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Alt URL Penny, David (November 2014). "Cooperation and selfishness both occur during molecular evolution". Biology Direct. 10 ( ... His research has focused on theoretical biology, molecular evolution, human evolution, and the history of science.. In the ... "Recovering evolutionary trees under a more realistic model of sequence evolution". Molecular Biology and Evolution. 11 (4): 605 ... 2009). "Toward Resolving Deep Neoaves Phylogeny: Data, Signal Enhancement, and Priors". Molecular Biology and Evolution. 26 (2 ...
Neylon, David Cameron (1999). Towards the directed molecular evolution of DNA-binding specificity (PhD thesis). Australian ... University where they were awarded a Doctor of Philosophy degree in Biophysics in 1999 for work on directed molecular evolution ... Neylon, C.; Wu, S. (2009). "Article-Level Metrics and the Evolution of Scientific Impact". PLOS Biology. 7 (11): e1000242. doi: ...
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... and its improvement by directed evolution". Molecular Cancer Therapeutics. 5 (1): 97-103. doi:10.1158/1535-7163.MCT-05-0365. ... Molecular and functional characterization of a carbon starvation gene of Escherichia coli. Journal of Molecular Biology, 218: ... Matin, A. (1991). "The molecular basis of carbon-starvation-induced general resistance in Escherichia coli". Molecular ... "Analysis of novel soluble chromate and uranyl reductases and generation of an improved enzyme by directed evolution". Applied ...
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The Maxygen legacy was revived in 2018 with a focus on Directed Evolution of Proteins using Molecular Breeding. Maxygen LLC is ... Applied Molecular Evolution and Genencor International. Another company, Enchira Biotechnology, was also as direct competitor. ... known as its Molecular Breeding directed evolution platform. These technologies allow the generation of millions of variant ... Maxygen has demonstrated that the MolecularBreeding directed evolution platform has commercial potential in a number of areas, ...
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Site-directed mutagenesis Restriction digest DNA footprinting Kamvysselis, M. (2003). Computational molecular genomics: genes, ... regulation, evolution. (Doctoral Dissertation). Retrieved from http://web.mit.edu/manoli/www/thesis/Intro.html Chalfie, M., & ... Non-directed PCR-based mutagenesis can also be used; the parameters of the mutagenic PCR reaction can be adjusted to introduce ... Promoter bashing is a technique used in molecular biology to identify how certain regions of a DNA strand, commonly promoters, ...
"Live blog: directed evolution takes chemistry Nobel prize". Chemistry World. Retrieved 23 February 2022. "PELHAM, Sir Hugh ( ... The emphasis on classical molecular biology shifted towards cell biology and development, so that the Molecular Genetics ... During the 1960s, molecular biology the world over flourished, the outline bones of the 1950s now having flesh put on them. The ... Finally, the molecular mechanisms elucidated by Neuberger may be of great importance in understanding the mutational pattern of ...
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... of the Department of Biology at the University of Oslo in 1998 and directed the laboratory of molecular ecology and evolution. ... Molecular Biology and Evolution 27(7) 1710-1733. Caetano-Anollés G, Wang M, Mittenthal JE (2009) The origin, evolution and ... genomics and molecular evolution. He is particularly interested in evolution of macromolecular structure. His research group ... He received the Emile Zuckerkandl Prize in molecular evolution in 2002 and became University Scholar of the University of ...
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... combinatorial libraries in which portions of the FN3 scaffold are diversified using molecular display and directed evolution ... "Directed evolution of high-affinity antibody mimics using mRNA display". Chem. Biol. 9 (8): 933-42. doi:10.1016/s1074-5521(02) ... The native FN3 scaffold consists of 94 amino acids and has a molecular mass of about 10 kDa, fifteen times smaller than an IgG ... Monobodies are synthetic binding proteins constructed using a fibronectin type III domain (FN3) as a molecular scaffold. ...
... directed molecular evolution MeSH E05.393.420.238 - dna shuffling MeSH E05.393.420.301 - gene therapy MeSH E05.393.420.451 - ... direct MeSH E05.200.750.551.512.240.310 - fluorescent antibody technique, indirect MeSH E05.200.750.551.790 - periodic acid- ... site-directed MeSH E05.393.420.890 - sex preselection MeSH E05.393.525.085 - biotinylation MeSH E05.393.525.100 - blotting, ... direct MeSH E05.478.588.375.310 - fluorescent antibody technique, indirect MeSH E05.478.588.375.341 - fluoroimmunoassay MeSH ...
