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*  Muse cell
... s from different sources demonstrate reparative effects in animal disease models. The neural regeneration capability ... This phenomenon was observed by the infusion of green fluorescent protein-labeled naive human Muse cells into animal models wit ... This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle ... A three-dimensional culture model was used to assess Muse cell-derived melanocytes. In that model, the dermis was mimicked by ...
*  Malcolm Macleod
... the optimal use of animal models of disease; the neurobiology of the mineralocorticoid receptor; and impact of social ... CAMARADES is currently leading the way in advancing education about systematic reviews in animal research. Prof. Macleod is on ... and co-ordinator of the Collaborrative Approach to Meta-Analysis and Review of Animal Data in Experimental Studies (CAMARADES ... Advisory Board of the charity SABRE Research UK which raises awareness of the need for systematic reviews of existing animal ...
*  Elafibranor
Efficacy on histological NASH parameters (steatosis, inflammation, fibrosis) in animal disease models - anti-fibrotic ... in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis". Hepatology. 58 (6): 1941-1952. doi:10.1002/ ... and non-alcoholic fatty liver disease (NAFLD). Elafibranor is a dual PPARα/δ agonist. Administered to over 800 patients and ... is an experimental medication that is being studied and developed by Genfit for the treatment of cardiometabolic diseases ...
*  Alexander Fleming Biomedical Sciences Research Center
Main areas of research: Functional genomics and proteomics; Molecular and cellular immunology; Animal models of human disease; ... Fleming researchers have established transgenic animal models for rheumatoid arthritis, inflammatory bowel disease and multiple ... Fleming's Animal house (certified with ISO 9001) provides husbandry of animals and services to the biomedical research ... The Animal House has a capacity to house more than 20,000 mice and is currently the largest Mouse Unit in Greece in terms of ...
*  Marsh rice rat
Animal models for periodontal disease. Journal of Biomedicine and Biotechnology 2011:754857. Post, W. 1981. The influence of ... the animal has been proposed as a model for research on the disease in humans. The identity of the bacterial agent remains ... The marsh rice rat is quite susceptible to periodontitis and has been used as a model system for the study of that disease. The ... Animal model: periodontitis in the rice rat (Oryzomys palustris). American Journal of Pathology 96(2):643-646. Lodge, T.E. 2005 ...
*  Uberon
"Linking Human Diseases to Animal Models Using Ontology-Based Phenotype Annotation". PLoS Biology. 7 (11): e1000247. doi:10.1371 ... Uberon is a comparative anatomy ontology representing a variety of structures found in animals, such as lungs, muscles, bones, ... Hoehndorf, R.; Schofield, P. N.; Gkoutos, G. V. (2011). "PhenomeNET: A whole-phenome approach to disease gene discovery". ... Candidate disease genes from mouse phenotype data". Human Mutation. 33 (5): 858-866. doi:10.1002/humu.22051. PMC 3327758 . PMID ...
*  Kindling model
Neuromethods: Animal Models of Neurological Disease. Totowa, NJ: Humana Press. pp. 153-155. ISBN 0-89603-211-6. PK Sahoo; KI ... However, in both human epilepsy and in some animal models, evidence suggests that a process like that found in kindling does ... The kindling model was first proposed in the late 1960s by Goddard and colleagues. Although kindling is a widely used model, ... a method by which seizure severity is quantified in animal models of epilepsy) Bertram E (2007). "The relevance of kindling for ...
*  Post-traumatic epilepsy
Neuromethods: Animal Models of Neurological Disease. Totowa, NJ: Humana Press. pp. 153-155. ISBN 0-89603-211-6. Menkes JH, ... No animal model has all the characteristics of epileptogenesis in humans, so research efforts aim to identify one. Such a model ... Pitkänen A, McIntosh TK (2006). "Animal models of post-traumatic epilepsy". Journal of Neurotrauma. 23 (2): 241-261. doi: ... Animal experiments using rats have shown that epileptic seizures can be produced by injecting iron into the brain. Iron ...
