Idiopathic inflammatory demyelinating diseases Demyelinating disease "Demyelinating Autoimmune Diseases, CNS - MeSH - NCBI". {{ ... CNS demyelinating autoimmune diseases are autoimmune diseases which primarily affect the central nervous system. Examples ... Autoimmune diseases, Demyelinating diseases of CNS, All stub articles, Nervous system disease stubs). ... CNS demyelination autoimmune disease causes the myelin sheath to deteriorate since the sense of recognition of self is lost. ...

Chastain EM, Miller SD (2012). "Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease". Immunol. ... The molecular mimicry of some LOS molecules is thought to cause autoimmune-based host responses, such as flareups of multiple ... Endotoxemia is associated with obesity, diet, cardiovascular diseases, and diabetes, while also host genetics might have an ... "Association of lipopolysaccharide-binding protein and coronary artery disease in men". J. Am. Coll. Cardiol. 50 (1): 25-31. doi ...

... they can induce inflammation in autoimmune diseases very fast. γδ T cells have clinical association with many autoimmune ... and these cells accumulate in demyelinated areas of CNS and make plaques. In the mice models, different subsets of γδ T cells ... T1D is an autoimmune disease where β cells of the pancreas, which produce insulin, are damaged by autoreactive T cells. There ... Psoriasis is one of the autoimmune diseases in which the γδ T cells together with Th1 and Th17 play an essential role in the ...

Other demyelinating diseases are usually not congenital and have a toxic or autoimmune cause.[needs update] When damage occurs ... This accumulation of sulfatides is toxic to oligodendrocytes, the myelin-producing cells of the CNS, effectively leading to a ... Krabbe disease, Canavan disease, and Alexander disease. The one exception to this is any type of leukodystrophy carried on a ... Alexander disease (E75.2) Canavan disease (E75.2) Hypomyelinating leukodystrophy type 7 (4H syndrome) (E75.2) Krabbe disease ( ...

... an auto-immune demyelinating disease affecting the CNS.Clemastine and ketoconazole are promyelinating drugs that function as ... Given that, they can be used to model various diseases and understand disease mechanisms associated with myelin defects ... including neurodegenerative diseases, CNS injury, PMD, and NFASC. PMD is a rare monogenic disease caused by various mutations ... Hobson, Grace M.; Garbern, James Y. (February 2012). "Pelizaeus-Merzbacher Disease, Pelizaeus-Merzbacher-Like Disease 1, and ...

Still's disease, adult-onset MeSH C20.111.258.250 - demyelinating autoimmune diseases, cns MeSH C20.111.258.250.175 - diffuse ... nervous system autoimmune disease, experimental MeSH C20.111.258.625.300 - encephalomyelitis, autoimmune, experimental MeSH ... Aleutian mink disease MeSH C20.673.774.535 - granulomatous disease, chronic MeSH C20.673.774.600 - Job's syndrome MeSH C20.683. ... heavy chain disease MeSH C20.683.780.490.512 - immunoproliferative small intestinal disease MeSH C20.683.780.640 - monoclonal ...

Autoimmune diseases, Demyelinating diseases of CNS). ... diseases and demyelinating leukodystrophic diseases. In the ... "Childhood demyelinating diseases with a prolonged remitting course and their relation to Schilder's disease: report of two ... The name comes from a traditional classification of demyelinating diseases in two groups: demyelinating myelinoclastic ... de Lacour A, Guisado F, Zambrano A, Argente J, Acosta J, Ramos C (1998). "[Pseudotumor forms of demyelinating diseases. Report ...

Demyelinating diseases of CNS, Autoimmune diseases, Rare diseases). ... It has been proposed that BCS lesions may not denote a single disease, but a final pathway of various demyelinating diseases, ... Baló's concentric sclerosis is a demyelinating disease similar to standard multiple sclerosis, but with the particularity that ... However, in some patients, the pathology underlying the disease appears to burn out and hence the disease may halt, hence the ...

Autoimmune diseases, Demyelinating diseases of CNS, Myelin disorders, Rare diseases). ... Medicine portal Anti-AQP4 disease Demyelinating disease Idiopathic inflammatory demyelinating diseases Multiple sclerosis ... "13 Demyelinating Diseases of the CNS (Brain and Spine)". In Hodler J, Kubik-Huch RA, von Schulthess GK (eds.). Diseases of the ... Some authors propose to use the name "autoimmune aquaporin-4 channelopathy" for these diseases, while others prefer a more ...

CNS). It is mostly used with rodents and is widely studied as an animal model of the human CNS demyelinating diseases, ... Demyelinating diseases of CNS, Animal testing, Laboratory mice). ... It is an inflammatory demyelinating disease of the central ... EAE is also the prototype for T-cell-mediated autoimmune disease in general.[citation needed] EAE development was motivated by ... has been reported to induce a MS-like disease Also some experimental therapies for other diseases has produced MS artificially ...

