Loading...
*  Breast cancer classification
... which estimate disease outcomes such as disease-free or overall survival in the absence of therapy, or true predictive factors ... The main stages are: Stage 0 which is in situ disease or Paget's disease of the nipple. Stage 0 is a pre-cancerous or marker ... TX refers to an inability to assess that site; Tis refers to DCIS, LCIS, or Paget's disease; T4d refers to inflammatory breast ... There is some nuance to the official definitions for N0 disease, which includes N0(i+) which refers to Isolated Tumor Cell ...
*  Metastatic breast cancer
... the extent of the extra-cranial metastatic disease, and the treatment applied). The mean 1-year survival is estimated at 20%. ... There is free peer support and an online platform to interact with others going through various therapies, including Abraxane. ... Mean survival from diagnosis of a brain metastasis varies between studies, ranging from 2 to 16 months (depending on ... Metastatic disease to the liver causes jaundice, elevated liver enzymes, abdominal pain, loss of appetite, nausea, and vomiting ...
*  Autologous immune enhancement therapy
which has been published with significant disease free survival rates. One of the largest studies in 1400 patients. has proven ... Randomized controlled studies in different cancers with significant increase in survival and disease free period have been ... May 1995). "Prolonged disease-free period in patients with advanced epithelial ovarian cancer after adoptive transfer of tumor- ... Auto-Immune diseases like the Auto-Immune Hemolytic Anemia (AIHA) have been known to be associated with malignancies. In ...
*  P21
When combined with low p27 and high p53, DFS (Disease-Free Survival) decreases. p21 mediates the resistance of hematopoietic ... Marone M, Bonanno G, Rutella S, Leone G, Scambia G, Pierelli L (2002). "Survival and cell cycle control in early hematopoiesis ... overall survival rate). A study on immunohistochemical markers in malignant thymic epithelial tumors shows that p21 expression ... Journal of Thoracic Disease. AME Publishing Company. 8 (9): 2580-2591. doi:10.21037/jtd.2016.08.82. PMC 5059354 . PMID 27747012 ...
*  Pediatric ependymoma
... progression-free survival. The 10-year disease-free survival is 40-50%. Younger ages showed lower 5 and 10-year survival rates ... The 5-year disease-free survival for age >5 years is 50-60%. Another report found a similar 5-year survival at about 65% with ... progression-free and overall survival. Some evidence suggests chromosome 6q25.3 deletion may provide additional survival ... The protein nucleolin and expression of MMP2 and MMP14 have been found to inversely correlate with progression free survival in ...
*  Cardiac fibroma
If the tumor is completely resected, individuals will have a disease-free survival. If the tumor is incomplete it will continue ...
*  Follicular dendritic cell sarcoma
Radiation and/or chemotherapy had no significant effect in improving patients' disease-free survival. With developments in our ... In 1998 the largest study on the disease was a retrospective review with fifty-one patients. Of these fifty-one patients, no ... Using a chemotherapy regimen designed for another cancer is an archaic "guess-and-check" way of treating a disease. In 2008 the ... An important hallmark of cancer, Akt is part of the cell survival pathways by inhibiting apoptosis. There is also evidence that ...
*  GemIdent
"Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free Survival in Breast Cancer". PLOS Medicine. 2 (9): e284. ...
*  Vascular endothelial growth factor
Numerous studies show a decreased overall survival and disease-free survival in those tumors overexpressing VEGF. The ... although the cause of disease and the typical source of neovascularization differs between the two diseases. VEGF-D serum ... VEGF-A plays a role in the disease pathology of the wet form age-related macular degeneration (AMD), which is the leading cause ... Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. Drugs such as ...
*  Medulloblastoma
The addition of radiation to the entire neuraxis and chemotherapy may increase the disease-free survival. Some evidence ... The 20-year survival rate is 51% in children. Children and adults have different survival profiles, with adults faring worse ... Decerebrate attacks appear late in the disease. Extraneural metastasis to the rest of the body is rare, and when it occurs, it ... Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995 (PDF). Bethesda MD: National ...
*  Progression-free survival
Similarly, "disease-free survival" is when patients have had operations and are left with no detectable disease. Time to ... leptomeningeal disease etc. Progression-free survival is often used as an alternative to overall survival (OS): this is the ... Progression-free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a ... "Progression-free survival (PFS) and time to progression (TTP) as surrogate endpoints for median overall survival (mOS) in ...
*  Breast cancer
Prognosis is usually given for the probability of progression-free survival (PFS) or disease-free survival (DFS). These ... has improved the 5-year disease free survival of stage 1-3 HER2-positive breast cancers to about 87% (overall survival 95%). ... the entire breast will still be stage zero and consequently an excellent prognosis with a 10-year disease free survival of ... Outcomes for breast cancer vary depending on the cancer type, extent of disease, and person's age. Survival rates in the ...
*  MammaPrint
Women with a low risk result can safely forego chemotherapy without decreasing likelihood of disease free survival. MammaPrint ... to interrogate all 25,000 genes in untreated tumor samples from women where follow-up categorized them as being disease free or ... MammaPrint can be considered as a part of standard of care disease management for early stage breast cancer and has significant ... The NKI hypothesized that breast cancer is a genetic, heterogeneous disease, where gene expression would be different in ...
*  Adrenocortical carcinoma
Five-year disease-free survival for a complete resection of a stage I-III ACC is approximately 30%. The most important ... The 5-year survival rate after successful surgery is 50-60%, but unfortunately, a large percentage of patients are not surgical ... Free Full Text. www.endotext.org article Cancer.Net: Adrenal Gland Tumor AdrenalCancerSupport.org Reference Information for ... A retrospective analysis showed a survival benefit for mitotane in addition to surgery when compared to surgery alone. The two ...
