"MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes". ... Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene. The protein encoded by this gene is a putative zinc ... with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines". Jpn. J. Cancer Res. 90 ( ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

Huang W, Zhou X, Lefebvre V, de Crombrugghe B (June 2000). "Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A ... August 1999). "Functional and structural studies of wild type SOX9 and mutations causing campomelic dysplasia". The Journal of ... SOX9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) SOX9 human gene location in the ... The Sox9 protein has been implicated in both initiation and progression of multiple solid tumors. Its role as a master ...

... of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit of L-type voltage-dependent calcium ... Voltage-dependent L-type calcium channel subunit beta-2 is a protein that in humans is encoded by the CACNB2 gene. Mutation in ... Bünemann M, Gerhardstein BL, Gao T, Hosey MM (1999). "Functional regulation of L-type calcium channels via protein kinase A- ... GeneReviews/NIH/NCBI/UW entry on Brugada syndrome CACNB2+protein,+human at the U.S. National Library of Medicine Medical ...

For example, type I and type II cyclic-AMP dependent protein kinases have identical catalytic subunits but different regulatory ... Activation loop Autophosphorylation Ca2+/calmodulin-dependent protein kinase Cell signaling Cyclin-dependent kinase G protein- ... the JAK kinases (a family of protein tyrosine kinases), and the PIP3-dependent kinase cascade were discovered. Kinases are ... For this reason protein kinases are named based on what regulates their activity (i.e. Calmodulin-dependent protein kinases). ...

1996), "Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RIα2C2) with the antigen ... 1991), "Cyclic AMP modulation of human B cell proliferative responses: role of cAMP-dependent protein kinases in enhancing B ... Saxena, M. (1999), "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase", Nat. Cell ... 1993), "Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in ...

... type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5 ... "MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes". ... "Ezrin is a cyclic AMP-dependent protein kinase anchoring protein". The EMBO Journal. 16 (1): 35-43. doi:10.1093/emboj/16.1.35. ... "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent ...

"Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes ... it is a tumor suppressor protein involved in neurofibromatosis type II. Sequence data reveal its similarity to the ERM protein ... protein kinase A, and p21 activated kinases. Work in Drosophila identified Merlin as an upstream regulator of the Hippo tumor ... Merlin is a member of the ERM family of proteins including ezrin, moesin, and radixin, which are in the protein 4.1 superfamily ...

... two sites on glycogen synthetase phosphorylated by cyclic AMP-dependent protein kinase and their dephosphorylation by protein ... Patients with type 2 diabetes normally exhibit low glycogen storage levels because of impairments in insulin-stimulated ... "A reinvestigation of the phosphorylation of rabbit skeletal-muscle glycogen synthase by cyclic-AMP-dependent protein kinase. ... protein kinase A (PKA), and casein kinase 2 (CK2). Each of these protein kinases leads to phosphorylated and catalytically ...

Pan, X, Heitman, J (July 1999). "Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces ... "Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein ... Pan, X, Heitman, J (June 2002). "Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation ... Lorenz, MC, Pan, X, Harashima, T, Cardenas, ME, Xue, Y, Hirsch, JP, Heitman, J (February 2000). "The G protein-coupled receptor ...

In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase). PKA is normally ... are not cAMP-dependent. Further effects mainly depend on cAMP-dependent protein kinase, which vary based on the type of cell. ... Not all protein kinases respond to cAMP. Several classes of protein kinases, including protein kinase C, ... Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the ...

"Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation". ... Tyrosine hydroxylase is also an autoantigen in Autoimmune Polyendocrine Syndrome (APS) type I. A consistent abnormality in ... that are phosphorylated by a variety of protein kinases. Ser40 is phosphorylated by the cAMP-dependent protein kinase. Ser19 ( ... is phosphorylated by the calcium-calmodulin-dependent protein kinase. MAPKAPK2 (mitogen-activated-protein kinase-activating ...

... enzyme called phosphorylase kinase was activated by another kinase that was dependent on the second messenger cyclic AMP (cAMP ... Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes ... The type I R subunits of which there are two isoforms (RIα, and RIβ) bind the catalytic subunits to create the type I PKA ... "Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science. 253 (5018): ...

A-kinase anchor proteins (AKAPs), which target cyclic AMP-dependent protein kinase (PKA) to various sites in the cell. This ... Such as type 4 collagen Shaw, Andrey S.; Filbert, Erin L. (January 2009). "Scaffold proteins and immune-cell signalling". ... Huntingtin protein co-localizes with ATM repair protein at sites of DNA damage. Huntingtin is a scaffolding protein in the ATM ... In three-kinase signaling cascades, scaffolds bind all three kinases, enhancing kinase specificity and restricting signal ...

... cyclic AMP or cAMP), which activates protein kinase A (cAMP-dependent protein kinase). This enzyme, in turn, activates ... It may occur alone or in the context of multiple endocrine neoplasia type 1. Elevated glucagon is the main contributor to ... cAMP binds to protein kinase A, and the complex phosphorylates glyocogen phosphorylase kinase. Phosphorylated glyocogen ... The enzyme protein kinase A (PKA) that was stimulated by the cascade initiated by glucagon will also phosphorylate a single ...

... which in turn produces cyclic AMP (cAMP). Protein kinase A, whose activation is dependent on the increased levels of cAMP, is ... "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel ... The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family ... "Receptor activity modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of ...

