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*  Alkaptonuria
It is caused by a mutation in the HGD gene for the enzyme homogentisate 1,2-dioxygenase (EC 1.13.11.5); if a person inherits ... Nitisinone inhibits the enzyme, 4-hydroxyphenylpyruvate dioxygenase, responsible for converting tyrosine to homogentisic acid, ... 2-dioxygenase (HGD) which can normally be found in numerous tissues in the body (liver, kidney, small intestine, colon and ...
*  Acireductone synthase
Identification and characterization of two novel dioxygenases". J. Biol. Chem. 270: 3147-3153. doi:10.1074/jbc.270.7.3147. PMID ...
*  FTO gene
FTO is a member of the superfamily of non-haem Fe(II) and 2-oxoglutarate (2OG)-dependent dioxygenases. Recombinant FTO protein ... Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans ... gene codes for a novel member of the non-heme dioxygenase superfamily". BMC Biochem. 8: 23. doi:10.1186/1471-2091-8-23. PMC ...
*  Aromatic-ring-hydroxylating dioxygenases
In the phthalate 4,5-dioxygenase system, phthalate dioxygenase reductase (PDR) has the same function. PDR is a single protein ... "Structure of an aromatic-ring-hydroxylating dioxygenase - naphthalene 1,2-dioxygenase". Structure. 6 (5): 571-586. doi:10.1016/ ... Aromatic-ring-hydroxylating dioxygenases (ARHD) incorporate two atoms of dioxygen (O2) into their substrates in the ... Thus, the electron transfer in ARHD systems can be summarised as: EC 1.14.12.3 benzene 1,2-dioxygenase benzene + NADH + H+ + O2 ...
*  Dioxygenase
... non-heme iron dioxygenases are catechol dioxygenases and 2-oxoglutarate (2OG)-dependent dioxygenases. The catechol dioxygenases ... Two dioxygenases, 1H-3-hydroxy-4-oxo-quinoline 2,4-dioxygenase (QDO) and 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (HDO), ... 3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO), which are heme dioxygenases that utilize iron coordinated by a heme B ... The mononuclear iron dioxygenases, or non-heme iron-dependent dioxygenases as they are also termed, all utilize a single ...
*  2-oxoglutarate (2OG)-dependent dioxygenases
Given the important biological roles that 2OG-dependent dioxygenase play, many 2OG-dependent dioxygenase inhibitors were ... 2OG-dependent dioxygenases share a common catalytic mechanism. The first step involves the binding of 2OG and substrate to the ... All 2OG-dependent dioxygenases contain a conserved double-stranded β-helix (DSBH, also known as cupin) fold, which is formed ... Many 2OG-dependent dioxygenase are also capable of uncoupled turnover, in which oxidative decarboxylation of 2OG into succinate ...
*  Cysteamine dioxygenase
... ". Methods Enzymol. Methods in Enzymology. 143: 410-5. doi:10.1016/0076-6879(87)43071-1. ISBN 978-0-12- ... In enzymology, a cysteamine dioxygenase (EC 1.13.11.19) is an enzyme that catalyzes the chemical reaction 2-aminoethanethiol + ...
*  Gallate dioxygenase
... (EC 1.13.11.57, GalA) is an enzyme with systematic name gallate:oxygen oxidoreductase. This enzyme ... Gallate dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... The prototype of a new subgroup of extradiol dioxygenases". J. Biol. Chem. 280 (42): 35382-35390. doi:10.1074/jbc.M502585200. ... 4-tricarboxylate Gallate dioxygenase contains non-heme Fe2+. Nogales, J.; Canales, A.; Jiménez-Barbero, J.; García, J.L.; Díaz ...
*  Trimethyllysine dioxygenase
Other names in common use include trimethyllysine alpha-ketoglutarate dioxygenase, TML-alpha-ketoglutarate dioxygenase, TML ... In enzymology, a trimethyllysine dioxygenase (TMLH; EC 1.14.11.8) is an enzyme that catalyzes the chemical reaction N6,N6,N6- ... beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase". J. Biol. Chem. 253 (5): ... dependent dioxygenase superfamily. The 3 substrates of this enzyme are N6,N6,N6-trimethyl-L-lysine, 2-oxoglutarate, and O2, ...
