Myozyme treatment clearly prolongs ventilator-free survival and overall survival in patients with infantile-onset Pompe disease ... Myozyme treatment prolongs ventilator-free survival and overall survival. Early diagnosis and early treatment leads to much ... GSD-II and Danon disease are the only glycogen storage diseases with a defect in lysosomal metabolism, and Pompe disease was ... GeneReview/NIH/UW entry on Glycogen Storage Disease Type II (Pompe Disease) Understanding Pompe Disease - US National Institute ...

which has been published with significant disease free survival rates. One of the largest studies in 1400 patients. has proven ... Randomized controlled studies in different cancers with significant increase in survival and disease free period have been ... May 1995). "Prolonged disease-free period in patients with advanced epithelial ovarian cancer after adoptive transfer of tumor- ... Auto-Immune diseases like the Auto-Immune Hemolytic Anemia (AIHA) have been known to be associated with malignancies. In ...

Similarly, "disease-free survival" is the length of time after patients have received treatment and have no detectable disease ... Progression-free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a ... Progression-free survival is commonly used as an alternative to overall survival (OS). In some cancers, PFS and OS are strictly ... "Progression-free survival (PFS) and time to progression (TTP) as surrogate endpoints for median overall survival (mOS) in ...

This applies to both incidence and event-free survival. It was therefore concluded that an elevated set point of thyroid ... In Parkinson's disease, JTI is significantly elevated in early sub-types of the disease compared to an advanced group. A ... Serum Free Thyroxine Concentration to Predict Ventricular Arrhythmia Risk in Euthyroid Patients with Structural Heart Disease ... of thyroid homeostasis are correlated with motor subtype and disease severity in euthyroid patients with Parkinson's disease". ...

... progression-free survival. The 10-year disease-free survival is 40-50%. Younger ages showed lower 5 and 10-year survival rates ... The 5-year disease-free survival for age >5 years is 50-60%. Another report found a similar 5-year survival at about 65% with ... progression-free and overall survival. Some evidence suggests chromosome 6q25.3 deletion may provide additional survival ... The protein nucleolin and expression of MMP2 and MMP14 have been found to inversely correlate with progression free survival in ...

The disease can tolerate warm or freezing temperature,[2] but favorable conditions for the disease include wet and humid ... Because the pathogen may still live in the soil, the use of clean seed is only effective if both the soil and seed are free of ... its survival rate is much greater when crop debris is present. However, the bacteria cannot survive on decomposing matter alone ... Bacterial leaf streak (BLS), also known as black chaff, is a common bacterial disease of wheat. The disease is caused by the ...

The prognosis is comparatively good with a median survival of more than 8 years. The disease was named by Siegfried Oberndorfer ... Radionuclide therapy with 177-Lutetium-DOTA-Octreotate increases progression-free survival. Traditionally, the primary tumor ... has been surgically removed even in the case of metastatic disease, although this was in 2017 shown not to improve survival in ... The tumors often spread to the mesenteries and the liver.[citation needed] Familial clustering of the disease, with several ...

When combined with low p27 and high p53, DFS (Disease-Free Survival) decreases. p21 mediates the resistance of hematopoietic ... Marone M, Bonanno G, Rutella S, Leone G, Scambia G, Pierelli L (2002). "Survival and cell cycle control in early hematopoiesis ... Journal of Thoracic Disease. 8 (9): 2580-2591. doi:10.21037/jtd.2016.08.82. PMC 5059354. PMID 27747012. Zhang J, Scadden DT, ... overall survival rate). A study on immunohistochemical markers in malignant thymic epithelial tumors shows that p21 expression ...

The disease cycle "starts" in the early spring as the oospores begin to germinate. Oospores are thick walled survival ... This spread can be limited by using proper sanitation before moving from an infected field to a disease free field. All of ... A cool environment also favors disease transmission. An integrated disease management program incorporating host resistance ... it requires free water to infect another plant. This disease is most prevalent in newly seeded fields that experience flooding ...

... a combination of docetaxel and prednisone improves survival rates and lengthens the disease-free period. Mitoxantrone is also ... It improves the survival rate of children suffering from acute lymphoblastic leukemia relapse. The combination of mitoxantrone ... used to treat multiple sclerosis (MS), most notably the subset of the disease known as secondary-progressive MS. In the absence ...

