*  Keratin
It does this through connections to desmosomes, cell-cell junctional plaques, and hemidesmosomes, cell-basement membrane ...
*  Desmosome
Desmosomes are composed of desmosome-intermediate filament complexes (DIFC), which is a network of cadherin proteins, linker ... Combined with -some, which comes from soma, body, it thus makes a desmosome a "binding body." Desmosomes are one of the ... "Desmosome". Oxford Dictionaries. Oxford University Press. Retrieved 2016-01-21. "Desmosome". Merriam-Webster Dictionary. ... The desmosome was first discovered by Giulio Bizzozero, an Italian pathologist. He named these "dense nodules" the "nodes of ...
*  Plakoglobin
It has become clear that ARVD/ARVC is a disease of the cardiac muscle desmosome; advances in molecular genetics have ... Plakoglobin was originally identified as a component of desmosomes, where it can bind to the cadherin family member desmoglein ... Plakoglobin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent ... Stokes DL (Oct 2007). "Desmosomes from a structural perspective". Current Opinion in Cell Biology. 19 (5): 565-71. doi:10.1016/ ...
*  DSC2
... are found at desmosome cell-cell junctions and are required for cell adhesion and desmosome formation via interactions with ... Desmosomes function to anchor intermediate filaments at sites of strong adhesion, which undergo high mechanical stress, such as ... Cheng X, Koch PJ (Mar 2004). "In vivo function of desmosomes". The Journal of Dermatology. 31 (3): 171-87. doi:10.1111/j.1346- ... Green KJ, Gaudry CA (Dec 2000). "Are desmosomes more than tethers for intermediate filaments?". Nature Reviews Molecular Cell ...
*  Gastroblastoma
Desmosomes and microvilli are present. The histological differential diagnosis includes Carcinosarcoma Biphasic synovial ...
*  Giulio Bizzozero
"The desmosome". Cold Spring Harb Perspect Biol. 1: a002543. doi:10.1101/cshperspect.a002543. PMC 2742091 . PMID 20066089. >Cold ... and the identification of desmosomes (nodes of Bizzozero), structures that he first discovered in the stratum spinosum of ... Spring Harb Perspect Biol >v.1(2); Aug 2009 > PMC 2742091, The Desmosome Works by Giulio Bizzozero at Open Library. ...
*  Epithelium
Desmosomes attach to the microfilaments of cytoskeleton made up of keratin protein. Hemidesmosomes resemble desmosomes on a ... There are mainly 5 different types of cell junctions: tight junctions, adherens junctions, desmosomes, hemidesmosomes, and gap ...
*  Tonofibril
... s are cytoplasmic protein structures in epithelial tissues that converge at desmosomes and hemidesmosomes. They ... In epithelial cells, tonofilaments loop through desmosomes. Electron microscopy has advanced now to illustrate the ...
*  Intercalated disc
Desmosomes stop separating during contraction by binding filaments, joining the cells together. Desmosomes are also known as ... Three types of cell junction make up an intercalated disc - fascia adherens, desmosomes and gap junctions. Fascia adherens are ... Mahoney, Mỹ G.; Müller, Eliane J.; Koch, Peter J. (2010). "Desmosomes and Desmosomal Cadherin Function in Skin and Heart ... Thus cardiomyocyte adherens junctions differ from epithelial adherens junctions and desmosomes. Franke, Werner W.; Borrmann, ...
*  Intestinal epithelium
Desmosomes leave a gap of 30 nanometers between cells. Adherens junctions, also called zonula adherens, are multiprotein ... Nekrasova, Oxana; Green, Kathleen J. (2013-11-01). "Desmosome assembly and dynamics". Trends in Cell Biology. 23 (11): 537-546 ... Gap junctions Desmosomes Adherens junctions Tight junctions Gap junctions bring the adjacent cells within 2 nanometers of each ...
*  Area composita
The desmosome and pemphigus. Histochem Cell Biol 130, 21-54.. ...
*  Glossary of biology
desmosome A desmosome (/ˈdɛzməˌsoʊm/; "binding body"), also known as a macula adhaerens (plural: maculae adhaerentes) (Latin ...
*  Plakophilin-1
McMillan JR, Haftek M, Akiyama M, South AP, Perrot H, McGrath JA, Eady RA, Shimizu H (2003). "Alterations in desmosome size and ... Wahl JK (2005). "A role for plakophilin-1 in the initiation of desmosome assembly". J. Cell. Biochem. 96 (2): 390-403. doi: ... Hatzfeld M, Kristjansson GI, Plessmann U, Weber K (1995). "Band 6 protein, a major constituent of desmosomes from stratified ... This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have ...
