Systematic reviews found no effect of niacin on cardiovascular disease or death, in spite of raising high-density lipoprotein ( ... "An orthomolecular approach to the prevention and treatment of psychiatric disorders". Adv Mind Body Med. 26 (2): 14-28. PMID ... "Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta- ...
... to form lipoproteins. They transport lipids in blood, cerebrospinal fluid and lymph. The lipid components of lipoproteins are ... ApoD level increases in nervous system with a large number of neurologic disorders inclusive of Alzheimer's disease, ... low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL). There are multiple classes of apolipoproteins and ... apolipoproteins interact with lipoprotein receptors and lipid transport proteins, thereby participating in lipoprotein uptake ...
... markedly raised level of low-density lipoprotein (LDL), normal level of high-density lipoprotein (HDL), and normal level of ... Heterozygous FH is a common genetic disorder, inherited in an autosomal dominant pattern, occurring in 1:250 people in most ... Several studies found that a high level of lipoprotein(a) was an additional risk factor for ischemic heart disease. The risk ... Vega GL, Grundy SM (1986). "In vivo evidence for reduced binding of low density lipoproteins to receptors as a cause of primary ...
Although uncommon, lipid abnormalities can occur in the form of raised triglyceride levels and low high-density lipoprotein ... A laboratory workup is needed primarily to investigate for the presence of associated disorders (metabolic, autoimmune, and ...
... lipoprotein (a) deficiency, factor VIII deficiency (hemophilia A), and factor V Leiden mutation. Infectious disorders such as ... Some maternal disorders that may contribute to neonatal strokes include: autoimmune disorders, coagulation disorders, prenatal ... Other disorders that may increase the risk of a neonatal stroke are blood, homocysteine and lipid disorders, such as ... Placental disorders that increase the risk of stroke include placental thrombosis, placental abruption, placental infection, ...
... lipoprotein lipase LSM1: U6 snRNA-associated Sm-like protein LSm1 MAK16: MAK16 homolog MCPH1: microcephaly, primary autosomal ... encoding protein Zinc finger protein 707 The following diseases and disorders are some of those related to genes on chromosome ... GPI-anchored high density lipoprotein binding protein 1 GRINA: encoding protein Glutamate receptor, ionotropic, N-methyl D- ... "Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and ...
... and low serum high-density lipoprotein). It is also associated with hormonal disorders (panhypopituitarism, hypothyroidism, ... ICD-11 does not use the term NAFL as it was deemed confusing with the family of disorders NAFLD. The preferred descriptions are ... NAFLD is the most common liver disorder worldwide and is present in approximately 25% of the world's population. It is very ... Raziel A, Sakran N, Szold A, Goitein D (April 2015). "Current solutions for obesity-related liver disorders: non-alcoholic ...
... lipoprotein lipase deficiency, familial MeSH C18.452.648.556.750 - peroxisomal disorders MeSH C18.452.648.556.750.025 - ... fetal nutrition disorders MeSH C18.654.521.750 - starvation MeSH C18.654.726.500 - obesity MeSH C18.654.726.500.695 - obesity ... amino acid transport disorders, inborn MeSH C18.452.648.088.400 - hartnup disease MeSH C18.452.648.088.600 - oculocerebrorenal ... peroxisomal disorders MeSH C18.452.100.100.680.100 - adrenoleukodystrophy MeSH C18.452.100.100.680.760 - Refsum disease MeSH ...
December 2008). "Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase- ... Meanwhile, Kastelein-who had, by 1998, become an international expert in lipid disorders-co-founded Amsterdam Molecular ... The adeno-associated virus serotype 1 (AAV1) viral vector delivers an intact copy of the human lipoprotein lipase (LPL) gene to ... Alipogene tiparvovec, sold under the brand name Glybera, is a gene therapy treatment designed to reverse lipoprotein lipase ...
... lipoprotein lipase deficiency, familial MeSH C16.320.565.556.750 - peroxisomal disorders MeSH C16.320.565.556.750.025 - ... sex chromosome disorders MeSH C16.131.260.800.240 - ectodermal dysplasia MeSH C16.131.260.800.240.350 - focal dermal hypoplasia ... sex chromosome disorders MeSH C16.320.180.800.240 - ectodermal dysplasia MeSH C16.320.180.800.240.350 - focal dermal hypoplasia ... amino acid transport disorders, inborn MeSH C16.320.565.088.400 - Hartnup disease MeSH C16.320.565.088.600 - oculocerebrorenal ...
In 2012, Glybera, a treatment for a rare inherited disorder, lipoprotein lipase deficiency, became the first treatment to be ... Such single gene disorders are good candidates for somatic cell therapy. The complete correction of a genetic disorder or the ... Multigene disorders - Some commonly occurring disorders, such as heart disease, high blood pressure, Alzheimer's disease, ... Glybera treats one such disease, caused by a defect in lipoprotein lipase. DNA must be administered, reach the damaged cells, ...
... a low density lipoprotein (LDL) and very low density lipoprotein (VLDL). Individuals with this condition are unable to properly ... In partnership with Abraham Kornzweig, Bassen identified Bassen-Kornzweig disease, a rare autosomal recessive disorder in which ... and the reduction or even absence of B-lipoproteins. Complications include retinitis pigmentosa, degenerative changes in the ...
Wiethe Lipomatosis central non-encapsulated Lipomatosis familial benign cervical Lipomucopolysaccharidosis Lipoprotein disorder ...