In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease. Finally, ... Maheras KJ, Peppi M, Ghoddoussi F, Galloway MP, Perrine SA, Gow A (February 2018). "Absence of Claudin 11 in CNS Myelin ... Devaux J, Gow A (December 2008). "Tight junctions potentiate the insulative properties of small CNS myelinated axons". The ... "CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice". Cell. 99 (6): 649-59. doi:10.1016/ ...

For example, some diseases like Autoimmune GFAP Astrocytopathy or variants of CIDP that affects the CNS (CIDP is the chronic ... See Anti-neurofascin demyelinating diseases Some anti-neurofascin demyelinating diseases were previously considered a subtype ... Autoimmune diseases, Central nervous system disorders, Idiopathic diseases). ... Inflammatory demyelinating diseases (IDDs), sometimes called Idiopathic (IIDDs) due to the unknown etiology of some of them, ...

This is in contrast to autoimmune demyelinating conditions, such as multiple sclerosis, or conditions such as central pontine ... A hereditary CNS demyelinating disease is a demyelinating central nervous system disease that is primarily due to an inherited ... Demyelinating diseases of CNS, All stub articles, Nervous system disease stubs). ... Alexander disease Canavan disease Krabbe disease leukoencephalopathy with vanishing white matter megalencephalic ...

... (MOGAD) or MOG antibody-associated encephalomyelitis (MOG-EM) is an inflammatory demyelinating disease of ... October 2017). "Longitudinal analysis of myelin oligodendrocyte glycoprotein antibodies in CNS inflammatory diseases". Journal ... A post-infectious autoimmune process has been proposed as a possible pathophysiologic mechanism. Other reports point to ... Reindl M, Di Pauli F, Rostásy K, Berger T (August 2013). "The spectrum of MOG autoantibody-associated demyelinating diseases". ...

... (CIDP) is an acquired autoimmune disease of the peripheral nervous system ... multifocal acquired demyelinating sensory and motor neuropathy). A variant with CNS involvement named combined central and ... Autoimmune disease Neurological disorder "Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Information Page". ninds.nih ... In some case EMG/NCV can be normal). Serum test to exclude other autoimmune diseases. Lumbar puncture and serum test for anti- ...

... since Poser demyelinating diseases normally refers to the myelinoclastic part. Demyelinating diseases of the CNS can be ... In the first group a normal and healthy myelin is destroyed by a toxic, chemical or autoimmune substance. In the second group, ... Demyelinating diseases are traditionally classified in two kinds: demyelinating myelinoclastic diseases and demyelinating ... Multiple sclerosis and other demyelinating diseases of the central nervous system (CNS) produce lesions (demyelinated areas in ...

For example, CCL1 and CCR8 mRNA expression has been detected in the CNS of mice with experimental autoimmune encephalomyelitis ... Because CCL1 binds to the CCR8 receptor, some diseases can be caused by dysregulation and dysfunction of this receptor. ... to be associated with phagocytic macrophages and activated microglia in MS lesions and directly correlate with demyelinating ... Due to these facts, the dysregulation of CCL1 can leads in pathogenesis of several diseases. Some single nucleotide ...

McPherson RC, Anderton SM (September 2013). "Adaptive immune responses in CNS autoimmune disease: mechanisms and therapeutic ... "The formation of inflammatory demyelinated lesions in cerebral white matter". Annals of Neurology. 76 (4): 594-608. doi:10.1002 ... t Hart BA, den Dunnen WF (September 2013). "Commentary on special issue: CNS diseases and the immune system". Journal of ... beginning the characteristic motor deficits of Parkinson's disease. Stage 4 of Parkinson's disease includes deficits caused by ...

CNS), mainly opiates, opioids, or other narcotics, especially in non-medical use (drug abuse) Lupus erythematosus Lyme disease ... or autoimmune diseases such as multiple sclerosis, complex regional pain syndrome, or lupus erythematosus.[citation needed] The ... such as chronic inflammatory demyelinating polyneuropathy (CIDP) Intravenous administering of strong pharmaceutical drugs ... Carpal tunnel syndrome Cerebral amyloid angiopathy Chiari malformation Coeliac disease (celiac disease) Complex regional pain ...

The demyelinating disease attacks the myelin of axons in the central nervous system through autoimmune defects. While ... This is a process naturally regulated in the body and tends to be very efficient in a healthy CNS. The process creates a ... In certain demyelinating diseases CXCL12 has been shown to be decreased, possibly playing a role in demyelination failure. ... Demyelinating diseases have been shown to cause this dysregulation. Possible genes involved inside this pathway are TCF4 and ...

... into the mechanisms of this protein presents a great potential for the treatment of auto-immune mediated demyelinating diseases ... Rust, R; Grönnert, L; Weber, RZ; Mulders, G; Schwab, ME (September 2019). "Refueling the Ischemic CNS: Guidance Molecules for ... Research suggests that blocking Nogo-A during neuronal damage (from diseases such as multiple sclerosis) will help to protect ... Ng CE, Tang BL (Mar 2002). "Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration". Journal of ...

