*  CFU-GEMM
... are the first branch of cell differentiation in hematopoiesis after the hemocytoblast (hematopoietic stem cell). In current ... researchers were in search of molecules to stimulate the proliferation of long-term hematopoietic stem cells (LT-HSC). They ... These results suggest that UM171+SR1 together enhance proliferation of progenitor cells and suppress differentiation. Carow CE ... CFU-GEMM cells are the multipotential progenitor cells for myeloid cells; they are thus also called common myeloid progenitor ...
*  Endothelial stem cell
Seita J, Weissman IL (2010). "Hematopoietic stem cell: self-renewal versus differentiation". Systems Biology and Medicine. 2: ... cell growth, proliferation, angiogenesis, and differentiation. IGF1 and IGF2 increase the production of ECs in EB. A method ... It is characteristic of hematopoietic stem cells, as well as muscle stem cells. The two lineages arising from the EPC and the ... ESCs have the characteristic properties of a stem cell: self-renewal and differentiation. These parent stem cells, ESCs, give ...
*  ALDH1B1
... involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells". Stem ... Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ... Cell. 154 (2): 452-64. doi:10.1016/j.cell.2013.06.022. PMC 3717207 . PMID 23870131. "Infection and Immunity Immunophenotyping ( ...
*  MTORC1
... plays a role in the differentiation and proliferation of hematopoietic stem cells. Its upregulation has been shown to ... The mechanisms of mTORC1's inhibition on proliferation and differentiation of hematopoietic stem cells has yet to be fully ... Treating stem cells with rapamycin will also slow their proliferation, conserving the stem cells in their undifferentiated ... Ho AD, Wagner W, Mahlknecht U (Jul 2005). "Stem cells and ageing. The potential of stem cells to overcome age-related ...
*  Reticular dysgenesis
Hematopoietic stem cells give rise to blood cells. Differentiation and proliferation of hematopoietic stem cells require a lot ... Hematopoietic Stem Cell Transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged ... Stem cells are taken from an affected child's blood or bone marrow. Then in laboratory conditions the stem cells are ... hematopoietic stem cells will not be able to differentiate or proliferate. The immune system consists of specialized cells that ...
*  Parathyroid hormone
In the bone marrow, estrogen downregulates the proliferation of hematopoietic stem cells through an IL-7 dependent mechanism. ... Estrogen suppresses T cell TNF production by regulating T cell differentiation and activity in the bone marrow, thymus, and ... Parathyroid cells express calcium-sensing receptors on the cell surface. PTH is secreted when [Ca2+] is decreased (Calcitonin ... Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ...
*  AGGF1
... is required for hematopoietic stem cell specification and the differentiation of hematopoietic and endothelial cell ... The proliferation of vascular smooth muscle cells is inhibited when AGGF1 is expressed. It has been found that AGGF1 is highly ... it also has activity in mast cells, cardiac cells, Kupffer cells and hematopoietic stem cells. AGGF1 mRNA has been detected in ... Additionally, it activates autophagy in specific cell types, such as endothelial cells, cardiac HL1 and H9C2 cells, and ...
*  Interleukin 3
... stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the ... Activated T cells can either induce their own proliferation and differentiation (autocrine signalling), or that of other T ... He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and ... In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (granulocytes, monocytes, and dendritic cells), ...
*  NOV (gene)
It is essential for self-renewal of CD34+ hematopoietic stem cells from umbilical cord blood. NOV can bind BMP2 and inhibit its ... NOV regulates multiple cellular activities including cell adhesion, migration, proliferation, differentiation, and survival. It ... functions as a regulator of human hematopoietic stem or progenitor cells". Science. 316 (5824): 590-3. doi:10.1126/science. ... Forced expression of NOV inhibits proliferation and restores growth control in CML cells, suggesting that NOV may be an ...
*  Hematopoietic stem cell niche
"Dynamic niches in the origination and differentiation of haematopoietic stem cells". Nat. Rev. Mol. Cell Biol. 12 (10): 643-655 ... "Conditions controlling the proliferation of hemopoietic stem cells in vitro". J. Cell. Physiol. 91 (3): 335-344. doi:10.1002/ ... immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). As these cells ... "Regulation of the HIF-1α level is essential for hematopoietic stem cells". Stem Cell. 7 (3): 391-402. doi:10.1016/j.stem. ...
*  PAK2
"Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation". Stem Cells. 33 (5): 1630-41. doi: ... Cell Death and Differentiation. 5 (8): 637-45. doi:10.1038/sj.cdd.4400405. PMID 10200518. Davis GE, Koh W, Stratman AN ( ... "miR-137 inhibits proliferation of melanoma cells by targeting PAK2". Experimental Dermatology. 24 (12): 947-52. doi:10.1111/exd ... 10.1002/stem.1951. PMC 4409559 . PMID 25586960. PAK2 Info with links in the Cell Migration Gateway. ...
*  MiR-150
The expression pattern of miR-150 varies during the differentiation of a hematopoietic stem cell lineage. Highest expression ... It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than 50x overexpressed ... resting B and T cells but miR-150 is downregulated in their progenitor cells, including Th1 and Th2 cells. miR-150 has been ... miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards ...
