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*  Cyclin D1
... cyclin D1 is translocated to the IgH promoter leading to cyclin D1 overexpression. Chromosomal translocation of the cyclin D1 ... Cyclin-D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human ... Cyclin D1 has been found to be overexpressed in breast carcinoma. Its potential use as a biomarker was suggested. Cyclin D1 is ... Cyclin D1 and the mechanisms it regulates have the potential to be a therapeutic target for cancer drugs: Cyclin D1 has been ...
*  Mir-503 microRNA precursor family
Jiang, Q.; Feng, M. G.; Mo, Y. Y. (2009). "Systematic validation of predicted microRNAs for cyclin D1". BMC Cancer. 9: 194. doi ...
*  MYBL2
It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. ... Horstmann S, Ferrari S, Klempnauer KH (Jan 2000). "Regulation of B-Myb activity by cyclin D1". Oncogene. 19 (2): 298-306. doi: ... The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses ... MYBL2 has been shown to interact with: CDK9, CREB-binding protein, Cyclin A1, Cyclin-dependent kinase inhibitor 1C EP300, PARP1 ...
*  MIR503
Jiang Q, Feng MG, Mo YY (2009). "Systematic validation of predicted microRNAs for cyclin D1". BMC Cancer. 9: 194. doi:10.1186/ ...
*  Estrogen receptor alpha
AKAP13 AHR BRCA1 CAV1 CCNC CDC25B CEBPB COBRA1 COUP-TFI CREBBP CRSP3 Cyclin D1 DDX17 DDX5 DNTTIP2 EP300 ESR2 FOXO1 GREB1 GTF2H1 ... "CDK-independent activation of estrogen receptor by cyclin D1". Cell. 88 (3): 405-15. doi:10.1016/S0092-8674(00)81879-6. PMID ... also a D1-like receptor full agonist (R,R)-Tetrahydrochrysene ((R,R)-THC) - actually not selective over ER╬▓, but rather an ... a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation ...
*  Androgen receptor
Cyclin D1, Cyclin-dependent kinase 7, DACH1, Death associated protein 6, L-DOPA, EFCAB6, Epidermal growth factor receptor, ... Reutens AT, Watanabe G, Albanese C, McPhaul MJ, Balk SP, Pestell RG (1998). "Cyclin D1 binds activating mutants of the androgen ... "Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)- ... "A central domain of cyclin D1 mediates nuclear receptor corepressor activity". Oncogene. 24 (3): 431-44. doi:10.1038/sj.onc. ...
*  Waun Ki Hong
Cyclin D1 and cancer development in laryngeal premalignancy patients. Cancer Prev Res (Phila) 2(1):14-21, 2009. Spitz MR, Hong ...
*  Akt/PKB signaling pathway
Akt promotes cyclin D1 translation via indirect activation of mTOR. mTOR increases translation of cyclin D1 by activating ... This prevents the phosphorylation and degradation of cyclin D1. Therefore, Akt promotes G1 phase progression in a positive ... Alao JP (2007). "The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic ... Akt both indirectly and directly regulates cyclin-dependent kinase (CDK) inhibitors p21Cip1 and p27Kip1 , allowing cell cycle ...
*  Genome instability
Mantle cell lymphoma is characterized by fusion of cyclin D1 to the immunoglobulin locus. Cyclin D1 inhibits Rb, a tumor ...
*  Parathyroid adenoma
Hsi ED, Zukerberg LR, Yang WI, Arnold A (May 1996). "Cyclin D1/PRAD1 expression in parathyroid adenomas: an immunohistochemical ... Parathyroid adenoma can be associated with overexpression of the cyclin D1 gene. Hyperparathyroidism is confirmed by blood ...
*  MyoD
Both MyoD and pRb are necessary for the repression of cyclin D1, but rather than acting directly on cyclin D1, they act on Fra- ... and thus cyclin D1) as either MyoD or pRb on its own is not sufficient alone to induce cyclin D1 repression and thus cell cycle ... This is done through regulation of the Cyclin, Cyclin D1. Cell cycle arrest (in which myoblasts would indicate the conclusion ... Zhang JM, Wei Q, Zhao X, Paterson BM (February 1999). "Coupling of the cell cycle and myogenesis through the cyclin D1- ...
