2010 Primer on Allergic and Immunologic Diseases. 125 (2, Supplement 2): S41-S52. doi:10.1016/j.jaci.2009.09.046. ISSN 0091- ... Complement-dependent cytotoxicity (CDC) is an effector function of IgG and IgM antibodies. When they are bound to surface ... Contrast with antibody-dependent cellular cytotoxicity (ADCC) Schroeder, Harry W.; Cavacini, Lisa (2010). "Structure and ... Zhou 2008 Complement dependent cytotoxicity activity of therapeutic antibody fragments is acquired by immunogenic glycan ...
It is an immunologic metric routinely performed by clinical laboratories on the blood of people awaiting organ transplantation ... From the extent and pattern of cytotoxicity an estimation of what percentage of the possible donor population the patient has ... Traditionally serum is exposed to panel lymphocytes and to an extent other leukocytes in a complement dependent cytotoxicity ... The Pre-Transplant Drop in Panel-Reactive Antibodies Titer Evaluated Using Complement-Dependent Cytotoxicity (PRA-CDC) and the ...
Infertility after anti-sperm antibody binding can be caused by autoagglutination, sperm cytotoxicity, blockage of sperm-ovum ... They are protected by other means like immunologic tolerance and immunomodulation. ...
... forms reactive metabolites that cause either direct cytotoxicity or immunologic response. The nonantibiotic sulfonamides lack ...
... cytotoxicity tests, immunologic MeSH E01.450.495.160.155 - complement hemolytic activity assay MeSH E01.450.495.225 - ... immunologic MeSH E01.450.495.620 - pregnancy tests, immunologic MeSH E01.450.495.735 - serologic tests MeSH E01.450.495.735.050 ... immunologic MeSH E01.450.865.100 - biopsy MeSH E01.450.865.100.100 - biopsy, needle MeSH E01.450.865.100.100.500 - biopsy, fine ... immunologic MeSH E01.370.378.625 - preimplantation diagnosis MeSH E01.370.378.630 - prenatal diagnosis MeSH E01.370.378.630.050 ...
... immunologic capping MeSH G04.335.880.400 - ion channel gating MeSH G04.335.880.560 - map kinase signaling system MeSH G04.335. ... antibody-dependent cell cytotoxicity MeSH G04.610.270.500 - macrophage activation MeSH G04.610.484.100 - clonal anergy MeSH ... immunologic capping MeSH G04.610.143.754 - passive cutaneous anaphylaxis MeSH G04.610.143.780 - rh isoimmunization MeSH G04.610 ... immunologic surveillance MeSH G04.610.555.545 - lymphocyte activation MeSH G04.610.555.545.150 - cross-priming MeSH G04.610. ...
MAbs facilitate destruction of tumor cells by complement-dependent cytotoxicity (CDC) and cell-mediated cytotoxicity (ADCC). In ... Drugs used for immunotherapy can act either passively by enhancing the immunologic response to MET-expressing tumor cells, or ...
Along with its splice variant NKG2B, these molecules are inhibitory and lead to a decrease in cytotoxicity. NKG2C and NKG2E ( ... Gunturi A, Berg RE, Forman J (2004). "The role of CD94/NKG2 in innate and adaptive immunity". Immunologic Research. 30 (1): 29- ... Many tumors avoid the cytotoxicity by excreting soluble NKG2D ligands or secreting TGF-β, leading to the downregulation of the ... leading to cytotoxicity. Ligands of CD94/NKG2 heterodimeric molecules are nonclassical MHC class I molecules - Qa1b molecules ...
The four known IgG subclasses are involved in antibody-dependent cellular cytotoxicity.Antibodies are a key component of the ... murine molecules were engineered to remove immunogenic content and to increase immunologic efficiency. This was initially ... Major problems associated with murine antibodies included reduced stimulation of cytotoxicity and the formation of complexes ...
