... is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with ... Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds ... Cyclin B2 has been shown to interact with TGF beta receptor 2. Cyclin B GRCh38: Ensembl release 89: ENSG00000157456 - Ensembl, ... "Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero". Proc. Natl. Acad. Sci. U.S.A. ...

"Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function". The Journal of Biological Chemistry. ...

"Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function". J. Biol. Chem. 278 (9): 6642-50. doi: ...

Specifically, miR-427 targets include cell cycle regulators such as Cyclin A1 and Cyclin B2. Lee MT, Bonneau AR, Takacs CM, ...

Gong D, Ferrell JE (Sep 2010). "The roles of cyclin A2, B1, and B2 in early and late mitotic events". Mol. Biol. Cell. 21 (18 ... Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is ... Cyclin A2 belongs to the cyclin family, whose members regulate cell cycle progression by interacting with CDK kinases. Cyclin ... The cyclin A2-CDK2 complex eventually phosphorylates E2F, turning off cyclin A2 transcription. E2F promotes cyclin A2 ...

It is known that cyclin B1 can compensate for loss of both cyclin B2 (and vice versa in Drosophila). Saccharomyces cerevisiae ... FoxM1 and B-Myb by upstream G1 and G1/S cyclin-CDK complexes. Increased levels of cyclin B1 cause rising levels of cyclin B1- ... In vertebrates, there are five cyclin B isoforms (B1, B2, B3, B4, and B5), but the specific role of each of these isoforms in ... However, cyclin A2/CDK complexes do not function strictly as activators of cyclin B1/CDK1 in G2, as CDK2 has been shown to be ...

"Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi ... "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction". EMBO J. 19 (6): 1378-88. doi: ... G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein ... Like all cyclins, levels of cyclin B1 oscillate over the course of the cell cycle. Just prior to mitosis, a large amount of ...

... differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsets". ... Cyclins function as regulators of cyclin-dependent kinases. Different cyclins exhibit distinct expression and degradation ... Brooks AR, Shiffman D, Chan CS, Brooks EE, Milner PG (Apr 1996). "Functional analysis of the human cyclin D2 and cyclin D3 ... "The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2". The ...

... followed by a buildup of cyclin B2 (CLB2) protein (resulting from increased CLB2 mRNA concentration that codes for the CLB2 ...

... cyclin B2, Nek2 and CENPF, and plays an important role in maintenance of chromosomal segregation and genomic stability. FOXM1 ...

... has been shown to interact with: AP2B1, Cyclin B2, Endoglin, Heat shock protein 90kDa alpha (cytosolic), ... "Functional association of TGF-beta receptor II with cyclin B". Oncogene. 18 (1): 269-75. doi:10.1038/sj.onc.1202263. PMID ...

Cyclin B1 and B2 can localize Cdk1 to the nucleus and the Golgi, respectively, through a localization sequence outside the CDK- ... CDK6; cyclin D1, cyclin D2, cyclin D3 CDK7; cyclin H CDK8; cyclin C CDK9; cyclin T1, cyclin T2a, cyclin T2b, cyclin K CDK10 ... cyclin A, cyclin B CDK2; cyclin A, cyclin E CDK3; cyclin C CDK4; cyclin D1, cyclin D2, cyclin D3 CDK5; CDK5R1, CDK5R2. See also ... Furthermore, cyclin binding determines the specificity of the cyclin-CDK complex for particular substrates. Cyclins can ...

... 1 Cyclin B2 PDB: 2B9R​; Petri, E.T.; Errico, A.; Escobedo, L.; Hunt, T. & Basavappa, R. (2007). "The crystal structure ... Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the ... Because cyclin B is necessary for cells to enter mitosis and therefore necessary for cell division, cyclin B levels are often ... The fact that cyclin B is often disregulated in cancer cells makes cyclin B an attractive biomarker. Many studies have been ...

Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes ... This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers ... associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". ... associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". ...

The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B1, B2) ... After phosphorylation by cyclin B/Cdk1, the nuclear lamina depolymerises and B-type lamins stay associated with the fragments ... The major types are LI and LII, which are considered homologs of lamin B1 and B2. LA are considered homologous to lamin A and ... Lamin B1 reaches the highest expression level, whereas the expression of B2 is relatively constant in the early stages and ...

Rapamycin induces dephosphorylation of 4EBP1 as well, resulting in an increase in p27 and a decrease in cyclin D1 expression. ... Example of these growth factors are angiopoietin 1 (ANG1), ANG 2, basic fibroblast growth factor (bFGF), ephrin-B2, vascular ...

... Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin- ... type B2/B3. When combined with low p27 and high p53, DFS (Disease-Free Survival) decreases. p21 mediates the resistance of ... Yam CH, Ng RW, Siu WY, Lau AW, Poon RY (January 1999). "Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein ... Cyclin-Dependent+Kinase+Inhibitor+p21 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Drosophila ...

By contrast, the roles of the B2 and B3 elements are less clear. The B2 region is similar to the ACS in sequence and has been ... In S-phase, Dbf4-dependent kinase (DDK) and Cyclin-dependent kinase (CDK) phosphorylate several Mcm2-7 subunits and additional ... These ARS regions are approximately 100-200 bp long and exhibit a multipartite organization, containing A, B1, B2, and ... Wilmes GM, Bell SP (January 2002). "The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific ...

... and the iridoid glycosides scyphiphorin A1-A2 and scyphiphorin B1-B2. Alvocidib is a synthetic analog of rohitukine that acts ... "Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors". J. ...

... cyclin D1. The recruitment of TLS to the promoter of cyclin D1 is directed by long ncRNAs expressed at low levels and tethered ... Many of the ncRNAs that interact with general transcription factors or RNAP II itself (including 7SK, Alu and B1 and B2 RNAs) ... Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q (October 2003). "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA ... Espinoza CA, Allen TA, Hieb AR, Kugel JF, Goodrich JA (September 2004). "B2 RNA binds directly to RNA polymerase II to repress ...

... cyclin a MeSH D23.348.353.120 - cyclin b MeSH D23.348.353.161 - cyclin d1 MeSH D23.348.353.180 - cyclin e MeSH D23.348.383.110 ... ephrin-b2 MeSH D23.348.479.500.800 - ephrin-b3 MeSH D23.348.479.750 - fibroblast growth factors MeSH D23.348.479.750.110 - ... thromboxane b2 MeSH D23.469.050.300 - histamine MeSH D23.469.050.375 - kinins MeSH D23.469.050.375.110 - bradykinin MeSH ...

... a G-protein coupled receptor Resolvin D2 Cyclin D2 (CCND2) Vitamin D2, or ergocalciferol D02, the ICD-10 code for carcinoma in ... a standard paper size between B2 and A1 D2 Subway, a planned Dallas, Texas light rail tunnel 2D (disambiguation) DII ( ...

... cyclin-dependent kinase 5 MeSH D12.644.360.250.067.900 - cyclin-dependent kinase 9 MeSH D12.644.360.250.323 - cyclin-dependent ... ephrin-b2 MeSH D12.644.276.500.800 - ephrin-b3 MeSH D12.644.276.625 - epidermal growth factor MeSH D12.644.276.750 - fibroblast ... kinase 2 MeSH D12.644.360.250.451 - cyclin-dependent kinase 4 MeSH D12.644.360.250.515 - cyclin-dependent kinase 6 MeSH D12.644 ... cyclin-dependent kinases MeSH D12.644.360.250.067 - cdc2-cdc28 kinases MeSH D12.644.360.250.067.249 - cdc2 protein kinase MeSH ...

"ERBB2 erb-b2 receptor tyrosine kinase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-06-14. " ... ISBN 978-1-259-64403-0. Le XF, Pruefer F, Bast RC (January 2005). "HER2-targeting antibodies modulate the cyclin-dependent ...

The TRIpartite motif consists of a zinc RING finger, two zinc binding domains, termed the B1 and B2 boxes, and an RBCC ... Marcello A, Ferrari A, Pellegrini V, Pegoraro G, Lusic M, Beltram F, Giacca M (May 2003). "Recruitment of human cyclin T1 to ... Promyelocytic leukemia protein has been shown to interact with: ANKRD2, CREB-binding protein, Cyclin T1, Death associated ...

"Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2 ... by driving the degradation of mitotic CDK1 activating cyclin subunits). Furthermore, βTrCP controls APC/C by targeting REST, ...

"Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2 ... by driving the degradation of mitotic CDK1 activating cyclin subunits). Furthermore, βTrCP controls APC/C by targeting REST, ...

"Entrez Gene: ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog ( ... "Estrogen and progesterone promote breast cancer cell proliferation by inducing cyclin G1 expression". Brazilian Journal of ...