, DNA Repair and Cancer". In Chen C. New Research Directions in DNA Repair. doi:10.5772/53919. ISBN 978-953-51-1114-6 ... "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein". Biochemical and ... is the primary DNA repair mechanism that removes the therapeutic platinum-DNA adducts from the tumor DNA. ERCC1 activity levels ...
*  Direct DNA damage
... they protect against direct DNA damage, because the UV light is absorbed by the sunscreen and not by the DNA. DNA repair John A ... Direct DNA damage can occur when DNA directly absorbs a UVB photon, or for numerous other reasons. UVB light causes thymine ... it is generally accepted that the direct DNA damages are the cause of sunburn. While the human body reacts to direct DNA ... DNA transforms more than 99.9% of the photons into harmless heat (but the damage from the remaining < 0.1% is still enough to ...
*  Indirect DNA damage
Sunscreen photoprotection direct DNA damage Free radical damage to DNA singlet oxygen induced DNA damage Cantrell, Ann; ... DNA\ {\xrightarrow {}}\ {}^{3}O_{2}+damaged\ DNA} } Unlike direct DNA damage, which occurs in areas directly exposed to UV-B ... These reactive chemical species can reach DNA by diffusion and the bimolecular reaction damages the DNA (oxidative stress). It ... Indirect DNA damage occurs when a UV-photon is absorbed in the human skin by a chromophore that does not have the ability to ...
*  DNA damage-binding protein
... or UV-DDB is a protein complex that is responsible for repair of UV-damaged DNA. This complex is ... Iovine, Barbara; Iannella, Maria Luigia; Bevilacqua, Maria Assunta (2011). "Damage-specific DNA binding protein 1 (DDB1): a ... for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics. 29 (1): 62-9. doi:10.1006/geno. ...
*  DNA damage (naturally occurring)
... brain AP site Direct DNA damage DNA DNA adduct DNA damage theory of aging DNA repair DNA replication Free radical damage to DNA ... This reflects the accumulation of DNA damage with age. DNA damage accumulation with age is further described in DNA damage ... One indication that DNA damages are a major problem for life is that DNA repair processes, to cope with DNA damages, have been ... DNA damage is distinctly different from mutation, although both are types of error in DNA. DNA damage is an abnormal chemical ...
*  G2-M DNA damage checkpoint
... causes recruitment of these proteins to sites of DNA damage where they mediate the activity of DNA polymerases involved in DNA ... The G2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms ranging from yeast to mammals. ... Inefficient repair of DNA damaged by ionizing radiation or chemical agents in these mutants revealed proteins essential in this ... The main rad3 effector is the kinase chk1, which is required for the G2-M arrest in response to DNA-damaging agents. This ...
*  DNA damage-inducible transcript 3
... has been shown to interact with [proteins]: ATF3, C-Fos, C-jun and CEBPB, CSNK2A1, JunD, and ... DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that ... "Entrez Gene: DDIT3 DNA-damage-inducible transcript 3". Chen BP, Wolfgang CD, Hai T (March 1996). "Analysis of ATF3, a ... CHOP also induces apoptosis during endoplasmic reticulum stress by activating growth arrest and DNA damage-inducible protein ...
*  DNA damage theory of aging
DNA damages and mutations are related because DNA damages often cause errors of DNA synthesis during replication or repair and ... If a DNA repair protein is deficient, unrepaired DNA damages tend to accumulate. Such accumulated DNA damages appear to cause ... a common type of oxidative DNA damage. DNA strand breaks also increased in atherosclerotic plaques, thus linking DNA damage to ... Some DNA damage may remain in any cell despite the action of repair processes. The accumulation of unrepaired DNA damage is ...
*  Free radical damage to DNA
... can occur as a result of exposure to ionizing radiation or to radiomimetic compounds. Damage to DNA ... Radical damage to DNA can also occur through the interaction of DNA with certain natural products known as radiomimetic ... Malignant melanoma can be caused by indirect DNA damage because it is found in parts of the body not exposed to sunlight. DNA ... 3.3.co;2-l. Povirk, L. F. (1996). "DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: Bleomycin, neocarzinostatin ...
