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*  PDE4B
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic ... The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a ... "The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family". Gene. 129 (2): 239-47. doi: ... Secchiero P, Zella D, Curreli S, Mirandola P, Capitani S, Gallo RC, Zauli G (Dec 2000). "Pivotal role of cyclic nucleoside ...
*  Cyclic nucleotide
The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic ... where it stimulates a protein kinase called cyclic AMP-dependent protein kinase. By phosphorylating proteins, cyclic AMP- ... Lincoln, TM; Cornwell TL (1991). "Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth ... Eckly-Michel A, Martin V, Lugnier C (September 1997). "Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP ...
*  PDE4C
Sullivan M, Olsen AS, Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene ... "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design ... cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene. PDE4C is ... down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic ...
*  Cyclic AMP receptors
... from slime molds are a distinct family of G-protein coupled receptors. These receptors control development ... In D. discoideum, the cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and ...
*  3',5'-cyclic-AMP phosphodiesterase
... cyclic-AMP 5'-nucleotidohydrolase. This enzyme catalyses the following chemical reaction adenosine 3',5'-cyclic phosphate + H2O ... 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, ... 3',5'-cyclic-AMP phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Lugnier, C.; Keravis, T.; Le Bec, A.; Pauvert, O.; Proteau, S.; Rousseau, E. (1999). "Characterization of cyclic nucleotide ...
*  Cyclic di-AMP
... (also called c-di-AMP and c-di-adenosine monophosphate) is a second messenger used in signal transduction in ... Corrigan, Rebecca (1 July 2013). "Cyclic di-AMP: another second messenger enters the fray". Nature Reviews Microbiology. doi: ... Cyclic di-GMP Dey, Bappaditya (2 March 2015). "A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and ...
*  Cyclic GMP-AMP synthase
"Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase". Cell. 153 (5 ... Gao, D; Wu, J; Wu, YT; Du, F; Aroh, C; Yan, N; Sun, L; Chen, ZJ (Aug 23, 2013). "Cyclic GMP-AMP synthase is an innate immune ... Wu, J; Sun, L; Chen, X; Du, F; Shi, H; Chen, C; Chen, ZJ (Dec 20, 2012). "Cyclic GMP-AMP is an endogenous second messenger in ... Sun, L; Wu, J; Du, F; Chen, X; Chen, ZJ (Dec 20, 2012). "Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the ...
*  Lac operon
Botsford, J L; Harman, J G (March 1992). "Cyclic AMP in prokaryotes". Microbiological Reviews. 56 (1): 100-122. ISSN 0146-0749 ... Montminy, M. (1997). "Transcriptional regulation by cyclic AMP". Annual Review of Biochemistry. 66: 807-822. doi:10.1146/ ... Cyclic adenosine monophosphate (cAMP) is a signal molecule whose prevalence is inversely proportional to that of glucose. It ...
*  Pituitary-specific positive transcription factor 1
... and cyclic AMP.[supplied by OMIM] Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2 and ...
*  Anagrelide
Jones GH, Venuti MC, Alvarez R, Bruno JJ, Berks AH, Prince A (February 1987). "Inhibitors of cyclic AMP phosphodiesterase. 1. ...
*  Forskolin
Cyclic AMP acts by activating cAMP-sensitive pathways such as protein kinase A and Epac. The heterocyclic ring is synthesized ... Forskolin is commonly used as a tool in biochemistry to raise levels of cyclic AMP (cAMP) in the study and research of cell ... Adenylyl cyclase Cyclic AMP "Forskolin" (pdf). Sigma Aldrich. Alasbahi, RH; Melzig, MF (January 2012). "Forskolin and ...
*  RAPGEF2
... is a cyclic AMP binding protein. Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP- ...
*  Chlorpyrifos
... likely associated with changes to the cyclic AMP system. Adults may develop lingering health effects following acute exposure ... affect components of the cyclic AMP system; and influence other chemical pathways. The enzyme paraoxonase 1 (PON1) detoxifies ...
*  Earl Wilbur Sutherland Jr.
