... s can be classified in different ways. In terms of regulatory mechanisms, some authors group asRNAs into RNA-DNA ... Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense ... In eukaryotic cells, DNA is tightly packed by histones. Modification on histones can change interactions with DNA which can ... Cis-natural antisense transcript Pelechano V, Steinmetz LM (December 2013). "Gene regulation by antisense transcription". ...

Weintraub, HM (1990). "Antisense RNA and DNA". Sci Am. 262 (1): 40-46. Bibcode:1990SciAm.262a..40W. doi:10.1038/ ... There, his studies of the nucleosome - a basic unit of DNA packaging - showed that its structure was altered when genes were ... When expressed, the myoD gene produces a protein referred to as MyoD (or MyoD1), which can bind certain DNA sequences, stop ... Lassar, AB; Buskin, JN; Lockshon, D; Davis, RL; Apone, S; Hauschka, SD; Weintraub, H (1989). "MyoD is a sequence-specific DNA ...

Epigenetic modifications like DNA methylation and post-translational modification of core histones form the basis of the second ... The NATsdb or Natural Antisense Transcript database is a rich tool for searching for antisense pairs from multiple organisms. ... Li YY, Qin L, Guo ZM, Liu L, Xu H, Hao P, Su J, Shi Y, He WZ, Li YX (2006). "In silico discovery of human natural antisense ... Cis-natural antisense transcripts (cis-NATs) on the other hand are transcribed from the same genomic locus as their target but ...

Both sense and antisense sequences can exist on different parts of the same strand of DNA (i.e. both strands can contain both ... DNA exists in many possible conformations that include A-DNA, B-DNA, and Z-DNA forms, although only B-DNA and Z-DNA have been ... In DNA replication, DNA-dependent DNA polymerases make copies of DNA polynucleotide chains. To preserve biological information ... DNA at Curlie DNA binding site prediction on protein DNA the Double Helix Game From the official Nobel Prize web site DNA under ...

The others include antisense RNAs and ctRNAs. Iterons complex with cognate replication (Rep) initiator proteins to achieve the ... Iterons are directly repeated DNA sequences which play an important role in regulation of plasmid copy number in bacterial ... Dhruba K. Chattoraj (2000). "Control of plasmid DNA replication by iterons: no longer paradoxical". Molecular Biology. 37 (3): ... Peter P. Papp; Gauranga Mukhopadhyay; Dhruba K. Chattoraj (1994). "Negative control of plasmid DNA replication by iterons. ...

Armstrong BC, Krystal GW (1992). "Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA ... The MYCN gene has an antisense RNA, N-cym or MYCNOS, transcribed from the opposite strand which can be translated to form a ... This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. N-Myc is highly ... It has been shown that the antisense RNA encodes for a protein, named NCYM, that has originated de novo and is specific to ...

... strand or antisense) RNA (e.g. Orthomyxoviruses, Rhabdoviruses) VI: ssRNA-RT viruses (+ strand or sense) RNA with DNA ... The domains Duplodnaviria and Varidnaviria consist of double-stranded DNA viruses; other double-stranded DNA viruses are ... Viruses with a DNA genome, except for the DNA reverse transcribing viruses, are members of three of the four recognized viral ... other single-stranded DNA viruses are incertae sedis. Group I: viruses possess double-stranded DNA. Viruses that cause ...

Hamilton AJ, Baulcombe DC (October 1999). "A species of small antisense RNA in posttranscriptional gene silencing in plants". ... DNA methylation can be lost passively with each cell division, because newly synthesized strands of DNA lack DNA methylation ... This general mechanism helps maintain DNA methylation homeostasis by tuning DNA demethylation activity to DNA methylation ... Repressive chromatin modifications, like DNA methylation, help promote DNA compaction and reduce DNA accessibility, while other ...

DNA is double-stranded containing both a sense strand and an antisense strand. Therefore, the complementary sequence will be to ... B-DNA is the most common form of DNA in vivo and is a more narrow, elongated helix than A-DNA. Its wide major groove makes it ... A-DNA, is a form of the DNA duplex observed under dehydrating conditions. It is shorter and wider than B-DNA. RNA adopts this ... Biology portal Biomolecular structure Crosslinking of DNA DNA nanotechnology DNA supercoil Gene structure Non-helical models of ...

