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*  Diketopiperazine
2,5-Diketopiperazines are cyclodipeptides often obtainable via condensation of two α-amino acids. 2,6-Diketopiperazines may be ... A diketopiperazine (DKP), also known as a dioxopiperazine or piperazinedione, is a class of organic molecules in which the two ... Of these three isomeric diketopiperazines, the 2,5-derivatives have attracted the greatest interest. DPKs can be visualized as ... The 2,3-diketopiperazines may be viewed as oxamides obtained from ethylenediamine. ...
*  2,5-Diketopiperazine
The diketopiperazine skeleton protects both the N and O termini of the glycine. For this application, the diketopiperazine is O ... The most studied of all the simple 2,5-diketopiperazines is the histidyl-proline 2,5-diketopiperazine cyclo(L-His-L-Pro) which ... 2,5-Diketopiperazines (2,5-DKPs) which include mono- and disubstituted 2,5-diketopiperazines, their annulated, spiro-annulated ... Formation of the 2,5-diketopiperazine ring by enolate acylation was used in the construction of the 2,5-diketopiperazine ring ...
*  Cyclol
Hence, alternative chemical models of proteins were considered, such as the diketopiperazine hypothesis of Emil Abderhalden. ... ISBN 0-585-35980-6. Abderhalden, E (1924). "Diketopiperazines". Naturwissenschaften. 12: 716-720. Bibcode:1924NW.....12..716A. ...
*  Meir Wilchek
"The circular dichroism of tyrosyl and tryptophanyl diketopiperazines". J. Biol. Chem. 243 (18): 4799-4805. PMID 5687722. CS1 ...
*  Pleurobranchus areolatus
These are the first diketopiperazine derivatives isolated from a mollusc. Similar diketopiperazines were isolated also from ... Rodriguesic acids and its esters (they are modified diketopiperazines) were isolated from P. areolatus in 2014. ... modified diketopiperazines from the gastropod mollusc Pleurobranchus areolatus". Journal of the Brazilian Chemical Society 25(4 ...
*  Fellutanine
... A, B, C and D are bio-active diketopiperazine alkaloids isolated from the cultures of Penicillium fellutanum, that ... Kozlovsky AG, Vinokurova NG, Adanin VM, Burkhardt G, Dahse HM, Gräfe U (March 2000). "New diketopiperazine alkaloids from ... Kozlovsky AG, Vinokurova NG, Adanin VM, Burkhardt G, Dahse HM, Gräfe U (2001). "New diketopiperazine alkaloids from Penicillium ... Kozlovsky AG, Vinokurova NG, Adanin VM (2000). "Diketopiperazine alkaloids from the fungus Penicillium piscarium Westling". ...
*  Penicillium dipodomyis
... a diketopiperazine from Penicillium dipodomyis". Phytochemistry. 51 (8): 1181. doi:10.1016/S0031-9422(99)00014-X. Timm Anke; ... is a species of the genus of Penicillium which occurs in kangaroo rats and produces penicillin and the diketopiperazine ...
*  Rhodotorulic acid
Borthwick AD, Da Costa NC (2017). "2,5-Diketopiperazines in Food and Beverages: Taste and Bioactivity". Critical reviews in ... Rhodotorulic acid is the smallest of the 2,5-diketopiperazine family of hydroxamate siderophores which are high-affinity ...
*  Brevianamide F
5-diketopiperazines found in food, cyclo(L-Trp-L-Pro) has only been found as a minor 2,5-diketopiperazine (8.2ppm) in autolyzed ... Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. It is the ... Borthwick AD, Da Costa NC (2017). "2,5-Diketopiperazines in Food and Beverages: Taste and Bioactivity". Critical reviews in ... Brevianamide Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural ...
