Unlike their closest relatives, the cyclin-dependent kinases (CDKs), where substrates are recognized by the cyclin subunit, ... The closest relatives of MAPKs are the cyclin-dependent kinases (CDKs). The first mitogen-activated protein kinase to be ...
It crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is ... Blachly JS, Byrd JC, Grever M (April 2016). "Cyclin-dependent kinase inhibitors for the treatment of chronic lymphocytic ... a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the ...
Cyclin H, Cyclin-dependent kinase 7, Estrogen receptor alpha, MCM7, MTA1, P53, and POU2F1. GRCh38: Ensembl release 89: ... Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (1997). "p53 is phosphorylated by CDK7-cyclin H in a ... Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and ... Tassan JP, Jaquenoud M, Fry AM, Frutiger S, Hughes GJ, Nigg EA (1995). "In vitro assembly of a functional human CDK7-cyclin H ...
Yoshihara T, Collado D, Hamaguchi M (2007). "Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function". ...
2005). "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the ... "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3 ... "Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin". Science ... Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene. The protein encoded by this gene ...
Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). "Human cyclin-dependent kinase-activating kinase exists in three ...
Takahashi-Yanaga F, Sasaguri T (Apr 2008). "GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy". Cellular ...
Diehl, JA; Yang, W; Rimerman, RA; Xiao, H; Emili, A (March 2003). "Hsc70 regulates accumulation of cyclin D1 and cyclin D1- ... For example, Hsc70 regulates the nuclear accumulation of cyclin D1, which is a key player in G1 to S phase cell cycle ...
Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (July 2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". ... Shi J, Feng Y, Goulet AC, Vaillancourt RR, Sachs NA, Hershey JW, Nelson MA (February 2003). "The p34cdc2-related cyclin- ... an RNA polymerase II-associated cyclin". Neuron. 32 (2): 277-87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997. S2CID ...
As the amount of cyclin increases, more and more cyclin dependent kinases attach to cyclin signaling the cell further into ... At the peak of the cyclin, attached to the cyclin dependent kinases this system pushes the cell out of interphase and into the ... The control of each checkpoint is controlled by cyclin and cyclin-dependent kinases. The progression of interphase is the ... Lindqvist A, van Zon W, Karlsson Rosenthal C, Wolthuis RM (May 2007). "Cyclin B1-Cdk1 activation continues after centrosome ...
Cyclin-dependent kinases promote transition through the cell cycle and cyclin-dependent kinase inhibitors are intended to stop ... Asghar U, Witkiewicz AK, Turner NC, Knudsen ES (2015). "The history and future of targeting cyclin-dependent kinases in cancer ... to the cell cycle provides a special rationale for investigating thymidine kinase as marker of effect of inhibitors to cyclin- ...
It was determined that he RV-cyclin bound to cyclin-dependent kinase 8 (CDK8) and increased its activity. The genes IEGs are ... This research investigated the role of retroviral cyclin (RV-cyclin) in sarcoma progression in walleyes as a comparable study ... Birkenheuer, C; Brewster, C; Quackenbush, S; Rovnak, J (2015). "Retroviral Cyclin Controls Cyclin-Dependent Kinase 8-Mediated ... "The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8". Virology. 409 (2): 299-307. doi: ...
"Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc". Molecular and Cellular Biology. 29 (17): 4623-39. doi: ... "The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene ...
... mitogens promote a relatively rapid G1-S transition through cooperative action of cyclin D-CDK4/6 and cyclin E-CDK2 to ... In the absence of mitogenic signals, cyclin-CDKs and the G1-S transition are suppressed by cell cycle inhibitors including Ink4 ... This reduces the sensitivity of stem cells to mitogenic signals by inhibiting cyclin-CDK complexes. As a result, either stem ... Mitogen stimulation mobilizes these cells into cycle by activating cyclin D expression. In old adult stem cells, let-7 microRNA ...
Subsequently, phosphorylation of chaperone protein HSP70 by a cyclin dependent kinase was shown to delay cell cycle progression ... "CDK-Dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-Cycle Progression". Cell. 151 (6): 1308-1318. doi: ... in yeast and mammals by altering cyclin D1 stability (a key regulator of the cell cycle). Phosphorylation of HSP90 (another ...
Fletcher AI, Shuang R, Giovannucci DR, Zhang L, Bittner MA, Stuenkel EL (February 1999). "Regulation of exocytosis by cyclin- ...
December 2012). "CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression". Cell. 151 (6): ...
"Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1". Cancer Research. 67 (22): ...
Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of ...
"Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation". Proceedings of the ...
Pines, J (1996). "Cyclin from sea urchins to He Las: Making the human cell cycle". Biochemical Society Transactions. 24 (1): 15 ...
"Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". The Journal of Biological Chemistry. 279 ...
In the Harlow laboratory, Tsai studied cyclin-dependent kinases in order to identify their role in cell division. Tsai became ... Tsai, L. H.; Takahashi, T.; Caviness, V. S.; Harlow, E. (1993-12-01). "Activity and expression pattern of cyclin-dependent ... "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5". Nature. 371 (6496): 419-423. Bibcode:1994Natur.371.. ...
Hoque M, Young TM, Lee CG, Serrero G, Mathews MB, Pe'ery T (March 2003). "The growth factor granulin interacts with cyclin T1 ... Granulin has also been shown to interact with Cyclin T1 and TRIB3. Although progranulin expression increases as cells mature, ... Progranulin can promote cyclin D1 expression in breast cancer lines and phosphorylation of proteins through extracellular ...
A CDK (cyclin-dependent kinase) inhibitor is any chemical that inhibits the function of CDKs. They are used to treat cancers by ... In some cases, very specific cancer types, such as 'melanoma positive for cyclin D1 expression' are targeted to maximize the ... Cyclin-dependent kinase ยง Medical significance Zotiraciclib "FDA approves Ibrance for postmenopausal women with advanced breast ... Singh R, Bhardwaj VK, Sharma J, Das P, Purohit R (March 2021). "Identification of selective cyclin-dependent kinase 2 inhibitor ...
This is consistent with the role of Pitx2 in regulating the growth-regulating genes cyclin D2, cyclin D1, and C-Myc. In renal ... promotes thyroid carcinogenesis by activation of cyclin D2". Cell Cycle. 9 (7): 1333-41. doi:10.4161/cc.9.7.11126. PMID ...
Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of ...
... has been shown to interact with: BRCA1, Cyclin T1, and FMR1. GRCh38: Ensembl release 89: ENSG00000083635 - Ensembl, May ...
This includes the cyclin-dependent kinase inhibitor P21 and the tumor suppressor gene Pten to promote neural stem cell ... Hilton TL, Li Y, Dunphy EL, Wang EH (May 2005). "TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 ...
... binds to the cyclin-dependent kinase, cdc2". Blood. 90 (3): 1047-54. doi:10.1182/blood.V90.3.1047. PMID 9242535. McMahon LW, ... binds to the cyclin-dependent kinase, cdc2". Blood. 90 (3): 1047-54. doi:10.1182/blood.V90.3.1047. PMID 9242535. Suzuki Y, ...