Mindell's paper explains that there was no direct correlation found between these and molecular evolution in the test taxa of ... Bromham, Lindell (1 March 2002). "Molecular Clocks in Reptiles: Life History Influences Rate of Molecular Evolution". Molecular ... Easteal, S. (1 January 1991). "The relative rate of DNA evolution in primates". Molecular Biology and Evolution. 8 (1): 115-127 ... Easteal, S. (January 1990). "The Pattern of Mammalian Evolution and the Relative Rate of Molecular Evolution". Genetics. 124 (1 ...
Biocontainment Bioorthogonal chemistry Biosafety Biosecurity Biosignature Central dogma of molecular biology Directed evolution ... "Molecular Biotechnology". Max Planck Institute. Archived from the original on June 10, 2007. Retrieved August 10, 2017. "List ... In 2015, the team led by Ned Budisa reported the successful completion of a long-term evolution experiment that resulted in ... This is a solid basis for the evolution of life with alternative building blocks, foldamers or biochemistries. At the same time ...
Cirino, Patrick C.; Arnold, Frances H. (2002), Directed Molecular Evolution of Proteins, Wiley-VCH Verlag GmbH & Co. KGaA, pp. ... One advantage of directed evolution is that the mutations do not have to be completely random; instead, they can be random ... In 2018 she was awarded the Nobel Prize in Chemistry for her work in directed evolution, making her the fifth woman to receive ... The directed evolution strategy involves iterative rounds of mutagenesis and screening for proteins with improved functions and ...
... "for her pioneering directed molecular evolution strategies, used worldwide to optimize the functions of enzymes and to engineer ... molecular biology, and biomedicine in the development of spherical nucleic acids and new types of nanostructures that are ...
... with comparison of direct and indirect surveys of mitochondrial DNA variation. Molecular Phylogenetics and Evolution, 39(2), ... Molecular Phylogenetics and Evolution, 47(2), 870-876. Wilson, D. E. and D. M. Reeder, Editors. Vampyressa. Mammal Species of ... Hoofer, S. R. & Baker, R. J. (2006). Molecular systematics of Vampyressine bats (Phyllostomidae: Stenodermatinae) ...
... with comparison of direct and indirect surveys of mitochondrial DNA variation. Molecular Phylogenetics and Evolution, 39(2), ... Molecular Phylogenetics and Evolution, 47(2), 870-876. Lee, T.E. Jr.; Scott, J.B. & Marcum, M.M. (2001). "Vampyressa bidens". ... Hoofer, S. R. & Baker, R. J. (2006). Molecular systematics of Vampyressine bats (Phyllostomidae: Stenodermatinae) ...
"Molecular breeding", a form of "Directed evolution". His contributions to malaria research over an 18-year period began in ... During this time, Molecular breeding or DNA shuffling Technology was conceived and the nascent company Maxygen Inc. incubated ... He was a pioneer in the fields of molecular parasitology, especially malaria, and in leading the commercialisation of one of ... From 1988 to 1992, he worked at the Laboratory of Infectious Diseases of the DNAX Research Institute of Molecular and Cellular ...
Dihybrid Dihybrid cross Dimerization Dimorphism Dioecious plant Diploid Directed evolution Directed mutagenesis Directed ... Modifier gene Molecular biology Molecular chaperone Molecular farming Molecular genetics Molecular imprinting Molecular ... Phe Phenocopy Phenotype Phenotypic variance Phenylketonuria Pheromone Phosphodiester bond Photoreactivation Phyletic evolution ... sequencing Directionality (molecular biology) Discrete generations Disease Disruptive selection Distribution DMD DNA DNA bank ...
... nanotube Catalysis Density functional theory Directed evolution Enzyme Fullerene Graphene Metal-organic framework Molecular ... A molecular imprinting strategy was developed to improve the selectivity of Fe3O4 nanozymes with peroxidase-like activity. A ... A nanozyme was developed for ratiometric molecular imaging. A Fe3O4/Ag/Bi2MoO6 photoactivatable nanozyme was developed for ... Zhang, Zijie; Zhang, Xiaohan; Liu, Biwu; Liu, Juewen (5 April 2017). "Molecular Imprinting on Inorganic Nanozymes for Hundred- ...
