Desmosterol
... has a characteristic m/z peak at 384, as seen in the mass spectra. Desmosterol has been identified through ... Desmosterol (Cholesta-5,24-dien-3β-ol) is a lipid present in the membrane of phytoplankton. Structurally, desmosterol has a ... This has led to the idea of an exogenous origin of desmosterol in phytoplankton. In 1967, desmosterol was also identified in ... There is insignificant data which shows that desmosterol has good preservation potential. As a biomarker, desmosterol is ...
Desmosterolosis
It results in an accumulation of desmosterol and a variety of associated symptoms. Only two cases have been reported as of 2007 ... and clomifene have been found to inhibit conversion of desmosterol into cholesterol and to induce desmosterolosis, for instance ...
Fucosterol-epoxide lyase
The systematic name of this enzyme class is (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming). This enzyme ... desmosterol + acetaldehyde This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon- ...
Smith-Lemli-Opitz syndrome
... as well as the reduction of 7-dehydrodesmosterol to desmosterol. It requires NADPH as a cofactor for this reduction, and may ... DHCR7 is required for the reduction of 7-Dehydrodesmosterol to desmosterol.[citation needed] Regulation of cholesterol ...
Azacosterol
Due to prevention of the metabolism of desmosterol, the drug causes it to accumulate, in turn producing side effects such as ... preventing the formation of cholesterol from desmosterol. Although it primarily acts to inhibit 24-DHCR, the drug also inhibits ...
ABCG4
... has demonstrated, in vitro, to participate in the efflux of desmosterol and amyloid-β peptide (Aβ). It is highly ...
RAR-related orphan receptor gamma
Various oxysterols and in particular the cholesterol percursor desmosterol is claimed to be the endogenous activator of RORγ. ...
2014 in science
22 February - ISMCBBPR through their president, Isidro A. T. Savillo, announces the Molecule of the Year 2012 as Desmosterol. ...
Triparanol
Although effective in reducing cholesterol levels, this results in tissue accumulation of desmosterol, which in turn is ... statins can lower cholesterol levels without resulting in accumulation of intermediates like desmosterol. Estrogen is known to ...
C27H44O
Cholecalciferol 7-Dehydrocholesterol Desmosterol Previtamin D3 Zymosterol, a cholesterol intermediate This set index page lists ...
Steroidogenesis inhibitor
... inhibitors such as azacosterol and triparanol inhibit the production of cholesterol from desmosterol, one of the last steps in ... but were withdrawn from the market due to toxicity caused by accumulation of desmosterol in tissues. Cholesterol side-chain ...
List of MeSH codes (D10)
... desmosterol MeSH D10.570.938.208.603 - hydroxycholesterols MeSH D10.570.938.208.650 - ketocholesterols MeSH D10.570.938.208.680 ...
List of MeSH codes (D04)
... desmosterol MeSH D04.808.247.222.222.347.389 - fusidic acid MeSH D04.808.247.222.222.347.557 - lanosterol MeSH D04.808.247.222. ... desmosterol MeSH D04.808.247.808.197.561 - hydroxycholesterols MeSH D04.808.247.808.197.580 - 19-iodocholesterol MeSH D04.808. ...