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*  CCNG2
The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST ... "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression ... "Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 ... Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene. The eukaryotic cell cycle is governed by cyclin-dependent ...
*  ACVR1C
2008). "Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin ...
*  BHLHE41
The gene is also mapped to 6 G2-G3 on the mouse chromosome, and 4q43 distal-q4 on the rat chromosome respectively. BHLHE41 has ... Breast cancer tumors that show high expression of BHLHE41 and CyclinG2 are believed to have a lower metastatic risk. GRCh38: ...
*  CCNG1
"Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression ... "Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1". Cell ... Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (2002). "Cyclin G2 associates with ... Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene. The eukaryotic cell cycle is governed by cyclin-dependent ...
*  PPP2CA
Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (Jul 2002). "Cyclin G2 associates ... PPP2CA has been shown to interact with: Bcl-2, Bestrophin 1, CCNG2, CTTNBP2NL, CTTNBP2, Cyclin-dependent kinase 2, Cyclin- ... Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell- ... Cheng A, Kaldis P, Solomon MJ (Nov 2000). "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C ...
*  PPP2R2A
Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (Jul 2002). "Cyclin G2 associates ... Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast ( ...
*  PPP2R2B
2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces ... 2002). "Cyclin G recruits PP2A to dephosphorylate Mdm2". Mol. Cell. 9 (4): 761-71. doi:10.1016/S1097-2765(02)00504-X. PMID ... Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143-9. doi:10.1038/sj.cr.7290279 ... 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving ...
*  Angelika Amon
G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle". Cell. 77 (7): 1037- ...
*  ZC3HC1
Cyclin B1, essential in the entry into mitosis, is targeted by SCFNIPA in interphase. Phosphorylation of NIPA occurs in G2 ... at G2/M involves cyclin B1/Cdk1". The Journal of Biological Chemistry. 282 (22): 15965-72. doi:10.1074/jbc.M610819200. PMID ... Oscillating ubiquitination of nuclear cyclin B1 driven by the SCFNIPA complex contributes to the timing of mitotic entry. NIPA ... phase, results in dissociation of NIPA from the SCF core, and has been proven critical for proper G2/M transition. ...
*  TSC1
"Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B". J. Neuropathol ... by cyclin-dependent kinase 1/cyclin B". J. Biol. Chem. 278 (51): 51372-9. doi:10.1074/jbc.M303956200. PMID 14551205. Nellist M ...
*  Cyclin B2
G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene. Cyclin B2 is a member of the cyclin ... Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds ... Cyclin B2 has been shown to interact with TGF beta receptor 2. Cyclin B GRCh38: Ensembl release 89: ENSG00000157456 - Ensembl, ... "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. ...
*  CCNF
G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene. This gene encodes a member of the cyclin ... "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction". The EMBO Journal. 19 (6): 1378- ... Cyclin F differs from other cyclins by its ability to monitor and regulate cell cycle without the need for cyclin-dependent ... D'Angiolella V, Esencay M, Pagano M (March 2013). "A cyclin without cyclin-dependent kinases: cyclin F controls genome ...
*  Cyclin B1
G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein ... "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction". EMBO J. 19 (6): 1378-88. doi: ... "G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently". J. ... Reduction of cyclin B1 can stop cells in the G2 phase of the cell cycle and triggers cell death by preventing the chromosomes ...
*  CDC2L1
2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. 277 (38): 35314-22. doi: ... 2004). "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human ... 2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and ... a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. United States. 277 (38): 35314-22. doi:10.1074/jbc.M202179200. ...
*  WTAP (gene)
2007). "Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA". Proc. Natl. Acad ...
*  Cyclin A2
... is involved in the G2/M transition but it cannot independently form a maturation promoting factor (MPF). Recent ... Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is ... Cyclin A2 belongs to the cyclin family, whose members regulate cell cycle progression by interacting with CDK kinases. Cyclin ... The cyclin A2-CDK2 complex eventually phosphorylates E2F, turning off cyclin A2 transcription. E2F promotes cyclin A2 ...