Directed evolution protein-protein interactions PelB leader sequence Competing techniques: Two-hybrid system mRNA display ... Initial work was done by laboratories at the MRC Laboratory of Molecular Biology (Greg Winter and John McCafferty), the Scripps ... Barbas CF, Hu D, Dunlop N, Sawyer L, Cababa D, Hendry RM, Nara PL, Burton DR (April 1994). "In vitro evolution of a ... Phage display is also a widely used method for in vitro protein evolution (also called protein engineering). As such, phage ...
There was a direct correlation between the risk of infection of people at other tables and how close they were to the sick ... 2016) Molecular ecolution of the capsid gene in human norovirus genogroup II. Sci Rep 6:29400 Ozaki K, Matsushima Y, Nagasawa K ... Several estimates of the evolution rate have been made varying from 8.98 × 10−3 to 2.03 × 10−3 substitutions per site per year ... fragment-based molecular docking and binding free energy calculations". Carbohydr. Res. 378: 133-8. doi:10.1016/j.carres. ...
Human PANO1 protein has a molecular weight of 22.8 kb and a theoretical, isoelectric point of 12.21. From an analysis of the ... When PANO1 is over-expressed, as a direct result, p14ARF expression also increases. When there is an abnormal expression of ... Grzybowska EA (July 2012). "Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in ...
Molecular Biology and Evolution. 29 (2): 1019-29. doi:10.1093/molbev/msr271. PMC 3278476. PMID 22045996. Lovejoy DA, Pavlović T ... Ten-m3 plays an important role during early development in directing the topographic neural projection and formation of the ... Like the Ten-m family, Ten-m3 is a large type II transmembrane glycoprotein that has a molecular weight of ~300 kDa and is ... Ten-m3 protein is expressed in the Purkinje's cell zone, molecular and granular layers and the white matter of the cerebellum. ...
Graur, Dan; Pupko, Tal (2001-02-15). "The Permian Bacterium that Isn't". Molecular Biology and Evolution. Oxford Journals. 18 ( ... with salt concentration having a direct impact. However, recent studies at Lake Hillier in Western Australia have shown that ... Journal of Molecular Biology. 6: 34-8. doi:10.1016/s0022-2836(63)80079-0. PMID 13964964. Peck, R. F.; Dassarma, S; Krebs, M. P ... "Evolution in the laboratory: The genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1". Genomics. 91 (4 ...
Burn DJ, Jaros E (December 2001). "Multiple system atrophy: cellular and molecular pathology". Molecular Pathology. 54 (6): 419 ... Hodos W (2009). "Evolution of Cerebellum". Encyclopedia of Neuroscience. Springer. pp. 1240-1243. doi:10.1007/978-3-540-29678-2 ... Histopathological investigation on six cases of pathologically confirmed MSA, using antibodies directed at a variety of α- ... Burn DJ, Jaros E (December 2001). "Multiple system atrophy: cellular and molecular pathology". Molecular Pathology. 54 (6): 419 ...
Molecular Phylogenetics and Evolution. 83: 250-257. doi:10.1016/j.ympev.2014.10.021. Tsuji, L. A.; Sidor, C. A.; Steyer, J. - S ... but a later 2019 study found that the bone histology provided no direct evidence of this lifestyle. Pareiasaurs appear very ... Gauthier, J., Kluge, A.G. and Rowe, T. (1988). "The early evolution of the Amniota." Pp. 103-155 in Benton, M.J. (ed.), The ... Schoch, Rainer R.; Sues, Hans-Dieter (2015). "A Middle Triassic stem-turtle and the evolution of the turtle body plan". Nature ...
Transformation (genetics) Evolution of sexual reproduction Dai, X; Wang, H; Zhang, Z; Li, K; Zhang, X; Mora-López, M; Jiang, C ... Sulfolobus is now used as a model to study the molecular mechanisms of DNA replication in Archaea. And because the system of ... Direct. 5: 53. doi:10.1186/1745-6150-5-53. PMC 2933680. PMID 20731852. Bernstein, H; Bernstein, C (2010). "Evolutionary Origin ... The viruses infecting archaea like Sulfolobus have to use a strategy to escape prolonged direct exposure to the type of ...
