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*  CYR61
"The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and ... "Silencing cAMP-response element binding protein (CREB) identifies cysteine-rich protein 61 (CYR61) as a tumor suppressor gene ... CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, ... Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded ...
*  Plasmodium falciparum erythrocyte membrane protein 1
... and then one or two cysteine-rich interdomain regions (CIDRs). Duffy-binding-like domains are so named because of their ... The new protein was unable to bind to melanoma cells and present only inside the cell. Hence, they named the earlier protein ... Since the antigenic protein could only be detected in infected cells, they asserted that the protein was produced by the ... The protein specifically binds to chondroitin sulphate A (CSA); hence the name VAR2CSA. The PfEMP1 proteins are regulated and ...
*  CCN protein
The CCN protein family includes the following six proteins: CCN1: CYR61 (cysteine-rich angiogenic protein 61) CCN2: CTGF ( ... Members of the CCN protein family are characterized by having four conserved cysteine-rich domains, which include the insulin- ... cysteine-rich angiogenic protein 61 or CCN1), CTGF (connective tissue growth factor or CCN2), and NOV (nephroblastoma ... CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling. Due to their ...
*  RNF31
... a new class of proteins with a novel cysteine-rich signature". Protein Sci. 8 (7): 1557-61. doi:10.1110/ps.8.7.1557. PMC ... a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein ... RING finger protein 31 is a protein that in humans is encoded by the RNF31 gene. The protein encoded by this gene contains a ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ...
*  ARIH2
... a new class of proteins with a novel cysteine-rich signature". Protein Sci. 8 (7): 1557-61. doi:10.1110/ps.8.7.1557. PMC ... Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene. GRCm38: Ensembl release 89: ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038/ ...
*  RNF216
... a new class of proteins with a novel cysteine-rich signature". Protein Sci. 8 (7): 1557-61. doi:10.1110/ps.8.7.1557. PMC ... TRIAD3 TRIAD3 protein". Chuang, Tsung-Hsien; Ulevitch Richard J (May 2004). "Triad3A, an E3 ubiquitin-protein ligase regulating ... The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating ... Chen D, Li X, Zhai Z, Shu HB (2002). "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and ...
*  SMCP
Sperm mitochondrial-associated cysteine-rich protein is a protein that in humans is encoded by the SMCP gene. Sperm ... "Entrez Gene: SMCP sperm mitochondria-associated cysteine-rich protein". Behne D, Kyriakopoulos A (2001). "Mammalian selenium- ... and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm". Molecular ... "Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in Lewis rats". Biology of Reproduction. 61 (2): ...
*  Triflin
... is a cysteine-rich secretory protein, which means it belongs to the CRISP family. This is a group of single chain ... Triflin is a cysteine-rich secretory protein (CRISP), which is excreted by the venom gland of the Habu snake (Trimeresurus ... two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels". Acta Crystallogr F. 61 (Pt ... Other snake venom proteins in the CRISP family: Piscivorin from the Eastern Cottonmouth Latisemin from the Erabu snake Ablomin ...
*  WNT1-inducible-signaling pathway protein 3
The CCN acronym is derived from the first three members of the family identified, namely CYR61 (cysteine-rich angiogenic ... WNT1-inducible-signaling pathway protein 3 (WISP3, also named CCN6) is a matricellular protein that in humans is encoded by the ... and a cysteine knot motif within the C-terminal (CT) domain. The CCN family of proteins regulates diverse cellular functions, ... These proteins, together with WISP1 (CCN4), and WISP2 (CCN5) comprise the six-member CCN family in vertebrates. CCN proteins ...
*  S100A3
2003). "Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles". Biochem. Biophys. Res. ... This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed ... S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene. The protein encoded by this ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
*  NOV (gene)
... cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV. These proteins, ... The human NOV protein contains 357 amino acids with an N-terminal secretory signal peptide followed by four structurally ... Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B (Feb 1999). "The C-terminal domain of the regulatory protein NOVH ... NOV (nephroblastoma overexpressed) also known as CCN3 is a matricellular protein that in humans is encoded by the NOV gene. NOV ...
*  Thyroglobulin
... a cysteine-rich module found in proteins from different families". Eur. J. Biochem. 240 (1): 125-33. doi:10.1111/j.1432- ... Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland. Human TG (HTG) is a ... Refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin heavy chain-binding protein". J. Biol. ... a short signal peptide may be removed from the N-terminus in the mature protein). The protein is a precursor of the thyroid ...
*  Von Willebrand factor type C domain
BMP binding endothelial regulator (BMPER) Cysteine-rich motor neuron 1 protein (CRIM1) Extracellular matrix protein 2 (ECM2) ... Hunt LT, Barker WC (1987). "von Willebrand factor shares a distinctive cysteine-rich domain with thrombospondin and procollagen ... Von Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B ... Cysteine-rich angiogenic inducer 61 (CYR61) CCN2: Connective tissue growth factor (CTGF) CCN3: Nephroblastoma overexpressed ( ...