It does not tell the individual patient's chance of survival. The main purpose of this calculation is to provide a value that ... SAPS II was designed to measure the severity of disease for patients admitted to Intensive care units aged 18 or more. 24 hours ... A free web-based SAPS II calculator is available at Clincalc.com. SAPS III Le Gall, JR; Lemeshow, S; Saulnier, F (1993). "A new ... SAPS II is a severity of disease classification system. Its name stands for "Simplified Acute Physiology Score", and is one of ...

Radiation and/or chemotherapy had no significant effect in improving patients' disease-free survival. With developments in our ... In 1998 the largest study on the disease was a retrospective review with fifty-one patients. Of these fifty-one patients, no ... Using a chemotherapy regimen designed for another cancer is an archaic "guess-and-check" way of treating a disease. In 2008 the ... An important hallmark of cancer, Akt is part of the cell survival pathways by inhibiting apoptosis. There is also evidence that ...

... absolute improvement in 5-year overall survival and disease free survival, respectively. Neoadjuvant platinum-based ... In 1995 a multicenter study reported improved long-term and disease-free survival in melanoma patients using interferon alpha ... His results, published in 1985, indicated increased disease-free survival for the former group. Despite the initial pushback ... It has been known for at least 30 years that adjuvant chemotherapy increases the relapse-free survival rate for patients with ...

More severe skin toxicities were associated with improved progression free survival and overall survival. Pulmonary fibrosis ... metastatic CRC with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing regimens, ... "the treatment of EGFR-expressing metastatic colorectal cancer with disease progression" despite prior treatment. Panitumumab ... and interstitial lung disease were observed in clinical trials. EGFR is a transmembrane protein. Panitumumab works by binding ...

However, radiotherapy for localized disease has given 5-year disease-free and overall survival rates of 76% and 96%, ... Disease-free rates found 5 and 10 years after these treatments are 57% and 43%, respectively. In disseminated disease, watchful ... Disease that moves past a localized stage to become disseminated, rapidly progressive disease, and symptomatic disease have ... and an estimated 5 year disease-free survival of 95%. Surgery plus radiotherapy does not appear to give better results that ...

Overall survival (OS), progression-free survival (PFS), and response rate (RR) were secondary endpoints. Eligible people were ... Demographics and baseline disease characteristics were similar between the two groups. The trial was stopped following a pre- ... as well as bortezomib plus melphalan and prednisone may result in a large increase in the progression-free survival. Gastro- ... and 1-year survival 80% vs 66%). New studies show that bortezomib may potentially help recover from vincristine treatment in ...

Norway have since been declared free of the disease in 2011. Although the disease is not a threat to humans, the most ... Viral survival and vector longevity is seen during milder winters. A significant contribution to the northward spread of ... Insect-borne diseases, Ruminant diseases, Animal viral diseases). ... Bluetongue disease is a noncontagious, insect-borne, viral disease of ruminants, mainly sheep and less frequently cattle, yaks ...

Moalem, Sharon (2007). Survival of the sickest: a medical maverick discovers why we need disease (1st ed.). New York: William ... "Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome". Ramachandran, P.P. (May 17, 2015). "Inheritance". Free Press. " ... "Ripped Genes: Let's Talk Orphan Diseases". Medium. January 17, 2018. Human Disease Database. " ... Moalem's first book Survival of the Sickest was published in 2007 by William Morrow (HarperCollins). The book, co-written by ...

When there is free water in the soil, conditions are met for sporangia to be produced. As the disease cycle mentioned, ... Oospores are the survival structure of P. cactorum. Chlamydospores produce mycelium that continues to infect the plant. Pythium ... The disease is primarily a root rot that causes symptoms of foliar blight. Sporangia are produced on the mycelium and can ... Potting media should also be sterilized as spores and hyphae can survive in dust or free water. Being careful not to over water ...

pcALCL has an estimated five-year failure-free survival rate of 55 percent. Nonetheless, the disease has a 10-year overall ... A small study reported overall response rates, complete response rates, and disease-free survival rates at 24 months of 63%, 45 ... it has a five-year disease-specific survival rate of 76 percent compared with 96 percent for disease in other locations. ... and 5-year overall survival rates of 56% and 44%, respectively). Progression-free survival rates with the latter two types of ...

Mogamulizumab is a CCR4 monoclonal antibody which has been shown to improve progression-free survival. It was approved by the ... In transformed cells, presence of the CD30 receptor is associated with improved survival To stage the disease, various tests ... The name mycosis fungoides is very misleading-it loosely means "mushroom-like fungal disease". The disease, however, is not a ... Notably, most pediatric persons with MF present with early-stage disease. The criteria for the disease are established on the ...

"Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free Survival in Breast Cancer". PLOS Medicine. 2 (9): e284. ...

Patients with non-localized (i.e. systemic Ann Arbor stage III and IV) disease who are free of symptoms have been treated with ... progression-free survival rate at 5 years. Frail stage III/IV patients have been successfully treated with rituximab or the ... Center for Disease Control. 9 June 2015. Retrieved 25 April 2017. Alfarouk KO, Bashir AH, Aljarbou AN, Ramadan AM, Muddathir AK ... He was the first to suggest a possible role of this organism in the pathogenesis of gastric diseases. His work was included in ...

At moderate doses, UDCA has been demonstrated to slow disease progression and improve transplant-free survival. A complete ... Due to disease progression, 40% of patients eventually require liver transplantation, which has survival rates (91% at 1 year, ... One study found UDCA had improved biochemical functions but did lower the rate for death or transplant-free survival. An ... The disease has an incidence is 0.4-2.0 cases/100,000 and a prevalence of 16.2 cases/100,000, making it a rare disease. ...

These have the advantage of being less of a burden for the patient and the disease-free survival is comparable to that of open ... However in 2021 Pembrolizumab was approved for adjuvant treatment after showing promising disease-free survival improvements. ... and overall disease-free rates are not as good as those obtained with surgical removal. Surgery for metastatic disease: If ... A Korean study estimated a disease-specific overall five-year survival rate of 85%. Taken as a whole, if the disease is limited ...

Numerous studies show a decreased overall survival and disease-free survival in those tumors overexpressing VEGF. The ... although the cause of disease and the typical source of neovascularization differs between the two diseases. VEGF-D serum ... VEGF-A plays a role in the disease pathology of the wet form age-related macular degeneration (AMD), which is the leading cause ... Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. Drugs such as ...

PELP1 expression is an independent prognostic predictor of shorter breast cancer-specific survival and disease free interval. ... PELP1 is a proto-oncogene that provides cancer cells with a distinct growth and survival advantage. PELP1 interacts with ... PELP1 is a proto-oncogene that provides cancer cells with a distinct growth and survival advantage. PELP1 overexpression has ... activation of the AKT pathway and cytoplasmic PELP1 induces signaling pathways that converge on ERRγ to promote cell survival ...

... stable disease, and progressive disease in 1, 12, 37, and 12 patients, respectively; median progression-free survival time (i.e ... and other manifestations of this disease. FAP is an autosomal dominant genetic disease which in ~70-80% of cases is due to ... Individuals with FAP also bear the risks of developing a wide range of the disease's other disorders such as: stomach and ... In the majority of cases, GF tumors are manifestations of the genetic disease, familial adenomatous polyposis (FAP), or its ...

ACC, generally, carries a poor prognosis, with an overall 5-year survival rate of about 50%. Five-year disease-free survival ... The FIRM-ACT trial demonstrated higher rates of response and longer progression-free survival with EDP + mitotane than with ... "Diseases of the Adrenal Cortex: Adrenal Cancer". EndocrineWeb. Updated on: 04/14/16 Albano D, Agnello F, Midiri F, Pecoraro G, ... The 5-year survival rate after successful surgery is 50-60%, but unfortunately, many patients are not surgical candidates. A ...

... the median Progression-Free Survival was 9.4 months and the Duration of Response was 9.6 months. Efficacy was evaluated in ... In a Phase 1/2 trial, in solid tumor patients refractory to standard therapy, response evaluation showed disease stabilization ... Including an Initial Report on Progression Free Survival". Archived from the original on 6 March 2016. Retrieved 3 March 2016. ... whose disease is refractory to at least one proteasome inhibitor, one immunomodulatory agent, and one anti-CD38 monoclonal ...

AEL patients did have a significantly shorter disease-free survival period, a median of 32 weeks, but this effect was explained ... A 2010 study of 124 patients found a median overall survival of 8 months. A 2009 study on 91 patients found a median overall ... survival for erythroleukemia patients of 36 weeks, with no statistically significant difference to other AML patients. ... leukemia as defined in the World Health Organization classification is a rare and pathogenetically heterogeneous disease". Mod ...

... the curve for the actual survival would look better than disease free survival curve. The Progression Free Survival is usually ... The disease free survival is usually used to analyze the results of the treatment for the localized disease which renders the ... Just as in the survival curves not all patients die, in "disease-free survival curves" not all patients relapse and the curve ... patient apparently disease free, such as surgery or surgery plus adjuvant therapy. In the disease-free survival, the event is ...