Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L (Jul 1997). "Specific regulation of E2F family members by cyclin-dependent ... He Y, Cress WD (Jun 2002). "E2F-3B is a physiological target of cyclin A". The Journal of Biological Chemistry. 277 (26): 23493 ... This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to ... "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". European Journal of Biochemistry. 268 (23): 6076-82. doi: ...

DP00016 corresponds to the Cyclin-dependent kinase inhibitor 1 protein. It featured a new web interface based on Angular.JS. ...

Cyclin dependant kinases (CDK) Cyclins DNA helicase DnaA Pre-replication complex Origin+Recognition+Complex at the U.S. ... Weinreich M, Liang C, Chen HH, Stillman B (September 2001). "Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the ... Nguyen VQ, Co C, Li JJ (June 2001). "Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms". Nature. ... Cell cycle-regulated phosphorylation of Orc2, Orc6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates ...

This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during ... Nakamura T, Sanokawa R, Sasaki YF, Ayusawa D, Oishi M, Mori N (Jan 1996). "Cyclin I: a new cyclin encoded by a gene isolated ... Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which ... Cyclin-I is a protein that in humans is encoded by the CCNI gene. The protein encoded by this gene belongs to the highly ...

Cheng A, Ross KE, Kaldis P, Solomon MJ (November 1999). "Dephosphorylation of cyclin-dependent kinases by type 2C protein ... This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. ...

This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle ... Cheng A, Ross KE, Kaldis P, Solomon MJ (2000). "Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases ... Cheng A, Kaldis P, Solomon MJ (2000). "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha ... "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms". J. Biol. Chem. ...

Garriga J, Peng J, Parreño M, Price DH, Henderson EE, Graña X (1999). "Upregulation of cyclin T1/CDK9 complexes during T cell ...

... including cyclins and cyclin-dependent kinases. Unlike bacteria, eukaryotic DNA replicates in the confines of the nucleus. The ... If environmental conditions are right in late G1 phase, the G1 and G1/S cyclin-Cdk complexes are activated, which stimulate ... This regulation is best understood in budding yeast, where the S cyclins Clb5 and Clb6 are primarily responsible for DNA ... ISBN 0-8153-3218-1. Intracellular Control of Cell-Cycle Events: S-Phase Cyclin-Cdk Complexes (S-Cdks) Initiate DNA Replication ...

... can be associated with overexpression of the cyclin D1 gene. It is also associated with multiple endocrine ... Hsi ED, Zukerberg LR, Yang WI, Arnold A (May 1996). "Cyclin D1/PRAD1 expression in parathyroid adenomas: an immunohistochemical ...

G1/S-specific cyclin Cln3 is a protein that is encoded by the CLN3 gene. The Cln3 protein is a budding yeast G1 cyclin that ... It is a 65 kD, unstable protein; like other cyclins, it functions by binding and activating cyclin-dependent kinase (CDK). Cln3 ... It is an upstream regulator of the other G1 cyclins, and it is thought to be the key regulator linking cell growth to cell ... Vergés E, Colomina N, Garí E, Gallego C, Aldea M (June 2007). "Cyclin Cln3 is retained at the ER and released by the J ...

Specifically it is the interactions of cyclins and cyclin dependent kinases that are responsible for the transition from G1 ... In addition to cyclin dependent kinases a new round of replication is thought to be prevented through the downregulation of ... At the transition of the G1 stage to the S phase of the cell cycle, S phase-specific cyclin-dependent protein kinase (CDK) and ... Labib K, Diffley JF, Kearsey SE (November 1999). "G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the ...

De Moor, C.H.; Richter, J.D. (1999). "Cytoplasmic polyadenylation mediate masking and unmasking of cyclin B1 mRNA". EMBO J. 18 ...

de Moor, C.H.; Richter, J.D. (1999). "Cytoplasmic polyadenylation mediate masking and unmasking of cyclin B1 mRNA". EMBO J. 18 ...

Pur-alpha also binds Cyclin T1, a regulatory partner of Cdk9 protein kinase, necessary for Tat activity. Cyclin T1/Cdk9 ... Several cell cycle regulatory functions may be mediated by Pur-alpha binding to Cyclin/Cdk protein kinases, which phosphorylate ... "Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2". Biochemical and Biophysical Research Communications ...

When cyclin E is overexpressed in U-2-OS cell lines, the ATM/ATR-regulated DNA damage network results in increases in Ser 15- ... This checkpoint response activates due to overexpression of cyclin E, which has been shown to be important in regulating the ... Nguyen VQ, Co C, Li JJ (June 2001). "Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms". Nature. ... These control mechanisms rely on cyclin-dependent kinase (CDK) activity. DNA replication control mechanisms cooperate to ...

"CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)". U.S. National Library of Medicine. Archived from ... Another mutation in the same gene results in a nonfunctional inhibitor of CDK4, a cyclin-dependent kinase that promotes cell ... a low-molecular weight protein inhibitor of cyclin-dependent protein kinases (CDKs) - which has been localised to the p21 ...

