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*  Biological functions of hydrogen sulfide
"Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype". Journal of Vascular Research. 34 (4): 245 ... Lincoln, T. M.; Cornwell, Taylor (March 1990). "cGMP-dependent protein kinase mediates the reduction of Ca2+ by cAMP in ... increased cGMP triggers an increase in protein kinase G (PKG) activity. PKG reduces intracellular Ca2+ in vascular smooth ... "Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent ...
*  Gaseous signaling molecules
"Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype". Journal of Vascular Research. 34 (4): 245 ... which is a heterodimeric enzyme with subsequent formation of cyclic-GMP. Cyclic-GMP activates protein kinase G, which causes ... Lincoln, T. M.; Cornwell, Taylor (March 1990). "cGMP-dependent protein kinase mediates the reduction of Ca2+ by cAMP in ... Ethylene is perceived by a family of five transmembrane protein dimers such as the ETR1 protein in Arabidopsis. The gene ...
*  PPP1R17
A Purkinje cell substrate of the cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 274 (6): 3485-95. ... a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells". Proceedings of the ... Hall KU, Collins SP, Gamm DM, Massa E, DePaoli-Roach AA, Uhler MD (Feb 1999). "Phosphorylation-dependent inhibition of protein ... Protein phosphatase 1 regulatory subunit 17 is a protein that in humans is encoded by the PPP1R17 gene. GRCh38: Ensembl release ...
*  ITPR1
5-trisphosphate receptor by cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 269 (12): 8701-7. PMID ... Hirota J, Ando H, Hamada K, Mikoshiba K (Jun 2003). "Carbonic anhydrase-related protein is a novel binding protein for inositol ... ITPR1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) GeneReviews/NCBI/NIH/UW entry on ... Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene. ITPR1 has been shown to ...
*  Vasodilator-stimulated phosphoprotein
"The vasodilator-stimulated phosphoprotein is regulated by cyclic GMP-dependent protein kinase during neutrophil spreading". J. ... "Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human ... 2000). "KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial ... VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. Vasodilator-stimulated phosphoprotein has been shown ...
*  Nicorandil
Vrolix, M; Raeymaekers, L; Wuytack, F; Hofmann, F; Casteels, R (Nov 1, 1988). "Cyclic GMP-dependent protein kinase stimulates ... "Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular ... Nicorandil stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). cGMP activates protein kinase G (PKG), ... including increased Rho-kinase activity. Increased levels of Rho-kinase inhibit myosin phosphatase activity, leading to ...
*  PRKG1
"Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell ... of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha". ... 5-trisphosphate receptor by cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 269 (12): 8701-7. PMID ... cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene. PRKG1 has been shown ...
*  Thromboregulation
In vivo phosphorylation of thromboxane by cyclic GMP-dependent protein kinase" (PDF). Journal of the Salk Institute for ... Nitric oxide (NO) stimulates cGMP production and therefore the activation cGMP-dependent protein kinase (G kinase). This kinase ... cAMP, cyclic adenosine monophosphate, phosphorylate messengers via protein kinase A (PKA). These signaling elements include ... Siess, Wolfgang; Eduardo, Lapetina (1990). "Functional relationship between cyclic AMP-dependent protein phosphorylation and ...
*  CGMP-dependent protein kinase
EC 2.7.11.12 Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System cGMP-Dependent Protein Kinases at the US ... cGMP-dependent protein kinase or Protein Kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP ... "A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of ... "Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor ...
*  FHOD1
... is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells". J. Biol. Chem. 279 ( ... FH1/FH2 domain-containing protein 1 is a protein that in humans is encoded by the FHOD1 gene. This gene encodes a protein which ... The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. ... It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. FHOD1 has been shown to interact ...
*  Discovery and development of phosphodiesterase 5 inhibitors
Cyclic GMP binds to the cGMP-dependent protein kinase (PKG1) which phosphorylates several proteins that results in decreased ... cGMP binding proteins and protein kinase G (PKG). The effect on PKG reduces levels of calcium leading to relaxation of smooth ... Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine ... PDEs are enzymes that hydrolyze cyclic adenosine 3,5-monophosphate (cAMP) and cyclic guanosine 3,5-monophospahate (cGMP), which ...
*  Min Zhuo
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal potentiation and pain ... 10;74(3):517-29 Saywell SA, Babiec WE, Neverova NV, Feldman JL (2010) Protein kinase G-dependent mechanisms modulate ... Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature 368, 635-639. Zhuo, M., Hu, Y., ... Schultz, C., Kandel, E. R., and Hawkins, R. D. (1994). Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term ...
*  Biological functions of nitric oxide
... cyclic GMP) from guanosine triphosphate (GTP). The soluble cGMP activates cyclic nucleotide-dependent protein kinase G (PKG or ... PKG is a kinase that phosphorylates a number of proteins that regulate calcium concentrations and calcium sensitization, ... The neuronal enzyme (NOS-1) and the endothelial isoform (NOS-3) are calcium-dependent and produce low levels of this gas as a ... NO production by eNOS is dependent on calcium-calmodulin and other cofactors. NO diffuses into the smooth muscle cells of the ...
*  List of MeSH codes (D12.644)
... cyclic gmp-dependent protein kinases MeSH D12.644.360.200.575 --- protamine kinase MeSH D12.644.360.250 --- cyclin-dependent ... cyclic nucleotide-regulated protein kinases MeSH D12.644.360.200.125 --- cyclic amp-dependent protein kinases MeSH D12.644. ... map kinase kinase kinase 1 MeSH D12.644.360.400.200 --- map kinase kinase kinase 2 MeSH D12.644.360.400.300 --- map kinase ... kinase kinase 3 MeSH D12.644.360.400.400 --- map kinase kinase kinase 4 MeSH D12.644.360.400.500 --- map kinase kinase kinase 5 ...
*  Haemodynamic response
... inducing a signaling cascade that results in the activation of cGMP-dependent protein kinase (PKG) and an ultimate decrease in ... In addition to this, it has already been shown that NO stimulates increased cyclic GMP (cGMP) levels in the smooth muscle cells ... When these proteins are active, they turn on SREBP2 which inhibits LRP-1. LRP-1 helps the brain remove amyloid beta. Therefore ... Two proteins are involved in this accumulation of amyloid beta: serum response factor or SRF and myocardin. Together, these 2 ...
*  Cyclic nucleotide
... where it stimulates a protein kinase called cyclic AMP-dependent protein kinase. By phosphorylating proteins, cyclic AMP- ... G proteins). The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) ... Eckly-Michel A, Martin V, Lugnier C (September 1997). "Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP ... Wolter S, Golombek M, Seifert R (December 2011). "Differential activation of cAMP- and cGMP-dependent protein kinases by cyclic ...
*  Cyclic guanosine monophosphate
cGMP is involved in the regulation of some protein-dependent kinases. For example, PKG (protein kinase G) is a dimer consisting ... Numerous cyclic nucleotide phosphodiesterases (PDE) can degrade cGMP by hydrolyzing cGMP into 5'-GMP. PDE 5, -6 and -9 are cGMP ... cyclic monophosphate (8-Br-cGMP) Francis SH, Corbin JD (August 1999). "Cyclic nucleotide-dependent protein kinases: ... Unlike with the activation of some other protein kinases, notably PKA, the PKG is activated but the catalytic and regulatory ...
*  8-Bromoguanosine 3',5'-cyclic monophosphate
It acts as an activator of cGMP-dependent protein kinases. 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) Rapoport, RM ... "Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP" (Free full text). ... 8-Bromoguanosine 3',5'-cyclic monophosphate is a brominated derivative of cyclic guanosine monophosphate (cGMP). ...
*  List of MeSH codes (D08)
... beta-adrenergic-receptor kinase MeSH D08.811.913.696.620.682.700.150.150 --- cyclic gmp-dependent protein kinases MeSH D08.811. ... cyclic nucleotide-regulated protein kinases MeSH D08.811.913.696.620.682.700.150.125 --- cyclic amp-dependent protein kinases ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 2 MeSH D08.811.913.696.620.682.700.559.300 --- map kinase kinase kinase 3 MeSH D08.811.913.696.620.682 ...
*  Biochemical cascade
"Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes". Biology of ... These proteins activate protein tyrosine kinase (PTK) that phosphorylates various proteins important for capacitation and ... Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase) regulates gene transcription through successive kinase ... "Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte". Development. 136 (11): ...
*  CREB1
"Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (Jul 1996). "Calmodulin-dependent protein kinase II potentiates ... The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal ... This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein ...
*  Nitric oxide
... which is a heterodimeric enzyme with subsequent formation of cyclic-GMP. Cyclic-GMP activates protein kinase G, which causes ... In plants, nitric oxide can be produced by any of four routes: (i) L-arginine-dependent nitric oxide synthase, (although the ... ADP ribosylation of proteins, protein sulfhydryl group nitrosylation, and iron regulatory factor activation. ·NO has been ... Hemoglobin is a prominent example of a heme protein that may be modified by ·NO by both pathways: ·NO may attach directly to ...
*  Tyrosine hydroxylase
"Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation". ... Roskoski R, Roskoski LM (Jan 1987). "Activation of tyrosine hydroxylase in PC12 cells by the cyclic GMP and cyclic AMP second ... that are phosphorylated by a variety of protein kinases. Ser40 is phosphorylated by the cAMP-dependent protein kinase. Ser19 ( ... is phosphorylated by the calcium-calmodulin-dependent protein kinase. MAPKAPK2 (mitogen-activated-protein kinase-activating ...
*  Calcium in biology
... through a protein kinase C-dependent mechanism". Biochem J. 466 (2): 379-390. doi:10.1042/bj20140881. PMID 25422863. Milo, Ron ... Pugh Jr, E. N.; Lamb, T. D. (1990). "Cyclic GMP and calcium: The internal messengers of excitation and adaptation in vertebrate ... Calcium coordination plays an important role in defining the structure and function of proteins. An example a protein with ... Calcium can bind to several different calcium-modulated proteins such as troponin-C (the first one to be identified) and ...
*  PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene. GRCh38: Ensembl release ... Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/ ... Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A ... 2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood ...
*  Placental growth factor
... cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor". Growth Factors. 19 (3): 193-206. doi: ... Placental growth factor is a protein that in humans is encoded by the PGF gene. Placental growth factor (PGF) is a member of ... Serum levels of PGF and sFlt-1 (soluble fms-like tyrosine kinase-1, also known as soluble VEGF receptor-1) are altered in women ... Shibuya M (April 2008). "Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis". BMB Reports ...