"Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly". J. Biol. ...
"Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts". The Journal ... Arold ST, Hoellerer MK, Noble ME (March 2002). "The structural basis of localization and signaling by the focal adhesion ... Schlaepfer DD, Hauck CR, Sieg DJ (1999). "Signaling through focal adhesion kinase". Progress in Biophysics and Molecular ... "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase". Molecular and ...
1999). "Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts". J. ... This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 ( ... 1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". ...
... and this forms the basis of a focal adhesion. The dynamic assembly and disassembly of focal adhesions plays a central role in ... MBInfo - Focal Adhesion MBInfo - Focal Adhesion Assembly MBInfo - Regulation of Focal Adhesion Assembly AdhesomeFAnetwork ... both the composition and the morphology of the focal adhesion change. Initially, small (0.25μm²) focal adhesions called focal ... is possible that calpain degrades these components to aid in focal adhesion disassembly The assembly of nascent focal adhesions ...
Alternatively, LRP1 may regulate focal adhesion disassembly of cancer cells through the ERK and JNK pathways to aid invasion. ... "Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly". The ...
"Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly". The ...
"Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts". J. Cell ... Calalb MB, Polte TR, Hanks SK (1995). "Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain ... 1994). "Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src". Mol. Cell. Biol ... "Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces ...
"Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase". Nature Cell Biology. 7 (6): ... Dynamic microtubules are also required to trigger focal adhesion disassembly, which is necessary for migration. It has been ... Ren XD, Kiosses WB, Schwartz MA (February 1999). "Regulation of the small GTP-binding protein Rho by cell adhesion and the ... Dynamic instability refers to the coexistence of assembly and disassembly at the ends of a microtubule. The microtubule can ...
... and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus ... "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". ...
... signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly ...
"Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src ... and focal adhesion kinase as well as other tyrosine-phosphorylated proteins, including BCAR1, DOK1, beta-catenin and cortactin ...
"Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts". The Journal ... the focal adhesion targeting domain (FAT), has been shown to be responsible for targeting FAK to focal adhesions. This domain ... also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion- ... a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase". ...
Focal adhesions are usually connected to stress fibers-in fact, stress fiber contractility is necessary for focal adhesion ... Transduction of forces from the outside to the inside of the cell can control the maturation or disassembly of adhesions, and ... like they are for focal adhesions and adherens junctions. Focal adhesions are macromolecular assemblies that are used to ... In the actin cytoskeleton, mechanotransduction can occur at cell-ECM and cell-cell adhesions, through focal adhesions and ...
Thus, tensin functions as a platform for assembly and disassembly of signaling complexes at focal adhesions by recruiting ... a 220 kDa multi-domain protein localized to the specialized regions of plasma membrane called integrin-mediated focal adhesions ... MBInfo - Tensin in Cell Adhesion Tensin review 2014 tensin review (All articles with vague or ambiguous time, Vague or ... Le Clainche, C; Carlier, MF (2008). "Regulation of actin assembly associated with protrusion and adhesion in cell migration". ...
The presence of focal adhesion complexes driving cell movement during adventurous motility is suggested by the localization of ... The entirety of the cell then travels along this mechanism of adhesion/disassembly. These complexes were found through the ... This motor would attach to these "focal adhesion complexes," and move the cell forward through its gliding motility. This ... This exploring movement is possible through a mix of slime secretion, motor proteins, and focal adhesion complexes. Social ...
In addition, it regulates the cellular localization of NM IIA and contributes to the maturation of focal adhesions. Other ... coiled-coil region prevents filament formation and S100A4 binding to previously formed filaments promotes filament disassembly ... and focal adhesion kinase from in thrombospondin-treated smooth muscle cells". Journal of Investigative Medicine. 48 (3): 190-7 ... Conti MA, Even-Ram S, Liu C, Yamada KM, Adelstein RS (October 2004). "Defects in cell adhesion and the visceral endoderm ...
Focal adhesion targeting (FAT) domain The FAT-like C-terminal domain is highly conserved in focal adhesion proteins, and ... Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA (2007). "HEF1-dependent Aurora A activation induces disassembly ... Hayashi I, Vuori K, Liddington RC (2002). "The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix ... This cleavage is prevented by focal adhesion formation, which suggests NEDD9 as a sensor of altered adhesion states. ...
Pugacheva EN, Golemis EA (October 2005). "The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and ... "HEF1-dependent Aurora A activation induces disassembly of the primary cilium". Cell. 129 (7): 1351-63. doi:10.1016/j.cell. ... These include association with FAK and Src family kinases at focal adhesions to transmit integrin-initiated signals to ... "Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated ...