*  Cysteine dioxygenase
... (CDO, CAS number: 37256-59-0) is a mammalian non-heme iron enzyme that catalyzes the conversion of L- ... cysteine dioxygenase)". Biochimica et Biophysica Acta. 422 (2): 273-9. doi:10.1016/0005-2744(76)90138-8. PMID 2307. Chai SC, ... "Structure and mechanism of mouse cysteine dioxygenase". Proceedings of the National Academy of Sciences of the United States of ... and characterization of recombinant rat cysteine dioxygenase". The Journal of Biological Chemistry. 280 (11): 9865-9. doi: ...
*  Sulfur dioxygenase
In humans, sulfur dioxygenase is needed to detoxify sulfide. Suzuki, I.; Silver, M. (1966). "The initial product and properties ... Sulfur dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal ... Sulfur dioxygenase (EC 1.13.11.18, sulfur oxygenase, sulfur:oxygen oxidoreductase) is an enzyme with systematic name S- ...
*  Toluene dioxygenase
In enzymology, a toluene dioxygenase (EC 1.14.12.11) is an enzyme that catalyzes the chemical reaction toluene + NADH + H+ + O2 ... Subramanian V, Liu TN, Yeh WK, Gibson DT (1979). "Toluene dioxygenase: purification of an iron-sulfur protein by affinity ... Renganathan V (1989). "Possible involvement of toluene-2,3-dioxygenase in defluorination of 3-fluoro-substituted benzenes by ... 3-dioxygenase. This enzyme participates in toluene and xylene degradation. ...
*  Catechol dioxygenase
2-dioxygenase (EC 1.13.11.1), catechol 2,3-dioxygenase (EC 1.13.11.2), and protocatechuate 3,4-dioxygenase (EC 1.13.11.3). The ... Catechol dioxygenases are metalloprotein enzymes that carry out the oxidative cleavage of catechols. This class of enzymes ... An example of the reaction carried out by catechol 1,2-dioxygenase is the formation of cis,cis-muconic acid from catechol, ... The Pseudomonas putida xylE gene, which encodes catechol 2,3-dioxygenase, is often used as a reporter to quantitate gene ...
*  Thymine dioxygenase
In enzymology, a thymine dioxygenase (EC 1.14.11.6) is an enzyme that catalyzes the chemical reaction thymine + 2-oxoglutarate ... Liu CK, Hsu CA, Abbott MT (1973). "Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase". Arch. Biochem ... 5-hydroxy-methyluracil dioxygenase, and 5-hydroxymethyluracil oxygenase. It has 2 cofactors: iron, and Ascorbate. Bankel L, ... "Markedly different ascorbate dependencies of the sequential alpha-ketoglutarate dioxygenase reactions catalyzed by an ...
*  Taurine dioxygenase
Other names in common use include 2-aminoethanesulfonate dioxygenase, and alpha-ketoglutarate-dependent taurine dioxygenase. ... In enzymology, a taurine dioxygenase (EC 1.14.11.17) is an enzyme that catalyzes the chemical reaction taurine + 2-oxoglutarate ... "Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli". J. Biol. Chem. 272 (37): 23031-6 ...
*  Torulene dioxygenase
... (EC 1.13.11.59, CAO-2, CarT) is an enzyme with systematic name torulene:oxygen oxidoreductase. This enzyme ... Torulene dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ...
*  Acireductone dioxygenase
... may refer to: Acireductone dioxygenase (iron(II)-requiring), an enzyme Acireductone dioxygenase (Ni2+- ...