*  Bioremediation of radioactive waste
These compounds mutate DNA strands and produce genetic damage, inducing newly lysis and subsequent cell death. Its action on ... DNA damage. Cancer, particularly leukemia. Leukopenia. Growth reduction. Reproductive deficiencies: sterility, reduction in ... D. radiodurans is capable to resist oxidative stress and DNA damage from radiation, and reduces technetium, uranium and ... This effect is accentuated if the absorbed dose is between 0.5 and 2 Sv, in whose first damage, nausea and hair loss are ...
*  Thymidylate synthase
... (TS) plays a crucial role in the early stages of DNA biosynthesis. DNA damage or deletion occur on a daily ... Both cause DNA damage. The following reaction is catalyzed by thymidylate synthetase: 5,10-methylenetetrahydrofolate + dUMP ... The enzyme is essential for regulating the balanced supply of the 4 DNA precursors in normal DNA replication: defects in the ... Therefore, synthesis and insertion of healthy DNA is vital for normal body functions and avoidance of cancerous activity. In ...
*  Benzophenone
Consuelo Cuquerella, M.; Lhiaubet-Vallet, V.; Cadet, J.; Miranda, M. A. (2012). "Benzophenone Photosensitized DNA Damage". Acc ... The interaction with DNA and the successive photo-induced energy transfer is at the base of the benzophenone activity as a DNA ... Benzophenone prevents ultraviolet (UV) light from damaging scents and colors in products such as perfumes and soaps. ... From a molecular chemistry point of view interaction of benzophenone with B-DNA has been demonstrated experimentally. ...
*  Senescence
Free radicals can damage proteins, lipids or DNA. Glycation mainly damages proteins. Damaged proteins and lipids accumulate in ... and further indicated that DNA damage due to reactive oxygen species was a major source of the DNA damages causing aging. The ... "Cancer and aging as consequences of un-repaired DNA damage.". In Kimura, Honoka; Suzuki, Aoi. New Research on DNA Damage. Nova ... examples of which ranging from damage to DNA, damage to tissues and cells by oxygen radicals (widely known as free radicals ...
*  Cockayne syndrome
The premature aging features of CS are likely due, at least in part, to the deficiencies in DNA repair (see DNA damage theory ... If either the ERCC6 or the ERCC8 gene is altered (as in Cockayne Syndrome), DNA damage is not repaired. As this damage ... particularly the DNA in active genes. DNA damage is caused by ultraviolet rays from sunlight, radiation, or free radicals in ... Within the damaged cell, the CSA protein normally localizes to sites of DNA damage, particularly inter-strand cross-links, ...
*  Neoplasm
DNA damage is very common. Naturally occurring DNA damages (mostly due to cellular metabolism and the properties of DNA in ... Deficiencies in DNA repair cause increased mutation rates. A deficiency in DNA repair, itself, can allow DNA damages to ... Tobacco smoke causes increased exogenous DNA damage, and these DNA damages are the likely cause of lung cancer due to smoking. ... Bernstein C, Prasad AR, Nfonsam V, Bernstei H (2013). "DNA Damage, DNA Repair and Cancer". New Research Directions in DNA ...
*  HBx
ROS cause more than 20 types of DNA damage. Oxidative DNA damage is mutagenic. HBx has large effects on the transcription ... Higgs MR, Chouteau P, Lerat H (2014). "'Liver let die': oxidative DNA damage and hepatotropic viruses". J. Gen. Virol. 95 (Pt 5 ... It interacts with DDB1 (Damaged DNA Binding Protein 1) redirecting the ubiquitin ligase activity of the CUL4-DDB1 E3 complexes ... Dizdaroglu M (2012). "Oxidatively induced DNA damage: mechanisms, repair and disease". Cancer Lett. 327 (1-2): 26-47. doi: ...
