Loading...
*  CRKL
Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ...
*  NEDD9
... a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G". J. Biol. Chem. 273 (11): 6446-51. doi: ... CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of ... NEDD9 is a member of the CAS (Crk-associated substrate) protein family, which has 4 members in vertebrates. The other ... Huang Z, Yazdani U, Thompson-Peer KL, Kolodkin AL, Terman JR (2007). "Crk-associated substrate (Cas) signaling protein ...
*  Embryonal fyn-associated substrate
... allowing the CAS protein to function as a scaffold for other proteins including CRK proteins and C3G, a guanine nucleotide ... EFS is a member of the CAS (Crk-Associated Substrate) family of proteins. In humans and mammals, this group consists of four ... Embryonal fyn-associated substrate is a protein that in humans is encoded by the EFS gene. It is also known as CASS3. EFS ( ... In humans, the 561 amino acid EFS protein acts as a scaffolding protein for cell signaling based on interactions with SRC, FAK ...
*  RAPGEF1
... a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G". The Journal of Biological Chemistry. ... The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor- ... a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins ... "The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376-85 ...
*  ABL (gene)
Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes". J. ... Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl ... Yamanashi Y, Baltimore D (January 1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein ...
*  PTK2
... a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes". The ... FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine ... PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by ... The encoded protein is a member of the FAK subfamily of protein tyrosine kinases that included PYK2, but lacks significant ...
*  List of MeSH codes (D12.644)
... crk-associated substrate protein MeSH D12.644.360.024.297 --- grb2 adaptor protein MeSH D12.644.360.024.298 --- grb7 adaptor ... 14-3-3 proteins MeSH D12.644.360.024.318 --- proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins ... rap gtp-binding proteins MeSH D12.644.360.525.475.100 --- rap1 gtp-binding proteins MeSH D12.644.360.525.500 --- ras proteins ... smad5 protein MeSH D12.644.360.024.334.500.800 --- smad8 protein MeSH D12.644.360.024.334.750 --- smad4 protein MeSH D12.644. ...
*  GRB2
Ren R, Ye ZS, Baltimore D (Apr 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". ... the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated ... a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins ...
*  Adapter molecule crk
... a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G". J. Biol. Chem. 273 (11): 6446-51. doi: ... Adapter molecule crk also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene. The CRK ... Oncogene Protein v-crk at the US National Library of Medicine Medical Subject Headings (MeSH) Human CRK genome location and CRK ... Crk Info with links in the Cell Migration Gateway Proto-Oncogene Proteins c-crk at the US National Library of Medicine Medical ...
*  NCK1
Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes". J. ... a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes". J. ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ...
*  CASS4
... (Crk associated substrate 4) is the fourth and last described member of the CAS protein family. CASS4 was detected by ... A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates". The Journal of ... CAS proteins have an amino terminal SH3 domain enabling interaction with poly-proline motif-containing proteins such as FAK. ... Cas scaffolding protein family member 4 is a protein that in humans is encoded by the CASS4 gene. ...
*  FYN
"Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized ... The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. ... Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ...
*  NPHP1
"Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized ... "Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized ... Nephrocystin-1 is a protein that in humans is encoded by the NPHP1 gene. This gene encodes a protein with src homology domain 3 ... "A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile ...
*  BCAR1
Crk-associated substrate) of adaptor proteins which is characterized by the presence of multiple conserved motifs for protein- ... Embryonal Fyn-associated substrate), and CASS4 (Cas scaffolding protein family member 4). These Cas proteins have a high ... BCAR1 is a ubiquitously expressed adaptor molecule originally identified as the major substrate of v-Src and v-Crk . p130Cas/ ... Garton AJ, Flint AJ, Tonks NK (1996). "Identification of p130(cas) as a substrate for the cytosolic protein tyrosine ...
*  PTK2B
This protein has been shown to bind a CRK-associated substrate, a nephrocystin, a GTPase regulator associated with FAK, and the ... The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to ... "Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing sarcoma RNA-binding protein EWS". Curr. Biol. ... Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene. This gene encodes a cytoplasmic ...
