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*  Malignant hyperthermia
Dantrolene is a muscle relaxant that appears to work directly on the ryanodine receptor to prevent the release of calcium. ... The efficacy of dantrolene as a treatment was discovered by South African anesthesiologist Gaisford Harrison and reported in a ... In MH-susceptible swine, azumolene was as potent as dantrolene. It has yet to be studied in vivo in humans, but may present a ... Treatment is with dantrolene and rapid cooling along with other supportive measures. The avoidance of potential triggers is ...
*  Ryanodine receptor
Dantrolene the clinically used antagonist Ruthenium red procaine, tetracaine, etc. (local anesthetics) Activators:Agonist: 4- ...
*  Dantrolene
Azumolene has a bromine residue instead of the nitro group found in dantrolene, and is 30 times more water-soluble. Dantrolene ... The poor water solubility of dantrolene leads to certain difficulties in its use. A more water-soluble analog of dantrolene, ... It is currently unclear whether Dantrolene has carcinogenic effects. Dantrolene depresses excitation-contraction coupling in ... where seven of his eight experiments survived after intravenous administration of dantrolene. The efficacy of dantrolene in ...
*  Multiple sclerosis signs and symptoms
Dantrolene oral. US National Library of Medicine (Medline) (2003-04-01). Retrieved on 2007-10-17. Diazepam. US National Library ... There is evidence, albeit limited, of the clinical effectiveness of THC and CBD extracts, baclofen, dantrolene, diazepam, and ...
*  Management of multiple sclerosis
Dantrolene oral. US National Library of Medicine (Medline) (1 April 2003). Retrieved on 17 October 2007. Diazepam. US National ... There is evidence, albeit limited, of the clinical effectiveness of baclofen, dantrolene, diazepam, and tizanidine. In the most ...
*  Muscle relaxant
The hydantoin derivative dantrolene is a spasmolytic agent with a unique mechanism of action outside of the CNS. It reduces ... However, it is now known not every agent in this class has CNS activity (e.g. dantrolene), so this name is inaccurate. Most ... Dantrolene interferes with the release of calcium by binding to the ryanodine receptor and blocking the endogenous ligand ... Dantrolene, although thought of primarily as a peripherally acting agent, is associated with CNS effects, whereas baclofen ...
*  2,4-Dinitrophenol
There is little risk to dantrolene administration. Since dantrolene may be effective in reducing hyperthermia caused by agents ... Dantrolene inhibits calcium release from the sarcoplasmic reticulum which reduces intracellular calcium. The resulting muscle ... Kumar S, Barker K, Seger D (2002). "Dinitrophenol-Induced Hyperthermia Resolving With Dantrolene Administration. Abstracts of ... one case report notes that dinitrophenol-induced hyperthermia has been successfully resolved with dantrolene administration. " ...
*  Neuroleptic malignant syndrome
Dantrolene has been used when needed to reduce muscle rigidity, and more recently dopamine pathway medications such as ... Medications used include dantrolene, bromocriptine, and diazepam. The risk of death among those affected is about 10%. Many ...
*  Para-Methoxyamphetamine
Serotonin antagonists and dantrolene may be used as required. Despite the seriousness of the condition, the majority of ...
*  Porcine stress syndrome
Under anaesthesia, dantrolene sodium is a very effective treatment. Genetic testing enables animals to be removed from the herd ...
*  Antispasmodic
Effectiveness has not been clearly shown for metaxalone, methocarbamol, chlorzoxazone, baclofen, or dantrolene. Applicable ... Medications such as baclofen, tizanidine, and dantrolene have been used. Muscarinic antagonist Parasympatholytic Phloroglucinol ...
*  Fever
Dantrolene may also be associated with improved survival and reduced complications, especially in patients with extreme (≥ 42°C ... Dantrolene may also be associated with improved survival and reduced complications, especially in patients with extreme (≥ 42°C ... Grunau BE, Wiens MO, Brubacher JR (September 2010). "Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic ... Grunau BE, Wiens MO, Brubacher JR (September 2010). "Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic ...
*  Heat stroke
Dantrolene, a direct-acting paralytic which abolishes shuddering and is effective in many other forms of hyperthermia, ... Hausfater, Pierre (2004). "Dantrolene and heatstroke: A good molecule applied in an unsuitable situation". Critical Care. 9 (1 ...
*  Carbon monoxide poisoning
Increased muscle activity and seizures should be treated with dantrolene or diazepam; diazepam should only be given with ...
*  Upper motor neuron syndrome
... dantrolene, or clonazepam. Phenol injections or botulinum toxin injections into the muscle belly can be used to attempt to ...
*  Tumefactive multiple sclerosis
Medical treatments include baclofen, diazepam and dantrolene which is a muscle-relaxant. Dantrolene has many side effects and ...
*  Suxamethonium chloride
When MH develops during a procedure, treatment with dantrolene sodium is usually initiated; dantrolene and the avoidance of ...
*  Paroxysmal sympathetic hyperactivity
Dantrolene helps combat dystonia and fever by affecting muscle contraction and relaxation cycles. It hinders the release of ...
*  Equine exertional rhabdomyolysis
The human drug dantrolene is sometimes given to alleviate the muscle spasms and prevent further degeneration of muscle tissue. ... dantrolene, and dimetyl glycine. Bicarbonate and NSAIDs are of no use in preventing ER. King, Christine & Mansmann, Richard, ...
*  RYR1
Dantrolene may be the only known drug that is effective during cases of malignant hyperthermia.[citation needed] RYR1 has been ...
*  Lacosamide
Borowicz, KK; Gaisor M; Kleinrok Z; Czuczwar SJ (1997). "Influence of isradipine, niguldipine and dantrolene on the ...
*  Hypertonia
Baclofen, diazepam and dantrolene remain the three most commonly used pharmacologic agents in the treatment of spastic ... Baclofen is generally the drug of choice for spinal cord types of spasticity, while sodium dantrolene is the only agent which ...
*  Hydantoin
The hydantoin derivative dantrolene is used as a muscle relaxant to treat malignant hyperthermia, neuroleptic malignant ...
*  Spastic hemiplegia
Drugs such as baclofen, benzodiazepines (e.g., diazepam), tizanidin, and sometimes dantrolene have shown promise in the effort ...