*  4-Hydroxyphenylpyruvate dioxygenase
... (HPPD), also known as α-ketoisocaproate dioxygenase (KIC dioxygenase), is an Fe(II)- ... Johnson-Winters K, Purpero VM, Kavana M, Nelson T, Moran GR (Feb 2003). "(4-Hydroxyphenyl)pyruvate dioxygenase from ... Buckthal DJ, Roche PA, Moorehead TJ, Forbes BJ, Hamilton GA (1987). "4-Hydroxyphenylpyruvate dioxygenase from pig liver". ... In nearly all aerobic beings, 4- Hydroxyphenylpyruvate dioxygenase is responsible for converting 4- Hydroxyphenylpyruvate into ...
*  Nitric oxide dioxygenase
A 'nitric oxide dioxygenase' is an enzyme that is capable of carrying out this reaction. NO dioxygenase belongs to the family ... and reduction of globins appear optimized for a NO dioxygenase function. Historically, nitric oxide dioxygenase (around 1.8 ... Nitric oxide dioxygenase (EC 1.14.12.17) is an enzyme that catalyzes the conversion of nitric oxide (NO) to nitrate (NO− 3) . ... Nitric oxide dioxygenase was discovered, and first reported in 1998, as an inducible O2-dependent enzymatic activity that ...
*  2-hydroxyethylphosphonate dioxygenase
... at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... 2-hydroxyethylphosphonate dioxygenase (EC 1.13.11.72, HEPD, phpD (gene)) is an enzyme with systematic name 2- ... formate 2-hydroxyethylphosphonate dioxygenase contains non-heme-Fe(II). Cicchillo, R.M.; Zhang, H.; Blodgett, J.A.; Whitteck, J ... "On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase". J. Am. Chem. Soc. 133 (12): 4236-4239. doi:10.1021/ja1113326 ...
*  Chloridazon-catechol dioxygenase
Muller R, Schmitt S, Lingens F (1982). "A novel non-heme iron-containing dioxygenase. Chloridazon-catechol dioxygenase from ... Chloridazon-catechol dioxygenase (EC 1.13.11.36) is an enzyme that catalyzes the chemical reaction 5-amino-4-chloro-2-(2,3- ... Muller R, Haug S, Eberspacher J, Lingens F (1977). "[Catechol 2,3-dioxygenase from pyrazon-degrading bacteria (author's transl ...
*  2-nitropropane dioxygenase
Kido T, Soda K, Suzuki T, Asada K (1976). "A new oxygenase, 2-nitropropane dioxygenase of Hansenula mrakii Enzymologic and ... In enzymology, a 2-nitropropane dioxygenase (EC 1.13.11.32) is an enzyme that catalyzes the chemical reaction 2 2-nitropropane ... Yoon HJ, Suh SW (2006). "Crystal structure of 2-nitropropane dioxygenase complexed with FMN and substrate. Identification of ... "Involvement of a flavosemiquinone in the enzymatic oxidation of nitroalkanes catalyzed by 2-nitropropane dioxygenase". J. Biol ...
*  Phytanoyl-CoA dioxygenase
In enzymology, a phytanoyl-CoA dioxygenase (EC 1.14.11.18) is an enzyme that catalyzes the chemical reaction phytanoyl-CoA + 2- ... Production of alpha-hydroxyphytanoyl-CoA and formate is enhanced by dioxygenase cofactors". European Journal of Biochemistry / ...
*  Gamma-butyrobetaine dioxygenase
... belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily. It catalyses the ... Gamma-butyrobetaine dioxygenase (also known as BBOX, GBBH or γ-butyrobetaine hydroxylase) is an enzyme that in humans is ... Gamma-butyrobetaine dioxygenase catalyses the formation of L-carnitine from gamma-butyrobetaine, the last step in the L- ... Gamma-butyrobetaine dioxygenase is unique among other human 2OG oxygenases that it catalyses both hydroxylation (e.g.: L- ...
*  3-phenylpropanoate dioxygenase
Hca dioxygenase, and 3-phenylpropionate dioxygenase. Diaz E, Ferrandez A, Garcia JL (1998). "Characterization of the hca ... In enzymology, a 3-phenylpropanoate dioxygenase (EC 1.14.12.19) is an enzyme that catalyzes the chemical reaction 3- ...