Annexin A2 CAF-1 CDC25C CHTF18 Cyclin D1 Cyclin O Cyclin-dependent kinase 4 Cyclin-dependent kinase inhibitor 1C DNMT1 EP300 ... "Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T ... Matsuoka S, Yamaguchi M, Matsukage A (April 1994). "D-type cyclin-binding regions of proliferating cell nuclear antigen". The ... Xiong Y, Zhang H, Beach D (August 1993). "Subunit rearrangement of the cyclin-dependent kinases is associated with cellular ...

Mikolajczyk M, Shi J, Vaillancourt RR, Sachs NA, Nelson M (2003). "The cyclin-dependent kinase 11(p46) isoform interacts with ... and cyclin-dependent kinase 11. RANBP9 has been shown to interact with: Androgen receptor, C-Met, DISC1, DYRK1B, Glucocorticoid ...

Nature 332, 800-805 Deshaies, R.J., Chau, V., and Kirschner, M.W. (1995). Ubiquitination of the G1 cyclin Cln2p by a Cdc34p- ... they established that an early step in the release of Cdc14 from Net1 is the phosphorylation of Net1 by the mitotic cyclin-Cdk ... Phosphorylation by cyclin B-Cdk underlies release of mitotic exit. Science 305, 516-519 Kyprolis official website. [1] Cleave ... Phosphorylation of Sic1p by G1 cyclin/Cdk is required for its degradation and entry into S phase. Science 278, 455-460 Seol, J. ...

Yano M, Naito Z, Yokoyama M, Shiraki Y, Ishiwata T, Inokuchi M, Asano G (Mar 1999). "Expression of hsp90 and cyclin D1 in human ... For example, the co-chaperone CDC37 (cell division cycle 37) stabilizes the cell cycle regulatory proteins CDK4 (cyclin ...

p16Ink4a also activates pRB, but through inactivation of cyclin-dependent kinase 4 (Cdk 4) and cyclin-dependent kinase 6 (Cdk 6 ... The p16 protein is a cyclin dependent kinase inhibitor (CDK) inhibitor and it activates Rb tumor suppressor. p16 binds to CDK 4 ... Narasimha, Anil M.; Kaulich, Manuel; Shapiro, Gary S.; Choi, Yoon J.; Sicinski, Piotr; Dowdy, Steven F. (2014-06-04). "Cyclin D ... p53 activates p21 which deactivates cyclin-dependent kinase 2(Cdk 2). Without Cdk 2, retinoblastoma protein (pRB) remains in ...

Cyclin-dependent kinase inhibitor 1C, or p57, also affects corticogenesis. It has been shown the p57 induces cells to exit from ... PLoS ONE, 7(3). doi: 10.1371/journal.pone.0034088 Tury, A., Mairet-Coello, G., & DiCicco-Bloom, E. (2011). The Cyclin-Dependent ...

... is a gene that provides instructions for making a protein called cyclin-dependent kinase-like 5 also known as serine/ ... "Preclinical Program for Cyclin-Dependent Kinase-Like 5 (CDKL5) Deficiency". Amicus Therapeutics Press Release. 6 July 2016. ... G40.42 Cyclin-dependent kinase Rett syndrome West syndrome CDKL5 deficiency disorder GRCh38: Ensembl release 89: ...

In addition, cyclin E dsRNA only diminished cyclin E RNA - a similar result was also shown using dsRNA corresponding to cyclin ... Cells transfected with cyclin E dsRNAs only showed degradation in cyclin E transcripts - the lacZ transcripts were stable. ... Cyclin E dsRNA arrested the cell cycle at the G1 phase (before the S phase). Therefore, RNAi can target endogenous genes. ... S2 cells were then transfected with Drosophila cyclin E dsRNA. Cycline E is an essential gene for cell cycle progression into ...

These include: Roscovitine is an inhibitor of cyclin-dependent kinase. It increases the current of calcium in neostriatal ...

This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Other well ... Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI (2001). "Human F-box protein hCdc4 targets cyclin E for ... Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK (2001). "Archipelago regulates Cyclin E levels in Drosophila and is ... Cassia R, Moreno-Bueno G, Rodríguez-Perales S, Hardisson D, Cigudosa JC, Palacios J (2004). "Cyclin E gene (CCNE) amplification ...

Cyclin expression levels control progression through the eukaryotic cell cycle. Regulation of transcription can be broken down ...

It, combined with the Ras pathway, downregulate cyclin D1, a cyclin-dependent kinase, if they are not stimulated by the ... In the presence of mitogens, sufficient cyclin D1 can be produced. This process cascades onwards, producing other cyclins which ... Smad proteins then trigger an increase in p15, which inhibits cyclin D1 and prevents cell cycle progression. In many cancers, ... and depends on cyclins to be passed. One of the most important of these is TP53, a gene which produces a family of proteins ...

Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene. The protein encoded by this ... "Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)". Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai ... Patzke H, Tsai LH (March 2002). "Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29". The Journal ... Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 ...

This is achieved by continuous control of cyclins or CDKs levels through ubiquitination and degradation. When cyclin E is ... SKP2 targets p27Kip-1, an inhibitor of cyclin-dependent kinases (CDKs). CDKs2/4 partner with the cyclins E/D, respectively, ... The level of cyclins, as the name suggests, is high only at certain a time point during the cell cycle. ... Li H, Okamoto K, Peart MJ, Prives C (February 2009). "Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha ...