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*  Calcineurin
"Pharmacology and side effects of cyclosporine and tacrolimus". UpToDate. 2014-04-10. Bannai H, Lévi S, Schweizer C, Inoue T, ... Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes cyclosporin, voclosporin, ...
*  Tacrolimus
Also like ciclosporin, it has a wide range of interactions. Tacrolimus is primarily metabolised by the cytochrome P450 system ... Although this activity is similar to that of ciclosporin, the incidence of acute rejection is reduced by tacrolimus use over ... "Cyclosporin versus Tacrolimus for Liver Transplanted Patients". Cochrane Database of Systematic Reviews. 4 (CD005161): CD005161 ... Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long-term ...
*  Anti-lymphocyte globulin
"Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. The German ...
*  Nephrotic syndrome
Frequent relapses treated by: cyclophosphamide or nitrogen mustard or cyclosporin or levamisole. Patients can respond to ...
*  Mycophenolic acid
... ciclosporin or tacrolimus) and prednisolone. Mycophenolate mofetil is the morpholino‌ethyl ester of mycophenolic acid; the ...
*  Liver transplantation
... also spelled cyclosporine and cyclosporin) plus a purine antagonist such as mycophenolate mofetil. Clinical outcome is better ... Most liver transplant recipients receive corticosteroids plus a calcineurin inhibitor such as tacrolimus or ciclosporin, ( ... The introduction of ciclosporin by Sir Roy Calne, Professor of Surgery Cambridge, markedly improved patient outcomes, and the ... with tacrolimus than with ciclosporin during the first year of liver transplantation. If the patient has a co-morbidity such as ...
*  Ciclosporin
... , also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product. It is used by ... Ciclosporin is highly metabolized in humans and animals after ingestion. The resulting metabolites include cyclosporin B, C, D ... Ciclosporin was isolated in 1971 from the fungus Tolypocladium inflatum and came into medical use in 1983. It is on the World ... Ciclosporin is approved by the FDA to prevent and treat graft-versus-host disease in bone-marrow transplantation and to prevent ...
*  Inhaled ciclosporin
Ciclosporin was brought to market in 1983 but the first non human aerosol studies were not published until the late 1980s. ... Ciclosporin is a cyclic polypeptide that has been used widely as an orally-available immunosuppressant. It was originally used ... Inhaled ciclosporin has also shown promise in several other lung conditions. Early stage studies in mice have shown some ... Ciclosporin has been touted as a therapeutic option in moderate to severe asthmatic patients as a corticosteroid sparing agent ...
*  Gingival enlargement
As in humans, it may be seen as a side effect to the use of ciclosporin. Newman MG, Takei HH, Klokkevold PR, Carranza FA, eds ... cyclosporine, an immunosuppresant. Of all cases of DIGO, about 50% are attributed to phenytoin, 30% to cyclosporins and the ... Guaguère E, Steffan J, Olivry T (2004). "Cyclosporin A: a new drug in the field of canine dermatology". Vet Dermatol. 15 (2): ... Butler RT, Kalkwarf KL (1987). "Drug-induced gingival hyperplasia: phenytoin, cyclosporine, and nifedipine". JADA (114): 56. ...
*  Sebaceous adenitis
Oral cyclosporine may be used. Corticosteroids (e.g. prednisone) are used only if pruritus is a major clinical feature. ... For some breeds, cyclosporine or corticosteroids and immunosuppressant drugs may be effective, and it is postulated, through ...
*  Vernal keratoconjunctivitis
Topical Cyclosporine is reserved for unresponsive cases.[citation needed] Systemic therapy- Oral antihistamines and oral ...
*  Azathioprine
... until ciclosporin was introduced into clinical practice (by Calne as well) in 1978. Ciclosporin has now replaced some of the ... and cyclosporine (ciclosporin) as adjuvant drugs in pemphigus vulgaris". American journal of clinical dermatology. 8 (2): 85-92 ... Henry, M. L.; Sommer, B. G.; Ferguson, R. M. (1985). "Beneficial effects of cyclosporine compared with azathioprine in ... 1993). "Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen". Lancet. 342 (8863 ...