It has two splice isoforms, CAAX which localizes to the endoplasmic reticulum and non-CAAX which localizes to focal adhesions ... but also accelerates disassembly of actin through encircling and severing filaments. It can be associated with Focal segmental ... "Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis". Nature Genetics. 42 (1): 72-6. doi:10.1038/ng.505 ...
"Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion ... "Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly". Nature Cell ... they localize to a cell adhesion structure such as focal adhesion or adherens junction. 2. they directly interact with one of ... Kuo, J. C.; Han, X.; Yates Jr, 3rd; Waterman, C. M. (2012-01-01). Shimaoka, Motomu (ed.). Isolation of Focal Adhesion Proteins ...
"Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". J. Biol. Chem. ... In addition, SOCE-induced Pyk2 activation mediates disassembly of endothelial adherens junctions, via tyrosine (Y1981-residue) ... Astier A, Avraham H, Manie SN, Groopman J, Canty T, Avraham S, Freedman AS (January 1997). "The related adhesion focal tyrosine ... Hiregowdara D, Avraham H, Fu Y, London R, Avraham S (April 1997). "Tyrosine phosphorylation of the related adhesion focal ...
... is also involved in the formation of focal adhesions, so loss of DLC1 leads to reduced cell adhesion and increased ... which in turn promotes the disassembly of actin stress fibers and cause cells to adopt a rounded morphology. Overexpression of ... dephosphorylation of FAK ultimately leads to an increase in focal adhesion turnover and cellular adhesion, and inhibition of ... which results in the disassociation of focal adhesion complexes which are required for cell adhesion; therefore, ...
Other cell signaling pathways and protein kinases (Protein kinase C, Rho kinase, Zip kinase, Focal adhesion kinases) have been ... resulting in some disassembly of vimentin polymers. Also, the number of myosin filaments is dynamic between the relaxed and ... Notably the phosphorylation of specific tyrosine residues on the focal adhesion adapter protein-paxillin by specific tyrosine ... also called focal adhesions) in the cell membrane of the smooth muscle cell, called the sarcolemma. The adherens junctions ...
... role in turnover of RhoA-type focal adhesions". Circ. Res. 94 (8): 1041-1049. doi:10.1161/01.RES.0000125627.77235.0C. PMID ... "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly". Mol. Cell. Biol. 20 (17): 6354-63 ... "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly". Mol. Cell. Biol. 20 (17): 6354- ...
These membrane protrusions then attach to the substrate, forming structures known as focal adhesions that connect to the actin ... Rapid assembly and disassembly of actin network enables cells to migrate (Cell migration). Actin is extremely abundant in most ... Cellular adhesion and development. The adhesion between cells is a characteristic of multicellular organisms that enables ... Once attached, the rear of the cell body contracts squeezing its contents forward past the adhesion point. Once the adhesion ...
α-keratin synthesis begins near focal adhesions on the cell membrane. There, the keratin filament precursors go through a ... "The keratin-filament cycle of assembly and disassembly". J Cell Sci. 123 (13): 2266-2272. doi:10.1242/jcs.068080. ISSN 0021- ...
Signal transduction pathways regulated via RhoA link plasma membrane receptors to focal adhesion formation and the subsequent ... RhoA's stimulation of PKN2 kinase activity regulates cell-cell adhesion through apical junction formation and disassembly. ... similar to the attachment and detachment process found in the focal adhesion mechanism. ... RhoA also regulates the integrity of the extracellular matrix and the loss of corresponding cell-cell adhesions (primarily ...
It is also proposed that microdomain interaction marks the formation of new focal adhesion sites at the cell periphery. Myosin ... Pollard, Thomas D; Borisy, Gary G (2003). "Cellular Motility Driven by Assembly and Disassembly of Actin Filaments". Cell. 112 ... Finally, continuous application of stress on the old focal adhesion sites could result in the calcium-induced calpain ... and consequently the detachment of focal adhesions which completes the cycle. Migrating cells have a polarity-a front and a ...
"Focal adhesion kinase is required for actin polymerization and remodeling of the cytoskeleton during sperm capacitation". ... This calcium-regulated protein also plays a role in assembly and disassembly of cilia which plays a crucial role in handedness ...
Proteins such as focal adhesion kinase (FAK) and Src have been shown to transduce force signals in response to cellular ... and these are all capable of rapid growth or disassembly dependent on the cell's requirements. A multitude of functions can be ... Mechanotransduction relies heavily on focal adhesions, which essentially connect the intracellular cytoskeleton with the ... Through focal adhesions, the cell is able to integrate extracellular forces into intracellular ones as the proteins present at ...