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*  Intramolecular Heck reaction
5-Exo cyclization, which establishes a five-membered ring with an exocyclic alkene, is the most facile cyclization mode in ... 7) Endo cyclization is observed most often when small or large rings are involved. For instance, 5-endo cyclization is ... 12) The closest competing method to IMHR is radical cyclization. Radical cyclizations are often reductive, which can cause ... 6) 6-Exo cyclization is also common. The high stability of Heck reaction catalysts permits the synthesis of highly strained ...
*  Sonogashira coupling
... after cyclization, yield natural products such as benzylisoquinoline or indole alkaloids An example is the synthesis of the ...
*  Supramolecular catalysis
To by pass that problem, the product of the cyclization reaction could be reacted with a dienophile transforming it into a ... Almost a decade later, it was exploited as a catalyst for Nazarov cyclization. Fujita and coworkers discovered a self-assemble ... Raymond utilized this property to perform acid-catalyzed Nazarov cyclization. The catalyst accelerates the reaction by over one ... "Enzymelike Catalysis of the Nazarov Cyclization by Supramolecular Encapsulation". Journal of the American Chemical Society. 132 ...
*  Electrocyclic reaction
The Nazarov cyclization reaction is a named electrocyclic reaction converting divinylketones to cyclopentenones. A classic ...
*  Cascade reaction
... which underwent a 5-exo-trig cyclization to afford reactive species 30. A subsequent 5-exo-dig radical cyclization lead to ... Subsequent cyclization by the intramolecular Michael addition of the enolate into the triple bond of the system gave species 16 ... Scheme 6. Cascade radical cyclization in the total synthesis of (±)-hirsutene A cascade radical process was also used in one of ... One of the most widely recognized examples of the synthetic utility of radical cascades is the cyclization sequence employed in ...
*  Alkyne
Non-carbon reagents also undergo cyclization, e.g. Azide alkyne Huisgen cycloaddition to give triazoles. Cycloaddition ... Ene-diynes undergo rearrangement via the Bergman cyclization, generating highly reactive radical intermediates that attack DNA ...
*  Chiral auxiliary
In 2015, Brown group published an efficient method in permanganate-mediated oxidative cyclization with this type of chiral ... 2-Tritylcyclohexanol as a Chiral Auxiliary in Permanganate-Mediated Oxidative Cyclization of 2-Methylenehept-5-enoates: ...
*  Bergman cyclization
The Bergman cyclization or Bergman reaction or Bergman cycloaromatization is an organic reaction and more specifically a ... "Reversible Bergman cyclization by atomic manipulation". Nature Chemistry. Bibcode:2016NatCh...8..220S. doi:10.1038/nchem.2438. ... demonstrated a reversible Bergman cyclisation for the first time using an atomic force microscope. When learning about the ...
*  Radical cyclization
Anionic Michael-type cyclization is an alternative to radical cyclization of activated olefins. Metal-catalyzed cyclization ... Radical cyclizations are much faster than analogous anionic cyclizations, and avoid β-elimination side reactions. ... 8) In comparison to cationic cyclizations, radical cyclizations avoid issues associated with Wagner-Meerwein rearrangements, do ... exo cyclization is favored over endo cyclization (macrocyclizations constitute the major exception to this rule). 5-hexenyl ...
*  Pschorr cyclization
The Pschorr cyclization is a name reaction in organic chemistry, which was named after its discoverer, the German chemist ... The Pschorr cyclization has a relatively good atom economy, since essentially only nitrogen is produces as a waste material. ... However, when considering the atom economy it as to be mentioned that the Pschorr cyclization has often only low yields. Robert ... The following reaction scheme shows the Pschorr cyclization for the example of phenanthrene: In the course of the Pschorr ...
*  Nazarov cyclization reaction
The Nazarov cyclization reaction (often referred to as simply the Nazarov cyclization) is a chemical reaction used in organic ... Diastereoselective cyclizations are also known, in which extant stereocenters direct the cyclization. Almost all of the ... The development of an enantioselective Nazarov cyclization is a desirable addition to the repertoire of Nazarov cyclization ... These are typically referred to as retro-Nazarov cyclization reactions. Nitrogen analogues of the Nazarov cyclization reaction ...
