... has been shown to interact with: AKT1, CKS1B, Cyclin D3, Cyclin E1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4 ... "Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)". ... "Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas". ... Cyclin-dependent kinase inhibitor 1B (p27Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes ...
D'Angiolella V, Esencay M, Pagano M (March 2013). "A cyclin without cyclin-dependent kinases: cyclin F controls genome ... Cyclin F differs from other cyclins by its ability to monitor and regulate cell cycle without the need for cyclin-dependent ... Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein ... "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction". The EMBO Journal. 19 (6): 1378- ...
... has been shown to interact with MED8, Cyclin-dependent kinase 8, POLR2A, MED12 and MED28. It also acts synergistically to ... 127 (3): 635-648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. (Articles with short description, Short ... The hydrophobic core residues of helices 2, 3, and 4 are well conserved among TFIIS domains, although helix 1 is less conserved ...
... cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II ... cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II ... Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene. The protein encoded by this ... "Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)". Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai ...
"The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner". ... p21 p53 Cyclin-dependent kinase Cyclin D GRCh38: Ensembl release 89: ENSG00000147889 - Ensembl, May 2017 GRCm38: Ensembl ... "Entrez Gene: CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)". Nobori T, Miura K, Wu DJ, Lois A, ... p16 is an inhibitor of cyclin-dependent kinases (CDK). It slows down the cell cycle by prohibiting progression from G1 phase to ...
Cyclins; Cyclin-dependent kinases "Biotin Carboxyl Carrier Protein - an overview , ScienceDirect Topics". www.sciencedirect.com ... Cyclin-dependent kinases in cancer: Role, regulation, and therapeutic targeting, Editor(s): Rossen Donev, Advances in Protein ... Cyclin-dependent kinase 4; SNPs; Pathogenicity; Stability; Amino acid conservation; Physico-chemical properties; Molecular ... Computational screening and structural analysis of Gly201Arg and Gly201Asp missense mutations in human cyclin-dependent kinase ...
2007). "Functional characterization of human PFTK1 as a cyclin-dependent kinase". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9248- ... Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene. PFTK1 has been shown to ... Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem ... "Entrez Gene: PFTK1 PFTAIRE protein kinase 1". Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin ...
... also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) ... 1994). "p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest ... "Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor ... Cyclin-Dependent+Kinase+Inhibitor+p21 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Drosophila ...
... phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase ... A dose-dependent response was not observed, raising questions about the robustness of the findings. Genes,+tat at the U.S. ... of cellular CDK9 and cyclin T1, and hence increases the production of full-length viral RNA. Tat protein also associates with ... 13 (3): 355-63. doi:10.1111/j.1600-0854.2011.01286.x. PMID 21951552. Jeang KT (June 1997). "HIV-1 TAT: Structure and Function ...
... cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of ... "Entrez Gene: CDK12 cyclin-dependent kinase 12". Human CDK12 genome location and CDK12 gene details page in the UCSC Genome ... cyclin-dependent kinase protein family. GRCh38: Ensembl release 89: ENSG00000167258 - Ensembl, May 2017 GRCm38: Ensembl release ... Ko TK, Kelly E, Pines J (Oct 2001). "CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles ...
Jain SK, Bharate SB, Vishwakarma RA (2012). "Cyclin-dependent kinase inhibition by flavoalkaloids". Mini Rev Med Chem. 12 (7): ... Bose P, Simmons GL, Grant S (2013). "Cyclin-dependent kinase inhibitor therapy for hematologic malignancies". Expert Opin ... One example is alvocidib, a potent CDK9 kinase inhibitor that is being developed for the treatment of chronic lymphocytic ... doi:10.1016/S0031-9422(00)82304-3. Zhen, J., Dai, Y., Villani, T., Giurleo, D., Simon, J. and Wu, Q., 2017. Synthesis of novel ...
... encoding cyclin dependent kinase inhibitor 2B multiple tumor suppressor 2) (inactivation of either CDKN2 gene causes genome ... "MAP2K1 mitogen-activated protein kinase kinase 1 [Homo sapiens (human)] - Gene - NCBI". Lones MA, Raphael M, McCarthy K, ... encoding a guanylate kinase which interacts with BCL10 and activates NF-κB to regulate cell survival); 2) changes in the ... Bruon's tyrosine kinase inhibitor, ibrutinib, to block the B-cell maturating actions of this kianase; 4) BCL inhibitor ...
"Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission". ... Cyclin-dependent kinase 5 (Cdk5), a major regulator of neuronal migration and positioning, is known to phosphorylate DAB1 and ... Ohshima T, Suzuki H, Morimura T, Ogawa M, Mikoshiba K (April 2007). "Modulation of Reelin signaling by Cyclin-dependent kinase ... Keshvara L, Magdaleno S, Benhayon D, Curran T (June 2002). "Cyclin-dependent kinase 5 phosphorylates disabled 1 independently ...
"Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor ... Pratt RL, Kinch MS (October 2002). "Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade". ... "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of ... "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases". The Journal ...
... and the cyclin dependent kinase inhibitors P27 and P21". Leuk. Lymphoma. 43 (1): 51-7. doi:10.1080/10428190210195. PMID ... Specifically, TGF-β1 prevents the interleukin(IL)-1- & interleukin-2-dependent proliferation in activated T cells, as well as ... "Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis". Proc. ... "Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation". J. ...
The cyclin-dependent kinase inhibitor p21 is induced by both p53-dependent and p53-independent mechanisms and can arrest the ... ISBN 978-1-58829-500-2.[page needed] Gartel AL, Tyner AL (June 2002). "The role of the cyclin-dependent kinase inhibitor p21 in ... cell cycle at the G1/S and G2/M checkpoints by deactivating cyclin/cyclin-dependent kinase complexes. The SOS response is the ... In one of the earliest steps, the stress-activated protein kinase, c-Jun N-terminal kinase (JNK), phosphorylates SIRT6 on ...
Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (November 1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly ... Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, ... "The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase". J. Biol. ... La Boissière S, Hughes T, O'Hare P (January 1999). "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480-9. doi:10.1093/ ...
"Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the ... 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". ... doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Luo P, Wang A, Payne KJ, Peng H, Wang JG, Parrish YK, Rogerio JW, Triche TJ, ... doi:10.1016/S0021-9258(18)98890-3. PMID 2061311. "Entrez Gene: ALDH1B1 aldehyde dehydrogenase 1 family, member B1". Gerdin AK ( ...
"Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 ... These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDKs) ... "Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9". Journal of Molecular Biology. 366 (2 ... a positive regulator of cyclin-dependent kinase 9". Journal of Molecular Biology. 366 (2): 563-73. doi:10.1016/j.jmb.2006.11. ...
... is a gene that provides instructions for making a protein called cyclin-dependent kinase-like 5 also known as serine/ ... "Preclinical Program for Cyclin-Dependent Kinase-Like 5 (CDKL5) Deficiency". Amicus Therapeutics Press Release. 6 July 2016. ... G40.42 Cyclin-dependent kinase Rett syndrome West syndrome CDKL5 deficiency disorder GRCh38: Ensembl release 89: ... The CDKL5 protein acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of ...
In parallel and independently from Bert Vogelstein's group, he discovered and characterized p21, a cyclin-dependent kinase ... "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases" (PDF). Cell. 75 (4): 805-816. doi: ... Zhou, Zheng; Elledge, Stephen J. (1993). "DUN1 encodes a protein kinase that controls the DNA damage response in yeast". Cell. ... Elledge, S.J.; Spottswood, M.R. (1991). "A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 ...
Cyclins function as regulators of CDKs (cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation ... "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proceedings of the National ... Cyclin D1 is a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. The protein dimerizes with CDK4/6 to regulate the ... Hall M, Peters G (1996). Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Advances ...
Cyclins are proteins that control progression through the cell cycle by activating cyclin-dependent kinases. Destruction of a ... The suspected mechanism is dependent on p27Kip1, a cyclin-dependent kinase inhibitor. p27Kip1 protein levels are elevated in ... Driving this conversion is Cdc7 and S-phase cyclin-dependent kinases, which are both upregulated after the G1/S transition. ... Different classes of cyclins are up- and down-regulated at different parts of the cell cycle. Measurement of the cyclins from ...