*  Utpal Banerjee
Banerjee's research focuses on the maintenance of blood stem cells, specifically hematopoietic stem cells that are maintained ... resulting in increased proliferation and eventual differentiation. His research examines this phenomenon in the Drosophila ... a local signal generated by Wingless/Wnt and a reverse signal from the differentiated cells to the stem cells. His team has ... In addition, they have examined the role of the mitochondrion in controlling cell cycle, particularly that when cells become ...
*  DNMT1
"DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells". Cell Stem Cell. 5 (4 ... crypt expansion and altered differentiation timing of ISCs, and proliferation and maintenance of MaSCs. GRCh38: Ensembl release ... It has also been shown to be critical for other stem cell types such as Intestinal stem cells (ISCs) and Mammary stem cells ( ... DNMT1 plays a critical role in Hematopoietic stem cell (HSC) maintenance. HSCs with reduced DNMT1 fail to self-renew ...
*  MECOM
... mouse embryos have been shown to have defects in both the development and proliferation of hematopoietic stem cells (HSCs). It ... has also been shown in vitro to upregulate the cell cycle and block granulocytic differentiation of murine hematopoietic cells ... "Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression". The EMBO ... Cell cycle and differentiation In vitro experiments using both human and mouse cell lines have shown that EVI1 prevents the ...
*  FLT3LG
"The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in ... Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. For example, it is a major ... 2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor ... Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and ...
*  Stem cell secretome
Impact on Neuronal Cell Proliferation, Survival and Differentiation". Scientific Reports. 6 (1). doi:10.1038/srep27791. ISSN ... Stem Cell therapies, here referred to as therapies employing non-hematopoietic, mesenchymal stem cells, have a wide range of ... The most commonly used type of stem cells for therapeutic use are human (autologous) Mesenchymal Stem Cells, hMSCs. hMSCs' ... the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their ...
*  Cancer stem cell
The Notch pathway plays a role in controlling stem cell proliferation for several cell types including hematopoietic, neural ... De-differentiation of mutated cells may create stem cell-like characteristics, suggesting that any cell might become a cancer ... "Critical appraisal of the side population assay in stem cell and cancer stem cell research". Cell stem cell. 8 (2): 136-47. doi ... They examined cancer stem cell plasticity in which cancer stem cells can transition between non-cancer stem cells (Non-CSC) and ...
*  Adult stem cell
Its role in control of stem cell proliferation has now been demonstrated for several cell types including haematopoietic, ... To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). ... such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell ... Such cells are one of the various classes of induced stem cells. Hematopoietic stem cells are found in the bone marrow and ...
*  Stem cell marker
"Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells". Proceedings of ... "Mediation of apoptosis and proliferation of human embryonic stem cells by sphingosine-1-phosphate". Stem Cells and Development ... Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can ... 2005). "Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors". Stem Cells. 23 (6 ...
*  CD69
It is activated in hematopoietic stem cells, T cells, and many other cell types in the immune system. The activation of T ... cells, and platelets (Cambiaggi et al., 1992) [supplied by OMIM]. Cluster of differentiation GRCh38: Ensembl release 89: ... is involved in lymphocyte proliferation and functions as a signal-transmitting receptor in lymphocytes, including natural ... Stem Cells (Dayton, Ohio). 12 (5): 456-465. doi:10.1002/stem.5530120502. ISSN 1066-5099. PMID 7804122. "Entrez Gene: CD69 CD69 ...
*  Stem cell theory of aging
... and self-renewal of hematopoietic stem cells are favoring elements of stem cell pool maintenance while differentiation, ... Maintaining the dynamic balance of stem cell pools requires several conditions. Balancing proliferation and quiescence along ... "Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle". Cell Stem ... have reviewed evidence that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell ...
*  Mir-129 microRNA precursor family
miR-129 may also play a role in hematopoietic stem cell development. It has been shown that miR-129 may participate in a stem ... with the induction of cell differentiation. It is postulated that miR-129 may affect differentiation and the cell cycle ... 2010). "miR-129 regulates cell proliferation by downregulating Cdk6 expression". Cell Cycle. 9 (9): 1809-18. doi:10.4161/cc.9.9 ... 2008). "MicroRNAs play a role in the development of human hematopoietic stem cells". J Cell Biochem. 104 (3): 805-17. doi: ...
*  CLEC11A
... stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells ... "Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation". Bone Marrow ... "In vitro differentiation of endothelial cells from AC133-positive progenitor cells". Blood. 95 (10): 3106-12. PMID 10807776. ... Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC (August 2004). "Stem cell factor and c-kit are expressed by ...
*  Granulocyte colony-stimulating factor
... of hematopoietic stem cells in the blood of the donor before collection by leukapheresis for use in hematopoietic stem cell ... initiates proliferation and differentiation into mature granulocytes. G-CSF stimulates the survival, proliferation, ... hematopoietic system G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the ... G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate for conditioning regimens. ...
*  ABL (gene)
Era T (2002). "Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells". ... "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science. 253 (5019): 562-5. ... "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". ... encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell ...
*  HOXB6
... has the ability to cause the indefinite proliferation of murine marrow cells, as well as expand hematopoietic stem cells ... "Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation". Leukemia ... The research has shown that HOX B6 is not expressed in hematopoietic stem cells located in the red bone marrow, which are the ... precursor cells to all types of blood cells, or primordial germ cells (PGCs), the precursor to cells passed on in each ...