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*  Staphylococcal scalded skin syndrome
These exotoxins are proteases that cleave desmoglein-1, which normally holds the granulosum and spinosum layers together, ... 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. "exfoliatin" at Dorland's Medical Dictionary Mockenhaupt M, Idzko M, ...
*  Desmoglein-2
These desmoglein gene family members are located in a cluster on chromosome 18. This second family member, desmoglein-2 is ... a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to ... Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. Desmoglein-2 is highly expressed in epithelial cells and ... Desmoglein-2 is a 122.2 kDa protein composed of 1118 amino acids. Desmoglein-2 is a calcium-binding transmembrane glycoprotein ...
*  DSC1
1997). "A YAC contig joining the desmocollin and desmoglein loci on human chromosome 18 and ordering of the desmocollin genes ... These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the ... DSC1 has been shown to interact with Desmoglein 2. GRCh38: Ensembl release 89: ENSG00000134765 - Ensembl, May 2017 GRCm38: ... Chitaev NA, Troyanovsky SM (1997). "Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and ...
*  Plakoglobin
Abnormal distribution of plakoglobin due to mutations in genes encoding for Desmoglein 1 and 3 have also been implicated in ... Plakoglobin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble ... desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". Genomics. 10 (3): ... where it can bind to the cadherin family member desmoglein I. Plakoglobin also associates with classical cadherins such as E- ...
*  Desmosome
Desmoglein and desmocollin have a single pass transmembrane region plus an intracellular anchor to secure its position in the ... Desmogleins and the desmocollin Dsc "a" form contain an intracellular cadherin domain, which binds to plakoglobin. The outer ... Loss of Desmoglein 4 leads to defective hair-follicle differentiation. Epidermolysis bullosa simplex is an epidermal blistering ... Desmoglein 1 haploinsufficiency leads to striate palmoplantar keratoderma, a disease which causes extreme thickening of the ...
*  Degradomics
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by ... 28, 281-288 (2010). Prudova A., auf dem Keller U., Butler G.S., Overall C.M. Multiplex N-terminome analysis of MMP-2 and MMP-9 ... As the second largest class of enzymes behind ubiquitin ligases and responsible for ~2% of any organism's genes, proteases have ...
*  List of MeSH codes (D12.776.395)
... desmogleins MeSH D12.776.395.550.200.200.500.500.500 -- desmoglein 1 MeSH D12.776.395.550.200.200.500.500.625 -- desmoglein 2 ... MeSH D12.776.395.550.200.200.500.500.750 -- desmoglein 3 MeSH D12.776.395.550.200.210 -- carcinoembryonic antigen MeSH D12.776. ... lysosomal-associated membrane protein 2 MeSH D12.776.395.550.625.136 -- antigens, cd36 MeSH D12.776.395.550.625.298 -- integrin ...
*  List of MeSH codes (D23)
... desmogleins MeSH D23.050.301.350.200.500.500.500 --- desmoglein 1 MeSH D23.050.301.350.200.500.500.625 --- desmoglein 2 MeSH ... desmoglein 1 MeSH D23.050.422.249 --- desmoglein 3 MeSH D23.050.422.500 --- heymann nephritis antigenic complex MeSH D23.050. ... D23.050.301.350.200.500.500.750 --- desmoglein 3 MeSH D23.050.301.350.210 --- carcinoembryonic antigen MeSH D23.050.301.350.230 ... h-2 antigens MeSH D23.050.301.500.400.370 --- HLA-A MeSH D23.050.301.500.400.370.372 --- HLA-A1 MeSH D23.050.301.500.400.370. ...
*  List of MeSH codes (D12.776.543)
... desmogleins MeSH D12.776.543.550.200.200.500.500.500 -- desmoglein 1 MeSH D12.776.543.550.200.200.500.500.625 -- desmoglein 2 ... MeSH D12.776.543.550.200.200.500.500.750 -- desmoglein 3 MeSH D12.776.543.550.200.210 -- carcinoembryonic antigen MeSH D12.776. ... toll-like receptor 2 MeSH D12.776.543.750.705.910.500.300 -- toll-like receptor 3 MeSH D12.776.543.750.705.910.500.400 -- toll- ... erbb-2 MeSH D12.776.543.750.060.437 -- receptor, erbb-3 MeSH D12.776.543.750.060.468 -- receptor, igf type 1 MeSH D12.776. ...
*  Plakophilin-2
... desmoglein 1, desmoglein 2, desmoplakin, connexin 43, plakoglobin, Kir6.2, and SCN5A. Skin fragility syndrome GRCh38: Ensembl ... Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. Plakophilin 2 is expressed in skin and cardiac muscle, ... Plakophilin-2 over time has shown to be more than components of cell-cell junctions; rather the plakophilins are emerging as ... Plakophilin-2 has shown to localize to nuclei, in addition to desmosomal plaques in the cytoplasm. Studies have shown that ...
*  DSC2
Desmosomal cadherins, including the desmocollin family members and desmogleins, are found at desmosome cell-cell junctions and ... and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18". Genomics. 21 (3): 510-6. doi:10.1006/ ... cadherins than to desmogleins". Genomics. 44 (3): 330-5. doi:10.1006/geno.1997.4894. PMID 9325054. Syed SE, Trinnaman B, Martin ... desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". Genomics. 10 (3): ...
*  Desmoglein
The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation ... "Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction ... Desmogleins are targeted in the autoimmune disease pemphigus. Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D ... April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and ...
*  Desmoglein-3
Desmoglein 3 has been shown to interact with PKP3. Desmoglein List of target antigens in pemphigus List of conditions caused by ... 2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. Invest. Dermatol. 119 (6): 1231-6. ... Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene. Desmosomes are cell-cell junctions between epithelial, ... "Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)". Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F ( ...
*  Desmoglein-1
... has been shown to interact with PKP3, PKP2, and PTPRT(PTPrho) Desmoglein List of target antigens in pemphigus List ... Hanakawa Y, Amagai M, Shirakata Y (2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. ... Martínez RD (1992). "[Characterization of the desmoglein in renal cells in culture]" [Characterization of the desmoglein in ... Desmoglein-1 is a protein that in humans is encoded by the DSG1 gene. Desmosomes are cell-cell junctions between epithelial, ...
*  Desmoglein-4
... is a protein that in humans is encoded by the DSG4 gene. List of conditions caused by problems with junctional ... "Entrez Gene: DSG4 desmoglein 4". Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more ... 2006). "Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle ... 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and ...
*  Paraneoplastic pemphigus
Through immunoprecipitation, target antigens have been found to include desmoglein-3, desmoglein-1, envoplakin, periplakin, ... This piece labeled PNP as a "multiorgan disease characterized by antibodies against plakins, desmogleins and the α2- ... 48 (2): 162-9. doi:10.1111/j.1365-4632.2009.03995.x. PMID 19200194. Poot, A.M.; Diercks, G.F.H.; Kramer, D.; Schepens, I.; ... 410 (1-2): 13-8. doi:10.1016/j.cca.2009.08.022. PMID 19737550. Huang, Yongchu; Li, Jing; Zhu, Xuejun (2009). "Detection of anti ...
*  Cadherin
Desmoglein (DSG1, DSG2, DSG3, DSG4) Desmocollin (DSC1, DSC2, DSC3) Protocadherins PCDH1; PCDH10; PCDH11X; PCDH11Y; PCDH12; ... The cadherin superfamily includes cadherins, protocadherins, desmogleins, and desmocollins, and more. In structure, they share ... 3.0.CO;2-D. PMID 9744472. Bryant DM, Stow JL (2005). "The ins and outs of E-cadherin trafficking". Trends Cell Biol. 14 (8): ... 41 (2): 349-69. doi:10.1016/j.biocel.2008.09.027. PMID 18848899. Angst B, Marcozzi C, Magee A (February 2001). "The cadherin ...
*  DSC3
These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the ... 1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG ... 1994). "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18". ... 2000). "Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes ...
