... serum is exposed to panel lymphocytes and to an extent other leukocytes in a complement dependent cytotoxicity test. From the ... It is an immunologic metric routinely performed by clinical laboratories on the blood of people awaiting organ transplantation ... It is a test of the degree of alloimmunity in a graft recipient and thus a test that quantifies the risk of transplant ... is a group of antibodies in a test serum that are reactive against any of several known specific antigens in a panel of test ...
When potentially suitable couple is found, crossmatch test is done to exclude that patient produces donor-specific anti-HLA ... 2010 Primer on Allergic and Immunologic Diseases. 125 (2, Supplement 2): S41-S52. doi:10.1016/j.jaci.2009.09.046. ISSN 0091- ... Complement-dependent cytotoxicity (CDC) is an effector function of IgG and IgM antibodies. When they are bound to surface ... CDC assay is usually used for performing crossmatch test. The basic version involves incubation of patient's serum with donor's ...
This vaccine has been tested in animals with a view to use as effective contraceptive for humans. Normally, spermatozoa fuse ... Infertility after anti-sperm antibody binding can be caused by autoagglutination, sperm cytotoxicity, blockage of sperm-ovum ... They are protected by other means like immunologic tolerance and immunomodulation. ...
... cytotoxicity tests, immunologic MeSH E01.450.495.160.155 - complement hemolytic activity assay MeSH E01.450.495.225 - ... patch tests MeSH E01.450.495.750.800 - tuberculin test MeSH E01.450.620.620 - pregnancy tests, immunologic MeSH E01.450.865.100 ... placental function tests MeSH E01.370.378.620 - pregnancy tests MeSH E01.370.378.620.620 - pregnancy tests, immunologic MeSH ... immunologic MeSH E01.450.495.620 - pregnancy tests, immunologic MeSH E01.450.495.735 - serologic tests MeSH E01.450.495.735.050 ...
... who found that Transplant recipients who were positively tested for DSA using a complement-dependent cytotoxicity crossmatch ... Mechanisms of immunologic enhancement. Transplant Proc. 1970; 2(1):68-75. Kerman RH, Kimball PM, Van Buren CT, Lewis RM, DeVera ... The degree of cytotoxicity is expressed as percentage PRA (panel reactive antibody). It is a tool that can be employed to ... Basic histocompatibility testing methods. In:Chandraker A, editor. Core concepts in renal transplantation. New York:Springer ...
The liver function tests are usually elevated. A low level of the protein albumin in the blood is common.[citation needed] The ... Impaired NK-cell cytotoxicity is the hallmark of HLH. All genetic defects for familial HLH are related to granule-dependent ... immunologic abnormalities, and lymphohistiocytosis. Most cases have been diagnosed between 4 months and 7 years of age, with a ... Molecular genetic testing for four of the causative genes, PRF1 (FHL2), UNC13D (FHL3), STX11 (FHL4), and STXBP2 (FHL5), is ...
MAbs facilitate destruction of tumor cells by complement-dependent cytotoxicity (CDC) and cell-mediated cytotoxicity (ADCC). In ... IFNs have been tested as therapies for many types of cancers and have demonstrated therapeutic benefits. IL-2 has been approved ... Drugs used for immunotherapy can act either passively by enhancing the immunologic response to MET-expressing tumor cells, or ... Neutralizing anti-HGF antibodies were initially tested in combination, and it was shown that at least three antibodies, acting ...
Laboratory tests that might show abnormalities include blood count, kidney function, electrolyte, and liver enzyme tests. ... In trials these have been a type of T-cell capable of cytotoxicity. Inserting the DNA into the effector cell can be ... This effect has been attributed to making an immunologic space within which the cells populate. The process as a whole result ... Immunohistochemical testing may reveal TdT or CALLA antigens on the surface of leukemic cells. TdT is a protein expressed early ...
... forms reactive metabolites that cause either direct cytotoxicity or immunologic response. The nonantibiotic sulfonamides lack ... However, it had no effect at all in the test tube, exerting its antibacterial action only in live animals. Later, it was ... This and the lack of testing requirements led to the elixir sulfanilamide disaster in the fall of 1937, during which at least ...
Sequential arming and re-direction: OmniCAR was tested sequentially against a co-culture of GBM cells expressing antigens Her2 ... rested and then re-armed to exhibit the same levels and kinetics of cytotoxicity as pre-armed OmniCAR-T cells. ... Virax had been previously unsuccessful in developing a viral delivery of immunologic genes for the treatment of HIV. Paul ... In-silico tests confirmed non-immunogenic profile of OmniCAR's key components (SpyTag/ SpyCatcher), demonstrating a lower ...
Immunoglobulin light chain Immunoglobulin M Immunoglobulin Y Immunohaematology Immunoisolate Immunologic activation Immunologic ... CXCL16 CXCL17 CXCL2 CXCL3 CXCL5 CXCL6 CXCL7 CXCL9 CXCR4 CXCR6 CXCR7 Cytokine Cytokine redundancy Cytokine storm Cytotoxicity ... caseosa Viral phylodynamics Virus quantification Voltage-gated proton channel Wheat germ agglutinin White blood cell Widal test ... Anti-cholesterol Anti-gliadin antibodies Antibody Antibody opsonization Antibody-dependent cell-mediated cytotoxicity Antibody- ...