*  HK3
Gao HY, Luo XG, Chen X, Wang JH (Jan 2015). "Identification of key genes affecting disease free survival time of pediatric ... Overall, HK3 may promote cell survival by controlling ROS levels and boosting energy production. Currently, only hypoxia is ... "PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells". Blood. 119 (21): 4963-70. ... transcription of the antiapoptotic BCL2A1 gene or inhibit transcription of the p53 tumor suppressor to promote cell survival, ...
*  AGK (gene)
... poorer disease-free survival, and shorter overall survival in primary ESCC. More importantly, AGK expression was significantly ... Diseases associated with AGK include cataracts and cardiomyopathy. An important paralog of this gene is CERKL. The AGK gene is ... It's also correlated tumor-nodule-metastasis (TNM) classification breast cancer, and an overall shorter overall survival. In ...
*  FOXA1
Conversely, in ERα− breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. ...
*  Docetaxel
... survival time and response indicates that docetaxel slows metastatic cancer progression and can lead to disease-free survival. ... While some clinical trials show median survival times to be increased by approximately only three months, the range of survival ... Conjunctive treatment of prednisone with docetaxel has been shown to lead to improved survival rate as well as improved quality ... This leads to a significant decrease in free tubulin, needed for microtubule formation and results in inhibition of mitotic ...
*  Head and neck cancer
This study found no improvement in survival or disease-free survival with the addition of cetuximab to the conventional ... The presence of acid reflux disease (GERD - gastroesphogeal reflux disease) or larynx reflux disease can also be a major factor ... HPV-positive oropharyngeal cancer generally has a better outcomes than HPV-negative disease with a 54% better survival, but ... This study found that concurrent cetuximab and radiotherapy improves survival and locoregional disease control compared to ...
*  Prophylactic cranial irradiation
Indeed, subsequent studies showed that an increased rate of disease-free survival and overall survival in those children ... For small-cell lung cancer with limited and select cases of extensive disease, PCI has shown to reduce recurrence of brain ... Oncologists hypothesized that treatment of this sub-clinical disease with radiation therapy may stamp out the malignant process ... "Risk of brain metastasis from small cell carcinoma of the lung related to length of survival and prophylactic irradiation". ...
*  Biovest
After a median follow-up of 4.71 years (56.6 months, range: 12.6 - 89.3 months), the median disease-free survival in the ... BiovaxID demonstrated that it can induce powerful anti-tumor immune responses while providing a median disease-free survival ... Vaccine Isotype Determines Improvement in Disease-Free Survival Following Vaccine Therapy". BusinessWire. Retrieved 1 Dec 2011 ...
*  Kathleen I. Pritchard
... that extending treatment with an aromatase inhibitor like Letrozole to ten years further increases disease-free survival rates ... There was no significant difference in the rate of survival between the two treatment groups. However, the group treated with ... Some of her research investigates the use of genetic factors to predict disease progression and to formulate tailored treatment ... 3.0.CO;2-P. "Endocrine Therapy of Advanced Disease: Analysis and Implications of the Existing Data". Clinical Cancer Research. ...
*  MSH2
"MSH2 promoter hypermethylation in circulating tumor DNA is a valuable predictor of disease-free survival for patients with ... Mutations in the MSH2 gene account for 40% of genetic alterations associated with this disease and is the leading cause, ... Kastan MB (April 2008). "DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture ... International journal of colorectal disease. 22 (7): 739-48. doi:10.1007/s00384-006-0228-0. PMID 17109103. Wei Q, Xu X, Cheng L ...
*  Trastuzumab
... and disease-free survival (HR = 0.60). Increased risk of heart failure (RR = 5.11) and decline in left ventricular ejection ... The overall hazard ratios for overall survival and progression free survival were 0.82 and 0.61, respectively. It was difficult ... "HER2 Disease in the Metastatic and Adjuvant Settings". Medscape Education. Archived from the original on 10 April 2011. ... Other severe side effects include heart failure, allergic reactions, and lung disease. Use during pregnancy may harm the baby. ...
*  Hepatocellular carcinoma
Expanded Shanghai criteria in China have resulted in overall survival and disease-free survival rates similar to those achieved ... HCC, hepatocellular carcinoma; TACE, transarterial embolization/chemoembolization; PFS, progression-free survival; PS, ... Specifically, children with biliary atresia, infantile cholestasis, glycogen-storage diseases, and other cirrhotic diseases of ... median survival time) in Sub-Saharan Africa according to Manson's textbook of tropical diseases. HCC is one of the deadliest ...
*  Cervical cancer
About 35% of women with invasive cervical cancer have persistent or recurrent disease after treatment. Five year survival in ... If a cone biopsy does not produce clear margins (findings on biopsy showing that the tumor is surrounded by cancer free tissue ... Dunne, EF; Park, IU (Dec 2013). "HPV and HPV-associated diseases". Infectious Disease Clinics of North America. 27 (4): 765-78 ... Survival rates decrease to 30-40% for women with stage III cancer and 15% or fewer of those with stage IV cancer five years ...
*  Management of prostate cancer
Multiple retrospective analyses have demonstrated that overall survival and disease-free survival outcomes are similar between ... The risk of disease progression and metastasis (spread of the cancer) may be increased, but this increase risk appears to be ... In metastatic disease, where cancer has spread beyond the prostate, removal of the testicles (called orchiectomy) may be done ... Which option is best depends on the stage of the disease, the Gleason score, and the PSA level. Other important factors are the ...