*  Testicle
4) Protection against DNA damage. Mild, transient scrotal heat stress causes DNA damage, reduced fertility and abnormal ... transient scrotal heat stress causes DNA damage, subfertility and impairs formation of blastocysts in mice". Reproduction. 136 ... DNA strand breaks were found in spermatocytes recovered from testicles subjected to 40 °C or 42 °C for 30 minutes. These ... The gametes contain DNA for fertilization of an ovum Sertoli cells - the true epithelium of the seminiferous epithelium, ...
*  15-Hydroxyeicosatetraenoic acid
Lee, S. H.; Williams, M. V.; Dubois, R. N.; Blair, I. A. (2005). "Cyclooxygenase-2-mediated DNA damage". Journal of Biological ...
*  Establishment of sister chromatid cohesion
DNA damage can lead to cohesin loading at non-CAR sites and establishment of cohesion at these sites even during G2 phase. In ... Changes in patterns of sister chromatid cohesion have been observed in cases of DNA damage. Cohesin is required for repair of ... ATM is a key kinase in the DNA damage checkpoint. Defects in cohesion can increase genome instability, a result consistent with ... the ties between cohesion and DNA damage pathways. In the bacterium Escherichia coli, repair of mitomycin C-induced DNA damages ...
*  Aspergillus unguis
Some compounds introduced DNA damage. Only depsidone 1 showed significant anti-proliferatory activity on human cancer cells. ... It has also been reported as a colonist of water damaged construction materials in Finland where it was found to produce the ... "Mycotoxins in Crude Building Materials from Water-Damaged Buildings". Applied and Environmental Microbiology. 66 (5): 1899-1904 ...
*  Point accepted mutation
CS1 maint: Multiple names: authors list (link) Pal JK, Ghaskadbi SS (2009). "DNA Damage, Repair and Recombination". ... At the molecular level, there are regulatory systems that correct most - but not all - of these changes to the DNA before it is ... PAM matrices are also used as a scoring matrix when comparing DNA sequences or protein sequences to judge the quality of the ... This definition does not include all point mutations in the DNA of an organism. In particular, silent mutations are not point ...
*  BLOSUM
Pal JK, Ghaskadbi SS (2009). "DNA Damage, Repair and Recombination". Fundamentals of Molecular Biology (1st ed.). Oxford ... DNA sequences of HBsAg were obtained from 180 patients, in which 51 were chronic HBV carrier and 129 newly diagnosed patients, ... At the molecular level, there are regulatory systems that correct most - but not all - of these changes to the DNA before it is ... BLOSUM matrices are also used as a scoring matrix when comparing DNA sequences or protein sequences to judge the quality of the ...
*  Malondialdehyde
Marnett LJ (1999). "Lipid peroxidation-DNA damage by malondialdehyde". Mutat. Res. 424 (1-2): 83-95. doi:10.1016/S0027-5107(99) ... Malondialdehyde reacts with deoxyadenosine and deoxyguanosine in DNA, forming DNA adducts, the primary one being M1G, which is ...
*  Phir Wohi Mohabbat
The entire family grows suspicious of Alishba's true identity and a DNA test is demanded to which Alishba refuses. This causes ... Waleed walks away and she shoots herself, damaging her brain and paralyzing herself. At that time, Alishba goes into labor and ...
*  DNA repair
Human DNA repair diseases DNA repair special interest group DNA Repair DNA Damage and DNA Repair Segmental Progeria DNA-damage ... DNA damage theory of aging DNA replication Direct DNA damage Gene therapy Human mitochondrial genetics Indirect DNA damage Life ... Reduced expression of DNA repair genes causes deficient DNA repair. When DNA repair is deficient DNA damages remain in cells at ... It is important to distinguish between DNA damage and mutation, the two major types of error in DNA. DNA damage and mutation ...