Olvido (Oblivion): Able to take anything directed at him into what he calls "the void" and direct it back at his opponents in ... Serafina is also able to detect genetic and bio-chemical data down to the molecular level. This makes her an extraordinary ... and Synch also learn that any Children who have died are resurrected by the City through cloning to further the evolution ... She can also manipulate bio-molecular ingredients to some degree. Aguja (Needle): She possesses powers that include the ...
Molecular Phylogenetics and Evolution. 43 (1): 309-327. doi:10.1016/j.ympev.2006.10.026. PMID 17197200. Orlando, L.; Calvignac ... 1. Impensis Direct. Laurentii Salvii. Louis, E.E., Jr.; Engberg, S.E.; Lei, R.; Geng, H.; Sommer, J.A.; Randriamampionona, R.; ... Molecular tests may offer support, since they show that the aye-aye was the first to diverge in the lemur clade and that the ... Two competing phylogenies exist based on genetic and molecular data. One approach (Horvath et al.) looks at a larger number of ...
Molecular Cell Biology. 16 (3): 155-166. doi:10.1038/nrm3951. PMC 4963239. PMID 25693131. Mikhaylichenko O, Bondarenko V, ... March 2022). "The evolution, evolvability and engineering of gene regulatory DNA". Nature. 603 (7901): 455-463. Bibcode: ... to direct the level of transcription of a given gene. A promoter is induced in response to changes in abundance or conformation ... Journal of Molecular Biology. 346 (2): 399-409. doi:10.1016/j.jmb.2004.11.075. PMID 15670592. Martins L, Mäkelä J, Häkkinen A, ...
Mazumdar spearheaded Biocon's evolution from an industrial enzymes manufacturing company to a fully integrated bio- ... As of 2014, Biocon directed about 10% of its revenue into research and development, a much higher proportion than most Indian ... to manufacture and market a select range of biotherapeutics in a joint venture with the Cuban Center of Molecular Immunology. ...
An important step was taken in the evolution of quantum theory at the first Solvay Congress of 1911. There the top physicists ... thereby giving direct empirical verification of the atomic theory. Also in 1905, Einstein explained the photoelectric effect by ... Slater into various theories such as Molecular Orbital Theory or Valence Theory. Beginning in 1927, researchers attempted to ...
Molecular Phylogenetics and Evolution. 48 (3): 964-985. doi:10.1016/j.ympev.2008.05.046. PMID 18590827. Price, SA.; Bininda- ... Pinnipeds have been especially affected by the direct loss of food supplies and in some cases the harvesting of fish has led to ... Molecular Phylogenetics and Evolution. 41 (2): 345-354. doi:10.1016/j.ympev.2006.05.022. PMID 16815048. Perrin 2009, pp. 861- ... Molecular Biology and Evolution. 11 (3): 357-364. doi:10.1093/oxfordjournals.molbev.a040118. PMID 8015431. Agnarsson, I.; May- ...
"Molecular Dynamics Simulations Suggest that Electrostatic Funnel Directs Binding of Tamiflu to Influenza N1 Neuraminidases". ... "Klaus Schulten Talks about the Evolution of Computational Biophysics". Scientific Computing. March 14, 2014. Retrieved 4 ... we need to understand life at the molecular level and to know how all the molecular components work together like clockwork. ... The molecular dynamics package NAMD and the visualization software VMD are estimated to be used by at least 300,000 researchers ...
By studying the evolution of atoms under the influence of these Hamiltonians, insight about the solutions to the Hamiltonian ... Titanium-sapphire lasers, with their large tunable range, provide a possible platform for direct tuning of wavelength in ... Molecular, and Optical Physics, Elsevier, pp. 95-170, arXiv:physics/9902072, doi:10.1016/s1049-250x(08)60186-x, ISBN 978-0-12- ... techniques applied to trapped atom optical-lattice systems can even provide single-site imaging resolution of their evolution. ...
Ulam's work on non-Euclidean distance metrics in the context of molecular biology made a significant contribution to sequence ... Throughout his participation in the Manhattan Project, Teller's efforts had been directed toward the development of a "super" ... which applied his earlier ideas on branching processes to evolution. Another, report, with William Beyer, Temple F. Smith, and ... Goad, Walter B (1987). "Sequence Analysis: Contributions of Ulam to Molecular Genetics" (PDF). Los Alamos Science. Los Alamos ...