This gene provides instructions for making a protein (cyclin-dependent kinase-like 5) that is essential for normal brain ... Olson, Heather E. (2019). Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder: clinical review (PDF). CDKL5 Alliance ... or Cyclin-Dependent Kinase-Like 5 (CDKL5) Deficiency Disorder". ClinicalTrials.gov. Retrieved 21 June 2021. Devinsky, Orrin ( ... "Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Clinical Review". Pediatric Neurology. 97: 18-25. doi:10.1016/j. ...
Woo RA, Poon RY (2003). "Cyclin-dependent kinases and S phase control in mammalian cells". Cell Cycle. 2 (4): 316-24. doi: ... including cyclin A-CDK2/1 and cyclin D/CDK4, and blocks the kinase activity of CDKs. Activated p21 can bind cyclin D/CDK4 and ... Cyclin A remains associated with CDK1 from late S into late G2 phase when it is replaced by cyclin B. Cyclin A/CDK1 is thought ... Cyclin A is the only cyclin that regulates multiple steps of the cell cycle. Cyclin A can regulate multiple cell cycle steps ...
... by cyclin-dependent kinase 1/cyclin B". The Journal of Biological Chemistry. 278 (51): 51372-9. doi:10.1074/jbc.M303956200. ... "Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B". Journal of ... Tsc1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including Tsc2, therefore preventing ... interacts with polo-like kinase 1 in a phosphorylation-dependent manner". Human Molecular Genetics. 15 (2): 287-97. doi:10.1093 ...
Laronga C, Yang HY, Neal C, Lee MH (July 2000). "Association of the cyclin-dependent kinases and 14-3-3 sigma negatively ... A member of a protein family that has been involved in the protein kinase C signalling pathway". Journal of Molecular Biology. ... "Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways". Neoplasia. 4 (2 ... 3 (8): 507-13. PMID 1390337. Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B ( ...
Cheng A, Ross KE, Kaldis P, Solomon MJ (November 1999). "Dephosphorylation of cyclin-dependent kinases by type 2C protein ... MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by ... This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. ... "Entrez Gene: PPM1A protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform". Flajolet M, Rakhilin S, Wang H, ...
... protein kinase C (PKC), ataxia telangiectasia mutated kinase (ATM), cyclin-dependent kinase 5 (CDK5), and casein kinase 1 (CK1 ... These sites include casein kinase 2 (CK2), cAMP-dependent protein kinase (PKA), ... There are 3 conserved domains in LENG9. The metal-ion binding zinc finger domain ZnF_C3H1 is found from amino acid 46 to 61. ... 20 (3): 308-317. doi:10.1177/1933719112453507. PMC 4077381. PMID 22902743. "LENG9 leukocyte receptor cluster member 9 [Homo ...
"CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)". U.S. National Library of Medicine. Archived from ... Another mutation in the same gene results in a nonfunctional inhibitor of CDK4, a cyclin-dependent kinase that promotes cell ... a low-molecular weight protein inhibitor of cyclin-dependent protein kinases (CDKs) - which has been localised to the p21 ... November 2016). "NTRK3 kinase fusions in Spitz tumours". The Journal of Pathology. 240 (3): 282-290. doi:10.1002/path.4775. PMC ...
Kinome Cyclin-dependent kinase Signal transduction Andrews, Paul D.; Knatko, Elena; Moore, William J.; Swedlow, Jason R. (2003 ... Aurora kinase inhibitors are a putative drug class for treating cancer. The Aurora kinase enzymes could be potential targets ... Serine/threonine-protein kinase 12, AIK2, AIM1, ARK2, STK12) Aurora-C (Serine/threonine-protein kinase 13, AIE2, AIK3, STK13) ... Aurora kinases regulate cell cycle transit from G2 through cytokinesis, and thus are targets in cancer therapy. There are three ...
Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins ... Cyclin-A1 interacts with: CDC20, Cyclin-dependent kinase 2, E2F1, GNB2L1, GPS2, MYBL2, and Retinoblastoma protein. GRCh38: ... "Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to ... cyclins and cyclin dependent kinases". Oncogene. 15 (2): 143-157. doi:10.1038/sj.onc.1201252. PMID 9244350. Suzuki Y, Yoshitomo ...