The most common division of dendritic cells is conventional dendritic cells (a.k.a. myeloid dendritic cells) vs. plasmacytoid ... three classical dendritic cell subsets and one plasmacytoid dendritic cell subset. At least some of these dendritic cell ... The morphology of dendritic cells results in a very large surface-to-volume ratio. That is, the dendritic cell has a very large ... A dendritic cell (DC) is an antigen-presenting cell (also known as an accessory cell) of the mammalian immune system. A DC's ...
Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. ... Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of ... and the skin of patients with pseudo B cells lymphoma. Follicular dendritic cells participate in HIV-1 infection development ... "Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell binding and activation". Frontiers ...
... blastic plasmacytoid dendritic cell neoplasm. In the bone marrow, common dendritic cell progenitors expressing Flt3 (CD135) ... and CD304 unlike other dendritic cell types. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare type of myeloid ... Plasmacytoid dendritic cells (pDCs) are a rare type of immune cell that are known to secrete large quantities of type 1 ... In humans, pDCs exhibit plasma cell morphology and express CD4, HLA-DR, CD123, blood-derived dendritic cell antigen-2 (BDCA-2 ...
"Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell ... Tolerogenic dendritic cells (a. k. a. tol-DCs, tDCs, or DCregs) are heterogenous pool of dendritic cells with immuno- ... "Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells". Blood. 105 (3): 1162-9. ... Treatment with these cells was safe and well tolerated. The whole pool of tolerogenic dendritic cells can be divided in two ...
Tew, John G.; Kosco, Marie H.; Burton, Gregory F.; Szakal, Andras K. (1990). "Follicular Dendritic Cells as Accessory Cells". ... Fonseca, Rafael; Tefferi, Ayalew; Strickler, John G. (1997). "Follicular dendritic cell sarcoma mimicking diffuse large cell ... Cyclophosphamide slows or stops cell growth. It targets cells that are rapidly dividing, which include cancer cells that are ... including resistance to cell death and evading growth suppressors. At the time of the follicular dendritic cell sarcoma ...
... is a form of malignant histiocytosis affecting dendritic cells. It can present in the ... Kawachi K, Nakatani Y, Inayama Y, Kawano N, Toda N, Misugi K (April 2002). "Interdigitating dendritic cell sarcoma of the ... Kanaan H, Al-Maghrabi J, Linjawi A, Al-Abbassi A, Dandan A, Haider AR (February 2006). "Interdigitating dendritic cell sarcoma ...
The dendritic cell-based cancer vaccine is an innovation in therapeutic strategy for cancer patients. Dendritic cells (DCs) are ... "The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed ... Plasmacytoid dendritic cells (pDCs) differentiate from lymphoid progenitor cells in the lymphoid tissues. They express CD123 ... "Dendritic cells: Immunological sentinels with a central role in health and disease". Immunology and Cell Biology. 78 (2): 91- ...
There are three types of dendritic cells, plasmacytic dendritic cells (pDC) and two types of conventional dendritic cells (cDC ... a malignancy of plasmacytoid dendritic cells rather than lymphocytes and therefore termed blastic plasmacytoid dendritic cell ... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. It was initially regarded as a form of ... Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy with features of cutaneous lymphoma (e.g. malignant ...
Lotze M (2001). Dendritic Cells. Boston: Academic Press. ISBN 0-12-455851-8. Li Y, Tan S, Zhang C, Chai Y, He M, Zhang CW, et ... T cells and trigger the increase in CD28− T cells. Unlike the activation of CD8+ T cells, the proliferation of CD28− T cells ... The activation of CD8+ T cells is essential in antitumor immunity. The 4-1BB/4-1BBL complex with the help of T-cell receptor ... 1BBL complex together with a signal provided by a T-cell receptor can provide costimulatory signals to CD4+ and CD8+ T cells in ...
Liu, L M; MacPherson, G G (1 May 1993). "Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen ... Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs ... "Endotoxin-mediated dendritic cell release from the intestine. Characterization of released dendritic cells and TNF dependence ... "A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric ...
It was previously shown that TGF-β was produced by intestinal dendritic cells, which has been considered to be the source of ... Th3 cells can also directly suppress Th1 and Th2 cells by secretion of TGF-β and provide help to B cells towards IgA secretion ... Th3 cells have different cytokine requirements for their growth from CD25+CD4+ Treg cells. The survival of CD25+CD4+ Treg cells ... Th3 cells are characterised as CD4+CD25−CD69+FOXP3-LAP+ cells. Unlike the well characterised T regulatory (Treg ) cells, Th3 ...
a.^ B: B cell. E: erythrocyte. Endo: endothelial cell. D: dendritic cell. FDC: follicular dendritic cell. Mac: macrophage. MC: ... whereas CR2 is expressed only on B cells as a co-receptor. Red blood cells (RBCs) also express CR1, which enables RBCs to carry ... White blood cells, particularly monocytes and macrophages, express complement receptors on their surface. All four complement ... mast cell. M0: monocyte. Pha: phagocyte. PMN: polymorphonuclear leukocyte. Deficits in complement receptor expression can cause ...