In trials these have been a type of T-cell capable of cytotoxicity. Inserting the DNA into the effector cell can be ... This effect has been attributed to making an immunologic space within which the cells populate. The process as a whole result ...
Reilly, C. A., Pritchard, D. J., Biskis, B. O., & Finkel, M. P. (1972). Immunologic evidence suggesting a viral etiology of ... USA). Pritchard, D. J., Reilly, C. A., Finkel, M. P., & Ivins, John C. (1974). Cytotoxicity of human osteosarcoma sera to ...
The degree of cytotoxicity is expressed as percentage PRA (panel reactive antibody). It is a tool that can be employed to ... Mechanisms of immunologic enhancement. Transplant Proc. 1970; 2(1):68-75. Kerman RH, Kimball PM, Van Buren CT, Lewis RM, DeVera ... who found that Transplant recipients who were positively tested for DSA using a complement-dependent cytotoxicity crossmatch ... and Terasaki in 1969 demonstrated the efficacy of complement-dependent lymphocytotoxic cross-match in defining immunologic risk ...
AIT type 2 is treated with a different regime due to its immunologic pathophysiology. The thyrotoxic phase in AIT type 2 is ... It also causes direct cytotoxicity and damages thyroid tissues. AIT often has a delayed clinical presentation, and studies have ... This causes pre-existing thyroid hormones to spill out from damaged cells into the circulation and a resultant immunologic ...
Impaired NK-cell cytotoxicity is the hallmark of HLH. All genetic defects for familial HLH are related to granule-dependent ... immunologic abnormalities, and lymphohistiocytosis. Most cases have been diagnosed between 4 months and 7 years of age, with a ... It can be dangerous to infer a genetic impairment of granule-mediated cytotoxicity in patients, especially older children and ... occurs after strong immunologic activation, such as that which can occur with systemic infection, immunodeficiency, or ...
The chronic activation of monocytes can lead to multiple metabolic, hematologic and immunologic abnormalities in patients with ... and increased tumour cell cytotoxicity. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By ...
This process is known as antibody-dependent cell-mediated cytotoxicity (ADCC). FcγRIII on NK cells can also associate with ... Sun PD (2003). "Structure and function of natural-killer-cell receptors". Immunologic Research. 27 (2-3): 539-48. doi:10.1385/ ... Another process involving Fc receptors is called antibody-dependent cell-mediated cytotoxicity (ADCC). During ADCC, FcγRIII ... Immunologic Research. 29 (1-3): 219-30. doi:10.1385/IR:29:1-3:219. PMID 15181284. S2CID 85351071. Sulica A, Chambers WH, ...
Immunoglobulin light chain Immunoglobulin M Immunoglobulin Y Immunohaematology Immunoisolate Immunologic activation Immunologic ... CXCL16 CXCL17 CXCL2 CXCL3 CXCL5 CXCL6 CXCL7 CXCL9 CXCR4 CXCR6 CXCR7 Cytokine Cytokine redundancy Cytokine storm Cytotoxicity ... Anti-cholesterol Anti-gliadin antibodies Antibody Antibody opsonization Antibody-dependent cell-mediated cytotoxicity Antibody- ...
A path for definitive treatment for XLPDR is at present unclear, but it is tempting to speculate whether the immunologic ... discovered that POLA1 deficiency is associated with decreased direct cytotoxicity of NK cells due to disturbances in vesicular ... Meanwhile, antibody-dependent cell cytotoxicity (ADCC) remains unchanged in XLPDR NK cells. The most common manifestations of ... and impaired direct cytotoxicity of NK cells are the most common symptoms. In females the disease is characterized by skin ...
Huang Z, Qi G, Miller JS, Zheng SG (2020-07-24). "CD226: An Emerging Role in Immunologic Diseases". Frontiers in Cell and ... DNAM-1 promotes lymphocyte signaling, lymphokine secretion and cytotoxicity of NK cells and cytotoxic CD8+ T lymphocytes. Cross ...