*  Roquefortine C
... is a mycotoxin that belongs to a class of naturally occurring 2,5-diketopiperazines produced by various fungi, ... Roquefortine C is a cyclodipeptide mycotoxin derived from the diketopiperazine cyclo(Trp-dehydro-His) and is a relatively ... Borthwick AD, Da Costa NC (2017). "2,5-Diketopiperazines in Food and Beverages: Taste and Bioactivity". Critical reviews in ... Aristolochene Aflatoxin Patulin Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and ...
*  Tadalafil
... is an annulated 2,5-diketopiperazine. It is also a 1,2,3,4-tetrahydro-β-carboline. Tadalafil can be synthesized ... This is followed by condensations with chloroacetyl chloride and methylamine to complete the diketopiperazine ring: The FDA's ... Borthwick AD (May 2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ...
*  Piscarinine
Borthwick AD (May 2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ... 5-diketopiperazines. The cytotoxic dehydroproline tryptophan derivatives piscarinines A and B were shown to be active against ... new polycyclic diketopiperazine alkaloids from Penicillium piscarium NKM F-691". Natural Product Letters. 14 (5): 333-340. doi: ...
*  Aurantiamine
... belongs to a class of naturally occurring 2,5-diketopiperazines featuring a dehydrohistidine residue that exhibit ... Larsen TO, Frisvad JC, Jensen SR (1992). "Aurantiamine, a diketopiperazine from two varieties of Penicillium aurantiogriseum". ... Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ...
*  Versicolamide B
Borthwick AD (May 2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ... 5-diketopiperazines. The versicolamides are structurally complex spiro-cyclized versions of prenylated cyclo(L-Trp-L-Pro) ...
*  Rugulosuvine
5-diketopiperazines. Kozlovskiĭ AG, Adanin VM, Dahse HM, Grafe U (2001). "[Rugulosuvines A and B--diketopiperazine alkaloids ... CID 3083399 from PubChem Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive ...
*  Cyclic peptide
Borthwick AD (May 2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ... 5-diketopiperazines, being derived from the cyclisation of a dipeptide. Cyclic isopeptides contain at least one non-alpha amide ...
*  Phenylahistin
doi:10.1016/S0960-894X(97)10104-4. Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and ... 5-diketopiperazines featuring a dehydrohistidine residue that exhibit important biological activities, such as anti-cancer or ...
*  Fumitremorgin
Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ... 5-diketopiperazines. Gallagher, RT; Latch, GC (1977). "Production of the Tremorgenic Mycotoxins Verruculogen and Fumitremorgin ...
*  Aplaviroc
... (INN, codenamed AK602 and GSK-873140) is a CCR5 entry inhibitor that belongs to a class of 2,5-diketopiperazines ... CCR5 receptor antagonist Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive ...
*  Stephacidin
5-diketopiperazines. This unusual family of fungal metabolites are complex bridged 2,5-diketopiperazine alkaloids that possess ... Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ... 5-diketopiperazine ring. The molecular architecture of stephacidin B, formally a dimer of avrainvillamide, reveals a complex ...
*  Spirotryprostatin A
... is an indolic alkaloid from the 2,5-Diketopiperazine class of natural products found in the Aspergillus ... Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ...
*  Bicyclomycin
It belongs to a class of naturally occurring 2,5-diketopiperazines, that are among the most numerous of all the naturally ... Most of the synthetic approaches to bicyclomycin, have started from the preformed 2,5-diketopiperazine ring. Williams synthesis ... Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ... starts from the para-methoxybenzyl protected 2,5-diketopiperazine 1, bis bromination to give the 3,6-dibromide followed by ...
*  Dideoxyverticillin A
Borthwick AD (May 2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ... 5-diketopiperazines. Dideoxyverticillin A potently inhibits the tyrosine kinase activity of the epidermal growth factor ...
*  Brevianamide
... s are indole alkaloids that belong to a class of naturally occurring 2,5-diketopiperazines produced as secondary ... Brevianamide F Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural ...
*  Gliotoxin
... is a sulfur-containing mycotoxin that belongs to a class of naturally occurring 2,5-diketopiperazines produced by ... It is the most prominent member of the epipolythiopiperazines, a large class of natural products featuring a diketopiperazine ... Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ...