Instead of desmogleins and desmocollins in the extracellular space, hemidesmosomes utilize integrins. Hemidesmosomes are found ... Type 2 hemidesmosomes contain integrin α6β4 and plectin without the BP antigens. Hemidesmosomes have two membrane-spanning ... 360 (2): 363-378. doi:10.1007/s00441-014-2061-z. ISSN 1432-0878. PMC 4544487. PMID 25487405. Wilhelmsen, Kevin; Litjens, Sandy ... 250 (2): 298-312. doi:10.1006/excr.1999.4549. ISSN 0014-4827. PMID 10413585. Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, ...
Three adhesive proteins desmoglein-1, desmocollin-1 and corneodesmosin compose the corneodesmosomes and provide the cohesive ... 84 (2): 195-202. PMID 21766769. Horii I, Nakayama Y, Obata M, Tagami H (1989). "Stratum corneum hydration and amino acid ... In healthy skin, desquamation is an invisible process and the stratum corneum is turned over completely within 2-4 weeks, while ... Colonization of pathogens in the skin is prevented via complete turnovers of corneocyte layer every 2-4 weeks. Corneocytes are ...
Pemphigus is an autoimmune disease caused by antibodies directed against both desmoglein 1 and desmoglein 3 present in ... are more anti-desmoglein 1 heavy. The disease arises most often in middle-aged or older people, usually starting with a blister ... human T cells are genetically engineered to recognize only those B cells that produce antibodies to desmoglein. In PV, ... is believed to be directly proportional to the levels of desmoglein 3. Milder forms of pemphigus (like foliacious and ...
... deposition of laminin and heparan sulfate proteoglycan within the basement membrane and increased expression of desmoglein. ... 2: 20. doi:10.1186/1750-1172-2-20. PMC 1878471. PMID 17448233. Davidson, G.P.; Cutz, E.; Hamilton, J.R.; Gall, D.G. (1978). " ... 135 (2): 429-347. doi:10.1053/j.gastro.2008.05.036. PMC 2574708. PMID 18572020. Sivagnanam, M.; Janecke, A.R.; Müller, T.; ... Reifen et al reported 2 additional cases in 1994 and coined the name congenital tufting enteropathy. Sivagnanam, Mamata; ...
When desmogleins are attacked, skin cells separate from each other and fluid can collect between the layers of skin, forming ... If there is an autoimmune IgG buildup in the epidermis, then nearly all of the antibodies are aimed against desmoglein 1. The ... Disruption of function: In this case, the antibody blocks the desmoglein 1 from being formed into a desmosome. This in turn ... The immune system produces antibodies against proteins in the skin known as desmogleins. These proteins form the glue that ...
2012). "Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface". J. Clin. Invest. ... Science News (2 June 2021). Luring bacteria into a trap. ScienceDaily. Accessed August 2021. Collier, Dami A.; et al. (2021). " ... 182 (2): 389-400. doi:10.1084/jem.182.2.389. PMC 2192110. PMID 7629501. Napolitani, G.; Rinaldi, A.; Bertoni, F.; Sallusto, F ... 2011). "A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins". ...
... desmoglein, E-cadherin, N-cadherin, and VE-cadherin. Purified wild-type PTPrho GST fusion protein was able to dephosphorylate E ... Desmoglein E-cadherin Fyn N-cadherin gamma-catenin p120-catenin Paxillin Neuroligin Neurexin STAT3 VE-cadherin/Cadherin-5 ... 9 (2): 193-204. doi:10.1016/S0955-0674(97)80063-4. PMID 9069265. Zhang X, Guo A, Yu J, Possemato A, Chen Y, Zheng W, et al. ( ... 92 (2): 291-4. doi:10.1016/S0925-4773(99)00345-7. PMID 10727868. S2CID 8417851. Park AR, Oh D, Lim SH, Choi J, Moon J, Yu DY, ...
... desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". Genomics. 10 (3): ... 43 (2): e5. doi:10.1136/jmg.2005.032904. PMC 2564645. PMID 16467215. van der Zwaag PA, Jongbloed JD, van den Berg MP, van der ... 2 (5): 735-42. doi:10.1002/j.1460-2075.1983.tb01493.x. PMC 555178. PMID 6416832. Gallicano GI, Kouklis P, Bauer C, Yin M, ... 42 (2): 319-27. doi:10.1016/s0735-1097(03)00628-4. PMID 12875771. Uzumcu A, Norgett EE, Dindar A, Uyguner O, Nisli K, Kayserili ...
January 2005). "Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease ... 124 (2): 360-366. doi:10.1111/j.0022-202X.2004.23583.x. PMID 15675955. Yamasaki K, Schauber J, Coda A, Lin H, Dorschner RA, ... 94 (2): 283-288. doi:10.1016/j.ygyno.2004.05.023. PMID 15297163. Rezze GG, Fregnani JH, Duprat J, Landman G (March 2011). "Cell ... 254 (1-2): 119-128. doi:10.1016/S0378-1119(00)00280-8. PMID 10974542. Sales KU, Masedunskas A, Bey AL, Rasmussen AL, Weigert R ...
"Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity". Nat ... 10 (2): 107. doi:10.3390/diagnostics10020107. PMC 7167948. PMID 32079129. Murphrey, Morgan B.; Miao, Julia H.; Zito, Patrick M ... ISBN 978-1-284-02568-2. Ovaere P; Lippens S; Vandenabeele P; Declercq W. (2009). "The emerging roles of serine protease ...
These exotoxins are proteases that cleave desmoglein-1, which normally holds the granulosum and spinosum layers together, ... 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1. "Staphylococcal Scalded Skin Syndrome". Johns Hopkins Medicine. 19 ...
... desmogleins, and desmocollins; desmin filaments are connected in a similar way in heart muscle cells. Dilated cardiomyoathy ( ... 117 (Pt 2): 133-41. doi:10.1242/jcs.00936. PMID 14676269. Herrmann H, Bär H, Kreplak L, Strelkov SV, Aebi U (July 2007). " ... 437 (1-2): 15-8. doi:10.1016/S0014-5793(98)01190-9. PMID 9804163. S2CID 7886395. Ishikawa H, Bischoff R, Holtzer H (September ... 2 (8): 795-952. PMID 8771189. Helfand BT, Chang L, Goldman RD (January 2004). "Intermediate filaments are dynamic and motile ...
Desmoglein 1, the protein that is targeted by the autoantibodies, is enriched in the upper skin layers. PF is characterized by ... When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes detached, a ... Pemphigus vulgaris (PV - ICD-10 L10.0) is the most common form of the disorder and occurs when antibodies attack desmoglein 3. ... The name is derived from the Greek root pemphix, meaning "pustule". In pemphigus, autoantibodies form against desmoglein, which ...
Furthermore, vezatin does not appear at focal adhesion sites and does not co-localise with desmogleins, which are molecules ... Vezatin has been shown to appear in the mouse blastocyst as early as the 2-cell stage, suggesting that this protein is in fact ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Maruyama K, Sugano S (January 1994). "Oligo-capping: a ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. (Articles with short description, Short description matches ...
... the three major subtypes that affects IgG autoantibodies that are characteristically raised against desmoglein 1 and desmoglein ... 69 (2): 303-311. doi:10.1002/ana.22297. PMC 3059252. PMID 21387375. van Sonderen A, Ariño H, Petit-Pedrol M, Leypoldt F, ... 48 (2): e9-10. doi:10.1016/j.oraloncology.2011.09.011. PMID 21985764. Zell JA, Chang JC (November 2005). "Neoplastic fever: a ... 15 (2): 201-209. doi:10.1007/s11940-013-0221-1. PMID 23378230. S2CID 21581917. Buckanovich RJ, Posner JB, Darnell RB (October ...
Instead of classical cadherins, non-classical cadherins such as desmogleins and desmocollins act as adhesion molecules and they ... 2 (2): 134-7. doi:10.4103/0976-237X.83074. PMC 3180831. PMID 21957393. Krachler, Anne Marie; Orth, Kim (2014). "Targeting the ... 51 (2): 445-57. doi:10.18388/abp.2004_3583. PMID 15218541. Hirohashi, Setsuo; Kanai, Yae (2003). "Cell adhesion system and ... 1 (2): a002543. doi:10.1101/cshperspect.a002543. PMC 2742091. PMID 20066089. Steed, Emily; Balda, Maria S.; Matter, Karl (2010 ...