*  DSC1
1998). "Compositionally different desmosomes in the various compartments of the human hair follicle". Differentiation. 63 (5): ... Smith EA, Fuchs E (1998). "Defining the Interactions Between Intermediate Filaments and Desmosomes". J. Cell Biol. 141 (5): ... 2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta ... 2001). "Assembly of desmosomal cadherins into desmosomes is isoform dependent". J. Invest. Dermatol. 117 (1): 26-35. doi: ...
*  Desmoglein-1
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein-1 is a calcium- ... Hanakawa Y, Amagai M, Shirakata Y (2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. ... Wheeler GN, Parker AE, Thomas CL (1991). "Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is ... Smith EA, Fuchs E (1998). "Defining the Interactions Between Intermediate Filaments and Desmosomes". J. Cell Biol. 141 (5): ...
*  Desmoplakin
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional ... Desmoplakin isoform DPI is highly expressed and is thought to play a role in both the assembly and stabilization of desmosomes ... Al-Jassar C, Bikker H, Overduin M, Chidgey M (Nov 2013). "Mechanistic basis of desmosome-targeted diseases". Journal of ... Desmoplakin is a critical component of desmosome structures in cardiac muscle and epidermal cells, which function to maintain ...
*  Plakophilin-2
These findings further support the notion that desmosomes crosstalk with sodium channels in the heart, and suggest that the ... These mutations in general appear to disrupt the assembly and stability of desmosomes. Mechanistic studies have shown that ... In cardiac muscle, plakophilin-2 is found in desmosome structures located within intercalated discs. Mutations in PKP2 have ... Plakophilin 2 localizes to cell desmosomes and nuclei and binds plakoglobin, desmoplakin, and the desmosomal cadherins via N- ...
*  Desmosoma
For other uses, see Desmosome. Desmosoma is a genus of isopods. Brix, S. (2007). Four new species of Desmosomatidae Sars, 1897 ...
*  Cell-cell interaction
Desmosomes also play a role in cell-cell signaling. Gap junctions are the main site of cell-cell signaling or communication ... Desmosomes also provide strength and durability to cells and tissues and are located just below adherens junctions. They are ... Of the three types of anchoring junctions, only two are involved in cell-cell interactions: adherens junctions and desmosomes. ... On the cytoplasmic side, plakins form plaques which anchor the desmosomes to intermediate filaments composed of keratin ...
*  Pinin
Shi J, Sugrue SP (2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome- ... "Entrez Gene: PNN pinin, desmosome associated protein". Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between ... Ouyang P (1999). "Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein ... a novel protein associated with the desmosome-intermediate filament complex". J Cell Biol. 135 (4): 1027-42. doi:10.1083/jcb. ...
*  Desmoglein-2
... is localized to desmosome structures at regions of cell-cell contact and functions to structurally adhere adjacent ... This second family member, desmoglein-2 is expressed in desmosome-containing tissues, such as cardiac muscle, colon, colon ... Desmoglein-2 is an integral component of desmosomes, which are cell-cell junctions between epithelial, myocardial, and certain ... Desmoglein-2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate cells. Currently, four ...
*  Corneodesmosin
2002). "Corneodesmosin, a component of epidermal corneocyte desmosomes, displays homophilic adhesive properties". J. Biol. Chem ... a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation". Arch. ... an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes". J Biol Chem. 272 (50): 31770-6. doi: ...
*  Arrhythmogenic right ventricular dysplasia
The desmosomes are composed of several proteins, and many of those proteins can have harmful mutations. The disease is a type ... ARVD is caused by genetic defects of the parts of heart muscle (also called myocardium or cardiac muscle) known as desmosomes, ... Desmin is an intermediate filament protein, which is linked to the desmosomes. Different DES muations cause an abnormal ...
*  Plasmodesma
Desmosome Gap junction Membrane nanotube Maule, Andrew (December 2008). "Plasmodesmata: structure, function and biogenesis". ...
*  Desmoglein-3
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium- ... Andl CD, Stanley JR (2001). "Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes". J ... 1993). "Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes". J. Cell Biol. ... 2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. Invest. Dermatol. 119 (6): 1231-6. ...