... encoding both an antisense RNA that regulates the p53 tumor suppressor and a protein involved in DNA repair, telomere ... a natural p53 antisense transcript required for p53 induction upon DNA damage". Molecular Cell. 33 (4): 462-71. doi:10.1016/j. ... WRAP53 (also known as WD40-encoding RNA antisense to p53) is a gene implicated in cancer development. The name was coined in ... WRAP53β also targets the ubiquitin ligase RNF8 to DNA double-strand breaks(Figure 2). In addition to localizing factors to ...

DNA and Cell Biology. 25 (3): 135-41. doi:10.1089/dna.2006.25.135. PMID 16569192. Mourtada-Maarabouni M, Pickard MR, Hedge VL, ... An antisense RNA, Tsix, is a negative regulator of Xist. X chromosomes lacking Tsix expression (and thus having high levels of ... The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene. Abundant and functionally ... The antisense RNA, BACE1-AS is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's ...

... allowing the DNA to be unwound. Topotecan unsilences the paternal UBE2A allele by reducing the transcription of an antisense ... This disruption prevents DNA replication and ultimately leads to cell death. This process leads to breaks in the DNA strand ... When the replication-fork collides with the trapped topoisomerase-I, DNA damage occurs. The unbroken DNA strand breaks and ... DNA Topoisomerases and Cancer, Yves Pommier Editor, Humana Press 2012 Dagli AI, Mueller J, Williams CA (1993-01-01). Adam MP, ...

The inhibiting of DNA binding utilizes RNA interference, antisense oligodeoxynucleotide, and short hairpin RNA. The inhibition ... Direct inhibition of STAT5 activity makes use of small molecule inhibitors that prevent STAT5 from properly binding to DNA or ...

It is antisense to the human gene, C16orf71, indicating possibility of regulated alternative expression. It is associated with ... The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor. ... 2008). "Identification of the DNA binding element of the human ZNF300 protein". Cell. Mol. Biol. Lett. 13 (3): 391-403. doi: ... DNA Seq. 18 (4): 312-5. doi:10.1080/10425170701243393. PMID 17541838. S2CID 12932222. Kimura K, Wakamatsu A, Suzuki Y, et al. ( ...

In the mid-80s Henk Buck focused his research on the use of antisense DNA as an inhibitor of virus replication. Paul C. ... Recent researches in this field are based on methyl phosphonate or phosphorothioate DNA. At present (2008) only one antisense ... Van Boeckel had also been working on synthesis of phosphate methylated DNA, and knew how difficult it was to make such DNA- ... 3916-3921 Buck, H.M. e.a. (1990) "Phosphate-Methylated DNA Aimed at HIV-1 RNA Loops and Integrated DNA Inhibits Viral ...

Additionally, these nanoparticles can be made to release antisense DNA oligonucleotides when under photo-activation. These ... This is accomplished because nanoparticle complexes are delivered inside of cells then undergo light induced release of DNA ... "Light-Induced Release of DNA from Gold Nanoparticles: Nanoshells and Nanorods". Journal of the American Chemical Society. 133 ( ...

... retrotransposons in some species of Drosophila express a male germline-specific and meiotic-specific antisense ... Micropia: a retrotransposon of Drosophila combining structural features of DNA viruses, retroviruses and non-viral transposable ... The Drosophila micropia retrotransposon encodes a testis-specific antisense RNA complementary to reverse transcriptase. Mol ...

She based her research on discovering if small portions of gene-stopping DNA (called antisense oligonucleotides) could be ... These complementary DNA pieces can bind to the HIV viral mRNA and prevent the HIV virus from replicating itself. The use of ... Small pieces of messenger RNA (or mRNA) carry a copy of the cell's DNA to the ribosomes where the mRNA directs the ribosomes to ... She worked to produce gene and antisense therapies to treat HIV/AIDS, and researched how the immune system controls HIV in ...

Additionally, these nanoparticles can be made to release antisense DNA oligonucleotides when under photo-activation. These ... This is accomplished because nanoparticle complexes are delivered inside of cells then undergo light induced release of DNA ...

H2A.Z regulates transcription, DNA repair, suppression of antisense RNA, and RNA Polymerase II recruitment. Notable features of ... H2A.B has a shortened docking domain, which wraps around a short DNA region. H2A.L and H2A.P variants are closely related to ... It becomes phosphorylated during the DNA damage response, chromatin remodeling, and X-chromosome inactivation in somatic cells ...