*  ADAM23
... cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal ... a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes". The Journal of ... Disintegrin and metalloproteinase domain-containing protein 23 is an enzyme that in humans is encoded by the ADAM23 gene. This ... Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been ...
*  CRISP3
Cysteine-rich secretory protein 3 is a cysteine-rich secretory protein that in humans is encoded by the CRISP3 gene. GRCh38: ... "Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative ... "Entrez Gene: CRISP3 cysteine-rich secretory protein 3". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace ... 2004). "Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma". Biochemistry. 43 (40): 12877-86 ...
*  ADAM22
... cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal ... specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 ... Disintegrin and metalloproteinase domain-containing protein 22 also known as ADAM22 is an enzyme that in humans is encoded by ... Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been ...
*  C-Raf
... rich in cysteines and stabilized by two zinc ions. It is similar to the diacylglycerol-binding C1 domains of protein kinase C ( ... Li W, Han M, Guan KL (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex ... Mott HR, Carpenter JW, Zhong S, Ghosh S, Bell RM, Campbell SL (August 1996). "The solution structure of the Raf-1 cysteine-rich ... Daub M, Jöckel J, Quack T, Weber CK, Schmitz F, Rapp UR, Wittinghofer A, Block C (November 1998). "The RafC1 cysteine-rich ...
*  LDL receptor
... a cysteine-rich protein with multiple Alu sequences in its mRNA". Cell. 39 (1): 27-38. doi:10.1016/0092-8674(84)90188-0. PMID ... A third domain of the protein is rich in O-linked oligosaccharides but appears to show little function. Knockout experiments ... This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like ... e.g. a truncation of the receptor protein at residue number 660 leads to domains 3,4 and 5 of the EGF precursor domain being ...
*  LRP6
2002). "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of ... Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key ... LRP6 acts as a co-receptor with LRP5 and the Frizzled protein family members for transducing signals by Wnt proteins through ... 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321-5. doi:10.1038/35077108. ...
*  Resistin
... or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) is a cysteine-rich adipose-derived peptide ... a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family". EMBO J. 19 (15): ... Each protein subunit comprises a carboxy-terminal disulfide-rich beta sandwich "head" domain and an amino-terminal alpha- ... Therefore, the most highly uncovered disulfide bonds found for intact proteins are resistin's disulfides in high-resolution. A ...
*  RECK
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose ... Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene, thought to be a metastasis ... 2007). "The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix ... RECK reversion-inducing-cysteine-rich protein with kazal motifs". Takahashi C, Sheng Z, Horan TP, et al. (1998). "Regulation of ...
*  Kinesin family member 11
"Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5". ... Kim ED, Buckley R, Learman S, Richard J, Parke C, Worthylake DK, Wojcik EJ, Walker RA, Kim S (2010). "Allosteric drug ... Kinesin-5 is a molecular motor protein that is essential in mitosis. Kinesin-5 proteins are members of kinesin superfamily, ... The unique assembly of Kinesin-5 proteins not only organizes the protein complex for a different cellular function ( ...
*  DMBT1
The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR- ... is the lung scavenger receptor cysteine-rich protein gp-340". J. Biol. Chem. 275 (51): 39860-6. doi:10.1074/jbc.M006928200. ... Deleted in malignant brain tumors 1 protein is a protein that in humans is encoded by the DMBT1 gene. Loss of sequences from ... a member of the scavenger receptor cysteine-rich superfamily". J. Biol. Chem. 277 (35): 32109-15. doi:10.1074/jbc.M203788200. ...
*  Caspase 10
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of ... 1997). "A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II". Nucleic ... This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene ... Vincenz, C; Dixit V M (March 1997). "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE ...
*  DEFB126
Beta-defensin 126 is a protein that in humans is encoded by the DEFB126 gene. Defensins are cysteine-rich cationic polypeptides ... The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found ... The encoded protein is highly similar to an epididymal-specific secretory protein (ESP13.2) from cynomolgus monkey. It has been ... Perry AC, Jones R, Moisyadi S, Coadwell J, Hall L (Oct 1999). "The novel epididymal secretory protein ESP13.2 in Macaca ...
*  Phage display
... is a laboratory technique for the study of protein-protein, protein-peptide, and protein-DNA interactions that ... pIII is composed of three domains (N1, N2 and CT) connected by glycine-rich linkers. The N2 domain binds to the F pilus during ... when using the BamHI site located at position 198 one must be careful of the unpaired Cysteine residue (C201) that could cause ... a gene encoding a protein of interest is inserted into a phage coat protein gene, causing the phage to "display" the protein on ...
*  Urease
... they are cysteine-rich enzymes, resulting in the enzyme molar masses between 190 and 300kDa. An exceptional enzyme is the ... Sumner's work was the first demonstration that a pure protein can function as an enzyme, and led eventually to the recognition ... Cysteine residues are common in the flap region of the enzymes, which have been determined not to be essential in catalysis, ... The breakdown of this intermediate is then helped by a sulfhydryl group of a cysteine located near the active site. A hydrogen ...