*  BCR (gene)
"The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1". The Journal of Cell Biology ... 24 (2): 310-3. PMID 8641358. Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E, Hallek M, Ernst T ( ... 9 (2): 117-20. doi:10.1038/nsb747. PMID 11780146. Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson ... 96 (2): 664-70. PMID 10887132. Ma G, Lu D, Wu Y, Liu J, Arlinghaus RB (May 1997). "Bcr phosphorylated on tyrosine 177 binds ...
*  Netherton syndrome
"Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity". Nat ... 25 (2): 141-142. doi:10.1038/75977. PMID 10835624. Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. ( ... These enzymes are involved in various aspects of epidermal remodelling, including desquamation, PAR-2 activation and ...
*  Stem-cell niche
A characteristic of EMT is loss of the epithelial markers (E-cadherin, cytokeratins, claudin, occluding, desmoglein, desmocolin ... Interesting, GDNF, FGF 2 and CSF 1 have also been shown to influence self-renewal of stem cells in other mammalian tissues. ... 94 (2): 251-260. doi:10.1016/s0092-8674(00)81424-5. PMID 9695953. Kai, T.; Spradling, A. (2003). "An empty Drosophila stem cell ... The GSC niche holds on average 2-3 GSCs, which are directly attached to somatic cap cells and Escort stem cells, which send ...
*  Hemidesmosome
Instead of desmogleins and desmocollins in the extracellular space, hemidesmosomes utilize integrins. Hemidesmosomes are found ... Type 2 hemidesmosomes contain integrin α6β4 and plectin without the BP antigens. Hemidesmosomes have two membrane-spanning ... 250 (2): 298-312. doi:10.1006/excr.1999.4549. ISSN 0014-4827. PMID 10413585. Fine, Jo-David; Bruckner-Tuderman, Leena; Eady, ... 360 (2): 363-378. doi:10.1007/s00441-014-2061-z. ISSN 1432-0878. PMC 4544487 . PMID 25487405. Wilhelmsen, Kevin; Litjens, Sandy ...
*  Pemphigus foliaceus
When desmogleins are attacked, skin cells separate from each other and fluid can collect between the layers of skin, forming ... If there is an autoimmune IgG buildup in the epidermis, then nearly all of the antibodies are aimed against desmoglein 1. The ... Disruption of function: In this case, the antibody blocks the desmoglein 1 from being formed into a desmosome. This in turn ... The immune system produces antibodies against proteins in the skin known as desmogleins. These proteins form the glue that ...
*  Bullous impetigo
Toxins are produced by S. aureus and target desmoglein, which is a desmosomal cell-cell adhesion molecule that is found in the ... Exfoliating toxins are serine proteases that specifically bind to and cleave desmoglein 1 (Dsg1). Previous studies suggested ... "Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1". Nat. Med. 6 (11): 1275-7. doi:10.1038 ... multiform Systemic Lupus Erythematosus Stevens-johnson syndrome Pemphigous vulgaris HPV insect bites burns Herpes simplex 1/2 ...
*  Corneocyte
Three adhesive proteins desmoglein-1, desmocollin-1 and corneodesmosin compose the corneodesmosomes and provide the cohesive ... In healthy skin, desquamation is an invisible process and the stratum corneum is turned over completely within 2-4 weeks, while ... Colonization of pathogens in the skin is prevented via complete turnovers of corneocyte layer every 2-4 weeks. Corneocytes are ... When filaggrin is degraded, urea, pyrrolidone carboxylic acid (1,2), glutamic acid and other amino acids are produced. These ...
*  Congenital tufting enteropathy
... deposition of laminin and heparan sulfate proteoglycan within the basement membrane and increased expression of desmoglein. ... Gastroenterology 135(2):429-347 Sivagnanam M, Janecke AR, Müller T, Heinz-Erian P, Taylor S, Bird LM (2010) Case of syndromic ... Reifen et al reported 2 additional cases in 1994 and coined the name congenital tufting enteropathy. Two genes have been ... associated with this condition: Epithelial cell adhesion molecule (EpCAM) on chromosome 2 (2p21) and SPINT2 on chromosome 19. ...