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*  Desmoglein
The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation ... "Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction ... Desmogleins are targeted in the autoimmune disease pemphigus. Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D ... April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and ...
*  Desmoglein-4
... is a protein that in humans is encoded by the DSG4 gene. List of conditions caused by problems with junctional ... "Entrez Gene: DSG4 desmoglein 4". Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more ... 2006). "Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle ... 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and ...
*  Desmoglein-2
... is the only desmoglein isoform expressed in cardiomyocytes. Desmoglein-2 is an integral component of desmosomes, ... Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. Desmoglein-2 is highly expressed in epithelial cells and ... These desmoglein gene family members are located in a cluster on chromosome 18. This second family member, desmoglein-2 is ... Desmoglein-2 is a 122.2 kDa protein composed of 1118 amino acids. Desmoglein-2 is a calcium-binding transmembrane glycoprotein ...
*  Desmoglein-3
Desmoglein 3 has been shown to interact with PKP3. Desmoglein List of target antigens in pemphigus List of conditions caused by ... 2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. Invest. Dermatol. 119 (6): 1231-6. ... Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene. Desmosomes are cell-cell junctions between epithelial, ... "Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)". Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F ( ...
*  Desmoglein-1
... has been shown to interact with PKP3, PKP2, and PTPRT(PTPrho) Desmoglein List of target antigens in pemphigus List ... Hanakawa Y, Amagai M, Shirakata Y (2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. ... Martínez RD (1992). "[Characterization of the desmoglein in renal cells in culture]" [Characterization of the desmoglein in ... Desmoglein-1 is a protein that in humans is encoded by the DSG1 gene. Desmosomes are cell-cell junctions between epithelial, ...
*  Pemphigus
Desmoglein 1, the protein that is destroyed by the autoantibody, is found in only the top dry layer of the skin. PF is ... Anti-desmoglein antibodies can also be detected in a blood sample using the ELISA technique. Pemphigus is a group of autoimmune ... When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes "unglued", a ... Pemphigus vulgaris (PV - ICD-10 L10.0) is the most common form of the disorder and occurs when antibodies attack Desmoglein 3. ...
*  Cadherin
Desmoglein (DSG1, DSG2, DSG3, DSG4) Desmocollin (DSC1, DSC2, DSC3) Protocadherins PCDH1; PCDH10; PCDH11X; PCDH11Y; PCDH12; ... The cadherin superfamily includes cadherins, protocadherins, desmogleins, and desmocollins, and more. In structure, they share ...
*  Hemidesmosome
Instead of desmogleins and desmocollins in the extracellular space, hemidesmosomes utilize integrins. Hemidesmosomes are found ...
*  DSC1
1997). "A YAC contig joining the desmocollin and desmoglein loci on human chromosome 18 and ordering of the desmocollin genes ... These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the ... DSC1 has been shown to interact with Desmoglein 2. GRCh38: Ensembl release 89: ENSG00000134765 - Ensembl, May 2017 GRCm38: ... Chitaev NA, Troyanovsky SM (1997). "Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and ...
*  Pemphigus foliaceus
When desmogleins are attacked, skin cells separate from each other and fluid can collect between the layers of skin, forming ... If there is an autoimmune IgG buildup in the epidermis, then nearly all of the antibodies are aimed against desmoglein 1. The ... Disruption of function: In this case, the antibody blocks the desmoglein 1 from being formed into a desmosome. This in turn ... The immune system produces antibodies against proteins in the skin known as desmogleins. These proteins form the glue that ...
*  Desmosome
Desmoglein and desmocollin have a single pass transmembrane region plus an intracellular anchor to secure its position in the ... Desmogleins and the desmocollin Dsc "a" form contain an intracellular cadherin domain, which binds to plakoglobin. The outer ... Loss of Desmoglein 4 leads to defective hair-follicle differentiation. Epidermolysis bullosa simplex is an epidermal blistering ... Desmoglein 1 haploinsufficiency leads to striate palmoplantar keratoderma, a disease which causes extreme thickening of the ...
*  Cell-cell interaction
They are made of two specialized cadherins, desmoglein and desmocollin. These proteins have extracellular domains that interact ...
*  Bullous impetigo
Toxins are produced by S. aureus and target desmoglein, which is a desmosomal cell-cell adhesion molecule that is found in the ... Exfoliating toxins are serine proteases that specifically bind to and cleave desmoglein 1 (Dsg1). Previous studies suggested ... "Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1". Nat. Med. 6 (11): 1275-7. doi:10.1038 ...
*  Pemphigus vulgaris
Pemphigus is an autoimmune disease caused by antibodies directed against both desmoglein 1 and desmoglein 3 present in ... are more anti-desmoglein 1 heavy. The disease arises most often in middle-aged or older people, usually starting with a blister ... human T cells are genetically engineered to recognize only those B cells that produce antibodies to desmoglein 3. List of ... is believed to be directly proportional to the levels of desmoglein 3. Milder forms of pemphigus (like foliacious and ...
*  BCR (gene)
"The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1". The Journal of Cell Biology ...
*  Netherton syndrome
"Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity". Nat ...
*  Plakoglobin
Abnormal distribution of plakoglobin due to mutations in genes encoding for Desmoglein 1 and 3 have also been implicated in ... Plakoglobin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble ... desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". Genomics. 10 (3): ... where it can bind to the cadherin family member desmoglein I. Plakoglobin also associates with classical cadherins such as E- ...
*  Lamellar bodies
"Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity". Nature ...
*  Intermediate filament
... desmogleins, and desmocollins; desmin filaments are connected in a similar way in heart muscle cells. Arrhythmogenic right ...
*  DSC2
Desmocollin-2 binds to desmoglein family members through a calcium-dependent interaction with its extracellular domains, and to ... Desmosomal cadherins, including the desmocollin family members and desmogleins, are found at desmosome cell-cell junctions and ... and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18". Genomics. 21 (3): 510-6. doi:10.1006/ ... cadherins than to desmogleins". Genomics. 44 (3): 330-5. doi:10.1006/geno.1997.4894. PMID 9325054. Syed SE, Trinnaman B, Martin ...
*  DSC3
These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the ... 1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG ... 1994). "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18". ... 2000). "Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes ...
*  Corneocyte
Three adhesive proteins desmoglein-1, desmocollin-1 and corneodesmosin compose the corneodesmosomes and provide the cohesive ...
*  Paraneoplastic pemphigus
Through immunoprecipitation, target antigens have been found to include desmoglein-3, desmoglein-1, envoplakin, periplakin, ... This piece labeled PNP as a "multiorgan disease characterized by antibodies against plakins, desmogleins and the α2- ...
*  Congenital tufting enteropathy
... deposition of laminin and heparan sulfate proteoglycan within the basement membrane and increased expression of desmoglein. ...
*  Plakophilin-2
PKP2 has been shown to interact with: ankyrin G, beta catenin, desmocollin 1, desmocollin 2, desmoglein 1, desmoglein 2, ...