Molecular Biology and Evolution. 33 (3): 670-678. doi:10.1093/molbev/msv258. PMID 26576851. "†Oligobombus Antropov 2014 (bee ... Many species nest underground, choosing old rodent burrows or sheltered places, and avoiding places that receive direct ... combining molecular, morphological and behavioural data, gives the following cladogram: On this hypothesis, the molecular data ... "Reproductive conflict in bumblebees and the evolution of worker policing". Evolution. 66 (12): 3765-3777. doi:10.1111/j.1558- ...
Grebel, Thomas (July 2012). "Network evolution in basic science". Journal of Evolutionary Economics. 22 (3): 443-457. doi: ... it is more likely that directed percolation, that is a directionally controlled percolation, is more useful to study divergent ... International Journal of Molecular Sciences. 12 (10): 6810-6833. doi:10.3390/ijms12106810. PMC 3211012. PMID 22072921. Rebello ...
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A queen can direct the evolution and maintenance of nonreproductive castes of offspring through parental manipulation with the ... The most recent molecular evidence suggests three to four independent origins of eusociality and frequent reversions from ... Possession of venomous stinger in the Halictinae were likely beneficial in the subfamily's evolution of eusociality by ... Andersson, M. (1984). "The Evolution of Eusociality". Annual Review of Ecology and Systematics. 15: 165-189. doi:10.1146/ ...
In The Chaos Balance, Nylan leaves Westwind for a more direct confrontation with Cyador. By this time, the fire-wagons and fire ... balanced by the various molecular forces (order) that bind matter into structured forms. These forces are understood, at a ... flesh out two of the areas of the world that were mostly ignored in earlier novels and provides insight into the evolution of ... sent Lerris to Candar with the suspicion that a strong order mage and strong chaos wizard will ultimately be drawn into direct ...
In molecular biology, trimeric autotransporter adhesins (TAAs), are proteins found on the outer membrane of Gram-negative ... 2007). "A conserved extended signal peptide region directs posttranslational protein translocation via a novel mechanism". ... new insights into protein folding and evolution". Acta Crystallogr F. 66 (Pt 10): 1190-7. doi:10.1107/S1744309110007177. PMC ... Gerlach RG, Hensel M (2007). "Protein secretion systems and adhesins: the molecular armory of Gram-negative pathogens". Int J ...
Y-DNA is present only in males and is passed down from a father to his sons (direct male line) with only minor mutations ... See, for example, the Molecular Genealogy Research Project. Some tests are limited to either the patrilineal or the matrilineal ... Thea Miller, "The German registry: The evolution of a recordkeeping model," Archival Science Volume 3, Number 1 / March, 2003 ...
Molecular Cell Biology. 7 (8): 612-6. doi:10.1038/nrm1946. PMID 16723972. S2CID 22274894. Feng J, Bi C, Clark BS, Mady R, Shah ... This, in addition to SINEs' direct role in regulatory networks (as discussed in SINEs as long non-coding RNAs) is crucial to ... Cordaux R, Batzer MA (October 2009). "The impact of retrotransposons on human genome evolution". Nature Reviews. Genetics. 10 ( ... 2008 suggested that short-interspersed nuclear elements can serve as direct signals in chromatin rearrangement and structure. ...
Yamagoe S, Mizuno S, Suzuki K (1998). "Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and ... 2004). "Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver". ... Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold". The Journal ...
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NIAC encouraged proposers to think decades into the future in pursuit of concepts that would "leapfrog" the evolution of ... A direct probe of dark energy interactions with a solar system laboratory In addition, seven projects were selected for ... Molecular Composition Analysis of Distant Targets Janson, Siegfried: Brane Craft Mann, Chris: Stellar Echo Imaging of ... Direct Multipixel Imaging and Spectroscopy of an exoplanet with a Solar Gravity Lens Mission Robert Youngquist: Solar Surfing ...
Holmiæ: Impensis Direct. Laurentii Salvii. pp. 554-555. Retrieved 28 July 2020. Missouri Botanical Garden But, Paul Pui-Hay; ... Evidence from pollen morphology and multiple molecular phylogenetic studies showed that when broadly circumscribed, Murraya was ... Journal of Systematics and Evolution (in Chinese and English). 24 (3): 186-192. Retrieved 2021-09-21. Mou, Feng-Juan & Zhang, ... based on the molecular phylogeny and morphological characters". Taiwania. 66 (3): 387-397. doi:10.6165/tai.2021.66.387. " ...
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