... was later termed cyclic AMP. Even though the discovery of cyclic AMP and the idea of second messengers were of great importance ... Cyclic AMP)". Circulation 37: 279-306. Robison, G.A.; Sutherland, E.W (1969). "The role of cyclic AMP in the control of ... namely cyclic adenosine monophosphate, or cyclic AMP. Sutherland died on March 9, 1974 in Miami, Florida, at the age of 58. ... Sutherland, Earl W (16 November 1970). "On the Biological Role of Cyclic AMP". The Journal of the American Medical Association ...
*  Gene Shearer
Modulation of inflammation and immunity by cyclic AMP. Science 184: 19 28, 1974. Shearer GM. Cell mediated cytotoxicity to ...
*  RAPGEF3
"Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent ... Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL (Sep 2008). "Structure of Epac2 in complex with a cyclic AMP ... Ponsioen B, Gloerich M, Ritsma L, Rehmann H, Bos JL, Jalink K (May 2009). "Direct spatial control of Epac1 by cyclic AMP". ... Rehmann H, Das J, Knipscheer P, Wittinghofer A, Bos JL (Feb 2006). "Structure of the cyclic-AMP-responsive exchange factor ...
*  Mauthner cell
Bhatt DH, Otto SJ, Depoister B, Fetcho JR (July 2004). "Cyclic AMP-induced repair of zebrafish spinal circuits". Science. 305 ( ...
*  Skin whitening
Rodríguez, Carlos Iván; Setaluri, Vijayasaradhi (2014). "Cyclic AMP (cAMP) signaling in melanocytes and melanoma". Arch. ... MC1R/cAMP signaling pathway: Activation of MC1R causes activation of adenylyl cyclase (AC), which produces cyclic adenosine ... a cyclic guanosine monophosphate (cGMP) analogue) increase melanin synthesis. MC1R ligands: alpha-melanocyte stimulating ... regulates melanogenesis via a cyclic adenosine monophosphate (cAMP)-dependent pathway [references omitted]. When binding to its ...
*  PRKAR1A
Guild BC, Strominger JL (1984). "HLA-A2 antigen phosphorylation in vitro by cyclic AMP-dependent protein kinase. Sites of ... Bourdeau I, Stratakis CA (2002). "Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease". Ann. N. Y. Acad ... transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent ...
*  ARPP-19
"Entrez Gene: ARPP-19 cyclic AMP phosphoprotein, 19 kD". Human ARPP19 genome location and ARPP19 gene details page in the UCSC ...
*  Carla J. Shatz
Stellwagen, David; Shatz, Carla J; Feller, Marla B (1999). "Dynamics of Retinal Waves Are Controlled by Cyclic AMP". Neuron. 24 ...
*  Striatum
Table 1 McDonald, M-L; MacMullen, C; Liu, D J; Leal, S M; Davis, R L (October 2012). "Genetic association of cyclic AMP ...
*  OLR1
Its gene is regulated through the cyclic AMP signaling pathway. The protein binds, internalizes and degrades oxidized low- ...
*  ARPP-21
Cyclic AMP-regulated phosphoprotein, 21 kD, also known as ARPP-21, is a human gene. GRCh38: Ensembl release 89: ENSG00000172995 ... ARPP-21 cyclic AMP-regulated phosphoprotein, 21 kD". Human ARPP21 genome location and ARPP21 gene details page in the UCSC ... a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia". Neuropharmacology. 39 (9): 1637-44. doi:10.1016/s0028- ...
*  Pacemaker current
DiFrancesco, D., Tortora, P. (1991). Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature, 351, ... Another unusual feature of If is its dual activation by voltage and by cyclic nucleotides. Cyclic adenosine monophosphate (cAMP ... The molecular determinants of the pacemaker current belong to the HCN channel (hyperpolarization-activated cyclic nucleotide- ...
*  Olfactory receptor neuron
The activated OR in turn activates the intracellular G-protein, GOLF (GNAL), adenylate cyclase and production of cyclic AMP ( ...
*  GPR6
... up-regulates cyclic AMP levels and promotes neurite outgrowth. Lysophospholipid receptor GRCh38: Ensembl release 89: ... and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry. 282 (14): 10506- ...