The antisense oligonucleotide drug oblimersen was developed by Genta Incorporated to target Bcl-2. An antisense DNA or RNA ... Oblimersen (INN, trade name Genasense; also known as Augmerosen and bcl-2 antisense oligodeoxynucleotide G3139) is an antisense ... Dias N, Stein CA (November 2002). "Potential roles of antisense oligonucleotides in cancer therapy. The example of Bcl-2 ... An antisense drug is a short sequence of RNA which hybridises with and inactivates mRNA, preventing the protein from being ...

An antisense oligonucleotide (ASO) is a single-strand DNA sequence complementary to a desired messenger RNA (mRNA) sequence. ... Antisense therapy targets gene sequences using antisense oligonucleotides by binding the ASO to the mRNA strand. This creates ... It is an antisense oligonucleotide (ASO) targeting clusterin expression. In metastatic prostate cancer, custirsen showed no ... They have high antisense activity due to their increased chirality, nuclease stability, and solubility. Second-generation ...

The "antisense" strand of DNA is complementary to the "sense" strand and is the actual template for mRNA synthesis. Knowing the ... The sense strand is the strand of DNA that has the same sequence as the mRNA, which takes the antisense strand as its template ... Sense and antisense strands of DNA: YouTube tutorial video v t e (Articles with short description, Short description matches ... Note that for each segment of double-stranded DNA, there will possibly be two sets of sense and antisense, depending on which ...

TCF21 activation is directed by an antisense long non-coding RNA, TARID (TCF21 antisense RNA inducing demethylation). TARID ... DNA methylation analysis revealed hypermethylation at CGI1 and CGI3, but not CGI2 in samples from various cancer tissues. ... in antisense orientation to TCF21. This lncRNA has been named TARID (for TCF21 antisense RNA inducing demethylation). TCF21 is ... However, in the presence of E12 plus capsulin, a DNA complex was generated with the probe that migrated faster than the E12 ...

... s are short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence. These linear ... and fever Antisense therapy Oligonucleotide synthesis Antisense RNA therapeutics Crooke, Stanley T.; Baker, Brenda F.; Crooke, ... In protein synthesis, DNA is first transcribed into mRNA, and then translated in an amino acid sequence. Gapmers take advantage ... In humans, the gapmer DNA-mRNA duplex is degraded by RNase H1. The degradation of the mRNA prevents protein synthesis The ...

These genes have the DNA base pairs AC and TG as repeated sequences at the ends of each intron. On the 3'ss (3' splicing site ... A common reverse genetics technique is to reduce gene expression or modify splicing using Morpholino antisense technology. ... Morpholino oligonucleotides (MO) are stable, synthetic macromolecules that contain the same bases as DNA or RNA; by binding to ... Tol2 is the only natural DNA transposable element in vertebrates from which an autonomous member has been identified. Examples ...

Antisense oligonucleotides (ASO) are single strands of DNA or RNA that are complementary to a chosen sequence. In the case of ... 1997). Antisense Oligodeoxynucleotides and Antisense RNA : Novel Pharmacological and Therapeutic Agents. Boca Raton, Florida: ... One subtype of DNA microarrays can be described as substrates (nylon, glass, etc.) to which oligonucleotides have been bound at ... Antisense oligonucleotides can be used to target a specific, complementary (coding or non-coding) RNA. If binding takes place ...

The repetitive DNA products can be transferred directly into cells or organisms to study the function of the repetitive DNA. ... A target oligonucleotide and a tandem repeated antisense probe are subjected to repeated cycles of denaturing, annealing, ... PEAR is a minimal DNA replication system, so it can be considered as a minimal life system. it is of therectical interests to ... Polymerase-endonuclease amplification reaction (PEAR) is a DNA amplification technology for the amplification of ...

2004). "Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs". J. Biol. Chem. 279 ( ... 2003). "Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the ... 2008). "Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD". EMBO J. 27 (7): 1172-81. doi ... 2003). "Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice". Mol. Cell. 11 (3): 807-15. ...

"Inhibition of dendrite formation in mouse melanocytes transiently transfected with antisense DNA to myosin Va". Journal of ...