... a lipoprotein complex Legius syndrome, also known as Neurofibromatosis 1-like syndrome, a genetic disorder Lichen sclerosus, a ...
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) ... Mutations within the VLDLR gene lead to a multitude of disorders of varying severities. These disorders are usually associated ... VLDLR is a peripheral lipoprotein receptor that functions in lipoprotein metabolism, cardiac fatty acid metabolism, and fat ... "The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared ...
... a low density lipoprotein (LDL) and very low density lipoprotein (VLDL). Individuals with this condition are unable to properly ... Bassen-Kornzweig disease, also called Bassen-Kornzweig Syndrome, is a rare congenital disorder in which the body fails to ... and the reduction or even absence of B-lipoproteins. Complications include retinitis pigmentosa, degenerative changes in the ...
... hyperglyceridemia 272.4 Other and unspecified hyperlipidemia Alpha-lipoproteinemia Combined hyperlipidemia 272.5 Lipoprotein ... 275 Disorders of mineral metabolism 275.0 Disorders of iron metabolism Aceruloplasminemia Hemochromatosis 275.1 Disorders of ... 252 Disorders of parathyroid gland 252.0 Hyperparathyroidism, unspec. 252.01 Hyperparathyroidism, primary 252.1 ... Gaucher's disease Niemann-Pick disease Sea-blue histiocyte syndrome 272.8 Other disorders of lipoid metabolism 273 Disorders of ...
Maeda then started to apply gene targeting to elucidate the function of lipoproteins, which had been shown by Jan and Judith ... rather than single-gene disorders such as cystic fibrosis and Lesch-Nyhan syndrome. Maeda and her coworkers found that deleting ... the mouse gene for apolipoprotein E (ApoE) - a component of very low-density lipoprotein - caused the animals to develop ...
Klapak D, Broadfoot S, Penner G, Singh A, Inapuri E (2018-10-11). "Development of novel aptamers for low-density lipoprotein ... "Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice". PLOS ONE. 13 (1): e0190212. Bibcode: ...
There are at least 3 ways in which retromer dysfunction can contribute to brain disorders, including Alzheimer and Parkinson ... Online Mendelian Inheritance in Man (OMIM): 605747 "Entrez Gene: LDLRAP1 low density lipoprotein receptor adaptor protein 1". ... De Matteis MA, Luini A (September 2011). "Mendelian disorders of membrane trafficking". The New England Journal of Medicine. ... Small SA, Petsko GA (March 2015). "Retromer in Alzheimer disease, Parkinson disease and other neurological disorders". Nature ...
"Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French- ... A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Cell Death Dis 11, 303 (2020). https://doi.org/ ...
In the case of GRAMD1b, the plasma membrane source of cholesterol is high-density lipoprotein (HDL). The VASt domain is ... Mutations and other genetic studies link GRAMD1B to neurodevelopmental disorders, such as intellectual disability and ...
September 2010). "Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export". Cell ... as well as in neurological disorders. For example, sortilin has been identified as an important receptor for brain ... Strong A, Rader DJ (June 2012). "Sortilin as a regulator of lipoprotein metabolism". Current Atherosclerosis Reports. 14 (3): ... Other processes involving sortilin include endocytosis, negative regulation of lipoprotein lipase activity, myotube ...
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... "Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations". ...
Batten disease is a rare and fatal recessive neurodegenerative disorder that begins in childhood. Batten disease is the common ... Apart from tubular structures, alpha-synuclein can also form lipoprotein nanoparticles similar to apolipoproteins. The most ... While PD is the second most common neurodegenerative disorder, problems with diagnoses still persist. Problems with the sense ... Along with being a neurodegenerative disorder, HD has links to problems with neurodevelopment. HD is caused by polyglutamine ...
"A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits ... Neurological Disorders Drug Targets. 8 (1): 16-30. doi:10.2174/187152709787601867. ISSN 1871-5273. PMC 2872930. PMID 19275634. ... "The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2- ... Yancey PG, Ding Y, Fan D, Blakemore JL, Zhang Y, Ding L, Zhang J, Linton MF, Fazio S (Jul 2011). "Low-density lipoprotein ...
Einstein researchers demonstrated the association between reduced levels of high-density lipoproteins (HDL) cholesterol and ... Wilf Family Cardiovascular Research Institute Center for Comparative Effectiveness Research Institute for Brain Disorders and ...
Blood plasma of these mice showed elevated levels of non-high-density lipoproteins, cholesterol, triglycerides, non-esterified ... which is often a manifestation of a broader underlying metabolic disorder termed as metabolic syndrome. Further studies on the ...
NPC1 Low density lipoproteins Receptor mediated endocytosis Hypercholesterolemia Infante RE, Wang ML, Radhakrishnan A, Kwon HJ ... type C is a rare disorder that results in the over accumulation of lipids and cholesterol in different types of tissues in the ... LDL particles are low density lipoproteins that carry cholesterol to cells. LDL particles are engulfed into cells by receptor ... "". "Niemann Pick Disease Type C". NORD (National Organization for Rare Disorders). Retrieved 2022-04-28. Vanier MT, Millat G ( ...
LipoProtein Lipase LXR-α - Liver X Receptor-α (a somewhat unusual example of receptor up-regulating its own expression) SREBP- ... LXRs in physiological lipid and cholesterol metabolism suggests that they may influence the development of metabolic disorders ...