Sánchez-Fueyo A, Strom TB (2011), Immunologic basis of graft rejection and tolerance following transplantation of liver or ... Increased natural cytotoxicity receptor expression and relevant IL-10 production in NK cells from chronically infected viremic ... 84(10):1215-9 - according to Sánchez-Fueyo A, Strom TB (2011), Immunologic basis of graft rejection and tolerance following ...
Increase of the cytotoxicity of anticancer drugs". Biochemical Pharmacology. 37 (24): 4727-33. doi:10.1016/0006-2952(88)90344-9 ... June 2019). "High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell ...
Specifically, the expression of granzyme B (a source of cytotoxicity) in Tc depends on the presence of BLIMP-1 and interleukin- ... Immunologic Research. 63 (1-3): 113-120. doi:10.1007/s12026-015-8694-5. PMC 4651792. PMID 26376898. Turner, C. Alexander; Mack ...
... and CR3-dependent cellular cytotoxicity. Complement-dependent cytotoxicity occurs when antibodies bind to the cancer cell ... T cells and immune system cytokines and have been investigated in clinical trials as immunologic adjuvants. Many tumors express ... Complement can lead to cell death by activation of the membrane attack complex, known as complement-dependent cytotoxicity; ... The antibody's mode of action is primarily through the induction of ADCC and complement-mediated cytotoxicity. Other mechanisms ...
... rested and then re-armed to exhibit the same levels and kinetics of cytotoxicity as pre-armed OmniCAR-T cells. Sequential ... Virax had been previously unsuccessful in developing a viral delivery of immunologic genes for the treatment of HIV. Paul ... EGFRviii where it was demonstrated OmniCAR cells can be redirected to a different antigen target with high target cytotoxicity ...
The mechanism of action includes B-cell lysis by antibody-dependent cellular cytotoxicity (ADCC), and complement-dependent ... Immunologic Concepts in Transfusion Medicine, Elsevier: 251-348, doi:10.1016/b978-0-323-67509-3.00016-0, ISBN 978-0-323-67509-3 ... There are three ways of action: antagonistic and agonistic reaction, complement-dependent cytotoxicity (CDC), and antibody- ... The mechanism of actions include: antagonistic and agonistic reaction, complement-dependent cytotoxicity (CDC), and antibody- ...
Rus H, Cudrici C, Niculescu F (2005). "The role of the complement system in innate immunity". Immunologic Research. 33 (2): 103 ... The "knobs-into-holes" shape facilitates antibody dependent cell mediated cytotoxicity. Single chain variable fragments (scFv) ... Immunologic Research. 36 (1-3): 27-32. doi:10.1385/IR:36:1:27. PMID 17337763. S2CID 27041937. Pier GB, Lyczak JB, Wetzler LM ( ... of natural killer cells by antibodies initiates a cytotoxic mechanism known as antibody-dependent cell-mediated cytotoxicity ( ...
The Fc region of IgG1 is responsible for mediating effector functions such as antibody-dependent cell-mediated cytotoxicity ( ... Zolla-Pazner, Susan (1986-11-01). "Immunologic Abnormalities in Infections With the Human Immunodeficiency Virus". Laboratory ... Specifically, CD4 immunoadhesin plays a role in antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells ...
1996). "Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41". Science. 274 (5294): 1917-21. ... causes increased sensitivity to cytotoxicity and early embryonic lethality". Proceedings of the National Academy of Sciences of ... They defined the role for NO generated from neuronal NO synthase or immunologic NO synthase leads in models of HIV dementia and ...
Eisenson DL, Hisadome Y, Yamada K (2022). "Progress in Xenotransplantation: Immunologic Barriers, Advances in Gene Editing, and ... both by direct complement attack and through initiation of Complement-dependent cytotoxicity, which synergises with specific ...
More recently, agonistic CD40 therapy has been shown to decrease T cell cytotoxicity in preclinical glioma models, and in fact ... Bhushan A, Covey LR (2002). "CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes". Immunologic Research. ...