Allen, JG: Tests of Liver Function. Kansas City Academy, Kansas City. 57. Finkel, M. P., & Hirsch, G. M. (1950). URANIUM ... Reilly, C. A., Pritchard, D. J., Biskis, B. O., & Finkel, M. P. (1972). Immunologic evidence suggesting a viral etiology of ... USA). Pritchard, D. J., Reilly, C. A., Finkel, M. P., & Ivins, John C. (1974). Cytotoxicity of human osteosarcoma sera to ...
This process is known as antibody-dependent cell-mediated cytotoxicity (ADCC). FcγRIII on NK cells can also associate with ... Sun PD (2003). "Structure and function of natural-killer-cell receptors". Immunologic Research. 27 (2-3): 539-48. doi:10.1385/ ... the current paradigm that T cells do not express FcRs and these findings were never challenged and experimentally tested. ... Another process involving Fc receptors is called antibody-dependent cell-mediated cytotoxicity (ADCC). During ADCC, FcγRIII ...
Animal toxicity studies: Acute toxicity testing, repeat-dose toxicity testing, long-term toxicity testing Pharmacokinetics and ... Rus H, Cudrici C, Niculescu F (2005). "The role of the complement system in innate immunity". Immunologic Research. 33 (2): 103 ... The "knobs-into-holes" shape facilitates antibody dependent cell mediated cytotoxicity. Single chain variable fragments (scFv) ... in vitro and in vivo testing for adventitious viruses, murine retrovirus testing..., product safety data needed before the ...
On the other hand, the preclinical efficacy has not yet been tested in the clinical setting, and none of these monoclonal ... More recently, agonistic CD40 therapy has been shown to decrease T cell cytotoxicity in preclinical glioma models, and in fact ... Bhushan A, Covey LR (2002). "CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes". Immunologic Research. ... antibodies have progressed beyond early testing phases. Because of toxicity, the use of CD40 monoclonal antibodies has been ...
The A4 study on older individuals who are positive for indicators of AD but are negative for genetic risk factors will test ... The four known IgG subclasses are involved in antibody-dependent cellular cytotoxicity.Antibodies are a key component of the ... murine molecules were engineered to remove immunogenic content and to increase immunologic efficiency. This was initially ... "Tumore, via negli Usa ai test sul primo farmaco anticancro: distrugge le cellule malate senza colpire quelle sane" [Tumor, ...
A cross-reaction test between potential donor cells and recipient serum seeks to detect presence of preformed anti-HLA ... the epitope can be recognized by immunologic structures like T-cell receptors (TCRs). The molecular region which binds to the ... causing damage via mechanisms such as direct cytotoxicity from CD8 cells. Acute humoral rejection and chronic disfunction ...
Even with standard blood compatibility testing, there is a risk of reaction against human blood group systems other than ABO ... Sánchez-Fueyo A, Strom TB (2011), Immunologic basis of graft rejection and tolerance following transplantation of liver or ... Increased natural cytotoxicity receptor expression and relevant IL-10 production in NK cells from chronically infected viremic ... 84(10):1215-9 - according to Sánchez-Fueyo A, Strom TB (2011), Immunologic basis of graft rejection and tolerance following ...
... to be administered to patients after testing for the BRAF genetic mutation. Tests of this sort are being widely advertised for ... and CR3-dependent cellular cytotoxicity. Complement-dependent cytotoxicity occurs when antibodies bind to the cancer cell ... T cells and immune system cytokines and have been investigated in clinical trials as immunologic adjuvants. Many tumors express ... In on-going trials the combination of CTLA-4 blockade with PD-1 or PD-L1 inhibitors is tested on different types of cancer. ...
Culture tests are rarely used as diagnostic tools; rather immunoblotting, immunofluorescent staining, hemadsorption tests, ... August 2004). "Impact of cethromycin (ABT-773) therapy on microbiological, histologic, immunologic, and respiratory indices in ... which would prevent initiation of cytotoxicity and subsequent symptoms. To date, vaccines targeted at the P1 adhesin have shown ... Causative diagnosis is dependent upon laboratory testing, however these methods are more practical in epidemiological studies ...
... that can be detected directly in intact bacteria using latex agglutination tests. The CAMP test is also another important test ... depending on the immunologic reactivity of their polysaccharide capsule. The plural term group B streptococci (referring to the ... of Streptococcus urinary tract infection depends on bacterial strain and β-hemolysin/cytolysin that mediates cytotoxicity, ... Nucleic acid amplification tests (NAAT) such as polymerase chain reaction (PCR) and DNA hybridization probes have been ...
Gaffen SL, Jain R, Garg AV, Cua DJ (September 2014). "The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing". ... Strober W (November 2010). "The LTi cell, an immunologic chameleon". Immunity. 33 (5): 650-2. doi:10.1016/j.immuni.2010.11.016 ... their cytotoxicity, and their resident marker expression. NK cells are cytotoxic cells, circulating in the bloodstream, killing ...
Kinchen JM, Ravichandran KS (October 2008). "Phagosome maturation: going through the acid test". Nature Reviews. Molecular Cell ... They also suggested that the presence of neutralizing antibody or antibody-dependent cellular cytotoxicity-mediating antibodies ... March 2005). "Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 ... most relevant to in vitro tests but known to have some in vivo relevances Tirado SM, Yoon KJ (2003). "Antibody-dependent ...