*  Animal testing on non-human primates
laboratories", Project R&R. Nonhuman Primate(NHP)Disease Models from animal research institutions.. ... Connolly's published animal model states that animals were kept alive for three days, and that animals that were successfully ... Many of the best-known allegations of abuse made by animal protection or animal rights groups against animal-testing facilities ... Although each animal model has its limitations, carefully designed drug studies in nonhuman primates can continue to advance ...
*  Proteasome
... inhibitors have also shown promise in treating autoimmune diseases in animal models. For example, studies in mice ... Parkinson's disease and Pick's disease, Amyotrophic lateral sclerosis (ALS), Huntington's disease, Creutzfeldt-Jakob disease, ... Studies in animal models suggest that ritonavir may have inhibitory effects on the growth of glioma cells. ... This approach of selectively inducing apoptosis in tumor cells has proven effective in animal models and human trials. ...
*  Psoriasis
Kunz M, Ibrahim SM (2009). "Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity". ... Topical agents are typically used for mild disease, phototherapy for moderate disease, and systemic agents for severe disease. ... The disease affects two to four percent of the population. Men and women are affected with equal frequency. The disease may ... There is a higher rate of celiac disease among people with psoriasis. When adopting a gluten-free diet, disease severity ...
*  BufferGel
"Tests of Buffergel for contraception and prevention of sexually transmitted diseases in animal models". Sexually transmitted ... Clinical Infectious Diseases. 32 (3): 476-482. doi:10.1086/318496. PMID 11170957. manufacturer's product page. ... diseases. 28 (7): 417-423. doi:10.1097/00007435-200107000-00010. PMID 11460027. Wijgert, Janneke van de; Andrew Fullem; Clifton ...
*  Phenotypic screening
Compounds are screened in cellular or animal disease models to identify compounds that cause a desirable change in phenotype. ... and Sosei have specialized in using phenotypic screening in animal disease models for drug positioning. Many other companies ... Phenotypic screening in animal-based systems utilize model organisms to evaluate the effects of a test agent in fully assembled ... Some have argued that cellular based systems are unable to adequately model human disease processes that involve many different ...
*  Cycasin
After failing to reproduce the symptoms of the disease in animal models, the hypothesis was rejected. Though the initial cycad ... The Lytico-bodig disease, also known as lateral sclerosis-parkinsonism-dementia, is a neurodegenerative disease of unknown ... The disease is fatal in all cases, with the diaphragm and respiratory accessory muscles becoming paralyzed in the later stages ... It induces hepatotoxicity and Zamia staggers, a fatal nervous disease affecting cattle resulting from browsing on the leaves or ...
*  Spinal and bulbar muscular atrophy
Merry, D. E. (2005). "Animal Models of Kennedy Disease". NeuroRX. 2 (3): 471-479. doi:10.1602/neurorx.2.3.471. PMC 1144490 . ... "Kennedy disease , Disease , Overview , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". rarediseases. ... In 1991, it was recognized that the AR gene is involved in the disease process. The disease is probably more common than ... The greater the expansion of the CAG repeat, the earlier the disease onset and more severe the disease manifestations. The ...
*  Obovatol
"Obovatol improves cognitive functions in animal models for Alzheimer's disease". Journal of Neurochemistry. 120 (6): 1048-59. ...
*  MPTP
In 2000, another animal model for Parkinson's disease was found. It was shown that the pesticide and insecticide rotenone ... It has been used to study disease models in various animal studies. While MPTP itself has no psychoactive effects, the compound ... Parkinson's Disease. Diagnosis and Clinical Management. Demos Medical Publishing. "Parkinson's Disease Models" (PDF). Neuro ... Luo Qin; Peng Guoguang; Wang Jiacai; Wang Shaojun (2010). "The Establishment of Chronic Parkinson's Disease in Mouse Model ...
*  Laboratory mouse
An article in The Scientist notes, "The difficulties associated with using animal models for human disease result from the ... Laboratory rat Animal testing Animal testing on rodents Animal model Animal Identification Mouse models of colorectal and ... Bart van der Worp, H (30 March 2010). "Can Animal Models of Disease Reliably Inform Human Studies?". PLOS Medicine. 2: 1385. ... Cavanaugh, Sarah; Pippin, John; Bernard, Neal (10 April 2013). "Animal models of Alzheimer disease: historical pitfalls and a ...