*  HSP90AB1
Yano M, Naito Z, Yokoyama M, Shiraki Y, Ishiwata T, Inokuchi M, Asano G (Mar 1999). "Expression of hsp90 and cyclin D1 in human ... For example, the co-chaperone CDC37 (cell division cycle 37) stabilizes the cell cycle regulatory proteins CDK4 (cyclin ...
*  Mitogen
P53, combined with the Ras pathway, downregulate cyclin D1, a cyclin-dependent kinase if they are not stimulated by the ... In the presence of mitogens, sufficient cyclin D1 can be produced. This process cascades onwards, producing other cyclins which ... and depends on cyclins to be passed. One of the most important of these is TP53, a gene which produces a family of proteins ... Required throughout the Mitogen Stimulation Phase of the Cell Cycle and Mediates the Anchorage-dependent Expression of Cyclin ...
*  TAF1
Adnane J, Shao Z, Robbins PD (January 1999). "Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1- ... Siegert JL, Rushton JJ, Sellers WR, Kaelin WG, Robbins PD (November 2000). "Cyclin D1 suppresses retinoblastoma protein- ...
*  G1/S transition
Fadila G, Jinho H, Vaddadi N, Abbas T (2015). "Novel regulation of cyclin D1 stability and the DNA damage response". ... Cyclin E either phosphorylates more pRb to further activate E2F and promote the expression of more Cyclin E, or it has the ... Alao JP (April 2007). "The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic ... In mid to late G1 phase, cyclin D bound to Cdk4/6 activates the expression of the S phase cyclin-Cdk components; however, the ...
*  Intranodal palisaded myofibroblastoma
Immunostains for smooth muscle actin and cyclin D1 are characteristically positive. The main histologic differential diagnosis ...
*  Endostatin
It reduces the growth of new cells by inhibiting cyclin D1. As a result, cells arrest during G1 phase and enter apoptosis. ... "Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1". J. Biol. Chem. 277 (19): 16464-9. doi: ...
*  Splenic marginal zone lymphoma
Mantle cell lymphoma is excluded due to the lack of CD5 and cyclin-D1 expression. Clonal rearrangements of the immunoglobulin ... July 1998). "Absence of cyclin D1 protein expression in splenic marginal zone lymphoma". Mod. Pathol. 11 (7): 601-6. PMID ... November 1999). "Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q ...
*  Mantle cell lymphoma
A defining characteristic of MCL is mutation and overexpression of cyclin D1, a cell cycle gene, that contributes to the ... MCL cells generally over-express cyclin D1 due to a t(11:14) chromosomal translocation in the DNA. Specifically, the ... cyclin D1 is expressed but it may not be required. The workup for Mantle cell lymphoma is similar to the workup for many ...
*  HDAC3
Lin HM, Zhao L, Cheng SY (August 2002). "Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors". J. Biol ... "A central domain of cyclin D1 mediates nuclear receptor corepressor activity". Oncogene. 24 (3): 431-44. doi:10.1038/sj.onc. ...
*  Cyclin-dependent kinase 4
Zhang JM, Wei Q, Zhao X, Paterson BM (1999). "Coupling of the cell cycle and myogenesis through the cyclin D1-dependent ... Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 ... 1993). "Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent ... 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. ...
*  CCNDBP1
Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene. This gene was identified by the ... CCNDBP1 has been shown to interact with GRAP2 and Cyclin D1. GRCh38: Ensembl release 89: ENSG00000166946 - Ensembl, May 2017 ... "Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1". Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (Jul 2000). "GCIP, ... The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce ...
*  Polyomaviridae
"Induction of cyclin D1 by simian virus 40 small tumor antigen". Proceedings of the National Academy of Sciences of the United ...
*  FBXO4
"Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-╬▒Bcrystallin complex". Mol. Cell. 24 (3): 355-66. doi: ...
*  Tsao George Sai Wah
Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells. Proc.Natl.Acad.Sci.U.S.A 109, E3473- ...
*  Cyclopentenone prostaglandins
Cyclin D1, Cdk4, and Insulin-like growth factor 1; and e) regulating agents such as HSP70, GPR78, Gadd153, Ubiquitin B, and ...