Cyclin-dependent kinase 5 (Cdk5), a major regulator of neuronal migration and positioning, is known to phosphorylate DAB1 and ... Beffert U, Weeber EJ, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J (February 2004). "Reelin and cyclin-dependent ... Ohshima T, Suzuki H, Morimura T, Ogawa M, Mikoshiba K (April 2007). "Modulation of Reelin signaling by Cyclin-dependent kinase ... Keshvara L, Magdaleno S, Benhayon D, Curran T (June 2002). "Cyclin-dependent kinase 5 phosphorylates disabled 1 independently ...

... publications from Europe PubMed Central Swanton, Robert Charles (1998). Viral cyclin disruption of mammalian ... "Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins". Nature. 390 (6656): 184-187. Bibcode:1997Natur. ...

"Cyclin Dependent Kinase (CDK) and Aurora Kinase (AK) inhibitors , Cyclacel R&D for anticancer drugs acting on cell cycle". www. ...

"Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1". Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (Jul 2000). "GCIP, ... Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene. This gene was identified by the ... Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Aug 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, ... The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce ...

2004). "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human ... 2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and ... 2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. 277 (38): 35314-22. doi: ... Mikolajczyk M, Shi J, Vaillancourt RR, Sachs NA, Nelson M (Sep 2003). "The cyclin-dependent kinase 11(p46) isoform interacts ...

"Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction". The EMBO Journal. 19 (6): 1378- ... Cyclin F differs from other cyclins by its ability to monitor and regulate cell cycle without the need for cyclin-dependent ... D'Angiolella V, Esencay M, Pagano M (March 2013). "A cyclin without cyclin-dependent kinases: cyclin F controls genome ... Cyclin F is the main member of the F-box protein family, which has about 40 amino acid motif, forming the F-box. Cyclin F most ...

Cyclin D1, Cyclin-dependent kinase 7, DACH1, Death associated protein 6, L-DOPA, EFCAB6, Epidermal growth factor receptor, ... Reutens AT, Watanabe G, Albanese C, McPhaul MJ, Balk SP, Pestell RG (1998). "Cyclin D1 binds activating mutants of the androgen ... Knudsen KE, Cavenee WK, Arden KC (May 1999). "D-type cyclins complex with the androgen receptor and inhibit its transcriptional ... "Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)- ...

Many factors including cyclins, cyclin-dependent kinases (CDKs), ubiquitin ligases, inhibitors of cyclin-dependent kinases, and ... APC ubiquitinates nine-amino acid motif known as the destruction box (D box) in the NH2-terminal domain of mitotic cyclins for ... Cdc20 and Cdh1, which are the activators of APC, recruit substrates such as securin and B-type cyclins(Clb) for ubiquitination ... Cdk1-inhibitors could induce mitotic exit even when degradation of B-type cyclins was blocked by expression of non-degradable ...

Cyclin D1 and cancer development in laryngeal premalignancy patients. Cancer Prev Res (Phila) 2(1):14-21, 2009. Spitz MR, Hong ...

Dynlacht BD, Flores O, Lees JA, Harlow E (August 1994). "Differential Regulation of E2F transactivation by cyclin/cdk2 complex ...

... phosphorylation leads to a stable association with CDK1-cyclin B1. Securin or CDK1-cyclin B binding is mutually ... In 2021, structures of human separase were determined in complex with either securin or CDK1-cyclin B1-CKS1 using cryo-EM by ... However, while securin contains its own pseudosubstrate motifs to occlude substrate binding, the CDK1-cyclin B complex inhibits ... August 2021). "Structural basis of human separase regulation by securin and CDK1-cyclin B1". Nature. 596 (7870): 138-142. doi: ...

Progression through the cell cycle is tightly regulated by cyclin-dependent kinases (CDKs), and their interactions with cyclins ... which is involved primarily in inhibiting cyclin E-CDK2 complexes (and to a lesser extent cyclin D-CDK4 complexes). Levels of ... Yam CH, Ng RW, Siu WY, Lau AW, Poon RY (January 1999). "Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein ... Skp2 forms a stable complex with the cyclin A-CDK2 S-phase kinase. It specifically recognizes and promotes the degradation of ...

She completed her PhD on B-type cyclins in the laboratory of Jonathon Pines at Trinity College, Cambridge. Draviam moved to the ... Draviam, Viji Mythily (2002). Studies on human B- type cyclins. cam.ac.uk (PhD thesis). University of Cambridge. OCLC 894595569 ...

"The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1". Proceedings of the National Academy of Sciences ...