*  Borsche-Drechsel cyclization
... is the central step in Borsche-Drechsel carbazole synthesis, where in the first step ... The Borsche-Drechsel cyclization is a chemical reaction used to synthesize tetrahydrocarbazoles by the acid-catalyzed ... cyclization of cyclohexanone arylhydrazones. The reaction is was first described by Edmund Drechsel in 1888 and by Walter ...
*  Volhard-Erdmann cyclization
The Volhard-Erdmann cyclization is an organic synthesis of alkyl and aryl thiophenes by cyclization of disodium succinate or ...
*  Enders SAMP/RAMP hydrazone-alkylation reaction
doi:10.1016/s0040-4020(02)00080-7. Schwaebe, M.; Little, R. D. (1996). "Asymmetric Reductive Cyclization. Total Synthesis of ...
*  Propyne
"Cyclization of Acetylenic Compounds". Angewandte Chemie International Edition in English. 8 (10): 727-733. doi:10.1002/anie. ...
*  Flavagline
Trost, B. M.; Greenspan, P. D.; Yang, B. V.; Saulnier, M. G. (1990). "An unusual oxidative cyclization. A synthesis and ...
*  Acetylene
Reppe, Walter; Kutepow, N; Magin, A (1969). "Cyclization of Acetylenic Compounds". Angewandte Chemie International Edition in ... Cyclization to give benzene (see Alkyne trimerisation), cyclooctatetraene, or hydroquinone: Fe ( CO ) 5 + 4 C 2 H 2 + 2 H 2 O ...
*  2-Butyne
Reppe, Walter; Kutepow, N; Magin, A (1969). "Cyclization of Acetylenic Compounds". Angewandte Chemie International Edition in ...
*  Rocaglamide
Trost BM, Greenspan PD, Yang BV, Saulnier MG (November 1990). "An unusual oxidative cyclization. A synthesis and absolute ...
*  Scott E. Denmark
He successfully elucidated the stereochemical course of the Nazarov cyclization by using a silicon group to direct the ... Denmark, S. E.; Jones, T. K. (1982-05-01). "Silicon-directed Nazarov cyclization". Journal of the American Chemical Society. ... Denmark began his independent research with investigation of Nazarov cyclization reaction and Claisen rearrangement. ...
*  Biosynthesis
This causes cyclization and gives rise to (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate. 4-hydroxy-tetrahydrodipicolinate ... this prevents spontaneous cyclization. The enzyme N-acetylglutamate synthase (glutamate N-acetyltransferase) is responsible for ...
*  Biomimetic synthesis
A more recent example is E.J. Corey's carbenium-mediated cyclization of an engineered linear polyene to provide a tetracyclic ... The key step in Heathcock's synthetic route involves a cyclization of acyclic dialdehydes A or B to form proto-daphniphylline. ... Eschenmoser A, Felix D, Gut M, Meier J, Stadler P (1959). "Some aspects of acid-catalysed cyclizations of terpenoid polyenes". ... Stork G, Burgstrahler AW (1955). "The stereochemistry of polyene cyclization". J. Am. Chem. Soc. 77 (19): 5068-77. doi:10.1021/ ...
*  Bucherer carbazole synthesis
Borsche-Drechsel cyclization Bucherer reaction. ...
*  Pictet-Spengler reaction
B. E. Maryanoff; H.-C. Zhang; J. H. Cohen; I. J. Turchi; C. A. Maryanoff (2004). "Cyclizations of N-acyliminium ions". Chem. ... Larghi, E. L.; Kaufman, T. S. (2006). "The oxa-Pictet-Spengler Cyclization. Synthesis of Isochromanes and Related Pyran-Type ... Instead of catalyzing the Pictet-Spengler cyclization with strong acid, one can acylate the iminium ion forming the ...
*  Methanesulfonyl chloride
Chamberlin, A. R.; Nguyen, H. D.; Chung, J. Y. L. (1984). "Cationic cyclization of ketene dithioacetals. A general synthesis of ...