*  Animal testing on rodents
Huntington's Disease Outreach Project for Education at Stanford Animal Model of Disease from Animal Research Organization. ... Animal Testing Animal model BALB/c C57BL/6 Mouse models of colorectal and intestinal cancer Preclinical imaging Rat Park ... Rodent Models of Autism, Epigenetics, and the Inescapable Problem of Animal Constraint. Animal Models of Behavior Genetics, ( ... An article in The Scientist notes, "The difficulties associated with using animal models for human disease result from the ...
*  Altogen Labs CRO
... cancer disease animal models, and animal xenograft models. In addition, other in vivo services including biomarker analysis, ... Altogen Labs offers in vivo tumor xenograft services for drug development studies involving inflammation, infectious diseases, ... cancer xenograft models, pharmacokinetics, pharmacodynamics, and toxicology testing. In 2013 Altogen Labs became part of Texas ...
*  Robert J. Desnick
ISBN 0-8451-1035-7 Desnick, R.J., Patterson, D.F. and Scarpelli, D.F., eds.: Animal Models of Inherited Metabolic Diseases. ... His translational research has led to the development of enzyme replacement therapy for Fabry disease and Niemann-Pick disease ... National Institute of Diabetes and Digestive and Kidney Diseases Gene Therapy: Lysosomal Diseases With Mental Retardation, ... ISBN 0-443-08773-3 Desnick, R.J. and Kaback, M.M., eds.: Tay-Sachs Disease, Academic Press, pp. 1-360, 2001. ISBN 0-12-017644-0 ...
*  Computational immunology
January 2008). "MUGEN mouse database; animal models of human immunological diseases". Nucleic Acids Res. 36 (Database issue): ... In the study of infectious diseases and host responses, the mathematical and computer models are a great help. These models ... Using this technology it is possible to know the model behind immune system. It has been used to model T-cell-mediated ... Models are helpful to predicts dynamics of pathogen toxicity and T-cell memory in response to different stimuli. There are also ...
*  Cat cognitive support diets
"The domestic cat as a natural animal model of Alzheimer's disease". Acta Neuropathologica Communications. 3: 78. doi:10.1186/ ... Cognitive dysfunction syndrome in companion animals is commonly paralleled to Alzheimer's Disease in humans due to several ... and comparative cognitive neurology of related animal models. Cognition claims appear primarily on kitten diets which include ... Arachidonic acid or AA is found in animal sources such as meat and eggs. AA is required in cat diets, as felines convert ...
*  Substantia nigra
Soon after, MPTP was tested in animal models for its efficacy in inducing Parkinson's disease (with success). MPTP induced ... Today, MPTP remains the most favored method to induce Parkinson's disease in animal models. Dopamine and serotonin Degradation ... The motor role of the pars compacta may involve fine motor control, as has been confirmed in animal models with lesions in that ... including parkinsonism and Parkinson's disease. Parkinson's disease is a neurodegenerative disease characterized, in part, by ...
*  Epoxyeicosatrienoic acid
... and polycystic kidney disease. The protective role of EETs in these animal model diseases may reflect, at least in part, their ... These interventions also gave beneficial results in animal models of non-alcoholic fatty liver disease and certain types ... Indeed, studies on in vivo animal and in vitro animal and human cell model systems indicate that the ETEs reduce infarct (i.e. ... In these models, EETs prevent arterial occlusive diseases such as heart attacks and brain strokes not only by their anti- ...
*  Chilean art
Animal figures and symbols abound but images of people did not appear unless they were important or had some magical ... The attempt to bring the European model to Chile by replicating its techniques has been seen as a failure in terms of the ... causing many to die young from diseases such as malaria and tuberculosis. The 13 Generation emerged from the country's poorest ... The historian Uriqueta viewed Haymhausen as a model for future generations of painters because, in addition his own talent as ...