Assembly of the pre-replication complex only occurs during late M phase and early G1 phase of the cell cycle when cyclin- ... Nguyen VQ, Co C, Li JJ (June 2001). "Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms". Nature. ...

"Distinct roles for cyclin-dependent kinases in cell cycle control." Science 262.5142 (1993): 2050-2054. Harlow, E. D., et al. " ... "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5." (1994): 419-423. Meyerson, Matthew, et al. "A family ... Tsai, L (1994). "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5". Nature. 371: 419-23. doi:10.1038/ ... van den Heuvel, S (1993). "Distinct roles for cyclin-dependent kinases in cell cycle control". Science. 262: 2050-4. doi: ...

"Characterization of a new family of cyclin-dependent kinase activators". The Biochemical Journal. 386 (Pt 2): 349-55. doi: ...

"Induction and expression of cyclin D3 in human pancreatic cancer". Journal of Cancer Research and Clinical Oncology. 127 (7): ...

". "CDK4 cyclin dependent kinase 4 [Homo sapiens (Human)] - Gene - NCBI". Nishio J, Iwasaki H, Shibata T, Nabeshima K, Naito M ...

Cyclins are molecules that manage the timing of cell cycle events. Cyclin dependent kinases pair up with cyclins to become ... Cyclins are named because they are created or destroyed at predetermined points within the cell cycle. Kinase inhibitors add ... These include INKS for inhibitors of kinase, KIPS for kinase inhibitors and CKIPS for cyclin dependent kinases inhibitors. ...

Mantle cell lymphoma is characterized by fusion of cyclin D1 to the immunoglobulin locus. Cyclin D1 inhibits Rb, a tumor ...

The syndrome is caused by a mutation in the CDK13 gene, which encodes the protein cyclin-dependent kinase 13. Cyclin-dependent ... Cyclin-dependent kinases are protein kinases, which have an essential function in the cell cycle and the transcription of DNA. ... The syndrome is caused by a mutation in one of the two copies of the gene CDK13, which encodes the protein cyclin dependent ... "Structural and Functional Analysis of the Cdk13/Cyclin K Complex". Cell Reports. 14 (2): 320-331. doi:10.1016/j.celrep.2015.12. ...

These transitions are controlled by the cyclin-dependent kinase Cdk1. Though the proteins that control Cdk1 are well understood ... a cyclin-dependent kinase, on a tyrosine residue. Cdc2 drives entry into mitosis by phosphorylating a wide range of targets. ...

More specifically, DDX3X was shown to directly bind to the 5´ UTR of Cyclin E1 and thereby facilitating the translation of the ... Lai MC, Chang WC, Shieh SY, Tarn WY (November 2010). "DDX3 regulates cell growth through translational control of cyclin E1". ... Increased protein levels of Cyclin E1 was demonstrated to mediate the transition of S phase entry. Melanoma survival, migration ... In HeLa cells DDX3X is reported to control cell cycle progression through Cyclin E1. ...

April 1991). "A novel cyclin encoded by a bcl1-linked candidate oncogene". Nature. 350 (6318): 512-5. Bibcode:1991Natur.350.. ...

Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L (Jul 1997). "Specific regulation of E2F family members by cyclin-dependent ... He Y, Cress WD (Jun 2002). "E2F-3B is a physiological target of cyclin A". The Journal of Biological Chemistry. 277 (26): 23493 ... This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to ... "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". European Journal of Biochemistry. 268 (23): 6076-82. doi: ...

DP00016 corresponds to the Cyclin-dependent kinase inhibitor 1 protein. It featured a new web interface based on Angular.JS. ...

Cyclin dependant kinases (CDK) Cyclins DNA helicase DnaA Pre-replication complex Origin+Recognition+Complex at the U.S. ... Weinreich M, Liang C, Chen HH, Stillman B (September 2001). "Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the ... Nguyen VQ, Co C, Li JJ (June 2001). "Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms". Nature. ... Cell cycle-regulated phosphorylation of Orc2, Orc6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates ...

This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during ... Nakamura T, Sanokawa R, Sasaki YF, Ayusawa D, Oishi M, Mori N (Jan 1996). "Cyclin I: a new cyclin encoded by a gene isolated ... Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which ... Cyclin-I is a protein that in humans is encoded by the CCNI gene. The protein encoded by this gene belongs to the highly ...

Cheng A, Ross KE, Kaldis P, Solomon MJ (November 1999). "Dephosphorylation of cyclin-dependent kinases by type 2C protein ... This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. ...