By the late 1960s, cyclic AMP-dependent protein kinase had been purified, and most attention was centered on kinases and ... Casein kinase activity was found to be present in most cell types and to be associated with multiple enzymes. The type 1 casein ... "Synergistic phosphorylation of rabbit muscle glycogen synthase by cyclic AMP-dependent protein kinase and casein kinase I. ... Hanks SK, Hunter T (May 1995). "Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain ...

Through these studies, the cyclic AMP-dependent protein kinase A signaling has been identified as a key mediator of cortisol ... A 2018 Cochrane Systematic review compared two different types of surgery: laparoscopic retroperotenial adrenalectomy and ... and the mutations associated with the dysregulation of cyclic AMP - protein kinase A pathways have been implicated in the ... The term "Cushing's disease" refers specifically to "secondary hypercortisolism" classified as "ACTH-dependent Cushing's ...

Expression of the promoter is shown to be induce by phorbol esters and cyclic-AMP-dependent protein kinase signaling. The four ... Circadian clocks dysregulation is associated with many types of cancer. PFKFB3 expression exhibits circadian rhythmicity that ... due to phosphorylation of Ser-460 by PKA or AMP-dependent protein kinase. The high '2-Kase' activity of PFKFB3 is also due to ... September 2009). "Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases ...

AMP-activated protein kinase). Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent ... As protein expression varies from cell type to cell type, the proteins that are available for phosphorylation will depend upon ... protein kinase A (PKA) is a family of serine-threonine kinase whose activity is dependent on cellular levels of cyclic AMP ( ... Cyclic+AMP-Dependent+Protein+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Drosophila cAMP- ...

Guild BC, Strominger JL (1984). "HLA-A2 antigen phosphorylation in vitro by cyclic AMP-dependent protein kinase. Sites of ... cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. cAMP ... sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase ... "Entrez Gene: PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)". Huang LJ, ...

Gαs activates the cAMP-dependent pathway by stimulating the production of cyclic AMP (cAMP) from ATP. This is accomplished by ... The specific mechanisms, however, differ between protein types. Receptor-activated G proteins are bound to the inner surface of ... cAMP can then act as a second messenger that goes on to interact with and activate protein kinase A (PKA). PKA can ... 5 Gβ proteins, and 12 Gγ proteins. G protein can refer to two distinct families of proteins. Heterotrimeric G proteins, ...

cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene. Cyclic AMP- ... 1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix". J. Virol. ... 1998). "Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal ... "Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells". Protein ...

Mayeenuddin LH, Garrison JC (January 2006). "Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the ... August 2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome ... 5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the PREX1 gene. The protein encoded ... March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human ...

... where it stimulates a protein kinase called cyclic AMP-dependent protein kinase. By phosphorylating proteins, cyclic AMP- ... Cyclic nucleotides can be found in many different types of eukaryotic cells, including photo-receptor rods and cones, smooth ... Eckly-Michel A, Martin V, Lugnier C (September 1997). "Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP ... G proteins). The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) ...

... nuclear located protein kinase C and cyclic AMP-dependent protein kinase". Frontiers in Bioscience. 13 (13): 1206-1226. doi: ... involved in calcium-mediated activation of protein kinase C; the prostaglandins, which are one type of fatty-acid derived ... Many polyketides are cyclic molecules whose backbones are often further modified by glycosylation, methylation, hydroxylation, ... Parodi AJ, Leloir LF (April 1979). "The role of lipid intermediates in the glycosylation of proteins in the eucaryotic cell". ...

... cyclic AMP receptor - cyclic AMP receptor protein - cyclic AMP-responsive DNA-binding protein - cyclic electron flow - cyclic ... nucleotide - cyclic peptide - cyclin - cyclin A - cyclin B - cyclin E - cyclin-dependent kinase - cycloleucine - cyclosporin - ... IGF type 1 receptor - IGF type 2 receptor - IgG - IgM - immediate-early protein - immune cell - immune system - immunoglobulin ... protein subunit - protein synthesis - protein targeting - protein translocation - protein-tyrosine kinase - protein-tyrosine- ...

... on the catalytic subunit of cyclic AMP-dependent protein kinase in cows as n-tetradecanoyl. Almost simultaneously in Claude B. ... This lipidation event is the most common type of fatty acylation and is present in many organisms, including animals, plants, ... "N-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine ... c-Src is a gene that codes for proto-oncogene tyrosine-protein kinase Src, a protein important for normal mitotic cycling. It ...

Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification ... "A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR". J. ... calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 ... and activation of Ca2+-calmodulin-dependent protein kinase IV by Ca2+-calmodulin-dependent protein kinase Ia kinase. ...

They are Gs/a coupled and can stimulate neurons by indirectly activating cyclic AMP-dependent protein kinase. The DRD1 gene ... It is one of the two types of D1-like receptor family - receptors D1 and D5. It is a protein that in humans is encoded by the ... January 2022). "Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals". International Journal of Molecular ... "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein". Nature Cell Biology. 3 (5): 492- ...

It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and ... is frequently over-expressed and functions as an oncogene in several tumor types". Biochemical Pharmacology. 137: 1-9. doi: ... calmodulin-dependent protein kinase II phosphorylation mechanism". The EMBO Journal. 16 (8): 1943-52. doi:10.1093/emboj/16.8. ... "Phosphorylation by protein kinase C inactivates an inositol 1,4,5-trisphosphate 3-kinase purified from human platelets". ...