The condition known as neuromyelitis optica, NMO, is a rare demyelinating, inflammatory disorder of the CNS that primarily ... Based on work in animal models, aquaporin-4 may have a role in several other diseases including Alzheimer's disease, ... Aquaporin-4 is the predominant autoimmune target in 2/3 neuromyelitis optica and higher AQP4 autoantibody levels are associated ... The expression of aquaporin 4 is reliant on the disease stage of TBI. In an acute stage of TBI, the lack of aquaporin 4 causes ...

Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare autoimmune disease marked by a ... Some early vaccines, later shown to have been contaminated with host animal CNS tissue, had ADEM incidence rates as high as 1 ... Autoimmune diseases, Central nervous system disorders, Enterovirus-associated diseases, Measles, Rare diseases). ... Reindl M, Di Pauli F, Rostásy K, Berger T (August 2013). "The spectrum of MOG autoantibody-associated demyelinating diseases". ...

This process is thought to be similar to the onset of autoimmune disease in humans when a complex protein antigen is the ... In order to track demyelinating diseases and diagnose them in patients, Cross began exploring various imaging techniques as a ... Evidence for the production of peroxynitrite in inflammatory CNS demyelination. J. Neuroimmunol. 1997; 80:121-130 Cross AH, ... "Spinal Cord Tract Diffusion Tensor Imaging Reveals Disability Substrate in Demyelinating Disease". Neurology. 80 (24): 2201- ...

... or Devic's disease Idiopathic inflammatory demyelinating diseases Leukodystrophic or dysmyelinating disorders: CNS neuropathies ... pertinent given that genetics and autoimmune deficiency hypotheses fail to explain many cases of demyelinating disease. As has ... Demyelinating diseases are traditionally classified into two types: demyelinating myelinoclastic diseases and demyelinating ... Demyelinating diseases can be divided in those affecting the central nervous system (CNS) and those affecting the peripheral ...

Reindl M, Di Pauli F, Rostásy K, Berger T (Aug 2013). "The spectrum of MOG autoantibody-associated demyelinating diseases". ... They present proteins that are in the CNS or in blood. Those that are in CNS but not in blood suggest a diagnosis of MS. MRZ- ... Anti-TNF associated MS: Several anti-TNF drugs like adalimumab are commonly prescribed by a number of autoimmune conditions. ... After that, a whole spectrum of diseases named NMO spectrum diseases (NMOSD) or anti-AQP4 diseases has been accepted. Later, it ...

Both develop from the CNS embrion, and recently it has been shown, by autopsies, that they are affected by the same diseases ... Some cases could belong to the anti-neurofascin demyelinating diseases category. Cortical lesions: Not all MS patients develop ... Given that retina cells have no myelin, damage must be different from the autoimmune attack of the brain. The underlying ... Anti-AQP4 disease Anti-MOG disease Anti-Neurofascin disease Lesions in MS are heterogeneous and there are four different ...

Interest in MBP has centered on its role in demyelinating diseases, in particular, multiple sclerosis (MS). The target antigen ... The human gene for MBP is on chromosome 18; the protein localizes to the CNS and to various cells of the hematopoietic lineage ... of the autoimmune response in MS has not yet been identified. However, several studies have shown a role for antibodies against ... Alternations in these post-translational modifications have been associated with demyelinating diseases. Notably, MBP isolated ...

... many CNS disease mechanisms. A select group of CNS conditions associated with gliosis are described below. Acute trauma to the ... Gliosis is a prominent feature of many autoimmune inflammatory disorders, notably multiple sclerosis, in which demyelinated ... Gliosis has historically been given a negative connotation due to its appearance in many CNS diseases and the inhibition of ... Oligodendrocyte precursor cells are also affected by CNS insult and are recruited to demyelinated areas within a week following ...

Ali MY, Akter Z, Mei Z, Zheng M, Tania M, Khan MA (February 2021). "Thymoquinone in autoimmune diseases: Therapeutic potential ... Their literature review at that time identified 34 other cases of demyelinating disease developing after the initiation of an ... Kemanetzoglou E, Andreadou E (April 2017). "CNS Demyelination with TNF-α Blockers". Current Neurology and Neuroscience Reports ... TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases". Nature Medicine. 9 (10): 1245-1250 ...

... a systemic autoimmune disease featuring a wide variety of neurological signs and symptoms Sarcoidosis: chronic inflammatory ... A brain MRI may be needed to identify the extent of central nervous system (CNS) involvement. Lumbar puncture is important for ... Studies show that NSCs that were transplanted into a demyelinating spinal cord lesion were found to regenerate oligodendrocytes ... The theory of autoimmune attack claims that a person with neuroimmunologic disorders have genetic predisposition to auto-immune ...