*  Dock4
The C-terminus of DOCK proteins interacts with another adaptor protein, Crk. Dock4 undergoes RhoG/ELMO-dependent recruitment to ... this has been shown to promote DOCK-dependent signalling by helping recruit the ELMO-DOCK complex to areas of high substrate ... April 1996). "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane". Mol. Cell ... The adaptor protein ELMO has been shown to bind DOCK proteins and induce a conformational change which relieves the inhibition ...
*  Dock180
September 2007). "A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in ... RhoG recruits the ELMO/Dock180 complex to the plasma membrane thereby bringing Dock180 into contact with its substrate, Rac. In ... November 1998). "Activation of Rac1 by a Crk SH3-binding protein, DOCK180". Genes Dev. 12 (21): 3331-36. doi:10.1101/gad.12.21. ... 1996). "Chromosomal mapping of the gene encoding DOCK180, a major Crk-binding protein, to 10q26.13-q26.3 by fluorescence in ...
*  IRS4
Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene. IRS4 encodes the insulin receptor ... "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II". Endocrinology. 142 ( ... 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. 277 (22): 19439-47. doi:10.1074/jbc. ... 2003). "Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor". ...
*  Integrin
1 The Integrin Protein Talin substrate for calpain - PMAP The Proteolysis Map animation. Integrins at the US National Library ... and Src kinase family members to phosphorylate substrates such as p130CAS thereby recruiting signaling adaptors such as CRK. ... Cells adhere to a substrate through their integrins. During movement, the cell makes new attachments to the substrate at its ... Moreover, talin proteins are able to dimerize and thus are thought to intervene in the clustering of integrin dimers which ...
*  CBL (gene)
... and therefore is able to catalyse the formation of a covalent bond between ubiquitin and Cbl's protein substrate - typically a ... CRK, CRKL, EGFR,< FRS2, FYN, Grb2, HCK, IGF1R, LCP2;, NCK1, PDGFRA, PIK3R1, PIK3R2, PLCG1, PTK2B, PTPN11, SH2B2, SH3KBP1 SHC1, ... is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ... is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. 257 (1): 129-38. doi:10.1006/bbrc ...
*  Tropomyosin receptor kinase A
The levels of distinct proteins can be regulated by the "ubiquitin/proteasome" system. In this system, a small (7-8 kd)protein ... Qian X, Riccio A, Zhang Y, Ginty DD (November 1998). "Identification and characterization of novel substrates of Trk receptors ... regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. ... Geetha T, Wooten MW (February 2003). "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve ...
*  PTPN12
"Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as ... role of PTP-PEST and adaptor proteins p130cas and Crk". Am. J. Physiol. Heart Circ. Physiol. United States. 285 (2): H710-21. ... This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein ... "Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as ...
*  EPS15
Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene. This gene encodes a ... "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins". J. Biol. Chem. 271 (24): 14468-72. ... a novel protein-protein interaction module". Genes Dev. 11 (17): 2239-49. doi:10.1101/gad.11.17.2239. PMC 275390 . PMID 9303539 ... The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is ...
*  RICS (gene)
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a ... RICS (gene) has been shown to interact with: BCAR1, CDC42, CRK, CRKL, FYN, GAB2, GRIN2B, NCK1, RAC1, RHOA, SHC3, Src, and TrkA ... a novel substrate that attenuates Rac signaling". Cell. Signal. 22 (11): 1626-33. doi:10.1016/j.cellsig.2010.06.001. PMID ... Rho GTPase-activating protein 32 is a protein that in humans is encoded by the RICS gene. RICS has two known isoforms, RICS ...
*  Short linear motif
Feller SM, Lewitzky M (2006). "Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk ... Stability - A subset of docking motifs recruit E3 ubiquitin ligase to their substrates. The resulting polyubiquitination ... are short stretches of protein sequence that mediate protein protein interaction. The first definition was given by Tim Hunt: " ... Linear motif mediated protein-protein interactions have shown promise in recent years as novel drug targets. Success stories ...
*  GAB2
... was initially discovered as a binding protein and substrate of protein tyrosine phosphatase Shp2/PTPN11. Two other groups ... domain that is contained in the adaptor protein families Crk, Grb2, and Nck. These adaptor proteins then couple to enzymes to ... CT10 regulator of kinase (Crk) is also known as the breast cancer anti-oestrogen resistance protein. It plays a role in both ... GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking ...