"Mucosal dendritic cell-epithelial cell cross-talk , Event Details , powered by RegOnline". Regonline.co.uk. Retrieved 2018-02- ... Cruickshank, Sheena (1998). The effects of pleiotropic cytokines on liver cells in vitro. leeds.ac.uk (PhD thesis). University ... She uses in vitro and in vivo approaches to characterise crosstalk between immune cells, commensal bacteria, pathogens and ... they are starting to understand how it affects cell function. Cruickshank won the Northwest BioNow award for her test for the ...
... natural killer cells, B cells and plasmacytoid dendritic cells. LAG3's main ligand is MHC class II, to which it binds with ... The first is IMP321, a soluble LAG3 which activates dendritic cells. The second are antibodies to LAG3 which take the brakes ... In 2003 the Triebel group was able to identify the MHC class II signal transduction pathways in human dendritic cells induced ... Andreae S, Buisson S, Triebel F (Sep 2003). "MHC class II signal transduction in human dendritic cells induced by a natural ...
O'Neill, David W. (November 2010). "Dendritic cells and T cells in immunotherapy". Journal of Drugs in Dermatology: JDD. 9 (11 ... An antigen-presenting cell vaccine, or an APC vaccine, is a vaccine made of antigens and antigen-presenting cells (APCs). As of ... ISBN 978-0-8261-7215-0.{{cite book}}: CS1 maint: multiple names: authors list (link) Antigen-presenting cell vaccine entry in ...
"Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells". European ... in early-phase clinical trials on RNA-transfected dendritic cells in cancer immunotherapy found that the use of Dendritic Cells ... Mitchell, Duane A.; Nair, Smita K. (2000-11-01). "RNA-transfected dendritic cells in cancer immunotherapy". The Journal of ... "Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients". Nature. 519 (7543): 366-369. ...
Dendritic cell apoptosis - immune system cells called dendritic cells present antigens to active lymphocytes. Dendritic cells ... The roles of specialized immunoregulatory cell types, such as regulatory T cells, NKT cells, γδ T-cells in the pathogenesis of ... or even of T-cells, by directly binding to the β-subunit of T-cell receptors in a non-specific fashion. T-cell-B-cell ... T-cell bypass - A normal immune system requires the activation of B cells by T cells before the former can undergo ...
The type of T-cell help raised is determined by the differentiated state of antigen presenting cells. Dendritic cells can ... which include dendritic cells, macrophages and specialised B-cells called professional antigen presenting cells (APC). After ... which are potent B-cell stimulators. T-cells can be stimulated by similar, germinal centre dendritic cells. FDC are able to ... "Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation ...
Induced activation in dendritic cell". Google.com. Retrieved 2015-06-25. "Houston's Bellicum Pharma Rides T-Cell Therapy Wave ... a re-engineered dendritic cell receptor protein which allows for the in-vivo activation of the immune system in a specific, ... "Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo". Nature ... Slawin is co-inventor of a number of novel technologies related to the enhancement and control of adoptive T cell therapy for ...
... dendritic cells express high levels of CD8). Human immunodeficiency virus (HIV) binds CD4 and a chemokine receptor on the ... This CD combination typically corresponds to a stem cell, as opposed to a fully differentiated endothelial cell. Some cell ... see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD ... Cell populations are usually defined using a '+' or a '−' symbol to indicate whether a certain cell fraction expresses or lacks ...
... + monocytes can differentiate into a host of different cells, including dendritic cells, a differentiation pathway ... It is also expressed by dendritic cells. The soluble form of the receptor (sCD14) is secreted by the liver and monocytes and is ... Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S (July 1989). "Mouse and human CD14 (myeloid cell-specific ... "CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of ...
T helper 17 cell Dendritic cell India portal Biology portal Biography portal "Profile on SERB" (PDF). Scientific and ... "DC Lab Team - Dendritic Cell Biology Laboratory @ IICB Ganguly Lab". sites.google.com. 27 December 2018. Retrieved 27 December ... Ganguly D, Haak S, Sisirak V, Reizis B (August 2013). "The role of dendritic cells in autoimmunity". Nature Reviews Immunology ... Research interests of Ganguly lab are exploring the role of dendritic cells in autoreactive inflammatory contexts, deciphering ...
Chief among these are dendritic cells (DCs). When a DC presents an antigen to a Treg cell, a signal is then sent to the nucleus ... research suggests that a lack of control by tolerogenic dendritic cells and T-regulatory cells (Treg) is possibly the primary ... Elevated cytokine production alters the innate immune response which leads to abnormal T-cell and B-Cell function that ... T-helper and T-cytotoxic cells are activated by presentation of antigens by antigen-presenting cells (APCs). ...
... histone and differentiation of dendritic cells. A molecular target for tumor-derived factors". Journal of Leukocyte Biology. 72 ... Cell. 123 (7): 1199-1212. doi:10.1016/j.cell.2005.10.028. ISSN 0092-8674. PMID 16377562. S2CID 8378657. Gabrilovich, Dmitry I ... "The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells". Cell Reports. 3 (6): 2142-2154. doi: ... In human and mouse cells 11 H1 variants have been described and are encoded by single genes. Six of the variants are mainly ...
Autoreactive T cells must normally be held in check by the suppressive environment produced by microglia and dendritic cells in ... Forrester JV, Xu H, Kuffová L, Dick AD, McMenamin PG (March 2010). "Dendritic cell physiology and function in the eye". ... Uveitis is driven by the Th17 T cell sub-population that bear T-cell receptors specific for proteins found in the eye. These ... to prevent damage to the eye by reducing inflammation and causing T cells to differentiate to inducible T reg cells. Innate ...
Cherian, SM; Bobryshev, YV; Inder, SJ; Lord, RS; Ashwell, KW (1999) Dendritic Cells in Venous Pathologies. 50: 393-402 Cronan, ... AM (1998) Fluid Shear Stress Stimulates Phosphorylation of Akt in Human Endothelial Cells: Involvement in Suppression of ...
Dendritic cell immunoreceptor (DCIR)/dendritic cell immunoactivating receptor (DCAR), characterized as a pair in mice, though ... In some cases, only one member of the pair is expressed in a cell type. Expression of the paired members in a single cell type ... Toyonaga, Kenji; Yamasaki, Sho (2020). "Recognition of Mycobacteria by Dendritic Cell Immunoactivating Receptor". C-Type ... Paired receptors are highly expressed in the cells of the immune system, especially natural killer (NK) and myeloid cells, and ...
... dendritic cells in the brain act as antigen-presenting cells and mediate the activation and entry of reactive T cells into the ... dendritic cells and further that Csf-2 is not necessary for the differentiation and function of inflammatory dendritic cells. ... Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells". ... Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells". ...
He also produced the first dendritic cell-specific monoclonal antibody and cloned the first dendritic cell receptor. ... As a Ph.D. student, Nussenzweig was the first to show that dendritic cells present foreign antigens to initiate T cell immunity ... Nussenzweig, M. C.; Steinman, R. M. (1 May 1980). "Contribution of dendritic cells to stimulation of the murine syngeneic mixed ... while work on innate immunity focuses on dendritic cells. The laboratory has isolated and cloned human antibodies to HIV-1 and ...
... a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?". Am. J. ... Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E (1996). "Circulating human dendritic cells ... "The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer". J. Immunol. 171 (4 ... "The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells". ...
Gasiorowski RE, Ju X, Hart DN, Clark GJ (January 2013). "CD300 molecule regulation of human dendritic cell functions". Immunol ... CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez- ... differential regulation of LMIR5/CLM-7 in mouse versus human cells". Blood. 111 (2): 688-98. doi:10.1182/blood-2007-04-085787. ...
Impaired dendritic differentiation of basket and stellate cells". Developmental Brain Research. 16 (1): 21-26. doi:10.1016/0165 ... It helps regulation of cell division, cell function, genetic regulation, helps enhance the immune system, and is required for ... Cell. 142 (6): 857-867. doi:10.1016/j.cell.2010.08.014. PMC 2943017. PMID 20817278. Chang S.; Zeng L.; Brouwer I. D.; Kok F. J ... Zinc is essential for the structure and function of thousands of proteins critical for the function of every cell. Zinc can ...
Several features were used to identify and purify dendritic cells from mouse spleen. Because dendritic cells were discovered ... Accessory cells contain a new cell type with probing cell process or "dendrites". These cells proved to be the missing link ... Steinman discovered that dendritic cells link innate to adaptive immunity, including adaptive T cell-mediated immunity. He ... Some general features of T cell responses that are initiated by dendritic cells (DCs): Adaptive immunity develops in two stages ...
Brandt K, Bulfone-Paus S, Foster DC, Rückert R (December 2003). "Interleukin-21 inhibits dendritic cell activation and ... cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/ ... and plasma cell generation during CD4+ T cell-B cell collaboration". Journal of Immunology. 179 (9): 5886-96. doi:10.4049/ ... cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells". ...
Expression is found on macrophages and dendritic cells. It can also be found at low levels in Langerhans cells and peripheral ... Possibly due to different cell wall ligands, as these two forms are known to slightly differ in terms of cell wall organization ... Its carbohydrate recognition domain is capable of binding α-mannans in fungal cell walls. Upon ligand binding, dectin-2 ... which are an important component of fungal cell wall. It has also been reported to recognize glycoproteins rich in O-mannobiose ...
Rescigno M, Rotta G, Valzasina B, Ricciardi-Castagnoli P (December 2001). "Dendritic cells shuttle microbes across gut ... The C-terminus of occludin is important in receiving and transmitting cell survival signals. In standard cells, loss or ... Recent work, using molecular modeling, supported by biochemical and live-cell experiments in human cells demonstrated that ... "Mammalian occludin in epithelial cells: its expression and subcellular distribution". European Journal of Cell Biology. 73 (3 ...
"Dendritic Cell Immunotherapy - The Provenge Prostate Cancer Vaccine". Archived from the original on 13 March 2011. "Review Memo ... The idea of harnessing the antigen presenting cells (APC)'s to recognize cancer and target tumor cells for apoptosis (cell ... EGFR and other cell products and attaching their antigens to the CD64 receptor cells also using GM-CSF to grow more cells. The ... BRMs alter the interaction between the body's immune defenses and cancer cells to boost, direct, or restore the body's ability ...
B cell driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 2006;24(2):203-215. [ ... monocyte differentiation to dendritic cells and macrophages and made advances in our understanding of dendritic cell ... She developed an in vitro model to assess monocyte differentiation into dendritic cells (DCs) or macrophages. They found that ... She worked under the mentorship of Bill Muller, vascular biologist, and Ralph Steinman studying dendritic cell maturation and ...
MHCII is restricted to so-called professional antigen-presenting cells, like dendritic cells, B cells, and macrophages, to name ... Cytotoxic T cells (TC cells, CTLs, T-killer cells, killer T cells) destroy virus-infected cells and tumor cells, and are also ... T helper cells (TH cells) assist other lymphocytes, including the maturation of B cells into plasma cells and memory B cells, ... Gamma delta T cells (γδ T cells) represent a small subset of T cells which possess a γδ TCR rather than the αβ TCR on the cell ...
... contributes to the induction of regulatory T-cells on the periphery. CD40, a molecule associated with dendritic cells (DCs). ... Sertoli cells are also able to inhibit the migration of immune cells by lowering immune cell infiltration to the site of ... Sertoli cell-only syndrome Sertoli cell nodule List of distinct cell types in the adult human body synd/518 at Who Named It? ... cytotoxic T-cells and NK cells are able to induce apoptosis in target cell. SCs produce PI-9 that irreversibly bonds Granzyme B ...
Professional antigen-presenting cells are primarily dendritic cells, macrophages and B cells, although dendritic cells are the ... Their main effector cells are NK cells as well as CD8 T cells, IgG B cells, and IL-10 CD4 T cells. The key THαβ transcription ... The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role ... such as follicular dendritic cells (these are not the same type of cells as the dendritic cells of the immune system but rather ...
"Dendritic cells in chronic myelomonocytic leukaemia: Dendritic Cells in CMML". British Journal of Haematology. 105 (4): 974-985 ... They are then trafficked to the cell surface of the monocytes (or macrophages or dendritic cells) and presented as antigens to ... which activates CD4 Th2 cells and inhibits CD4 Th1 cell function. Many factors produced by other cells can regulate the ... They are the largest type of leukocyte in blood and can differentiate into macrophages and monocyte-derived dendritic cells. As ...