... dendritic cells move to the T cell zone or to the B cell follicle along the fibroblast reticular cell network. Dendritic cells ... The sub-populations include: fibroblastic reticular cells (FRCs); folicular dendritic cells (FDCs); lymphatic endothelial cells ... Lymph node stromal cells can give rise to a number of malignancies including: follicular dendritic cell sarcoma; fibroblastic ... FRCs express chemokines such as CCL21 and CCL19 which assist the movement of T cells and dendritic cells with CCR7 receptors. ...
Dendritic cells (DC) can be stimulated to activate a cytotoxic response towards an antigen. Dendritic cells, a type of antigen- ... Immune effector cells such as lymphocytes, macrophages, dendritic cells, natural killer cells, and cytotoxic T lymphocytes work ... CD4+ helper T cells, cytotoxic CD8+ T cells and B cells). This initiates a cytotoxic response against tumour cells expressing ... Loss of T-cell tolerance then unleashes B-cells and other immune effector cells on to the target tissue. The ideal tolerogenic ...
Her research considered dendritic cells and their role in cancer and infectious disease. Margaret Baird grew up in Tauranga, a ... Baird investigated dendritic cells. She was made a lecturer in the Microbiology Department at the University of Otago, where ... She also studied how p53 was involved in the regulation of dendritic cell function. Baird taught immunology courses at the ... she investigated the role of dendritic cells in infectious diseases and cancer. She was promoted to Professor in 2011. When ...
Bigley V, Cytlak U, Collin M (February 2018). "Human dendritic cell immunodeficiencies". Seminars in Cell & Developmental ... The various presentations of GATA2 deficiency include: 1) Monocytopenia and Mycobacterium Avium Complex/Dendritic Cell, ... These individuals also have low numbers of two other types of circulating blood cells viz., B lymphocytes and NK cells. Other ... "Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency". Blood. 118 ...
CLIP also can affect the differentiation of T cells. MHC II + CLIP complexes are upregulated on maturing dendritic cells, which ... cells. Th cells can polarize into Th1 or Th2 effector cells depending on the presence of cytokines. High expression of CLIP ... Salter, Russell D. (2001). Dong, Xin (ed.). Dendritic Cells (2 ed.). Academic Press. pp. 151-163. Kastin, Abba; Call, Melissa ( ... This occurs in most cells expressing MHC II-however, in B cells, HLA-DO functions as the accessory protein. Both HLA-DM and HLA ...
Seminars in Cell & Developmental Biology. SI: Human dendritic cells. 86: 129-139. doi:10.1016/j.semcdb.2018.03.015. PMC 6167211 ... In this way some retroviruses can convert normal cells into cancer cells. Some provirus remains latent in the cell for a long ... Cell-to-cell Fluids Airborne, like the Jaagsiekte sheep retrovirus. The DNA formed after reverse transcription (the provirus) ... Later it was found that a similar gene in cells is involved in cell signaling, which was most likely excised with the proviral ...
Isolation of Dendritic Cells: Wiley. p. 3.7.14. Kassicieh et al. (1988), Conduction aphasia following metrizamide myelography, ...
... the dendritic cell. Once activated, dendritic cells migrate to lymph nodes, where they present the antigen to T cells and B ... These mRNA fragments are taken up by dendritic cells through phagocytosis. The dendritic cells use their internal machinery ( ... Dendritic cells display antigens on their surfaces, leading to interactions with T cells to initiate an immune response. ... Dendritic cells can be collected from patients and programmed with the desired mRNA, then administered back into patients to ...
Yang D, Chen Q, Gertz B, He R, Phulsuksombati M, Ye RD, Oppenheim JJ (Sep 2002). "Human dendritic cells express functional ... tissue macrophages and dendritic cells. The functions of FPR3 and the few ligands which activate it have not been fully ... "The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide ... 1 by cathepsin D cleavage that potently stimulates chemotaxis through FPR3 in monocytes and monocyte-derived dendritic cells. ...
FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development. A lack of ... "Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells ... In strains of plasmodium, FLT3L was shown to be released from mast cells and cause the expansion of dendritic cells, leading to ... June 2013). "Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection ...
"Dendritic Cell Development and Maturation". In Paola Ricciardi-Castagnoli (ed.). Dendritic Cells in Fundamental and Clinical ... "Expression of B7 Costimulator Molecules on Mouse Dendritic Cells". In Jacques Banchereau; Daniel Schmitt (eds.). Dendritic ... Inaho is known for her work on dendritic cells and she won the Asia pacific UNESCO Awards for Women in Science in 2014. She has ... Contributions of Dendritic Cells". In Ralph M. Steinman; Robert John North (eds.). Mechanisms of Host Resistance to Infectious ...
The link between atherosclerosis and autoimmunity is plasmacytoid dendritic cells (pDCs). PDCs contribute to the early stages ... Some foam cells are derived from smooth muscle cells and present a limited macrophage-like phenotype. Foam cell formation is ... "Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque". Cell Discovery ... Foam cells form the fatty streaks of the plaques of atheroma in the tunica intima of arteries. Foam cells are not dangerous as ...
... Interdigitating dendritic cell sarcoma/tumor Follicular dendritic cell sarcoma/tumor Dendritic cell ... Antigen-presenting cells are also termed Dendritic cells, of which Langerhans cells are a subtype. There are four main types ... These cells are surveillance cells that take foreign antigens and present them to antigen-processing cells, such as T-cells, ... Dendritic cell neoplasms are classified by the World Health Organization as follows: Langerhans cell histiocytosis ...
On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and ... a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells". Cell. 100 (5): 587-97. doi:10.1016/ ... a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology". J. Leukoc. Biol. 71 (6): 921-31. doi: ... "Antiviral Immune Responses by Human Langerhans Cells and Dendritic Cells in HIV-1 Infection". HIV Interactions with Dendritic ...
Its ligand is ICOSL, expressed mainly on B cells and dendritic cells. The molecule seems to be important in T cell effector ... dendritic cells and activated T-cells (SIGLEC9). SIGLECs 7 and 9 suppress the immune function of these cells by binding to ... Binding with its two ligands are CD80 and CD86, expressed on dendritic cells, prompts T cell expansion. CD28 was the target of ... CD40 signaling is known to 'license' dendritic cells to mature and thereby trigger T-cell activation and differentiation. A now ...
These immune cells include T cells, B cells, NK cells, dendritic cells, macrophages and mast cells. ITIMs have similar ... epithelial cells; DC, dendritic cells. (Modified according to) On the basis of the inhibitory effects of FcγRIIB, a lot of ... SHP-1 is expressed in hematopoietic cells and at lower levels in epithelial cells. Like SHIP, SHP-1 is involved in the negative ... allogeneic hematopoietic cell transplantations have shown that the development of donor NK cells in recipient patients lacking ...
... s are the committed progenitor cells that differentiated from a committed macrophage or dendritic cell precursor (MDP ... Each cell that does not contain much in their cytoplasm represents a type of precursor cell. Each cell name is above each cell ... in the case of a dendritic cell) through activating different parts of the Immune response. Additional images Blood cell ... Monocytes will then develop into macrophages or dendritic cells upon tissue damage and recruitment of monocytes into the ...
Her current research focuses on dendritic cells (a kind of immune cell), and includes allergic response work. In 2012, Ronchese ... Hilligan, K. L.; Ronchese, F. (2020). "Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell ... 2021). "Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell ... "Clec9A+ dendritic cells are not essential for antitumor CD8+ T cell responses induced by poly I:C immunotherapy". Journal of ...
Drakes M, Blanchard T, Czinn S (June 2004). "Bacterial probiotic modulation of dendritic cells". Infection and Immunity. 72 (6 ... Vangay P, Ward T, Gerber JS, Knights D (May 2015). "Antibiotics, pediatric dysbiosis, and disease". Cell Host & Microbe. 17 (5 ... A human's microbiome can change because of inflammatory processes, such as cell-mediated inflammation and host-mediated ... Type 1 diabetes is an autoimmune condition that affects the beta cells in the pancreas, causing insulin production to be ...
Cells like dendritic cells are involved in the innate immune system, whereas cells like lymphocytes are part of the active ... T-cells have several key functions, including activation of other cells such as B-cells, helper T-cells and CD4+ cells, as well ... These include B-cells, T-cells, and natural killer (NK) cells. B-cells become activated and produce antibodies to bind and tag ... These include histiocytes and dendritic cells. They typically range in size from 8 to 18 µm in diameter depending on cell type ...