Lei S, Jackson MF, Jia Z, Roder J, Bai D, Orser BA, MacDonald JF (June 2000). "Cyclic GMP-dependent feedback inhibition of AMPA ...

... 's function is related to two substances: cyclic AMP and cyclic GMP. They are derivatives of ATP and GTP, respectively, ... Mattsson, Hillevi (1980). "Bicyclic phosphates increase the cyclic GMP level in rat cerebellum, presumably due to reduced GABA ... GMP levels for all doses were relatively similar. They spiked after dosage, but each dose produced a similar sized spike. AMP ... Through testing a variety of doses of IPTBO on mice, researchers were able to study the corresponding effect on AMP and GMP ...

... cyclic di-GMP. At low cyclic di-GMP concentration, P. aeruginosa has a free-swimming mode of life. But when cyclic di-GMP ... and cyclic di-GMP form a positive feedback loop. PSL stimulates cyclic di-GMP production, while high cyclic di-GMP turns on the ... The intracellular concentration of cyclic di-GMP increases within seconds when P. aeruginosa touches a surface (e.g.: a rock, ... Recent studies have shown that the dispersed cells from P. aeruginosa biofilms have lower cyclic di-GMP levels and different ...

GMP can also exist as a cyclic structure known as cyclic GMP. Within certain cells the enzyme guanylyl cyclase makes cGMP from ... GMP was originally identified as the umami substance in dried shiitake mushroom. The drying process significantly increases GMP ... GMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase guanine; hence it is a ribonucleoside ... Guanosine monophosphate (GMP), also known as 5′-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide ...

"Nitric Oxide Regulation of Cyclic di-GMP Synthesis and Hydrolysis inShewanella woodyi". Biochemistry. 51 (10): 2087-2099. doi: ...

"Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases". Science Immunology. 8 (79): eabp9765. ...

Cyclic-GMP activates protein kinase G, which causes reuptake of Ca2+ and the opening of calcium-activated potassium channels. ... Krawutschke, Christian; Koesling, Doris; Russwurm, Michael (September 2015). "Cyclic GMP in Vascular Relaxation: Export Is of ... which increases the cGMP concentration by inhibiting the conversion to GMP. Nitric oxide (NO) contributes to vessel homeostasis ... activating guanylate cyclase and increasing intracellular levels of cyclic-guanosine 3',5'-monophosphate (cGMP). The elevation ...

Cyclic-di-GMP signaling had also been involved in the regulation of antimicrobial peptide resistance in Pseudomonas aeruginosa ... May 2013). "Bis-(3'-5')-cyclic dimeric GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa". Antimicrobial ... oral cyclic peptide Telavancin, bacterial infection, IV Vancomycin, bacterial infection, IV. Guavanin 2, bacterial infection ... cyclic peptide) Dalbavancin, bacterial infections, IV Daptomycin, bacterial infections, IV Enfuvirtide, HIV, subcutaneous ...

Murad, Ferid (1994). "The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication ... "Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/C 3T3 fibroblasts by a cyclic GMP- ... molecule that mediated vasodilation by binding to the heme cofactor in the enzyme soluble guanylyl cyclase to produce cyclic ...

Cyclic GMP stimulates Ca2+ uptake by rod outer segments disks in such media. Transduction heats in retinal rods: tests of the ... George, J. S.; Hagins, W. A. (May 26, 1983). "Control of Ca2+ in rod outer segment disks by light and cyclic GMP". Nature. 303 ... Control of Ca2+ in rod outer segment disks by light and cyclic GMP - Experiments are performed to show the required Ca2+ ...

Oettrich JM, Dao VT, Frijhoff J, Kleikers P, Casas AI, Hobbs AJ, Schmidt HH (April 2016). "Clinical relevance of cyclic GMP ...

Pugh, E. N. Jr.; Lamb, T. D. (1990). "Cyclic GMP and calcium: The internal messengers of excitation and adaptation in ...

Example- Cobalamine biosynthesis, Cyclic AMP-GMP switch, lysin biosynthesis, glycine biosynthesis, fluroide switch etc. These ...

Cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide (CDN) and the first to be found in metazoans. Other CDNs (c-di-GMP and c-di-AMP ... Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). ... specifically by the cyclic-GMP-AMP synthase (cGAS). Upon DNA recognition, cGAS dimerizes and stimulates the formation of cyclic ... PDB: 4O6A​ Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ (February 2013). "Cyclic GMP-AMP is an endogenous second messenger ...

C-di-GMP, cyclic diguanosine monophosphate, the second messenger in cells, is widespread in and unique to the bacterial kingdom ... c-di-GMP complex from Vibrio cholerae shows c-di-GMP contacting seven of nine strongly conserved residues. Binding of c-di-GMP ... Wolfe, AJ; Visick, KL (Jan 2008). "Get the message out: cyclic-Di-GMP regulates multiple levels of flagellum-based motility". ... PilZ is a c-di-GMP binding domain and PilZ domain-containing proteins represent the best studied class of c-di-GMP effectors. ...

... reducing cyclic GMP degradation. Endothelin receptor antagonist, another class of drugs used in PAH "Prescription medicines: ... NO binds to soluble guanylate cyclase (sGC) and mediates the synthesis of the secondary messenger cyclic guanosine ...

Pugh, E.N., Jr.; Lamb, T.D. (1990). "Cyclic GMP and calcium: The internal messengers of excitation and adaptation in vertebrate ... Sensitivity to light is modulated by changes in intracellular calcium ions and cyclic guanosine monophosphate. The sensitivity ...

Examples of second messenger molecules include cyclic AMP, cyclic GMP, inositol triphosphate, diacylglycerol, and calcium. ... He found that epinephrine had to trigger a second messenger, cyclic AMP, for the liver to convert glycogen to glucose. The ... Secondary messenger systems can be synthesized and activated by enzymes, for example, the cyclases that synthesize cyclic ... important feature of the second messenger signaling system is that second messengers may be coupled downstream to multi-cyclic ...

"Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles". ...

... cyclic GMP, that diffuses into the oocyte through the gap junctions. In the oocyte, cyclic GMP prevents the breakdown of cyclic ... "Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte". Development. 136 (11): ... The cyclic GMP is produced by the guanylyl cyclase NPR2. As follicles grow, they acquire receptors for luteinizing hormone, a ... Luteinizing hormone acts on receptors in the outer layers of granulosa cells of the follicle, causing a decrease in cyclic GMP ...

"Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment". Nature. 313 (6000): 310-3. ... Cyclic nucleotide gated channel alpha-subunits include Cyclic nucleotide-gated channel alpha 1 Cyclic nucleotide-gated channel ... Cyclic nucleotide-gated ion channels or CNG channels are ion channels that function in response to the binding of cyclic ... They are directly activated by cyclic nucleotides, and approximately 4 cyclic nucleotides are needed to activate each channel. ...

Komalavilas P, Lincoln TM (Mar 1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent ... "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell ...

Komalavilas P, Lincoln TM (Mar 1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent ...

Lawrence DW, Pryzwansky KB (2001). "The vasodilator-stimulated phosphoprotein is regulated by cyclic GMP-dependent protein ... VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. Vasodilator-stimulated phosphoprotein has been shown ... Halbrügge M, Eigenthaler M, Polke C, Walter U (1992). "Protein phosphorylation regulated by cyclic nucleotide-dependent protein ...

... increases cyclic GMP levels in the brain and liver by activation of guanylate cyclase. Sodium azide solutions ... Kimura, Hiroshi; Mittal, Chandra K.; Murad, Ferid (1975-10-23). "Increases in cyclic GMP levels in brain and liver with sodium ...

"Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel". Nature. ... Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein. Heterologously ... Chen, T.-Y.; Peng, Y.-W.; Dhallan, R. S.; Ahamed, B.; Reed, R. R.; Yau, K.-W. (April 1993). "A new subunit of the cyclic ... "Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1". Ncbi.nlm.nih.gov. Retrieved 2016-08-02. Kaupp, U. Benjamin; ...

"Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning". Nature. 423 (6943): 990-5 ...

... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ...

Méry PF, Pavoine C, Pecker F, Fischmeister R (July 1995). "Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated ... Podzuweit T, Nennstiel P, Müller A (September 1995). "Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide ...

... (EC 3.1.4.52, cyclic bis(3′→5')diguanylate phosphodiesterase, c-di-GMP-specific ... "Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP". J. Biol. ... Cyclic-guanylate-specific+phosphodiesterase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... Schmidt, A.J.; Ryjenkov, D.A.; Gomelsky, M. (2005). "The ubiquitous protein domain EAL is a cyclic diguanylate-specific ...