*  Graft-versus-host disease
Standard prophylaxis involves the use of cyclosporine for six months with methotrexate. Cyclosporin levels should be maintained ... Cyclosporin binds to the cytosolic protein Peptidyl-prolyl cis-trans isomerase A (known as cyclophilin), while tacrolimus binds ... cyclosporin and tacrolimus are common drugs used for GVHD prophylaxis.[citation needed] Graft-versus-host-disease can largely ... Cyclosporine and tacrolimus are inhibitors of calcineurin. Both substances are structurally different but have the same ...
*  Pyoderma gangrenosum
... mycophenolate mofetil and ciclosporin; tacrolimus; thalidomide; infliximab; or plasmapheresis. There is currently a phase III ... for disseminated or localized instances of pyoderma gangrenosum is systemic treatment by corticosteroids and ciclosporin. ...
*  Langerhans cell histiocytosis
Minkov, M.; Grois, N.; Broadbent, V.; Ceci, A.; Jakobson, A.; Ladisch, S. (1 November 1999). "Cyclosporine A therapy for ...
*  Self-microemulsifying drug delivery system
The first drug marketed as a SMEDDS was cyclosporin, and it had significantly improved bioavailability compared with the ... Postolache P; Petrescu O; Dorneanu V; Zanini AC (2002). "Cyclosporine bioavailability of two physically different oral ... cyclosporine, and idebenone. Actual applications of Self-microemulsifying drug delivery system' (SMEDDS) remain rare. ...
*  DOCK8 deficiency
Cyclosporine A is a current topic of research; preliminary results have shown it to be effective. Children with DOCK8 ...
*  Trichodysplasia spinulosa
TS was first described in a 1995 case report as "ciclosporin-induced folliculodystrophy", thought at the time to be an adverse ... A new cyclosporin side-effect]". Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. 46 (12): 841-6 ... pilomatrix dysplasia and ciclosporin-induced folliculodystrophy, although the last is a misnomer) is a rare cutaneous condition ... effect of ciclosporin treatment. A subsequent report in 1999, which introduced the term "trichodysplasia spinulosa", used ...
*  Dogger Bank itch
A study of two cases in 2001 suggests that the rash responds to oral ciclosporin. Initial treatment with oral and topical ... doi:10.1111/j.1365-2133.1957.tb13235.x. Bowers PW, Julian CG., PW; Julian, CG (2001). "Dogger Bank Itch and cyclosporin". ...
*  Cicatricial pemphigoid
Topical ciclosporin is sometimes used. Dapsone is sometimes used as a steroid sparing agent. The dose is often increased very ...
*  Cogan syndrome
These immunosuppressive drugs include methotrexate, cyclophosphamide, cyclosporine or azathioprine. In some cases, combinations ...
*  Generalized pustular psoriasis
With cyclosporine the lesions cleared in 10-14 days, but new lesions appeared. The patient gave birth to a healthy baby in the ... "Generalized Pustular Psoriasis of Pregnancy Successfully Treated with Cyclosporine." Indian Journal of Dermatology, Venereology ... "Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine" in Indian J Dermatol Venereol Leprol. As ... Methotrexate PUVA Hydroxyurea Dapsone Systemic corticosteroids Cyclosporin A Adalimumab Etretinate Isotretinoin (Accutane) ...
*  Dry eye syndrome
Topical ciclosporin (topical ciclosporin A, tCSA) 0.05% ophthalmic emulsion is an immunosuppressant. The drug decreases surface ... The medication ciclosporin or steroid eye drops may be used in some cases. Another option is lacrimal plugs that prevent tears ... Ciclosporin stimulates tear production and acts as a suppressant on the immune-mediated processes that cause the disease. ... Long term use of ciclosporin at high doses is associated with an increased risk of cancer. Cheaper generic alternatives are ...
*  Reperfusion injury
Cyclosporin has been confirmed in studies to inhibit the actions of cyclophilin D, a protein which is induced by excessive ... Ciclosporin is currently in a phase II/III (adaptive) clinical study in Europe to determine its ability to ameliorate neuronal ... In 2008, an editorial in the New England Journal of Medicine called for more studies to determine if cyclosporin can become a ... 2008). "Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infaction". New England Journal of Medicine. 359 (5): ...