*  Cyclin
... D / CDK4, Cyclin D / CDK6, and Cyclin E / CDK2 - regulates transition from G1 to S phase. G2/M cyclins - essential for ... The rise in presence of G1/S cyclins is paralleled by a rise in S cyclins. G1 cyclins do not behave like the other cyclins, in ... G1 cyclins, G1/S cyclins, S cyclins, and M cyclins. This division is useful when talking about most cell cycles, but it is not ... For example, cyclin F is an orphan cyclin that is essential for G2/M transition. A study in C. elegans revealed the specific ...
*  Anaphase-promoting complex
Emi1 association with Cdc20 allows for the stabilization of various cyclins throughout S and G2 phase, but Emi1's removal is ... Securin and M cyclins (cyclin A and cyclin B) are then targeted by APC/CCdc20 for degradation. Once degraded, separin is ... In this manner, cyclin A can be degraded while cyclin B and securin are degraded only once sister chromatids have achieved bi- ... Cyclin A is degraded early in mitosis, supporting the theory, but cyclin B and securin are not degraded until metaphase. The ...
*  Cyclin D3
"A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase ... Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, EIF3K, and Retinoic acid receptor alpha. Cyclin Cyclin D GRCh38: Ensembl ... The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into ... Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which ...
*  Biochemical switches in the cell cycle
G2 is commenced by E2F-mediated transcription of cyclin A, which forms the cyclin A-Cdk2 complex. In order to proceed into ... saw that untagged cyclin B migrated with the cyclin B influenced by iRap. The untagged cyclin is insentive to the treatment, ... Many factors including cyclins, cyclin-dependent kinases (CDKs), ubiquitin ligases, inhibitors of cyclin-dependent kinases, and ... Phosphorylation of cyclin B promotes translocation to the nucleus, and cyclin B in the nucleus is much more likely to be ...
*  KAT5
Therefore, cancer cells with uncontrolled growth and improper G2/M checkpoints lack KAT5 regulation by cyclin dependent kinase ... KAT5 catalytic activity is regulated by the phosphorylation of its histones during the G2/M phase of the cell cycle. ...
*  CDC25C
"Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. ... Zheng XF, Ruderman JV (1993). "Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25". ... It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53- ... 1991). "Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein". Nature. 351 (6323): ...
*  COPS6
"Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. ... Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast ( ... Elder RT, Yu M, Chen M, Edelson S, Zhao Y (2000). "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast ( ... a cellular factor linked to the G2/M phase transition of the mammalian cell cycle". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3419- ...
*  Ultrasensitivity
During G2 phase of the cell cycle, Cdk1 and cyclin B1 makes a complex and forms maturation promoting factor (MPF). The complex ... Cdc25C phosphatase is present in the cytoplasm and in late G2 phase it is translocated into the nucleus by signaling such as ... The system cannot be stable at intermediate levels of Cyclin B1, and the transition between the two stable states is abrupt ... Exhibiting hysteresis, for different levels of Cyclin B1, the switches from low to high and high to low states vary. However, ...
*  Control of chromosome duplication
At the same time, S-Cdks suppress formation of new pre-RCs during S phase, G2 and early M, when S cyclin levels remains high. ... Removal of cyclin E with antibodies blocks replication. Cyclin E-CDk2 is also important in Drosophila. Levels of cyclin E rise ... In S. cerevisiae, the S cyclins Clb5 and Clb6 play and important role in inititating replication. In frog embryos, cyclin E- ... Evidence for this is that inactivation of CDKs in cells arrested in G2/M or in S phase drives reassembly of pre-RCs. CDK acts ...
*  G1 phase
During G1 phase, the G1/S cyclin activity rises significantly near the end of the G1 phase. Complexes of cyclin that are active ... G1 phase together with the S phase and G2 phase comprise the long growth period of the cell cycle called interphase that takes ... which targets and degrades S and M cyclins (but not G1/S cyclins); and a high concentration of Cdk inhibitors is found during ... At the G1/S checkpoint, formation of the G1/S cyclin with Cdk to form a complex commits the cell to a new division cycle. These ...